Doctor insights on:
From the neoplasm: For example, some cancers cause syndromes that are different from the primary tumor symptoms. Let's say small cell lung cancer can cause a low sodium level. By treating the cancer, the low sodium level can improve. Symptoms of lung cancer are typically shortness of breath, cough, weight loss, fatigue. Another syndrome is called eaton lambert syndrome which causes weakness. Treatment can help. ...Read more
It doesnot make sens: The two words paraneoplastic degenative, juxtaposed next to each other do not make sense. So something is missing in what you are trying to say. Tell us what you have wrong and we can explain. _paraneoplastic means that one has some remote changes in the body which are due to a cancerous tumor somewhere in the body. Give us some details of your history like, you have any recent diagnosis of cancer. ...Read more
Does normal results in Paraneoplastic panel can deny the syndrome or not really? What is actually the meaning of negative results?
Paraneoplastic dis: If such tests refer to the antibody panel (blood test) that is done, then the answer is no or not entirely. The tests are done with the Internet of inclusion, in otherworldly, if positive then it supports the diagnosis. If negative, then it is less likely but still possible. ...Read more
Tumor related: A paraneoplastic syndrome is a condition related to presence of a neoplastic growth but not to the local presence of cancer cells It is mediated by humoral factors expressed by the tumor or from an immune response against the tumor. They most commonly result from the cancers of the lung, breast, ovaries or lymphoma. Symptoms include difficulty in walking, swallowing, and vewrtigo ...Read more
Neurologic and fever: Paraneoplastic syndromes are rare disorders triggered by altered immune system response to a neoplasm. They are defined as clinical syndromes involving nonmetastatic systemic effects. They arise from tumor secretion of hormones, peptides or cytokines arising in tumor and while fever is the most common presentation, several clinical situations observed simulating Cushing and Carcinoid syndrome. ...Read more
Multiple symptoms: There are several paraneoplastic syndromes. Most are related to the production of excess hormones or tumor necrosis factor or high blood calcium. Neurologic processes can also occur. Your symptoms could be due to a lot of things, but don't sound like a specifric paraneoplastic syndrome to me. ...Read more
Cancer patients: Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than metastases, metabolic and nutritional deficits, infections, coagulopathy or side effects of cancer treatment. They may occur before the obvious signs of a malignancy become apparent. ...Read more
Testing: In some patients, paraneoplastic syndromes are clinical findings that accompany existing cancers. These may include changes in the skin, bones, hormone levels, electrolytes, or organ function. Extensive blood testing or scans in a patient with suggestive findings can confirm the diagnosis. ...Read more
Paraneoplastic syndrome is a syndrome (constellation of symptoms of variable types) that occurs in association (para-) with cancer (-neoplastic).
Some specialized testing can detect antibodies involved in paraneoplastic syndrome, but sometimes it is not detectable.
The body parts effected depends on the type of syndrome but may involve the entire body -- eg myasthenia gravis and thymoma. ...Read more
Remote effect.: Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, and various autoimmune problems. ...Read more
Is there any new research in 2012 relating to a cure for paraneoplastic? If the disease is advanced are the effects irreversible?
Cure the cancer.: Paraneoplastic syndrome results from hormones secreted by tumor cells, that grow out of control to cause cancer. These proteins or hormones cause various and varied symptoms, often following a particular pattern directly related to the cancer cell type (lung cancer often). Resolving the paraneoplastic symptoms is directly related to the rx of the underlying cancer. Rx the cancer. ...Read more
Removal of primary:
Complete removal of the tumor causing the paraneoplastic syndrome should help. However, the lesions may not be reversible. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/paraneoplastic-syndromes/basics/definition/CON-20028459 ...Read more
Cancer related hormo: Cancers like lung cancer can produce chemicals which have hormone like effects on the body. This can cause, for example the calcium level or blood counts to go up. These are called paraneoplastic syndromes, they usually go away once the tumor is removed or controlled with chemotherapy. ...Read more
Depends on type: There r many paraneoplastic neurologic syndromes, each associated with specific types of cancers. Thus, there's no generic answer to ur question. Paraneoplastic lymphomas, 4 instance, can produce specific antibodies which can b detected by blood tests or lumbar puncture, depending. The best "test"? A thorough history & physical by some1 knowledgeable (oncologist, neurologist) who can guide u more ...Read more
Difficult matter: This test is only useful when it is Abnormal. But it does not help at all when it is normal panel (which means there is no abnormaility found but it does not exclude any diagnosis because there is nothing predictable about a paraneoplastic panel). So you can not say it is false negative. It is designed to be useful only if it shows an abnormality that supports a clinical diagnosis of cancer. ...Read more
Have had symptoms of paraneoplastic neurological syndrome for 3 years. What tests should I go for?
If this is your own: Self-diagnosis, then the only tests you need at this time is a proper history and evaluation by a competent clinician. That individual will then explain if tests are indicated and what they will be. ...Read more
Anti gad 65 is >1:2400 and says positive. In footnotes, it mentions paraneoplastic disorder. What are best next steps?
Ordering physician?: Ask the ordering physician. Depends why the test was ordered to begin with. Paraneoplastic syndromes are caused by a neoplastic process; it may be a concern if one has diagnosis of cancer. Anti-gad may be seen in association with paraneoplastic syndromes involving the nervous system. Note that the majority of patients with antibodies to gad do not have cancer. Discuss with ordering physician. ...Read more
What negative results in paraneoplastic serum panel mean? What the like hood to have the neurology syndrome with negative results?
Based on H&P: A para neoplastic syndrome is based on history and exam. Do not base the absence of a para neoplastic syndrome on a negative serum panel. I rarely get the panel because you treat the person and the disease not the test. Hope this helps. ...Read more
Can nerve discorder like sensory discorder of tickling, itching, crawling senstaion remain with no diagnose? Can it relegated to Paraneoplastic?
Neuropathy: Most cases of neuropathy remain undiagnosed as to their cause. PARANEOPLASTIC disease is a recognized causative factor of neuropathies but unless you have antibody positivity test results or some other really compelling solid clinical suspicion this should be the case then, making that the diagnosis is tenuous at best. ...Read more
Serum Ab: It is a clinical diagnosis. But detection of some well characterized paraneoplastic antibodies in serum or CSF can be helpful. For example, anti-hu (encephalomylitis/sclc), anti-yo (cerebellar degeneration/breast or gyn cancer), anti-calcium channel (lambert-eaton syndrome), etc. Of note, negative antibody does not exclude the diagnosis. ...Read more
Maybe: Some defined antibodies are associated with paraneoplastic syndromes (note: plural). In those cases the testing may be positive. However, a person could have a paraneoplastic syndrome with negative testing for the known paraneoplastic antibodies. It is possible that studies are being done to characterize tests for paraneoplastic syndromes. That might be experimental. ...Read more
Help. I have paraneoplastic syn. We can not find the cancer. Ivig tx is next. What if it does not work? Can I die from it?
Plasma exchange. Yes: Treatment will probably work, but next step would be plasma exchange. You should consider having a pet / ct scan if not already done and repeat this in 3-6 months intervals out to about 4 years (or 2 years in lems - your treatment with ivig suggests you have lems.). ...Read more
If my paraneoplastic ab test came back positive does that mean I have an underlying cancer or will get cancer in the near future?
Paraneoplastic: Paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body. So, if your panel is positive-depending on the sensitivity and the specificity of the panel- your doctor needs to make sure to look for presence of occult cancer in you. ...Read more
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