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Doctor insights on: Paxil And Wellbutrin

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What's the differentiating side effects between Paxil and Wellbutrin?

What's the differentiating side effects between Paxil and Wellbutrin?

Serotonin vs dopamin: Paxil, a serotonin med, will have more GI side effects- nausea, cramping, Bowel changes, since it has a short half life, if not taken regularly some ppl report 'withdrawals' that feel like electric impulses on the nerves. Wellbutrin, a dopamine med, will have more central/autonomic nervous system SE like headaches, bp changes, insomnia, moodiness. ...Read more

Dr. Alan Ali
792 Doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Unable to take anti-dep due to extreme sleepiness or fatigue (zoloft, paxil, (paroxetine) wellbutrin, etc.). Is this a common occurence or am I an exception?

Unable to take anti-dep due to extreme sleepiness or fatigue (zoloft, paxil, (paroxetine) wellbutrin, etc.). Is this a common occurence or am I an exception?

Depression: Some people do not do well on anti-depressants. Consult with a clinical psychologist as you may do much better if your are in psychotherapy than simply taking meds. Also my workbook on depression is featured on the soundmindz. Org web site along with updated articles on depression treatment. Best wishes. ...Read more

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In essential thrombocytosis does the serotonin given off have an effect on depression? Also is it safe to take paxil, (paroxetine) wellbutrin, Ambien with et?

In essential thrombocytosis does the serotonin given off have an effect on depression? Also is it safe to take paxil, (paroxetine) wellbutrin, Ambien with et?

ET and depression: Et is not a contraindication to take anti depression medication. If your doctor thinks that you should be on ssri, from et-perspective, you should be fine it is not clear to me, however your statement regarding the serotonin and et. There is no relationship between et and serotonin. If your serum serotonin is elevated, your md should do a bit w/u to find out the cause of the elevation. ...Read more

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What's the best way to loose weight while on Paxil (paroxetine) and wellbutrin?

The same way: As you would if you were not on them. Eating sensibly, sleeping well and getting daily exercise. ...Read more

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Hello, is it true that the effect of Paxil (paroxetine) and wellbutrin both become less or insignificant by the time (work to limit time then not working in body).

It can happen with: Any antidepressant. We do not know why this happens. We also unfortunately do not have any comparative data on the antidepressants in this regard. Clinically I would say that I have seen Prozac last the longest without requiring change (unpublished data from my practice). We have two year data on Paxil (paroxetine) in this regard. When it happens, we augment or switch. Godt nytt år! ...Read more

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If you have broken sleep can you feel chronic dizzy/balance? Does Paxil (paroxetine) or wellbutrin help insomnia anxiety depression?

If you have broken sleep can you feel chronic dizzy/balance? Does Paxil (paroxetine) or wellbutrin help insomnia anxiety depression?

Anxiety/ depression: Paxil (paroxetine) (SSRI) may help with anxiety/ depression and as a result may also improve insomnia. Wellbutrin is not used for insomnia. It is used to treat atypical depression. Although it is not FDA approved for anxiety - recently it is is coming to light that it may help to reduce some anxious sxs. ...Read more

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Psychiatrist put me on [paxil cr 12.5, wellbutrin (bupropion) 150, clomipramine 50mg, laxoberon] all od. My anxiety attacks gettin worse. Any advise to stop panic plz?

Psychiatrist put me on [paxil cr 12.5, wellbutrin (bupropion) 150, clomipramine 50mg, laxoberon] all od. My anxiety attacks gettin worse. Any advise to stop panic plz?

Unusual combination: Wellbutrin is unlikely to help anxiety at all. Either Paxil (paroxetine) (p) or clomipramine (c) would be sufficient for anxiety disorder, but usually at significantly higher doses. If both are continued as doses are raised, there is increased risk of serotonin syndrome and and of side-effects from just c, as p tends to raise levels of c. Laxoberon for constipation. Talk to your doc about this. Hope this helps. ...Read more

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Which is better for borderline personality disorder n mood swings? Prozac, topamax, paxil, effexor, (venlafaxine) lexaproor wellbutrin?

Which is better for borderline personality disorder n mood swings? Prozac, topamax, paxil, effexor, (venlafaxine) lexaproor wellbutrin?

Depends: Any of those drugs may be useful under certain circumstances. It's important to recognize the drug is an adjunct to the primary treatment, which is long term psychotherapy. ...Read more

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Can paxil be taken if on wellbutrin and nortriptyline also?

Can paxil be taken if on wellbutrin and nortriptyline also?

