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Doctor insights on: Para Supranuclear Palsy

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What is the difference between infranuclear and supranuclear paralysis?

What is the difference between infranuclear and supranuclear paralysis?

Different types: Supranuclear refers to loss of function due to a lack of high level cerebral control of a cranial nerve. E.G., in supranuclear gaze paresis there is difficulty voluntarily moving the eyes, but reflex eye movements are intact. Nuclear/ infranuclear refers to problems caused by damage to a cranial nerve nucleus or nerve itself. In this case voluntary & reflex movements would be impaired. ...Read more

Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


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What are the tests for supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Is progressive supranuclear palsy a demyelinating disease?

Is progressive supranuclear palsy a demyelinating disease?

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more

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How do you exactly prevent progressive supranuclear palsy?

You cannot: Psp is progressive supranuclear palsy in the group of parkinsonism plus=no response to treatment with Dopamine it is thought to be genetic and cause degeneration and changes in the neurotransmiters in basal ganglia and other locations in brain--less understood compare to parkinson disease. ...Read more

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Could anesthesia cause progressive supranuclear palsy (psp)?

Could anesthesia cause progressive supranuclear palsy (psp)?

Not likely: No one knows for sure what causes it. It is a degenerative neurologic disease a little similar to Parkinson's disease in a comparable area of the brain. The cause may be genetic, viral, though no one really knows. It is very very rare. ...Read more

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Is it possible for anesthesia cause progressive supranuclear palsy (psp)?

Is it possible for anesthesia cause progressive supranuclear palsy (psp)?

Unlikely: Though anesthetics do have an effect on the brain, it is unlikely that they would cause this problem. The anesthetics that we use can decrease blood flow to certain areas of the brain, so they might unmask a pre-existing psp, but again that is speculation. I would talk to your neurologist about this problem. ...Read more

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I was diagnosed with supranuclear palsy 5 years ago. Are there any treatments that can help?

No effective therapy: ...Has been proven. Look at this article - http://emedicine.Medscape.Com/article/1151430-treatment i assume there has been a thorough neurologic work-up and trial of a Dopamine agonist. There are some treatments in this article to consider with some benefit by case report. ...Read more

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What is the definition or description of: Supranuclear palsy?

What is the definition or description of: Supranuclear palsy?

Above nuclei: This refers to damage of nervous system structures above the nuclei of affected areas of palsy; typically, this involves those cranial nerves controlling ophthalmic muscles in Progressive Supranuclear Palsy, a neurodegenerative disorder. ...Read more

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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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How is progressive supranuclear palsy (psp) diagnosed?

How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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What are the tests for progressive supranuclear palsy?

What are the tests for progressive supranuclear palsy?

Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more

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What is the prognosis for progressive supranuclear palsy?

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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What are the complications of progressive supranuclear palsy?

Falls: Usually starts with falls swallowing difficulties are also seen. ...Read more

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What are the symptoms that characterize progressive supranuclear palsy?

What are the symptoms that characterize progressive supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Is possible for progressive supranuclear palsy to be cured / get better?

Is possible for progressive supranuclear palsy to be cured / get better?

Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Can you tell me about progressive supranuclear palsy getting cured/ better?

Read on: PSP ( Steel Richardson Syndrome) is a progressive degenerative condition in the involuntary movement disorder genre. See a neurologist specialist in this type of illness. There is no cure (as in most conditions!) and the treatment not ideal Your doctor will tell you how to cope with it and will give palliative treatment ...Read more

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Help plz! Can progressive supranuclear palsy occur in children or teenagers?

Very unlikely: From the Mayo clinic, progressive supranuclear palsy "typically affects people around the age of 60, and is virtually unknown in people under the age of 40." http://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/basics/definition/CON-20029502?p=1 ...Read more

Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

This refers to damage of nervous system structures above the nuclei of affected areas of palsy; typically, this involves those cranial nerves controlling ophthalmic muscles in Progressive Supranuclear ...Read more


Dr. William Singer
1,050 doctors shared insights

Paralysis (Definition)

A paralyzed limb cannot be voluntarily moved, and the term reflects leg involvement, paraplegia, full body, quadriplegia, and less than full, tetraplegia. Causes can be many, including stroke, trauma, ...Read more