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Doctor insights on: Pemphigus

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Dr. Lindsay Strowd
131 Doctors shared insights

Pemphigus (Overview)

A group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such as in the mouth.


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What causes pemphigus?

What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus. ...Read more

Dr. Lindsay Strowd
131 Doctors shared insights

Pemphigus (Overview)

A group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such as in the mouth.


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What are the most common symptoms of pemphigus?

What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately. ...Read more

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My cousin was diagnosed with pemphigus vulgaris. She is on steroid and imuran (azathioprine) therapy since last two years but not recovering completely. Please help.

My cousin was diagnosed with pemphigus vulgaris. She is on steroid and imuran (azathioprine) therapy since last two years but not recovering completely. Please help.

Tough one: You need an experienced dermatologist that deals with immune skin diseases and these are usually found in academic centers. If your friend lives close to a tertiary care referral hospital, I would look there. They know about all the new studies going on in the field and can try different treatment options. ...Read more

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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist. ...Read more

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What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

Pemphigus: Phemphigus vulgaris is a potentially fatal autoimmune mucocutaneous blistering disease. Conventional therapy consists of high-dose corticosteroids, imminosuppressove agents, and intravenous immune globulin. Studies show that the biologic Rituximab and intravenous Immune Globulin is very effective with refractory pemphigus vulgaris. Mestinon (pyridostigmine) is not as effective as rituximab. ...Read more

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I have pemphigus vulgaris and I am treating it with mycophenolate and prednisone. Currently, I have scabs on my scalp that apears to not heal. What is causing this not to heal? The prednisone?

Pemphigus: Your pemphigus condition could be causing sores/scabs in your scalp just as it could be causing other sores/scabs in other bodily areas. Follow-up with your dermatologist. Prednisone is anti-inflammatory and should generally help your pemphigus and not be causing spontaneous sores/scabs in your scalp. ...Read more

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What is the treatment for pemphigus?

What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Cure - doubtful: Acupuncture may help to reduce pain associated with pemhigus vulgaris. Major energy moving treatments may help with skin health in general. However - acupuncture is not likely to cure this autoimmune disorder. ...Read more

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Can pemphigus be hereditary?

Can pemphigus be hereditary?

Not really: Pv, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of pv might increase your risk. As of yet, no pv gene has been found that when mutated conveys the disease. ...Read more

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What is pemphigus?

Blisters: This is a cruel disease in which the patient makes antibodies against a protein that holds the skin cells together. This is one of the most serious diseases in dermatology practice, and calls for a lasting relationship with one who you trust. Appearing suddenly, it may warn of a cancer deep in the body. Good luck. ...Read more

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What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus. ...Read more

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Can pemphigus be hereditary?

Not really: Pv, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of pv might increase your risk. As of yet, no pv gene has been found that when mutated conveys the disease. ...Read more

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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist. ...Read more

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What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately. ...Read more

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What is the definition or description of: Pemphigus?

Pemphigus: Pemphigus = autoimmune disorder which causes blisters on skin & mucous membranes, often associated with burning & itching. ...Read more

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Is pemphigus curable?

Is pemphigus curable?

Not yet: There is not yet a cure for pemphigus vulgaris, but the condition is controllable with immunosuppressive treatment. The usual treatment is with corticosteroids, which are often started at high doses, together with immunosuppressive drugs (azathioprine, cyclophosphamide, cyclosporin, methotrexate, etc.). New medicines called biologics (such as rituximab) are being studied, for treating pemphigus. ...Read more

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Can pemphigus be contagious?

Can pemphigus be contagious?

Pemphigus: Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem. ...Read more

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What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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What is pemphigus vulgaris?

What is pemphigus vulgaris?

An immune skin Dx.: It is an autoimmune skin disease with many new treatment options. ...Read more

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What is the pemphigus vulgaris?

What is the pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes. The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Is pemphigus associated with cancer?

Is pemphigus associated with cancer?

Cancer risks: There are three types of pemphigus, 1) vulgaris that affects oral and other mucous membranes as well as the skin, 2) foliaceus that usually effects skin only and 3) paraneoplastic pemphagus that occurs in association with cancer; typically a lymphoma. Not all lymphomas have pemphigus reactions and not all pemphigus has an associated cancer. ...Read more

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What is the cause of pemphigus vulgaris?

Unknown: P.V. Is an autoimmune disease in which antibodies have been formed to proteins that bind skin cells together. As a result, bonds between cells are easily disrupted; a clinical finding referred to a nikolsky's sign in which skin blisters can be created by rubbing the skin. P.V. Typically causes skin and mucous membrane sores. Treatment typically begins with oral steroids and other immunosuppresants. ...Read more

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Which foods are prohibited in pemphigus vulgaris?

None: Diet is not the key to managing pemphigus. It is difficult enough to have this without people telling what to eat or criticizing your food choices. ...Read more

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What is the best medicine to treat pemphigus? Mestinon (pyridostigmine)?

What is the best medicine to treat pemphigus? Mestinon (pyridostigmine)?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

Pemphigus: Phemphigus vulgaris is a potentially fatal autoimmune mucocutaneous blistering disease. Conventional therapy consists of high-dose corticosteroids, imminosuppressove agents, and intravenous immune globulin. Studies show that the biologic Rituximab and intravenous Immune Globulin is very effective with refractory pemphigus vulgaris. Mestinon (pyridostigmine) is not as effective as rituximab. ...Read more

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What is the autoimmune disorder pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes. The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Pemphigus vulgaris. How do you protect your blistered skin?

Pemphigus vulgaris. How do you protect your blistered skin?

Pemphigus: The blistered skin can be protected from infection by careful attention to hygiene. Applying vaseline and covering the blisters with a bandage may also be helpful. ...Read more

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Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Cure - doubtful: Acupuncture may help to reduce pain associated with pemhigus vulgaris. Major energy moving treatments may help with skin health in general. However - acupuncture is not likely to cure this autoimmune disorder. ...Read more

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How long it is safe to give, low dose cyclophosphamide, in pemphigus?

How long it is safe to give, low dose cyclophosphamide, in pemphigus?

Indefinitely: With appropriate monitoring by a physician experienced in using this medication - as long as you need it. Is it working? That's the big question. ...Read more

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Can Pemphigus Vulgaris go away if its caused by taking to many medications/drug induced (clyndemycin, amoxcicillan, etc. A)?

It may: Pemphigus is rarely caused by medications but can go away once the medicine is stopped. Best that you see a Dermatologist. ...Read more