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Doctor insights on: Pathophysiology Of Hodgkin's Lymphoma

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Non-hodgkin lymphoma vs. Hodgkin lymphoma, what is the difference?

Non-hodgkin lymphoma vs. Hodgkin lymphoma, what is the difference?

Many.: Nhl is treated with different chemotherapy than hd. Stage for stage hd carries a better prognosis. Hd usually occurs in the young adult and the elderly; nhl occurs most often during middle age. Many different grades of nhl (low grade, intermediate, high) while hd is not divided into grades. ...Read more

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Dr. John Landi
7 doctors shared insights

Lymphoma (Definition)

Lymphoma is a malignancy developing in the lymphocytes of lymph glands. They present as an enlarging node that continues to grow and then progress to adjacent nodes. Bx shows loss of architecture of the node. It results from a virus such as MMYV entering the Wnt 1 gene of the lymphocyte and followed by over expression of B ...Read more


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What is the difference between hodgkin lymphoma and non-hodgkin lymphoma?

What is the difference between hodgkin lymphoma and non-hodgkin lymphoma?

Disease type: The 2 diseases are closely linked. The hodgkin lymphoma was described by the doctor bearing its name and usually has a specific cell associated with it. This cell is not the target of new therapies for relapsed disease. In general terms, this disease is highly curable whereas some of the many types of non-hodgkin lymphoma are not. ...Read more

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What is the stages of hodgkin's lymphoma?

What is the stages of hodgkin's lymphoma?

Determined by site: Stage 1: involvement of a single lymph node region or single non-lymph node site stage 2: involvement of two or more lymph node regions on the same side of the diaphragm stage 3: involvement of lymph node regions on both sides of the diaphragm stage 4: significant or widespread involvement of non-lymph node sites. ...Read more

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What's the difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma?

What's the difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma?

Different lymphomas: There are around 30 different types of lymphoma distinguished by how they look under the microscope, the proteins they bear on their cell surface, and the gene mutations that caused the problem to begin with. The type of treatment varies a lot between the different types and is too complicated to cover here. The Leukemia and Lymphoma Society of America website will be your best bet for more details. ...Read more

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What's the difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma?

Both Hodgkin's lymphoma and non-Hodgkin's lymphoma are lymphomas — a type of cancer that begins in a subset of white blood cells called lymphocytes: Lymphocytes are an integral part of your immune system, which protects you from germs. The main difference between Hodgkin's and non-Hodgkin's lymphoma is in the specific lymphocyte each involves. A doctor can tell the difference between Hodgkin's and non-Hodgkin's lymphoma by examining the cancer cells under a microscope. If in examining the cells, the doctor detects the presence of a specific type of abnormal cell called a Reed-Sternberg cell, the lymphoma is classified as Hodgkin's. If the Reed-Sternberg cell is not present, the lymphoma is classified as non-Hodgkin's. Additional tests may be used to determine the specific type of lymphoma. Your type of lymphoma helps your doctor determine your prognosis and your treatment options. The types of lymphoma have very different disease courses and treatment choices, so an accurate diagnosis is an integral part of getting the care you need. ...Read more

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What is Non-Hodgkin's Lymphoma cancer B type?

Cell type: There are two major types of lymphocytes, T and B. Both can cause lymphoma. What you are referring to is a lymphoma of the B cell type. ...Read more

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Describe the features of burkitt lymphoma?

Describe the features of burkitt lymphoma?

Very aggressive: One categorization of the many types of lymphoma is: indolent, aggresssive, very aggressive. Brukitt lymphoma (bl) is a very aggressive lymphoma. It proliferates (grows) very quickly. Intensive therapy is needed including intrathecal (cns fluid) chemotherapy. However, it usually responds quickly to treatment. That can cause rapid tumor death and tumor lysis syndrome (tls). ...Read more

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Is Hodgkin's lymphoma hereditary?

Is Hodgkin's lymphoma hereditary?

Genetics of HL: There might be a genetic component of Hodgkins Lymphoma in close family members of a HL patient. It is seen about 3-5 times more often than expected in the general population. Younger Siblings of HL patients may have a risk up to 7 times more frequently. ...Read more

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What's the difference between hodgkins lymphoma and non-hodgkins lymphoma?