Caution is advised: They can be taken together although caution is advised. Follow up with your prescribing physician if you experience any side-effects (falls, weakness or any other unusual symptoms). ...Read more

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Have tried pristiq, (desvenlafaxine) wellbutrin, paxil, celexa, effexor, lexapro, etc. With lithium, haliperidol &abilify. A couple improve mood. Still anxious! Thoughts?

Have tried pristiq, (desvenlafaxine) wellbutrin, paxil, celexa, effexor, lexapro, etc. With lithium, haliperidol &abilify. A couple improve mood. Still anxious! Thoughts?

Many meds: You've tried many meds already, although there are some you haven't mentioned that often help anxiety: buspirone, beta-blockers, other mood stabilizers besides lithium, etc. But after a person has tried so many medications and still has symptoms, i'd suggest non-medication approaches: psychotherapy, mindfulness, relaxation training, exercise/yoga, etc. ...Read more

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My doc gave me Buspar (buspirone) since 2 months now and it's not working. Also proved antidepressants like zoloft, efexor, cymbalta, prozac, wellbutrin, paxil?

My doc gave me Buspar (buspirone) since 2 months now and it's not working. Also proved antidepressants like zoloft, efexor, cymbalta, prozac, wellbutrin, paxil?

Antidepressants: What is your question, it is confusing. Have you been all the antidepressants you mentioned or would like to try. You should consult your psychiatrist and discuss your concern. ...Read more

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10mg paxil (paroxetine). Pdoc wants me to switch to wellbutrin by starting at 75mg and taking 10mg Paxil (paroxetine) for 5 days then stop paxil (paroxetine). Need for Paxil (paroxetine) ween?

See a psychiatrist: I can only guess your medication is for depression. First of all I am clueless as to why your dose of Remeron is so low and every other night. Secondly I don't understand why you were coming off of just 10 mg of Paxil (paroxetine) which is rarely therapeutic. Thirdly, 75 mg of wellbutrin is too low as a starting dose. Find yourself a psychiatrist who will dose your meds properly with full remission from the depression as a goal. This will generally take 300 mg a day of wellbutrin. You can taper the Paxil (paroxetine) to 5 mg down from 10 and then stop it if you wish. That may help make any potential withdrawal more tolerable. Best wishes. ...Read more

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I have to cold turkey wellbutrin and Paxil (paroxetine) because I can't afford them anymore, is this going to hurt me? I'm already having zaps...

I have to cold turkey wellbutrin and Paxil (paroxetine) because I can't afford them anymore, is this going to hurt me? I'm already having zaps...

Won't damage you...: But if you are already having "zaps" or discontinuation symptoms, don't cold turkey" it. Generic Paxil (paroxetine) is on the 4 $ list of meds at target ; walmart. So you can get 30 tabs of either the 10 or the 20 mg dose for 4 bucks, or a 90 day supply for just $10. There are also other ways to get low cost meds if you do an internet search. Stopping wellbutrin (bupropion) is not usually a problem, Paxil is. ...Read more

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I take PAXIL (paroxetine) CR 37.5 MG DAILY FROM THE LAST 5 YEARS I WANT TO SWITCH TO WELLBUTRIN SR BT HOW MUCH IS ALL I WANT TO KNW? ANY OTHER ADVICE THANK U :)

I take PAXIL (paroxetine) CR 37.5 MG DAILY FROM THE LAST 5 YEARS I WANT TO SWITCH TO WELLBUTRIN SR BT HOW MUCH IS ALL I WANT TO KNW? ANY OTHER ADVICE THANK U :)

Need physician.: Paxil (paroxetine) has to be taper down gradually first. And u have to discuss with your psychiatrist about side effect and benefit of wellbutrin first. It's not what is equivalent dose but most important is how much you needs it and why you needs it. It is not wise to change without physician guidance. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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What do abilify, (aripiprazole) wellbutrin and Paxil do?

Dr. Alan Ali Dr. Ali
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Combo: Together they treat depression which was not sufficiently managed with one antidepressant. ...Read more

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If im taking paxil (paroxetine) 30mg at what dose of wellbutrin to reverse sexual side effect?

ED / R/O. LOW T: Paxil (paroxetine) at does above 20mg may decreSe libido. You should get a full exam and lab check, especially free and total testosterone, you may be going through male menopause (ANDROPAUSE). If it is due to the Paxil (paroxetine) you can taper down or transistion to CYMBALTA which has less side effects. Also I recommend the Anxiety& Phobia Workbook for great overview of treatment strategies. ...Read more

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What to do if I developed a tolerance to Paxil (paroxetine) and the doctor changed me to wellbutrin.?

