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Doctor insights on: Paxil Serotonin Reuptake Blocker

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I was wondering does the antidepressant Effexor (venlafaxine) have a stronger serotonin reuptake blocker than paxil?

I was wondering does the antidepressant Effexor (venlafaxine) have a stronger serotonin reuptake blocker than paxil?

It is different: Paxil is only an SSRI . Effexor (venlafaxine) works on two receptor sites. They work in different ways and it depends on what helps more. They both work on serotonin but it is hard to compare strength. ...Read more

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Dr. Krishna Kumar
595 doctors shared insights

Paroxetine (Definition)

Brand name paxil, (paroxetine) it's an ssri used for treating depression, anxiety, ocd, and several other conditions. It ...Read more


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Take both gabapentin and Paxil (paroxetine) at what doses should I be concerned about serotonin syndrome developing.

Take both gabapentin and Paxil (paroxetine) at what doses should I be concerned about serotonin syndrome developing.

Talk with your doc: In general, a low dose of both should be safe. Low dose paxil (paroxetine) is 20-40 mg. Gabapentin dosing ranges from 300 mg to 2400 mg daily for some patients. Make sure your doc knows that you are on both meds, and that you are tapering up slowly. If you have been on a stable dose for a while, and are feeling well, you should be fine. Make sure to contact your doc if you have symptoms or start new meds. ...Read more

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What can I take for a cold while on Effexor (venlafaxine) and Paxil? I see information about some medicines causing Serotonin Syndrome when taken with SSRIs.

What can I take for a cold while on Effexor (venlafaxine) and Paxil?  I see information about some medicines causing Serotonin Syndrome when taken with SSRIs.

Avoid some mixtures: OTC cold remedies that contain dextromethorphan are ones to avoid due to the serotonin syndrome threat. There are many you can choose and your pharmacist can guide you. I hope you feel better real soon! ...Read more

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I had serotonin syndrome after being given zyvox while on 40 mg of Paxil (paroxetine) six years ago. What are long term effects? I still do not feel like myself.

I had serotonin syndrome after being given zyvox while on 40 mg of Paxil (paroxetine) six years ago.  What are long term effects?  I still do not feel like myself.

Well: I am not aware of any long term affects from seratonin syndrome. As a result, however, you probably got off all the meds that could help. Not feeling well may be related to undertreated anxiety but not due to brain damage from seratonin syndrome. Sleeping well? Panic attacks, sad? Low energy? It could be the same issues for which u were taking the meds 6 years ago. Good luc but care if not get. ...Read more

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Is it dangerous to take Zoloft 45 and Paxil (paroxetine) 20 if I half them and take it together to transition? Dr didn't tell me anything about serotonin syndrome.

Is it dangerous to take Zoloft 45 and Paxil (paroxetine) 20 if I half them and take it together to transition? Dr didn't tell me anything about serotonin syndrome.

Long half-life.: Both of these medications have a very long half-life so they will be in your body even if you stop them abruptly. Also, meds take ~4.5 half-lives (with regular dosing) before they are "steady state" effective (it depends on the exact drug & its "kinetics"). Less than 0.1% get serotonin syndrome (hard to say who). No prob stopping 1 SSRI & starting the other. Follow-up with your doctor/psychiatrist ...Read more

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In essential thrombocytosis does the serotonin given off have an effect on depression? Also is it safe to take paxil, (paroxetine) wellbutrin, Ambien with et ?

In essential thrombocytosis does the serotonin given off have an effect on depression? Also is it safe to take paxil, (paroxetine) wellbutrin, Ambien with et ?

ET and depression: Et is not a contraindication to take anti depression medication . If your doctor thinks that you should be on ssri , from et-perspective , you should be fine it is not clear to me, however your statement regarding the serotonin and et . There is no relationship between et and serotonin. If your serum serotonin is elevated , your md should do a bit w/u to find out the cause of the elevation. ...Read more

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Take Paxil (paroxetine) & zyprexa combo for mdd. (stil depressed) was put on Adderall for my add now as well. Am i at risk for serotonin syndrome? Is it common?

Risk is very slight: To put this in perspective for you, I have been practicing psychiatry about 30 years now and I have only seen two cases of serotonin syndrome. Your risk is higher given the combination of medications that you are on put your overall risk is very low. I recommend that you read the entire article that is in the link below. www.ncbi.nlm.nih.gov/pubmedhealth/pmh0004531 best wishes and i really wouldn't lose any sleep worrying about this. ...Read more

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What is the best way to avoid serotonin syndrome while changing from paroxetine cr to duloxetine? My doc is having trouble finding this info.

What is the best way to avoid serotonin syndrome while changing from paroxetine cr to duloxetine? My doc is having trouble finding this info.

A FEW COMMENTS: Seratonin syndrome in my experience is quite rare, and seems to be due to higher doses of meds which affect neurotransmitters. There is no real magic number, and the process is influenced by biological variation and metabolism. But, clearly, if you slowly drop the paroxetine dosage, and initiate the duloxetine at a very low dosage, you can taper off one, and slowly advance the other without risk ...Read more

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Currently taking 10mg Buspar (buspirone) twice daily along with Paxil 10 mg. Is it safe to add 10 mg of adderall to that? Concerned about seratonin syndrome.

Currently taking 10mg Buspar (buspirone) twice daily along with Paxil 10 mg. Is it safe to add 10 mg of adderall to that? Concerned about seratonin syndrome.

Caution: You're right be concerned with this med combination. Buspar (buspirone) with Paxil increases risk of serotonin syndrome. Adderall with Paxil increases risk of Adderall side effects and serotonin syndrome. Please review these medications with prescribing doctor. ...Read more

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Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


Paxil (Definition)

Paroxetine is a serotonin reuptake blocker which is a kind of ...Read more