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Doctor insights on: Pathophysiology Of Systemic Lupus Erythematosus

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Systemic lupus erythematosus--what is sle?

Systemic lupus erythematosus--what is sle?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

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Systemic (Definition)

A condition that involves the whole body as compared to a part of the body. For example diabetes ...Read more


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Is systemic lupus erythematosus fatal?

Sometimes.: Sle is generally treated with good response, but unfortunately it is sometimes fatal. ...Read more

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What is trigger systemic lupus erythematosus in antiquity?

Mysterious lupus: It is not known what causes lupus erythematosus. Referring to antiquity, lupus was used to describe several different rashes. It could be autoimmune, where the body attacks itself such as lupus erythematosus or discoid lupus. It could be caused by tuberculosis infection such as lupus vulgaris. It could be related to another inflammatory disease such as sarcoidosis which causes lupus pernio. ...Read more

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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What are the symptoms of systemic lupus erythematosus?

What are the symptoms of systemic lupus erythematosus?

Many: People with lupus may have joint pain, skin rashes, chest pain, heart probelms, hair loss, fingers changing color in the cold, rash in the sunshine, neuro-psychologic problems. These are only soemof the symtpoms peopel can have. They can also have none of these. Your physician will evaluate all of these, get labs tests and imaging. ...Read more

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How are systemic lupus erythematosus, coma & leukopenia related?

How are systemic lupus erythematosus, coma & leukopenia related?

SLE: Is a systemic disease and is a form of vascullitis, which means that there is inflammation in the blood vessels as a result it is a multi-system disease and can affect any organ in the body. When the brain is affected it can lead to changes in mood, psychosis and even coma. Leukopenia is a recognized feature of SLE at some point in the course of the disease. It can affect the kidneys, joints etc ...Read more

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Is systemic lupus erythematosus a kind of cancer?

Is systemic lupus erythematosus a kind of cancer?

No : It is an autoimmune disorder that can affect multiple organs. It is not cancer. ...Read more

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Is lupus erythematosus infectious?

No: Is a immune based disease does not recognize self and attacks multiple organs. ...Read more

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What gene causes lupus erythematosus?

What gene causes lupus erythematosus?

Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read more

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Whats death rate related to systemic lupus erythematosis?

Whats death rate related to systemic lupus erythematosis?

Less now: In the 1950s, 60% of lupus patients died within five years. Now, more than 90% survive beyond five years. Many lupus patients have non-life threatening disease. Kidney or brain involvement portends a worse prognosis. ...Read more

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What is 'systemic lupus erythematosus' in clear tems?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

See 1 more doctor answer
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Is systemic lupus erythematous contagious?

Is  systemic lupus erythematous contagious?

No: It is an autoimmune disease in which your body produces antibodies against your own body cells leading to organ damages if left untreated. It is not contagious. ...Read more

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Why is the butterfly rash in systemic lupus erythematosus?

Why is the butterfly rash in systemic lupus erythematosus?

Thin skin: Thin area around the nose/cheeks is very sensitive to sun and the first to show sle signs. ...Read more

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What are the tests for systemic lupus erythematosus?

What are the tests for systemic lupus erythematosus?

Positive ANA and...: Positive ANA and a positive double stranded dna antibody titer of significance. This coupled with clinical criteria is the least required for diagnosis. ...Read more

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What is treatment for systemic lupus erythematosus?

What is treatment for systemic lupus erythematosus?

S L E : Systemic lupus erythematosus is an auto immune disease, that can affect skin, joints, kodneys, brain, and other organs.Auto immune means bodys immune system mistakenly attacks healthy tissues it is treated with steroids and non steroidal anti inflammatory meds, avoid sun and wear protective clothing. Cytotoxic drugs if you do not respond to cortico steroids cytotoxics have side effects need to be monit. ...Read more

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Why hydroxychloroquine is effective in treating systemic lupus erythematosus?

Why hydroxychloroquine is effective in treating systemic lupus erythematosus?

It is magic?: 1the use of anti-malarials in autoimmune diseases was accidentally discovered in treating wwii vets for malaria. Those with RA improved. Chloroquine and ho-q were tested in sle, with very positive results. In the early 80's canadian researchers definitively showed fewer sle flares with ho-q. It is considered the rx of first choice for :sle. We now understand more of the mechanisms, but not all. ...Read more

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Atenolol-induced lupus erythematosus http://www.Ncbi.Nlm.Nih.Gov/pubmed/9270530?

Atenolol-induced lupus erythematosus           http://www.Ncbi.Nlm.Nih.Gov/pubmed/9270530?

Let me explain: I read the article, this medication could induce symptoms of autoimmune disease including lupus, but lupus has no cure to date but those symptoms disappear with the treatment. That the main difference. ...Read more

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Systemic lupus erythematosus--what is sle?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

See 1 more doctor answer
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Is there a cure for systemic lupus erythematosus (sle)?

SLE treatment: Systemic lupus erythematosus (sle) is a long-term autoimmune disorder that may affect the skin, joints, kidneys, brain, and other organs. There is no cure for sle. The goal of treatment is to control symptoms. ...Read more

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What are some alternative therapies for sle (systemic lupus erythematosus)?

