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Doctor insights on: Pemphigus

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Dr. Lindsay Strowd
131 Doctors shared insights

Pemphigus (Overview)

A group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such as in the mouth.


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What causes pemphigus?

What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus.

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Dr. Lindsay Strowd
131 Doctors shared insights

Pemphigus (Overview)

A group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such as in the mouth.


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What are the most common symptoms of pemphigus?

What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately.

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My cousin was diagnosed with pemphigus vulgaris. She is on steroid and imuran (azathioprine) therapy since last two years but not recovering completely. Please help.

My cousin was diagnosed with pemphigus vulgaris. She is on steroid and imuran (azathioprine) therapy since last two years but not recovering completely. Please help.

Tough one: You need an experienced dermatologist that deals with immune skin diseases and these are usually found in academic centers. If your friend lives close to a tertiary care referral hospital, I would look there. They know about all the new studies going on in the field and can try different treatment options.

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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist.

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What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

What is the best medicine to treat pemphigus. I have heard about mestinon (pyridostigmine) working?

Pemphigus: Phemphigus vulgaris is a potentially fatal autoimmune mucocutaneous blistering disease. Conventional therapy consists of high-dose corticosteroids, imminosuppressove agents, and intravenous immune globulin. Studies show that the biologic Rituximab and intravenous Immune Globulin is very effective with refractory pemphigus vulgaris. Mestinon (pyridostigmine) is not as effective as rituximab.

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I have pemphigus vulgaris and I am treating it with mycophenolate and prednisone. Currently, I have scabs on my scalp that apears to not heal. What is causing this not to heal? The prednisone?

Pemphigus: Your pemphigus condition could be causing sores/scabs in your scalp just as it could be causing other sores/scabs in other bodily areas. Follow-up with your dermatologist. Prednisone is anti-inflammatory and should generally help your pemphigus and not be causing spontaneous sores/scabs in your scalp.

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What is the treatment for pemphigus?

What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another.

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Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Can accupuncture cure pemphigus vulgaris? Need expert opinions!

Cure - doubtful: Acupuncture may help to reduce pain associated with pemhigus vulgaris. Major energy moving treatments may help with skin health in general. However - acupuncture is not likely to cure this autoimmune disorder.

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Can pemphigus be hereditary?

Can pemphigus be hereditary?

Not really: Pv, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of pv might increase your risk. As of yet, no pv gene has been found that when mutated conveys the disease.

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What is pemphigus?

Blisters: This is a cruel disease in which the patient makes antibodies against a protein that holds the skin cells together. This is one of the most serious diseases in dermatology practice, and calls for a lasting relationship with one who you trust. Appearing suddenly, it may warn of a cancer deep in the body. Good luck.

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What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus.

See 1 more doctor answer
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Can pemphigus be hereditary?

Not really: Pv, pemphigus vulgaris, is not thought to be a genetic disease. However, a family history of pv might increase your risk. As of yet, no pv gene has been found that when mutated conveys the disease.

See 1 more doctor answer
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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist.

See 1 more doctor answer
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What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately.

See 1 more doctor answer
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What is the definition or description of: Pemphigus?

Pemphigus: Pemphigus = autoimmune disorder which causes blisters on skin & mucous membranes, often associated with burning & itching.

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Is pemphigus curable?

Is pemphigus curable?

Not yet: There is not yet a cure for pemphigus vulgaris, but the condition is controllable with immunosuppressive treatment. The usual treatment is with corticosteroids, which are often started at high doses, together with immunosuppressive drugs (azathioprine, cyclophosphamide, cyclosporin, methotrexate, etc.). New medicines called biologics (such as rituximab) are being studied, for treating pemphigus.

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Can pemphigus be contagious?

Can pemphigus be contagious?

Pemphigus: Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem.

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What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another.

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What is pemphigus vulgaris?

What is pemphigus vulgaris?

An immune skin Dx.: It is an autoimmune skin disease with many new treatment options.

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What is the pemphigus vulgaris?

What is the pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes. The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, .