Probably a lot: But the biggies are reed-sternberg cells define hd, not found in nhl. Most nhl's are b-cell, where hd is not. Hd spreads contiguously, nhl does not. Both treated with chemo, different kinds, and rituxumab is the new targeted therapy for b-cells, with chemo or conjugated with radio-isotopes. ...Read more

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What is the statistics of hodgkin's disease?

Overall curable: Hodgkin lymphoma as it is now called is one of our success stories. If it is diagnosed in the early stages, the cure rate is >90%, even late stage disease has cure rates of greater than 80%. In those cases where there is disease recurrence, stem cell transplant has been successfully used to cure many people. ...Read more

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Classical hodgkin's lymphoma nodular sclerosis, what is the best treatment?

Classical hodgkin's lymphoma nodular sclerosis, what is the best treatment?

Depends: For early stage disease, it's usually 2-4 cycles abvd w/ involved site radiation. For advanced disease, it's at least 4-6 cycles of abvd or even beacopp with radiation reserved for sites of bulk disease. For relapse, new drugs like Adcetris (brentuximab vedotin) are in use as are the option of transplant. ...Read more

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What is non-hodgkin's lymphoma?

Lymph system cancer: Nhl is a large group of related cancers which originate in the lymph tissues of the body. These cells normally help fight infection but become cancerous and grow out of control. They may stay in the lymph nodes or also be found in any part of the body or organs. Some grow slowly (indolent) while others are more aggressive. You doctor will run a series of test to stage and type the lymphoma. ...Read more

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What is the prognosis of stage 4 cancer non hodgkins lymphoma b cell with walderstoms IgM protein 4000?

Fairly good: We have good treatments for nonhodgkins lymphoma such that a fairly large proportion of patients are cured and can live a normal life. At least we can keep them alive for many years with the use of chemotherapy along with a biologic agent/immunotherapy drug called rituximab. ...Read more

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What is the difference between hodgkin's disease and non-hodgkin's lymphoma?

What is the difference between hodgkin's disease and non-hodgkin's lymphoma?

A lot: Both hodgkin lymphoma (formerly known as hodgkin's disease) and non-hodgkin lymphoma (also known as non-hodgkin's lymphoma) are lymphomas, a type of cancer that originates in a subset of white blood cells called lymphocytes. Lymphocytes are an important part of your immune system. The main difference between hodgkin and non-hodgkin lymphoma is in the specific lymphocyte each involves. ...Read more

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What's the link between graves disease and non hodgkins lymphoma?

What's the link between graves disease and non hodgkins lymphoma?

Graves is a form of: Immune mediated excess thyroid hormone...It is anecdotally associated with cases of lymphoma in general, and the thyroid in particular. In animals, injection of thyroid hormone caused lymph nodes to enlarge, but most lymphoma has nothing to do with the thyroid. ...Read more

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What defect is responsible for hodgkin lymphoma?

Risk of Hodgkin's dz: There is no one "defect" that causes hodgkin's disease, but risk factors include a high socioeconomic status, having a family member with the disease, prior epstein-barr virus infection (mononucleosis), and immunosuppression as a result of conditions like aids, organ or marrow transplantation, autoimmune disease, and immunosuppressant medications. ...Read more

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What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read more

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How do hodgkin lymphoma and non hodgkin lymphoma differ?

How do hodgkin lymphoma and non hodgkin lymphoma differ?

Spread pattern: Primarily, hodgkins lymphoma teens to spread from one lymph node site to an adjacent site. Non hodgkins lymphoma is more likely to skip lymph node chains to spread distantly. This is why local radiation has historically be more important in the treatment of hodgkins than non hodgkins. ...Read more

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What is the mortality rate of burkitt's lymphoma?

Many are cured: Lymphoblastic lymphoma (LBL) and Burkitt lymphoma (BL) are both aggressive lymphomas with a rapid rate of cell division. For patients who are able to receive intensive chemotherapy regimens and rituximab antibody, recent trials have reported sustained disease-free survival in 60-90% of patients. ...Read more

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What causes an inhomogeneous spleen in hodgkin lymphoma?

Lymphoma vs. other: The spleen in hl may be heterogeneous/inhomogeneous/non-uniform due to lymphoma involvement, spleen infarction (death) due to cancer death in the spleen, or infection, or "other". The radiologist may or may not be able to determine that and your oncologist might be able to say more about it with knowing the clinical history. ...Read more

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Dr. Michael Thompson
1,769 doctors shared insights

Lymphoma (Definition)

A malignancy that develops in the lymph glands that causes nodes ...Read more