Doctor insights on:
Patient Hemolytic Anemia Injected Gadolinium
IgM antibodies,,,: These are known as cold agglutinins because they agglutinate or act at colder temperatures than IgG or "warm" agglutinins. That is, they act or agglutinate at colder than body temperature or 28-31 deg Centigrade. This is mostly due to idiopathic or unknown cause, lymphoma type disease or infection. The result is hemolysis of the red cells and anemia with its symptoms. They're IgM antibodies. ...Read more
Can zinadol (cefuroxime) induce hemolytic anemia to g6pd patients? There is a risk of hemolysis with cephalosporins, is it greater for g6pd patients?
Not likely a risk: The list of antibiotics to avoid in patients with G6PD deficiency include nitrofurans, sulfonamides and quinones (and chloramphenicol). Some of these are considered to be safe at usual doses for class II and III disease. Cephalosporins should not contribute to hemolysis. ...Read more
RBC breakdown: Hemolytic anemia is where red blood cells are destroyed too quickly. There are many possibilities that would cause this rbc breakdown. Antibodies, abnormal rbc membranes (spherocytosis), abnormal hemoglobins (sickle cell, thalassemia), abnormal rbc enzymes. If hemolytic anemia is is suspected, many tests may be ordered to determine the cause. ...Read more
Cause of hemolysis: Once hemolysis is thought to be occurring, the cause is saught. The causes are many. Some are inherent to the red blood cell (sickle cell, spherocytosis, thalassemia, g6pd deficiency). Some are from antibodies. Some are from other causes of destruction within the blood vessels (mechanical heart valves, hemolytic uremic syndrome). This work up is quite involved. ...Read more
Autoimmune reaction: Cephalosporins interact with red blood cell membranes. The body can sometimes produce antibodies against cephalosporins that also interact with the surface of red blood cells. These antibodies thus activate the body's immune system to attack its own red blood cells, causing hemolytic anemia. This is a rare but severe side effect of cephalosporins. ...Read more
Possibly: Hemolytic anemia may have numerous causes including toxins, infections, genetic diseases, autoimmune diseases, drugs, certain types of food, etc. So theoretically if you know what the cause is then it can be avoided. Therefore an adequate diagnostic workup by your doctor is necessary. ...Read more
Stopping dapsone: The best way to treat Dapsone related anemia is by discontinuing dapsone. Dapsone causes hemolytic anemia which is dose-dependent and can be stopped only with discontinuing the drug. Usual practice is to use the lowest possible doses of Dapsone and support with vitamin E and folic acid. ...Read more
Find the cause: You have to find the cause of why the red blood cells are being destroyed (hemolysed) then target it; certains cause of hemolysis are medication, heredity, malignancy, infection, enlarged slpeen etc... ...Read more
No: The oxygen carrying capacity of your blood, which is what anemia affects, does not affect fertility. However, depending upon how profound your anemia, it may make the pregnancy very difficult and risky. I would definitely correct the anemia before conception and remain in the care of your hematologist to maintain normal hemoglobin levels throughout your pregnancy. ...Read more
? necessary: Is it any of their business? If trying to explain it, suggest it is a breakup of blood cells in the blood stream. ...Read more
Haemoglobin is not found in the urine of a healthy person but is in a person with hemolytic anemia, is this true?
It's not so simple: Everyone has a little bit of blood in the urine. A runner usually has mild hematuria from the mechanics of running with a full bladder. Further, someone who has hemolysis that's not intravascular (i.e., autoimmune hemolysis, spherocytosis) won't spill hemoglobin, and somone with mild ongoing hemolysis (sickle cell) with enough haptoglobin to trap the hemoglobin won't spill it either. ...Read more
People with thalassemia or hemolytic anemia, why they present usually with hemoglobinuria? Inspite they have reduced rbcs!
Hemoglobinuria....: Is simply the presence of hemoglobin in the urine, and can be seen in any condition that results in intravascular hemolysis. It is not a specific finding. Indeed it can be seen in thalassemias, where red cells are more prone to oxidant stress and mechanical disruption. There many intrinsic and extrinsic reasons for hemolysis to occur. Hope this helps. ...Read more
Yes: Hemolytic anemia can be due to multiple causes such as medications, infections, cancers, autoimmune disorders, etc. Depending on the cause treatments can be done such as stopping causative drugs, treating infections or cancers, starting folic acid, sometimes transfusing blood, etc. ...Read more
Varies: Some people may be asymptomatic, others may have weakness, fatigue, fast heart rate, tire easily with exercise, shortness of breath with exercise, etc. Any form of anemia has to be diagnosed by a physician who will take a blood sample and run lab work. Once the cause of the anemia is properly diagnosed, it can be treated and the symptoms alleviated. ...Read more
Varies: Inherited hemolytic anemias such as sickle cell, thalassemias can run in families and are more common in african americans, hispanics, Asian indians for example. Acquired hemolytic anemias can be associated with blood cancer patients, patients with autoimmune disorders, infections (hiv, hepatitis), etc. ...Read more
Depends: There are basically two type of hemolytic anemia - congenital (your born with it) or acquired (you get it all of a sudden). Many acquired hemolytic anemias will run there course. The congenital hemolytic anemias will likely require some treatment and may never go away completely. ...Read more
No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more
Yes: You have to figure out why you are bleeding into your stomach and if there are any other places where you are bleeding and why and if you are making sufficient replacement blood and if not why not. This can be orchestrated, at least at first by your doc, and if things get really messy by a hematologist. Good luck! ...Read more
Uncommon.: This would be very uncommon. But it can happen. Definitely take the prescribed medicine and follow up with your doctor regularly. ...Read more