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Doctor insights on: Pancytopenia Myelodysplastic Syndrome

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How are pancytopenia and myelodysplastic syndrome differentiated?

How are pancytopenia and myelodysplastic syndrome differentiated?

Bone Marrow Biopsy: Pancytopenia is a clinical condition that can be caused by a variety of diseases such as aplastic anemia, myelodysplasia, drug toxicity. Myelodysplasia is a clinical syndrome that may manifest itself as pancytopenia. A bone marrow biopsy is the only way to tell what is going on. ...Read more

Dr. Aurea Tomeski
44 Doctors shared insights

Pre Leukemia (Myelodysplastic Syndrome) (Definition)

A bone marrow disorder which causes low blood counts (anemia and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of MDS and many different types of treatment. Hematologists and oncologists specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy. ...Read more


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What are the symptoms of Myelodysplastic syndrome?

The symptoms of Myelodysplastic syndrome include:: Fatigue, Autoimmune conditions, Bacterial infections, Enlarged liver, Enlarged lymph nodes, Exercise intolerance, Large spleen, Pale skin, Petechiae, Non blanching red or purple spots. ...Read more

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What happens to the marrow in myelodysplastic syndrome?

See below...: The bone marrow is usually hypercellular (high cellularity) in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read more

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What are the marrow features in myelodysplastic syndrome?

Myelodysplasia: The typical bone marrow features seen in myelodysplastic syndrome can include a hypercellular marrow (the marrow is too full of cells although in some cases the bone marrow can be more empty (hypocellular). There is typically disorder growth of cells so that they do not mature normally (dypsoiesis). Also, many times the chromosomes (cytogenetics) of the bone marrow cells will be abnormal. ...Read more

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With myelodysplastic syndrome why does the body stop producing healthy blood?

With myelodysplastic syndrome why does the body stop producing healthy blood?

See below...: The bone marrow (where blood elements are produced) has high cellularity in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read more

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What is the treatment for myelodysplastic syndrome?

See below...: Myelodysplastic syndromes (mds) represent a group of bone marrow cancers similar to leukemias in many respects but usually with a less aggressive evolution. Like many other types of cancer, treatment includes chemotherapy and sometimes bone marrow transplantation; however, if the mds is low grade sometimes treatment is not necessary, at least not initially (watchful waiting). ...Read more

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What is myelodysplastic syndrome?

Blood disorder: This is a family of diseases that cause bone marrow dysfunction. There are several types that have different prognoses. Some types are precursors to leukemia. They show up a low blood counts usually in older patients. ...Read more

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What does this procedure mean? Myelodysplastic syndrome

What does this procedure mean? Myelodysplastic syndrome

See below...: Myelodysplastic syndrome (mds) is not a procedure but a form of bone marrow cancer that is generally less aggressive than leukemia but still malignant. Mds usually evolves more slowly then leukemia and sometimes can transform into acute leukemia and become more aggressive and faster evolving. It can be treated with chemotherapy or bone marrow transplant but sometimes treatment is not necessary. ...Read more

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What are some of the tests for Myelodysplastic syndrome?

The tests for Myelodysplastic syndrome include:: Bone marrow biopsy, Complete blood count, Epoetin alfa, HIV test, HLA typing, Reticulocyte count, Vitamin B12 folate (folic acid) blood level, RBC folate (folic acid), Iron and iron binding capacity. ...Read more

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Would you define low grade myelodysplastic syndrome lesions?

MDS: MDS is a group of conditions that involve in abnormal bone marrow changes and lead to inffective blood cell production. Using a comlicated system, MDS can be devided into low-grade (20%). Low-grade MDS does not require chemotherapy and is primarily treated with supportive care. ...Read more

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What is the definition or description of: myelodysplastic syndrome?

What is the definition or description of: myelodysplastic syndrome?