What are some alternative therapies for sle (systemic lupus erythematosus)?

None: Diet and omega 3 fatty acids may help but there are no specific vitamin or herbal supplements for sle. Avoiding sugar and dairy is helpful for some people. Omega three fatty acids along with vitamin c and b complex may reduce symptoms. ...Read more

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What are the tests for systemic lupus erythematosus?

Positive ANA and...: Positive ANA and a positive double stranded dna antibody titer of significance. This coupled with clinical criteria is the least required for diagnosis. ...Read more

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What is 'systemic lupus erythematosus' in clear tems?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

See 1 more doctor answer
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What are the symptoms of systemic lupus erythematosus?

Many: People with lupus may have joint pain, skin rashes, chest pain, heart probelms, hair loss, fingers changing color in the cold, rash in the sunshine, neuro-psychologic problems. These are only soemof the symtpoms peopel can have. They can also have none of these. Your physician will evaluate all of these, get labs tests and imaging. ...Read more

See 1 more doctor answer
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What is trigger systemic lupus erythematosus in antiquity?

Mysterious lupus: It is not known what causes lupus erythematosus. Referring to antiquity, lupus was used to describe several different rashes. It could be autoimmune, where the body attacks itself such as lupus erythematosus or discoid lupus. It could be caused by tuberculosis infection such as lupus vulgaris. It could be related to another inflammatory disease such as sarcoidosis which causes lupus pernio. ...Read more

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Is systemic lupus erythematosus fatal?

Sometimes.: Sle is generally treated with good response, but unfortunately it is sometimes fatal. ...Read more

See 1 more doctor answer
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Docs can you explain what is 'systemic lupus erythematosus' in clear details?

Docs can you explain what is 'systemic lupus erythematosus' in clear details?

An auto immune disea: Systemic lupus is a auto immune disease that can affect any part of the body.The immune system of the patient attacks its own body cells and tissues, and that causes inflammation and damage to the tissues it most often affecrs heart, skin.Joints, blood vessels, lungs, kidneys , liver and nervous system the incidence of sle is 9 times in women than men. ...Read more

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Is systemic lupus erythematosus a kind of cancer?

No : It is an autoimmune disorder that can affect multiple organs. It is not cancer. ...Read more

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How can one cure systemic lupus erythematosus?

How can one cure systemic lupus erythematosus?

No cure but ...: Lupus cannot be cured but the symptoms can often be controlled. In the 1950s, 60% of lupus patients died within five years. Now, more than 90% survive beyond five years. Lupus can be mild. Many lupus patients have non-life threatening disease. Lupus can be severe. Kidney or brain involvement portends a worse prognosis. ...Read more

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What do you recommend for systemic lupus erythematosus?

See rheumatologist: It is critical to see a rheumatologist, who can determine if it is lupus, if it actually compromises your health, what body systems are affected and if treatment is needed, to tailor the treatment to the risks they present. ...Read more

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What is the definition or description of: systemic lupus erythematosus?

SLE: Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune system becomes hyperactive and attacks normal, healthy tissues.Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. ...Read more

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What is the definition or description of: systemic lupus erythematosus diagnostic panel?

What is the definition or description of: systemic lupus erythematosus diagnostic panel?

Labs for a + ANA: The antinuclear antibody test (ANA) is the initial screening test for lupus, but since it produces a lot of false positives, follow up testing for other auto antibodies is needed. The other tests in the panel are usually more specific for lupus, but less sensitive. Panels sometimes produce dubious results, so any positive test has to be taken in context. ...Read more

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How much should people with systemic lupus erythematosus pay extra for the insurance in usa?

None: The reason that insurance exists is to spread the risk of any single person having any disease is divided among many healthy people with no disease.Our current system is prejudiced against anybody with a "pre-existing" illness such as yours and makes you pay extra.Makes getting insurance(or keeping it ) tough.It is a lose-lose;dr and patient, win for insurance company.My gripe with aca. ...Read more

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How are systemic lupus erythematosus, coma & leukopenia related?

SLE: Is a systemic disease and is a form of vascullitis, which means that there is inflammation in the blood vessels as a result it is a multi-system disease and can affect any organ in the body. When the brain is affected it can lead to changes in mood, psychosis and even coma. Leukopenia is a recognized feature of SLE at some point in the course of the disease. It can affect the kidneys, joints etc ...Read more

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Why hydroxychloroquine is effective in treating systemic lupus erythematosus?

It is magic?: 1the use of anti-malarials in autoimmune diseases was accidentally discovered in treating wwii vets for malaria. Those with RA improved. Chloroquine and ho-q were tested in sle, with very positive results. In the early 80's canadian researchers definitively showed fewer sle flares with ho-q. It is considered the rx of first choice for :sle. We now understand more of the mechanisms, but not all. ...Read more

Dr. Andrew Seibert
3 doctors shared insights

Lupus (Systemic Lupus Erythematosus) (Definition)

An inflammatory disease caused when the immune system attacks its own tissues. ...Read more