Follow your doctor: Your physician had a reason for recommending the change. Ask him/her for the reason, try the wellbutrin (bupropion) and if it doesn't help in a couple of weeks, ask to try something else. ...Read more

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Haw adding wellbutrin to paxil (paroxetine) well help sexual side effect what well do well help The body or The brain explain for me pleas?

Haw adding wellbutrin to paxil (paroxetine) well help sexual side effect what well do well help The body or The brain explain for me pleas?

Helps the biology: Sexual problems often occur with conditions for which paroxetene (Paxil) is prescribed. But they are not uncommon as side effects. In that case, they are a result of the bological action on the brain of paroxetene. Buproprion (Wellbutrin) has biologic effects on the brain which can reverse those particular effects of paroxetene. ...Read more

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I increased my wellbutrin from 75 to 150mg and lowered my Paxil (paroxetine) from 20 to 15mg. I don't feel like my sleep is restful anymore and I'm exhausted?

I increased my wellbutrin from 75 to 150mg and lowered my Paxil (paroxetine) from 20 to 15mg. I don't feel like my sleep is restful anymore and I'm exhausted?

Dose timing: I agree with dr. Maes about making medication changes along with your physician, rather than all alone. What time are you taking your wellbutrin (bupropion)? It can be activating, and could disrupt your sleep if taken at bedtime. Please discuss any changes you want to make with your doctor -- s/he's there to be on your healing team with you. ...Read more

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Been on Paxil (paroxetine), mirtazipine, and zyprexa for yrs but. Recently feeling very depressed. Dr added wellbutrin, will this be helpful?

Wellbutrin (bupropion) for mood: I'm sorry to hear you've been struggling more with depression. It's great that you've already let your doc know that your condition has changed. Wellbutrin (bupropion) is an antidepressant that works primarily on a neurotransmitter that isn't the main target of your other meds -- so it is a logical choice and I'm hopeful it helps! Most importantly, keep working with your doc until you do improve :) ...Read more

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Wellbutrin xl does not seem to be helping like I thought it would for depression, I'm already on Paxil, (paroxetine) what's a good antidepressant I can add to paxi?

Wellbutrin xl does not seem to be helping like I thought it would for depression, I'm already on Paxil, (paroxetine) what's a good antidepressant I can add to paxi?

We're not allowed: To recommend drugs on this forum, but there are drugs that "enhance" the effects of anti-depressants. See your MD for a list, because s/he will know more about what your specific medical picture looks like and can avoid trouble by just picking one or the others. ...Read more

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Hello, my doctor would like to add another medication to Paxil which I use for (gad), he suggested Buspar (buspirone) or wellbutrin, which combo is better?

Hello, my doctor would like to add another medication to Paxil which I use for (gad), he suggested Buspar (buspirone) or wellbutrin, which combo is better?

For GAD, BuSpar (buspirone): Buspar (buspirone) works on its own in gad. If you do not have depression, then you may be able to come off the Paxil and just use the Buspar (buspirone) for gad. I always dose this conservatively: Buspar (buspirone) 5mg twice a day for one week, the 10mg twice a day for one week then 15 mg twice a day after that. I hope you feel better soon. Håper du vil føle deg bedre! (i love your city. My relatives came from south of oslo.). ...Read more

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Which is better for borderline personality disorder, prozac, Paxil cr, Effexor (venlafaxine) XR or wellbutrin?

Which is better for borderline personality disorder, prozac, Paxil cr, Effexor (venlafaxine) XR or wellbutrin?

No specific med: There is no specific medication approved to treat borderline personality disorder and there is no specific medication that is considered better than others off-label either. It is a question of working with your doctor to treat your symptoms and figuring what works best for you. Sorry, I wish I had an easier answer for you-- good luck! ...Read more

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I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could I try? How do u feel about paxil?

I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could I try? How do u feel about paxil?

Agree w/Dr. Buggie: I agree with dr. Buggie about the need for psychiatric evaluation and ongoing treatment. Wellbutrin does not help with anxiety. Paxil (paroxetine) is a reasonable choice, but whether it's right for you I cannot say. You're also on Adderall xr, which can exacerbate anxiety in some. Psychotherapy is an important part of treatment for anxiety also -- but you didn't mention pursuing that. ...Read more

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Witch is work better Ta add to paxil for low energy low sex drive wellbutrin or buspar (buspirone)? I tried many antidepressants but not work!!

