pemphigus

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Dr. Ed Friedlander answered:

What is pemphigus?

Blisters

Cancer
This is a cruel disease in which the patient makes antibodies against a protein that holds the skin cells together. This is one of the most serious diseases in dermatology practice, and calls for a lasting relationship with one who you trust. Appearing suddenly, it may warn of a cancer deep in the body. Good luck.
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Dr. Robert Kwok answered:

Is pemphigus curable?

Not yet

Open-uri20121011-17870-d7cv2s
There is not yet a cure for pemphigus vulgaris, but the condition is controllable with immunosuppressive treatment. The usual treatment is with corticosteroids, which are often started at high doses, together with immunosuppressive drugs (Azathioprine, Cyclophosphamide, Cyclosporin, Methotrexate, etc.). New medicines called biologics (such as Rituximab) are being studied, for treating pemphigus.
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What causes pemphigus?

Autoimmune antibody

Skin
A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus
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what is pemphigus vulgaris?

An immune skin Dx.

Sebum
It is an autoimmune skin disease with many new treatment options.
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Can pemphigus be contagious?

Pemphigus

Autoimmune_diseases
Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem.
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Can pemphigus be hereditary?

Not really

Dna
PV, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of PV might increase your risk. As of yet, no PV gene has been found that when mutated conveys the disease.
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Dr. Jack Mutnick answered:

What is the pemphigus vulgaris?

Pemphigus

Autoimmune
Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes.The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications,
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What are the tests for pemphigus?

Biopsy

Neck-throat
The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist.
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Is pemphigus associated with cancer?

Cancer risks

Cancer
There are three types of Pemphigus, 1) Vulgaris that affects oral and other mucous membranes as well as the skin, 2) foliaceus that usually effects skin only and 3) paraneoplastic pemphagus that occurs in association with cancer; typically a lymphoma. Not all lymphomas have pemphigus reactions and not all pemphigus has an associated cancer.
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What is the treatment for pemphigus?

No one best medicine

Prednisone
Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another.
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