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Doctor insights on: Para Supranuclear Palsy

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Dr. Darren Gitelman
Board Certified, Neurology
31 years in practice
383K people helped
1

1
What is the difference between infranuclear and supranuclear paralysis?

Dr. Darren Gitelman
Board Certified, Neurology
31 years in practice
383K people helped
What is the difference between infranuclear and supranuclear paralysis?

Different types: Supranuclear refers to loss of function due to a lack of high level cerebral control of a cranial nerve. E.G., in supranuclear gaze paresis there is difficulty voluntarily moving the eyes, but reflex eye movements are intact. Nuclear/ infranuclear refers to problems caused by damage to a cranial nerve nucleus or nerve itself. In this case voluntary & reflex movements would be impaired. ...Read more

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Dr. Adam Levy
Board Certified
32 years in practice
698K people helped
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Dr. Adam Levy
Board Certified
32 years in practice
698K people helped
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Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

Supranuclear palsy is a rare brain condition that causes serious problems with walking, eye movements, and balance. The disorder develops slowly over time as the cells in parts of the brain that control movement are destroyed. Although there is no cure, there are ways ...Read more


Dr. Djamchid Lotfi
Board Certified, Neurology
53 years in practice
2M people helped
2

2
What are the tests for supranuclear palsy?

Dr. Djamchid Lotfi
Board Certified, Neurology
53 years in practice
2M people helped

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Dr. Adam Levy
Board Certified
32 years in practice
698K people helped
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Dr. Adam Levy
Board Certified
32 years in practice
698K people helped
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Dr. Ari Weitzner
Board Certified, Ophthalmology
28 years in practice
1M people helped
3

3
What are the common symptoms of supranuclear palsy?

Dr. Ari Weitzner
Board Certified, Ophthalmology
28 years in practice
1M people helped
What are the common symptoms of supranuclear palsy?

Gaze palsy: Meaning, one can't look to the right or left. ...Read more

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Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
4

4
How can you treat progressive supranuclear palsy?

Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Dr. Adam Levy
Board Certified
32 years in practice
698K people helped
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Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
5

5
What can cause progressive supranuclear palsy?

Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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Dr. Djamchid Lotfi
Board Certified, Neurology
53 years in practice
2M people helped
6

6
How is progressive supranuclear palsy (psp) diagnosed?

Dr. Djamchid Lotfi
Board Certified, Neurology
53 years in practice
2M people helped
How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
7

7
Is possible for progressive supranuclear palsy to be cured / get better?

Dr. Robert Hutchman
Board Certified, Neurology
19 years in practice
760K people helped
Is possible for progressive supranuclear palsy to be cured / get better?

Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Dr. Richard Simmons
Board Certified, Pediatric Neurology
13 years in practice
77K people helped
8

8
Are there alternative names of progressive supranuclear palsy?

Dr. Richard Simmons
Board Certified, Pediatric Neurology
13 years in practice
77K people helped

YES: The previous name for psp was steele-richardson-olszewski syndrome. ...Read more

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Dr. Ian Stein
Board Certified, Neurology
16 years in practice
97K people helped
9

9
What are the complications of progressive supranuclear palsy?

Dr. Ian Stein
Board Certified, Neurology
16 years in practice
97K people helped

Falls: Usually starts with falls swallowing difficulties are also seen. ...Read more

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Dr. Kenneth Reichert
Board Certified, Neurosurgery
30 years in practice
323K people helped
10

10
What is the prognosis for progressive supranuclear palsy?

Dr. Kenneth Reichert
Board Certified, Neurosurgery
30 years in practice
323K people helped

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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Number Of Pregnancies (Definition)

Gravida refers to the number of times in the past a woman has been pregnant. Pregnancies that ended in abortion or miscarriage are still counted ...Read more


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Dr. Adam Levy
Board Certified,
32 years in practice
698K people helped
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