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Doctor insights on: Para Supranuclear Palsy

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What is the difference between infranuclear and supranuclear paralysis?

What is the difference between infranuclear and supranuclear paralysis?

Different types: Supranuclear refers to loss of function due to a lack of high level cerebral control of a cranial nerve. E.G., in supranuclear gaze paresis there is difficulty voluntarily moving the eyes, but reflex eye movements are intact. Nuclear/ infranuclear refers to problems caused by damage to a cranial nerve nucleus or nerve itself. In this case voluntary & reflex movements would be impaired. ...Read more

Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


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What are the tests for supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Is progressive supranuclear palsy a demyelinating disease?

Is progressive supranuclear palsy a demyelinating disease?

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more

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How do you exactly prevent progressive supranuclear palsy?

You cannot: Psp is progressive supranuclear palsy in the group of parkinsonism plus=no response to treatment with Dopamine it is thought to be genetic and cause degeneration and changes in the neurotransmiters in basal ganglia and other locations in brain--less understood compare to parkinson disease. ...Read more

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Could anesthesia cause progressive supranuclear palsy (psp)?

Could anesthesia cause progressive supranuclear palsy (psp)?

Not likely: No one knows for sure what causes it. It is a degenerative neurologic disease a little similar to Parkinson's disease in a comparable area of the brain. The cause may be genetic, viral, though no one really knows. It is very very rare. ...Read more

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Is it possible for anesthesia cause progressive supranuclear palsy (psp)?

Unlikely: Though anesthetics do have an effect on the brain, it is unlikely that they would cause this problem. The anesthetics that we use can decrease blood flow to certain areas of the brain, so they might unmask a pre-existing psp, but again that is speculation. I would talk to your neurologist about this problem. ...Read more

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I was diagnosed with supranuclear palsy 5 years ago. Are there any treatments that can help?

No effective therapy: ...Has been proven. Look at this article - http://emedicine.Medscape.Com/article/1151430-treatment i assume there has been a thorough neurologic work-up and trial of a Dopamine agonist. There are some treatments in this article to consider with some benefit by case report. ...Read more

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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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How is progressive supranuclear palsy (psp) diagnosed?

How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

Supranuclear palsy is a rare brain condition that causes serious problems with walking, eye movements, and balance. The disorder develops slowly over time as the cells in parts of the brain that control movement are destroyed. Although there is no cure, there are ways ...Read more


Dr. William Singer
1,029 doctors shared insights

Paralysis (Definition)

A paralyzed limb cannot be voluntarily moved, and the term reflects leg involvement, paraplegia, full body, quadriplegia, and less than full, tetraplegia. Causes can be many, including stroke, trauma, ...Read more