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Doctor insights on: Pedigree Autosomal Recessive

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Can a pedigree trace autosomal recessive or autosomal dominant diseases?

Can a pedigree trace autosomal recessive or autosomal dominant diseases?

Sort of: Animals that are "bred" have pedigrees -- whether the term "family history" is more appropriate for people is one question. You'll see these all the time in genetics journals. Best wishes. ...Read more

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What is the difference between autosomal recessive and dominant?

What is the difference between autosomal recessive and dominant?

Gene effect: In dominant disorders, the dominant member of the gene pair controls how the gene activities are expressed, so the other gene can carry the same or normal information.In recessive disorders, the normal gene compensates for the bad information in the other gene, allowing a person to function normally unless both genes carry the bad information. ...Read more

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Is a child with a autosomal recessive disease for sure going to be bad off?

Is a child with a autosomal recessive disease for sure going to be bad off?

Depends on the dz: This all depends on which disease the child has. Some autosomal recessive diseases can be relatively innocuous (e.g., mcardle's syndrome), whereas others can be quite serious (e.g., cystic fibrosis). The classification of "autosomal recessive" describes how the disease is inherited; it does not define the characteristics of the disease itself. ...Read more

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Celiac autosomal recessive?

Celiac autosomal recessive?

Possibly: There are several gene-markers which make a person more likely but not certainly to develop celiac disease. It is certainly not sex-linked. Perhaps there are still other genetic markers or mutations required for one to develop the full-blown disease. ...Read more

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What happens if a pedigree shows x linked recessive inheritance does it also show autosomal recessive inheritance?

What happens if a pedigree shows x linked recessive inheritance does it also show autosomal recessive inheritance?

No: X-linked recessive inheritance involves asymptomatic females passing a condition to their sons. An example is hemophilia A and B. Usually only males are affected. Autosomal recessive inheritance affects both sexes equally. Two asymptomatic parents can pass a condition to their children 25% of the time on average. ...Read more

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How is autosomal recessive inheritance different?

How is autosomal recessive inheritance different?

Both parents: Autosomal recessive inheritance means that you have to inherit the gene from both parents. Some examples: cystic fibrosis, sickle cell disease. ...Read more

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How can I calculate carrier frequency of autosomal recessive conditions?

How can I calculate carrier frequency of autosomal recessive conditions?

Depends of the gene.: Different genes have different carrier frequency rates. This site refers to the Hardy Weinberg equation. But more information is needed in order to complete the calculation. http://www.perinatology.com/calculators/Hardy-Weinberg.htm ...Read more