Witch is work better Ta add to paxil for low energy low sex drive wellbutrin or buspar (buspirone)? I tried many antidepressants but not work!!

Wellbutrin (bupropion): Of the SSRIs, paxil may be the most likely to affect energy and sex drive. Changing to a different SSRI may be the first option. Both wellbutrin and buspar (buspirone) may help with the sexual side effects of an SSRI, but between the two, wellbutrin has more evidence and may also be more activating. Would caution if anxiety is high, regular alcohol use, or any concerns for seizures. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Is it ok to take Paxil (paroxetine) and welbutrin together?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
Is it ok to take Paxil (paroxetine) and welbutrin together?

Paxil (paroxetine): They are both antidepressants belonging to different group. Sometimes wellbutrin is added to Paxil (paroxetine) to boost action, with wellbutrin given in daytime for its activating effect, and Paxil (paroxetine) in evening for its sedating effect. ...Read more

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On bupropion XL 150mg couple months gained weight, was on Paxil50mg too but recently switched from Paxil to 60mgProzac, possibly gained from bupropion?

On bupropion XL 150mg couple months gained weight, was on Paxil50mg too but recently switched from Paxil to 60mgProzac, possibly gained from bupropion?

Bupropion wt gain?: Bupropion is an antidepressant not likely to cause weight gain vs. SSRI's (eg. Prozac and Paxil). That said, weight gain is reported as an uncommon side effect of bupropion. If weight gain continues on Prozac, would consider Effexor. Discuss with prescribing doctor. Meantime, eat healthy foods, exercise regularly and keep track of your weight. I hope this helps. Best wishes. ...Read more

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Which is best? Paxil, (paroxetine) olanzapine, bupropion, or oxcarbazepine?

Agree w Dr. Ali: Which is best for treating which condition? . Paxil is an SSRI antidepressant which is good for treatment of typical depressive sx 's & anxiety. Bupropion is a unique antidepressant which is good for seasonal affective disorder, atypical depression & smoking cessation. Oxcarbazepine is a mood stabilizer and olanzapine is an antipsychotic. You are asking us to compare apples & organges. ...Read more

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Is there an OCD or anti anxiety med that will not put me to sleep so much? I tryed paxil, (paroxetine) wellbutin, elavil, but could not stay awake. Knocks me out.

Is there an OCD or anti anxiety med that will not put me to sleep so much? I tryed paxil, (paroxetine) wellbutin, elavil, but could not stay awake. Knocks me out.

Try few others: Surprisingly, medicine within same class may have totally difference side effects. Elavil is highly sedating to many. You may try cymbalta, (duloxetine) prestiq or luvox. You many have luck with another ssris, such as Lexapro or prozac. ...Read more

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I take these: valsartan (320 mg), amlodipine (10 mg), seroquel (100 mg), concerta (54 mg), depakote (500 mg), paxil (40mg), bupropion (300mg), and Nexium (esomeprazole) (40 mg). Can this combo cause severe low bp? Help.

I take these: valsartan (320 mg), amlodipine (10 mg), seroquel (100 mg), concerta (54 mg), depakote (500 mg), paxil (40mg), bupropion (300mg), and Nexium (esomeprazole) (40 mg). Can this combo cause severe low bp? Help.

Potentially yes: If you are getting lightheaded or dizzy from this combination you should contact your prescribing physicians or go to the er to have your medication adjusted so that you do not pass out. Stay well hydrated. It is possible for these medications to lower your blood pressure. ...Read more

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What distinguishes Paxil (paroxetine) from Paxil (paroxetine) cr?

Paxil (paroxetine) vs CR: Paxil (paroxetine) cr is a long acting formulation of paxil (paroxetine). ...Read more

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Can you take Claritin with Paxil?

Can you take Claritin with Paxil?

Should be ok if...: If a person had no problems taking paroxetine (Paxil) in the past for some medical condition, and separately had no problem taking loratadine (Claritin) or Clarinex in the past, then she should be ok taking the medications at the same time. If worried, she can ask her doctor who prescribed the Paxil. ...Read more

Dr. Alan Ali Dr. Ali
4 doctors agreed:
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Can pregnant women take Paxil (paroxetine)?

Dr. Alan Ali Dr. Ali
4 doctors agreed:

Paxil (paroxetine): Being Category D pregnancy drug, it is not recommended. ...Read more

Dr. Krishna Kumar
619 Doctors shared insights

Paroxetine (Definition)

Brand name paxil, (paroxetine) it's an ssri used for treating depression, anxiety, ocd, and several other conditions. It ...Read more


Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more