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Doctor insights on: Pemphigus In Children

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What is pemphigus?

What is pemphigus?

Blisters: This is a cruel disease in which the patient makes antibodies against a protein that holds the skin cells together. This is one of the most serious diseases in dermatology practice, and calls for a lasting relationship with one who you trust. Appearing suddenly, it may warn of a cancer deep in the body. Good luck. ...Read more

Dr. Lindsay Strowd
131 Doctors shared insights

Pemphigus (Definition)

A group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such ...Read more


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What causes pemphigus?

What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus. ...Read more

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Can pemphigus be hereditary?

Can pemphigus be hereditary?

Not really: Pv, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of pv might increase your risk. As of yet, no pv gene has been found that when mutated conveys the disease. ...Read more

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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist. ...Read more

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What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately. ...Read more

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What is the definition or description of: Pemphigus?

Pemphigus: Pemphigus = autoimmune disorder which causes blisters on skin & mucous membranes, often associated with burning & itching. ...Read more

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Is pemphigus curable?

Is pemphigus curable?

Not yet: There is not yet a cure for pemphigus vulgaris, but the condition is controllable with immunosuppressive treatment. The usual treatment is with corticosteroids, which are often started at high doses, together with immunosuppressive drugs (azathioprine, cyclophosphamide, cyclosporin, methotrexate, etc.). New medicines called biologics (such as rituximab) are being studied, for treating pemphigus. ...Read more

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What is the treatment for pemphigus?

What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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Can pemphigus be contagious?

Can pemphigus be contagious?

Pemphigus: Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem. ...Read more

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What is pemphigus vulgaris?

What is pemphigus vulgaris?

An immune skin Dx.: It is an autoimmune skin disease with many new treatment options. ...Read more

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What is the pemphigus vulgaris?

What is the pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes. The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Which foods are prohibited in pemphigus vulgaris?

None: Diet is not the key to managing pemphigus. It is difficult enough to have this without people telling what to eat or criticizing your food choices. ...Read more

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Is pemphigus associated with cancer?

Is pemphigus associated with cancer?

Cancer risks: There are three types of pemphigus, 1) vulgaris that affects oral and other mucous membranes as well as the skin, 2) foliaceus that usually effects skin only and 3) paraneoplastic pemphagus that occurs in association with cancer; typically a lymphoma. Not all lymphomas have pemphigus reactions and not all pemphigus has an associated cancer. ...Read more

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What is the cause of pemphigus vulgaris?

Unknown: P.V. Is an autoimmune disease in which antibodies have been formed to proteins that bind skin cells together. As a result, bonds between cells are easily disrupted; a clinical finding referred to a nikolsky's sign in which skin blisters can be created by rubbing the skin. P.V. Typically causes skin and mucous membrane sores. Treatment typically begins with oral steroids and other immunosuppresants. ...Read more

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What is the best medicine to treat pemphigus? Mestinon (pyridostigmine)?

What is the best medicine to treat pemphigus? Mestinon (pyridostigmine)?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

Pemphigus: Phemphigus vulgaris is a potentially fatal autoimmune mucocutaneous blistering disease. Conventional therapy consists of high-dose corticosteroids, imminosuppressove agents, and intravenous immune globulin. Studies show that the biologic Rituximab and intravenous Immune Globulin is very effective with refractory pemphigus vulgaris. Mestinon (pyridostigmine) is not as effective as rituximab. ...Read more

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What is the autoimmune disorder pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes. The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Pemphigus vulgaris. How do you protect your blistered skin?

Pemphigus vulgaris. How do you protect your blistered skin?

Pemphigus: The blistered skin can be protected from infection by careful attention to hygiene. Applying vaseline and covering the blisters with a bandage may also be helpful. ...Read more

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Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Cure - doubtful: Acupuncture may help to reduce pain associated with pemhigus vulgaris. Major energy moving treatments may help with skin health in general. However - acupuncture is not likely to cure this autoimmune disorder. ...Read more

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How long it is safe to give, low dose cyclophosphamide, in pemphigus?

How long it is safe to give, low dose cyclophosphamide, in pemphigus?

Indefinitely: With appropriate monitoring by a physician experienced in using this medication - as long as you need it. Is it working? That's the big question. ...Read more

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Can Pemphigus Vulgaris go away if its caused by taking to many medications/drug induced (clyndemycin, amoxcicillan, etc. A)?

It may: Pemphigus is rarely caused by medications but can go away once the medicine is stopped. Best that you see a Dermatologist. ...Read more

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Are there any natural or herbal remedies for pemphigus?

Are there any natural or herbal remedies for pemphigus?

None I know: Trouble with herbal remedies is no studies to show if effective or not. Notice how every bottle says "not to be used to treat or diagnose a medical problem" or something to that effect. This scares us;if we endorse this and you don't improve we have basically made you worse! ...Read more

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Can acupuncture treat pemphigus vulgaris?

Can acupuncture treat pemphigus vulgaris?

Energy Moving Tx: Although acupuncture will not cure pemphigus vulgaris; major energy moving treatments using meridians can benefit skin health overall & in that way are likely to be beneficial. ...Read more

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Which drugs and antibiotics are harmful in someone with pemphigus vulgaris?

None specifically: Pemphigus is a difficult illness but there are no medications that need to be avoided specifcially for other illnesses that you may have. ...Read more

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How long it is safe to give, low dose cyclophosphamide, in pemphigus foliaceus?

No firm rule.: Cyclophosphamide carries a risk of causing cancer. Bladder cancers and leukemia would be the most common. The risk is related to dose and duration of treatment. Case reports suggest treatment after 4-5 years may be more dangerous. If the drug is effective, the benefit may outweigh the risk, but concern should be raised if the tratment lasts more than 1-2 years. ...Read more

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Does ozone therapy help in treatment of pemphigus vulgaris?

Does ozone therapy help in treatment of pemphigus vulgaris?

Ozone: Ozone gas/oils topically in mouth may help healing. Ozone blood therapy may be part of the approach to help your immune system behave itself. To try to avoid drugs, you'd need an astute alt med doc / naturopathic doctor with great nutritional training and ozone training. Maybe someone like dr robert rowen. ...Read more

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Can homeopathy cure pemphigus vulgaris? Can any docs explain?

Can homeopathy cure pemphigus vulgaris? Can any docs explain?

Not known: There is no scientific proof that homeopathy works since the dose involved is usually in parts per billion or even non-existent. Pemphigus vulgaris is a serious condition and thus I would not recommend homeopathy for even a short period of time as a trial. ...Read more

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Can there be any treatment for the skin disease pemphigus vulgaris?

Can there be any treatment for the skin disease pemphigus vulgaris?

Treatment: Pemphigus is often treated with topical cortisone creams (for limited disease) or oral corticosteroids for more widespread disease. Oral antibiotics have also been used. See a dermatologist to diagnose and treat the condition. ...Read more