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Doctor insights on: Parkingson Disease

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Dr. Alan Ali Dr. Ali
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What is Parkinson's disease?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What is Parkinson's disease?

Parkinson: Rigidity such as stiff neck, tremors, and slow movements are part of parkinson. It involves the part of the midbrain called Substantia nigra. ...Read more

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What causes Parkinson's disease?

What causes Parkinson's disease?

Unknown: The cause of parkinson disease is unknown. It appears that the cause of parkinson disease leads to the depletion of Dopamine in the subtantia nigra in the brain that is responsible for the symptoms of the disease. ...Read more

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How is Parkinson's disease treated?

How is Parkinson's disease treated?

Good Rx available!!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more

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How is Parkinson's disease inherited?

How is Parkinson's disease inherited?

Mostly not inherited: The vast majority of people with parkinson's seem to get it sporadically, that is without any clear inheritance from family. That being said, we've found around 12 genetic variants that seem to greatly increase the risk of developing pd in some families. Some of them are recessive (rarely crops up), and some are dominant (50% chance of getting it from 1 affected parent). ...Read more

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What are the symtons of Parkinson's disease?

What are the symtons of Parkinson's disease?

Parkinson Symptoms: Non-motor Symptoms occur 3-20 yrs before motor symptoms. They are REM Sleep Behavior Disorder, Constipation, Decrease or loss of smell, anxiety and depression. Motor symptoms occur when 67% of the neurons that produce dopamine in the Substantia Nigra. They are Rigidity, Slowness of movement +/- tremor. A soft voice, masked face, small handwriting & shoulder pain can also occur. ...Read more

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How is Parkinson's disease dignosed and treated?

How is Parkinson's disease dignosed and treated?

Even DBS surgery!!: Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time). Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results. ...Read more

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I was wondering what are the causes of Parkinson's disease?

I was wondering what are the causes of Parkinson's disease?

No good answer yet: It is believed that parkinson's disease like many other neurodegenerative diseases arise from a combination of factors including genetics and environmental influences. Sometimes there are medications that can cause a parkinsonian syndrome and rarely there are structural lesions such as strokes that can cause a similar clinical picture. Take care and well wishes. ...Read more

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My grandpa had Parkinson's disease/ What are the chances I have it too?

My grandpa had Parkinson's disease/ What are the chances I have it too?

Unlikely unless: While there's a genetic component, it's unlikely that you currently have Parkinson's disease w/o knowing it unless you're ignoring resting tremor, difficulty getting moving, change in gait, change in handwriting, etc. Check out http://www.mayoclinic.org/diseases-conditions/parkinsons-disease/basics/definition/con-20028488 for more info. ...Read more

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Is Parkinson's disease preventable?

Is Parkinson's disease preventable?

Parkinson's disease: No. Parkinson's disease (pd) cannot be prevented. It appears a genetic predisposition added to environmental exposure predisposes to the development pd. Repetitive head trauma may increase risk of pd. Caffeine and smoking may reduce the incidence of pd (not recommended for prevention). Exercise and active lifestyle may offer benefit in patients with the disease but not shown to prevent onset. ...Read more

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Is parkinson’s disease hereditary?

Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there. ...Read more

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