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Doctor insights on: Parkingson Disease

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Dr. Alan Ali Dr. Ali
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What is Parkinson's disease?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What is Parkinson's disease?

Parkinson: Rigidity such as stiff neck, tremors, and slow movements are part of parkinson. It involves the part of the midbrain called Substantia nigra. ...Read more

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What causes Parkinson's disease?

What causes Parkinson's disease?

Unknown: The cause of parkinson disease is unknown. It appears that the cause of parkinson disease leads to the depletion of Dopamine in the subtantia nigra in the brain that is responsible for the symptoms of the disease. ...Read more

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How is Parkinson's disease treated?

How is Parkinson's disease treated?

Good Rx available!!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more

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How is Parkinson's disease inherited?

How is Parkinson's disease inherited?

Mostly not inherited: The vast majority of people with parkinson's seem to get it sporadically, that is without any clear inheritance from family. That being said, we've found around 12 genetic variants that seem to greatly increase the risk of developing pd in some families. Some of them are recessive (rarely crops up), and some are dominant (50% chance of getting it from 1 affected parent). ...Read more

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What are the symtons of Parkinson's disease?

What are the symtons of Parkinson's disease?

Parkinson Symptoms: Non-motor Symptoms occur 3-20 yrs before motor symptoms. They are REM Sleep Behavior Disorder, Constipation, Decrease or loss of smell, anxiety and depression. Motor symptoms occur when 67% of the neurons that produce dopamine in the Substantia Nigra. They are Rigidity, Slowness of movement +/- tremor. A soft voice, masked face, small handwriting & shoulder pain can also occur. ...Read more

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How is Parkinson's disease dignosed and treated?

How is Parkinson's disease dignosed and treated?

Even DBS surgery!!: Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time). Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results. ...Read more

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I was wondering what are the causes of Parkinson's disease?

I was wondering what are the causes of Parkinson's disease?

No good answer yet: It is believed that parkinson's disease like many other neurodegenerative diseases arise from a combination of factors including genetics and environmental influences. Sometimes there are medications that can cause a parkinsonian syndrome and rarely there are structural lesions such as strokes that can cause a similar clinical picture. Take care and well wishes. ...Read more

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My grandpa had Parkinson's disease/ What are the chances I have it too?

My grandpa had Parkinson's disease/ What are the chances I have it too?

Unlikely unless: While there's a genetic component, it's unlikely that you currently have Parkinson's disease w/o knowing it unless you're ignoring resting tremor, difficulty getting moving, change in gait, change in handwriting, etc. Check out http://www.mayoclinic.org/diseases-conditions/parkinsons-disease/basics/definition/con-20028488 for more info. ...Read more

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Is Parkinson's disease preventable?

Is Parkinson's disease preventable?

Parkinson's disease: No. Parkinson's disease (pd) cannot be prevented. It appears a genetic predisposition added to environmental exposure predisposes to the development pd. Repetitive head trauma may increase risk of pd. Caffeine and smoking may reduce the incidence of pd (not recommended for prevention). Exercise and active lifestyle may offer benefit in patients with the disease but not shown to prevent onset. ...Read more

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Is parkinson’s disease hereditary?

Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there. ...Read more

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Is Parkinson's disease hereditary?

Is Parkinson's disease hereditary?

Sometimes: Parkinson disease is the most common cause of parkinsonism, a symptomatic triad of tremor, muscular rigidity, and slow movement. Most of parkinson disease is caused by contributions of multiple genes, no one of which is necessary nor sufficient, aided by poorly defined environmental factors. About seven types of parkinson disease are inherited in an autosomal dominant or recessive pattern. ...Read more

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Is Parkinson's disease hereditary?

Is Parkinson's disease hereditary?

It can be, yes: As a general rule, the younger the age of onset (<45yo is early onset), & the more affected relatives (especially close ones), then the more likely it is genetic & the higher the risk to blood relatives. Average age of pd onset is 58. The older you are @ disease onset, the less likely it is genetically inheritable. Look @ this link for help on genetics: http://www.Ncbi.Nlm.Nih.Gov/books/nbk1223/. ...Read more

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Is Parkinson's disease hereditary?

Is Parkinson's disease hereditary?

A bit: There are some hereditary factors but they are seemingly minor. If you have a first-degree relative with parkinson’s disease you are more likely to get it, but the risk is small (< 5 % according to mayo clinic reports). It can run very strongly in some families in rare situations of abnormalities of alpha-synuclein synthesis or protein disposal problems. ...Read more

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Tell me about Parkinson's disease.?

Tell me about Parkinson's disease.?

Neurodegenerative: Parkinson’s results from destruction of dopamine-producing neurons in part of the brain (substantia nigra). A lack of these neurons causes decreased excitation of the motor part of the brain. This results in the classic signs of a resting tremor (“pill-rolling”), slowness of movement (shuffling steps), rigidity (resistance to being moved), and postural instability (balance issues). ...Read more

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What is pseudo Parkinson's disease?

Not Parkinson's: Parkinson's disease is a disorder of the brain characterized by slowness of movement, rigidity of muscles and is caused by a deficiency of Dopamine in the brain. Many drugs such as the anti-psychotics can cause a parkinson's-like picture, as can some severe infections and metabolic disorders. I believe the term is more of a lay term than what is truly found in medical books. ...Read more

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How to diagnose Parkinson's disease?

Diagnose PD: Parkinsons disease is often diagnosed by a history and a clinical exam. The history helps to evaluate if there are any medicines or other factors that can explain the symptoms. The exam should show evidence of muscular rigidity, postural instability or slowness of movement- these are clinical features that are needed to make the diagnosis. Hope that helps! ...Read more

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How is Parkinson's disease diagnosed?

How is Parkinson's disease diagnosed?

History and exam: Parkinson's is usually diagnosed based upon it having very characteristic symptoms and exam findings - namely asymmetric (i.e. Usually starts on one side) tremor at rest, slowness of movements (bradykinesia), and stiffness (rigidity). There are some nuclear medicine tests that show the pathology of pd fairly reliably, but they are fairly new and considered experimental by most insurers. ...Read more

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Can you die from Parkinson's disease?

Can you die from Parkinson's disease?

Yes: Parkinsons disease is a progressive neurologic illness and often has dementia as part of the course of the disease. However, it is not rapidly fatal. ...Read more

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Can you die from Parkinson's disease?

Can you die from Parkinson's disease?

Yes, many reasons: Sleep disturbances with resultant auto accidents, trauma from falling with fractures and subsequent complications, swallowing difficulties with aspiration pneumonia, blood pressure drops resulting in fainting or falling, associated dementia causing further complications. Since a disease of older adults, any of the above could be catastrophic. ...Read more