MDS: Myelodysplastic syndrome (mds) is a bone marrow disorder which causes low blood counts (anemia, and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of mds and many different types of treatment. Hematologists and oncologists are the doctors that specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy. ...Read more

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If myelodysplastic syndrome is mainly caused by exposure to certain elements. How long ago would that exposure have been?

If myelodysplastic syndrome is mainly caused by exposure to certain elements. How long ago would that exposure have been?

MDS Carcinogens: Alkylating chemotherapies can cause MDS 5-7 years from last dose. Radiation can cause MDS 10-40 years after last dose. Although it's debatable whether modern radiation therapy can cause MDS (see my PubMed article: 24577814). Benzene can cause bone marrow aplasia, MDS or AML 4-14 years after exposure. Tobacco (benzene et al) smoking is significantly associated with MDS with onset 10-20 years. ...Read more

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I have been diagnosed with myelodysplastic syndrome and just saw "with high grade lesions" but can't find any definition of the lesions.?

See below...: This is not standard terminology. Make sure your diagnostic samples have been reviewed by a hematopathologist (a pathologist specialized in the diagnosis of hematologic diseases) and discuss the report with your hematologist/oncologist. ...Read more

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I have mgus and myelodysplastic syndrome and my dr is not treating me should I change drs?

See below...: Both monoclonal gammopathy of undetermined significance (mgus) and myelodysplastic syndrome (mds) are disease entities that may be managed by watchful waiting. If your physician is a hematologist/oncologist then he or she probably has significant experience with these diseases and manages them accordingly. ...Read more

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Can amalgams in teeth cause myelodysplastic syndrome???

No: The simple answer is no. To my knowledge, there has never been any study to show that link, and in fact, your question is the first time in my lifetime that I have even had the question asked or link suggested. See: http://www.cancer.org/cancer/myelodysplasticsyndrome/ ...Read more

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For myelodysplastic syndrome (mds) patients, how does genome sequencing help?

Diagnosis: For certain patients, genomic sequencing can help establish a diagnosis of mds, especially those without large chromosomal abnormalities. In addition, sequencing can be used to help monitor for response to treatment. There are also limited data to suggest that certain mutations can be useful in prognosis. This is an emerging field of medicine and hopefully your oncologist can help guide you. ...Read more

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My husbands mother wad diagnosed with myelodysplastic syndrome in her mid 50's, passed away she was deficient of chromosome 8. Is this hereditary?

My husbands mother wad diagnosed with myelodysplastic syndrome in her mid 50's, passed away she was deficient of chromosome 8. Is this hereditary?

Probably not: Even though a history of mds in first degree relatives may slightly increase the overall risk to develop mds, the risk is still minimal and these diseases are usually not hereditary. ...Read more

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Will people who have had breast cancer likely to get myelodysplastic syndrome?

Will people who have had breast cancer likely to get myelodysplastic syndrome?

Side effect: This is a side effect of some chemotherapy agents. This side effect does not happen to everyone. It is important to follow up with your medical oncologist after treatment is complete so they can keep track of your blood cell counts. If have concerns that you may have developed this, speak to your doctor. ...Read more

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Is it possible to have a normal white blood count, and end up diagnosed with myelodysplastic syndrome from a bone marrow biopsy?

Is it possible to have a normal white blood count, and end up diagnosed with myelodysplastic syndrome from a bone marrow biopsy?

Yes: It is a little confusing, but it is possible. We have 3 different cell lines in our blood: white blood cells, red blood cells and platelets or clotting cells. They all start their maturation in the marrow with young forms that evolve in mature, circulating cells. Myelodysplasia can affect 1, 2 or all cell lines and will eventually affect the number and/or the proportion of immature forms in blood ...Read more

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Very low iron even w/ Venofer. HGB and HCT normal. MCV is normal but RDW is 19.2%. Folate, (folic acid) B12, etc = normal. Could this be myelodysplastic syndrome?

