Doctor insights on:
Paraneoplastic Syndromes In Children
Neurologic and fever: Paraneoplastic syndromes are rare disorders triggered by altered immune system response to a neoplasm. They are defined as clinical syndromes involving nonmetastatic systemic effects. They arise from tumor secretion of hormones, peptides or cytokines arising in tumor and while fever is the most common presentation, several clinical situations observed simulating Cushing and Carcinoid syndrome. ...Read more
Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, ...Read more
Cancer patients: Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than metastases, metabolic and nutritional deficits, infections, coagulopathy or side effects of cancer treatment. They may occur before the obvious signs of a malignancy become apparent. ...Read more
Testing: In some patients, paraneoplastic syndromes are clinical findings that accompany existing cancers. These may include changes in the skin, bones, hormone levels, electrolytes, or organ function. Extensive blood testing or scans in a patient with suggestive findings can confirm the diagnosis. ...Read more
Remote effect.: Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, and various autoimmune problems. ...Read more
Are there any oncologists in georgia with a strong interest in paraneoplastic syndromes affecting the nervous system?
ASCO directory: You can look at the american society of clinical oncology's directory and look for somebody at your region. Majority but not all oncologist would be listed there. ...Read more
Do paraneoplastic syndromes often antedate the physical formation of contrast CT detectable neoplasms? Or are detectable tumors usually already there?
What kind of test can diagnose Peripheral neuropathy- Paraneoplastic syndromes of the nervous system?
Physical & labs: If physical exam suggests peripheral neuropathy, the workup will include assays for a few of the paraneoplastic autoantibodies known to cause it, and a diligent search for an underlying cancer should be undertaken. This is a difficult workup for physician and patient alike, and I wish you luck. Stay proactive. ...Read more
Tumor related: A paraneoplastic syndrome is a condition related to presence of a neoplastic growth but not to the local presence of cancer cells It is mediated by humoral factors expressed by the tumor or from an immune response against the tumor. They most commonly result from the cancers of the lung, breast, ovaries or lymphoma. Symptoms include difficulty in walking, swallowing, and vewrtigo ...Read more
Multiple symptoms: There are several paraneoplastic syndromes. Most are related to the production of excess hormones or tumor necrosis factor or high blood calcium. Neurologic processes can also occur. Your symptoms could be due to a lot of things, but don't sound like a specifric paraneoplastic syndrome to me. ...Read more
Paraneoplastic syndrome is a syndrome (constellation of symptoms of variable types) that occurs in association (para-) with cancer (-neoplastic).
Some specialized testing can detect antibodies involved in paraneoplastic syndrome, but sometimes it is not detectable.
The body parts effected depends on the type of syndrome but may involve the entire body -- eg myasthenia gravis and thymoma. ...Read more
Does normal results in Paraneoplastic panel can deny the syndrome or not really? What is actually the meaning of negative results?
Paraneoplastic dis: If such tests refer to the antibody panel (blood test) that is done, then the answer is no or not entirely. The tests are done with the Internet of inclusion, in otherworldly, if positive then it supports the diagnosis. If negative, then it is less likely but still possible. ...Read more
Removal of primary:
Complete removal of the tumor causing the paraneoplastic syndrome should help. However, the lesions may not be reversible. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/paraneoplastic-syndromes/basics/definition/CON-20028459 ...Read more
Cancer related hormo: Cancers like lung cancer can produce chemicals which have hormone like effects on the body. This can cause, for example the calcium level or blood counts to go up. These are called paraneoplastic syndromes, they usually go away once the tumor is removed or controlled with chemotherapy. ...Read more
Depends on type: There r many paraneoplastic neurologic syndromes, each associated with specific types of cancers. Thus, there's no generic answer to ur question. Paraneoplastic lymphomas, 4 instance, can produce specific antibodies which can b detected by blood tests or lumbar puncture, depending. The best "test"? A thorough history & physical by some1 knowledgeable (oncologist, neurologist) who can guide u more ...Read more
Have had symptoms of paraneoplastic neurological syndrome for 3 years. What tests should I go for?
If this is your own: Self-diagnosis, then the only tests you need at this time is a proper history and evaluation by a competent clinician. That individual will then explain if tests are indicated and what they will be. ...Read more
What negative results in paraneoplastic serum panel mean? What the like hood to have the neurology syndrome with negative results?
Based on H&P: A para neoplastic syndrome is based on history and exam. Do not base the absence of a para neoplastic syndrome on a negative serum panel. I rarely get the panel because you treat the person and the disease not the test. Hope this helps. ...Read more
Serum Ab: It is a clinical diagnosis. But detection of some well characterized paraneoplastic antibodies in serum or CSF can be helpful. For example, anti-hu (encephalomylitis/sclc), anti-yo (cerebellar degeneration/breast or gyn cancer), anti-calcium channel (lambert-eaton syndrome), etc. Of note, negative antibody does not exclude the diagnosis. ...Read more
Maybe: Some defined antibodies are associated with paraneoplastic syndromes (note: plural). In those cases the testing may be positive. However, a person could have a paraneoplastic syndrome with negative testing for the known paraneoplastic antibodies. It is possible that studies are being done to characterize tests for paraneoplastic syndromes. That might be experimental. ...Read more
Hem/Onc: See a hematologist oncologist.Get a more detailed answer ›
Many: Neurologic paraneoplastic syndromes are caused by an abnormal immune response to the tumor, which makes the body accidentally attack its own nervous tissue. Muscle weakness, stiff limbs, dizziness, coordination problems, vision problems, confusion, difficulty swallowing, memory problems and numbness are some of the many possible symptoms. ...Read more
What are the Paraneoplastic antibodies blood tests? Why negative results can not rull out the syndrome?
Paraneoplastic syndromes are uncommon and the presence or absence of antibodies is only one evidence for making the diagnosis. See this site for more info.
uncohttp://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC3299076 ...Read more
How long does paraneoplastic syndrome last if the entire tumor was removed and no further treatment is necessary?
Tough to know: The paraneoplastic syndrome is caused by an inappropriate immune response. The immune system was "allowed" to mount an attack on your body (sometimes attacking nerves, blood vessels, muscle, etc). Treating the tumor could result in a reset so that the immune system is rebooted, but this could take weeks to years and is highly dependent on specific factors that vary from person to person. ...Read more
What is the like hood to have a paraneoplastic neurology syndrome if the paraneoplastic panel (anti body) blood test is negative?
Need more info: It would be worthwhile to discuss this with an oncologist that your family physician can suggest. ...Read more