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Doctor insights on: Para Supranuclear Palsy

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Dr. Darren Gitelman
Board Certified, Neurology
30 years in practice
383K people helped
1

1
What is the difference between infranuclear and supranuclear paralysis?

What is the difference between infranuclear and supranuclear paralysis?

Different types: Supranuclear refers to loss of function due to a lack of high level cerebral control of a cranial nerve. E.G., in supranuclear gaze paresis there is difficulty voluntarily moving the eyes, but reflex eye movements are intact. Nuclear/ infranuclear refers to problems caused by damage to a cranial nerve nucleus or nerve itself. In this case voluntary & reflex movements would be impaired. ...Read more

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Dr. Cindy Juster
Board Certified
30 years in practice
2M people helped
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Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


Dr. Djamchid Lotfi
Board Certified, Neurology
52 years in practice
2M people helped
2

2
What are the tests for supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Dr. Cindy Juster
Board Certified
30 years in practice
2M people helped
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Dr. Ari Weitzner
Board Certified, Ophthalmology
27 years in practice
1M people helped
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Dr. Robert Hutchman
Board Certified, Neurology
18 years in practice
758K people helped
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4
How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Dr. Cindy Juster
Board Certified
30 years in practice
2M people helped
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Dr. Robert Hutchman
Board Certified, Neurology
18 years in practice
758K people helped
5

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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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Dr. Djamchid Lotfi
Board Certified, Neurology
52 years in practice
2M people helped
6

6
How is progressive supranuclear palsy (psp) diagnosed?

How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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Dr. Robert Hutchman
Board Certified, Neurology
18 years in practice
758K people helped
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7
Is possible for progressive supranuclear palsy to be cured / get better?

Is possible for progressive supranuclear palsy to be cured / get better?

Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Dr. Richard Simmons
Board Certified, Pediatric Neurology
12 years in practice
77K people helped
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Dr. Ian Stein
Board Certified, Neurology
15 years in practice
97K people helped
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Dr. Kenneth Reichert
Board Certified, Neurosurgery
29 years in practice
323K people helped
10

10
What is the prognosis for progressive supranuclear palsy?

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

Supranuclear palsy is a rare brain condition that causes serious problems with walking, eye movements, and balance. The disorder develops slowly over time as the cells in parts of the brain that control movement are destroyed. Although there is no cure, there are ways ...Read more


Dr. William Singer
979 doctors shared insights

Paralysis (Definition)

A paralyzed limb cannot be voluntarily moved, and the term reflects leg involvement, paraplegia, full body, quadriplegia, and less than full, tetraplegia. Causes can be many, including stroke, trauma, ...Read more


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Dr. Cindy Juster
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