Very low iron even w/ Venofer. HGB and HCT normal. MCV is normal but RDW is 19.2%. Folate, (folic acid) B12, etc = normal. Could this be myelodysplastic syndrome?

Low iron: Is it definitely iron deficiency? What is the level of iron, TIBC and ferritin level. How about the WBC and platelet.
What is the retic count.? It is difficult to diagnose MDS without a bone marrow picture which can also evaluate the
bone marrow iron and special tests for MDS. Discuss with your PCP. She can refer you to a hematologist. I hope this
will help you. Take care ...Read more

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My dad (85) has myelodysplastic syndrome (mds), hgb recently fell to 9 and red cell count near critical. Getting transfusion and procrit (epoetin alfa). Outlook?

My dad (85) has myelodysplastic syndrome (mds), hgb recently fell to 9 and red cell count near critical. Getting transfusion and procrit (epoetin alfa). Outlook?

MDS not curable: First transfusion? Or becoming transfusion dependent.
Are newer possibilities to help control transfusion requirement.
Different subtypes of mds. Would need more specifics. ...Read more

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What are the symptoms of myelodysplastic syndromes (mds)?

What are the symptoms of myelodysplastic syndromes (mds)?

It varies: There may be none or the patient may feel tired from anemia, show signs of bruising from low platelets or infections from low white blood counts. ...Read more

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Are there treatment guidelines for myelodysplastic syndromes?

Are there treatment guidelines for myelodysplastic syndromes?

Yes: Nccn, a nationaly recognized organization publishes guidlines for the treatments of all malignancies including mds. ...Read more

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Myelodysplastic syndromes are what?

Blood disease: These are a group of blood disorders that cause anemia or problems with the white cells, platelets or all three.
There are several different forms that have varied prognosis. Some are very close to leukemia.
These are diagnosed on bone marrow testing. There are some damaged chromosomes that can be found with this group of diseases. Some are very treatable, and some not so. ...Read more

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What are the tests for myelodysplastic syndromes?

Bone marrow: The only way to diagnose a myelodysplastic syndrome completely and accurately including prognostic factors is by performing a bone marrow biopsy and aspiration with subsequent multi-pronged assessment: morphology, flow cytometry, cytogenetics, and molecular studies. Some changes in the peripheral blood may suggest mds but a complete diagnosis still relies on bone marrow examination. ...Read more

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Are some people more prone to getting myelodysplastic syndromes?

Yes: There are some risk factors for myelodysplastic syndrome (mds). People exposed to certain chemotherapy drugs are at increased risk due to damage to the bone marrow dna from some chemo drugs. There is a higher risk of mds as people age. Certain genetic disorders (such as down syndrome) put people at risk for mds. Tobacco use is also associated with an increased risk of mds. ...Read more

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My brother has myelodysplastic syndromes. Should I be worried about this?

My brother has myelodysplastic syndromes. Should I be worried about this?

Possibly: This would depend upon your brothers age, and his risk factors. For instance if he is elderly, and has significant chemical exposure, than no. If he is young, under the age of 50, mds is uncommon and I would seek a second opinion to confirm the diagnosis. If it turns out to actually be mds than yes, you would be at a higher risk. ...Read more

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What is myelodysplastic syndromes (mds)?

Bone marrow disease: MDS is a disease of bone marrow that causes blood precursor cells to have an abnormal appearance ("dysplasia"), and prevents normal production of mature RBC or WBC. This can cause seriously low blood cell counts. It arises from gene mutations acquired during your lifetime, in bone marrow cells. There is a risk that, with additional mutations, it can evolve into acute leukemia. ...Read more

Dr. Lois Freisleben-Cook
38 Doctors shared insights

Pancytopenia (Definition)

This is a decrease in all the cell lines of your blood. Meaning the white count, hemoglobin and platelets. If someone is anemic, the hemoglobin is low. If someone us thrombocytopenic, the platelet count is low. If someone is pancytopenic, all cell lines are ...Read more