Doctor insights on:
Pancytopenia Myelodysplastic Syndrome
Bone Marrow Biopsy: Pancytopenia is a clinical condition that can be caused by a variety of diseases such as aplastic anemia, myelodysplasia, drug toxicity. Myelodysplasia is a clinical syndrome that may manifest itself as pancytopenia. A bone marrow biopsy is the only way to tell what is going on. ...Read more
Pre Leukemia (Myelodysplastic Syndrome) (Definition)
A bone marrow disorder which causes low blood counts (anemia and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of MDS and many different types of treatment. Hematologists and oncologists specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy. ...Read more
See below...: The bone marrow is usually hypercellular (high cellularity) in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read more
Myelodysplasia: The typical bone marrow features seen in myelodysplastic syndrome can include a hypercellular marrow (the marrow is too full of cells although in some cases the bone marrow can be more empty (hypocellular). There is typically disorder growth of cells so that they do not mature normally (dypsoiesis). Also, many times the chromosomes (cytogenetics) of the bone marrow cells will be abnormal. ...Read more
See below...: The bone marrow (where blood elements are produced) has high cellularity in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read more
See below...: Myelodysplastic syndromes (mds) represent a group of bone marrow cancers similar to leukemias in many respects but usually with a less aggressive evolution. Like many other types of cancer, treatment includes chemotherapy and sometimes bone marrow transplantation; however, if the mds is low grade sometimes treatment is not necessary, at least not initially (watchful waiting). ...Read more
See below...: Myelodysplastic syndrome (mds) is not a procedure but a form of bone marrow cancer that is generally less aggressive than leukemia but still malignant. Mds usually evolves more slowly then leukemia and sometimes can transform into acute leukemia and become more aggressive and faster evolving. It can be treated with chemotherapy or bone marrow transplant but sometimes treatment is not necessary. ...Read more
MDS: Myelodysplastic syndrome (mds) is a bone marrow disorder which causes low blood counts (anemia, and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of mds and many different types of treatment. Hematologists and oncologists are the doctors that specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy. ...Read more
If myelodysplastic syndrome is mainly caused by exposure to certain elements. How long ago would that exposure have been?
MDS Carcinogens: Alkylating chemotherapies can cause MDS 5-7 years from last dose. Radiation can cause MDS 10-40 years after last dose. Although it's debatable whether modern radiation therapy can cause MDS (see my PubMed article: 24577814). Benzene can cause bone marrow aplasia, MDS or AML 4-14 years after exposure. Tobacco (benzene et al) smoking is significantly associated with MDS with onset 10-20 years. ...Read more
I have been diagnosed with myelodysplastic syndrome and just saw "with high grade lesions" but can't find any definition of the lesions.?
See below...: This is not standard terminology. Make sure your diagnostic samples have been reviewed by a hematopathologist (a pathologist specialized in the diagnosis of hematologic diseases) and discuss the report with your hematologist/oncologist. ...Read more
The non drug treatments for Myelodysplastic syndrome include:: Transfusions.Get a more detailed answer ›
See below...: Both monoclonal gammopathy of undetermined significance (mgus) and myelodysplastic syndrome (mds) are disease entities that may be managed by watchful waiting. If your physician is a hematologist/oncologist then he or she probably has significant experience with these diseases and manages them accordingly. ...Read more
Diagnosis: For certain patients, genomic sequencing can help establish a diagnosis of mds, especially those without large chromosomal abnormalities. In addition, sequencing can be used to help monitor for response to treatment. There are also limited data to suggest that certain mutations can be useful in prognosis. This is an emerging field of medicine and hopefully your oncologist can help guide you. ...Read more
My husbands mother wad diagnosed with myelodysplastic syndrome in her mid 50's, passed away she was deficient of chromosome 8. Is this hereditary?
Probably not: Even though a history of mds in first degree relatives may slightly increase the overall risk to develop mds, the risk is still minimal and these diseases are usually not hereditary. ...Read more
Side effect: This is a side effect of some chemotherapy agents. This side effect does not happen to everyone. It is important to follow up with your medical oncologist after treatment is complete so they can keep track of your blood cell counts. If have concerns that you may have developed this, speak to your doctor. ...Read more
Is it possible to have a normal white blood count, and end up diagnosed with myelodysplastic syndrome from a bone marrow biopsy?
Yes: It is a little confusing, but it is possible. We have 3 different cell lines in our blood: white blood cells, red blood cells and platelets or clotting cells. They all start their maturation in the marrow with young forms that evolve in mature, circulating cells. Myelodysplasia can affect 1, 2 or all cell lines and will eventually affect the number and/or the proportion of immature forms in blood ...Read more
Very low iron even w/ Venofer. HGB and HCT normal. MCV is normal but RDW is 19.2%. Folate, (folic acid) B12, etc = normal. Could this be myelodysplastic syndrome?
Is it definitely iron deficiency? What is the level of iron, TIBC and ferritin level. How about the WBC and platelet.
What is the retic count.? It is difficult to diagnose MDS without a bone marrow picture which can also evaluate the
bone marrow iron and special tests for MDS. Discuss with your PCP. She can refer you to a hematologist. I hope this
will help you. Take care ...Read more
My dad (85) has myelodysplastic syndrome (mds), hgb recently fell to 9 and red cell count near critical. Getting transfusion and procrit (epoetin alfa). Outlook?
MDS not curable:
First transfusion? Or becoming transfusion dependent.
Are newer possibilities to help control transfusion requirement.
Different subtypes of mds. Would need more specifics. ...Read more
Yes: Nccn, a nationaly recognized organization publishes guidlines for the treatments of all malignancies including mds. ...Read more
These are a group of blood disorders that cause anemia or problems with the white cells, platelets or all three.
There are several different forms that have varied prognosis. Some are very close to leukemia.
These are diagnosed on bone marrow testing. There are some damaged chromosomes that can be found with this group of diseases. Some are very treatable, and some not so. ...Read more
Bone marrow: The only way to diagnose a myelodysplastic syndrome completely and accurately including prognostic factors is by performing a bone marrow biopsy and aspiration with subsequent multi-pronged assessment: morphology, flow cytometry, cytogenetics, and molecular studies. Some changes in the peripheral blood may suggest mds but a complete diagnosis still relies on bone marrow examination. ...Read more
Yes: There are some risk factors for myelodysplastic syndrome (mds). People exposed to certain chemotherapy drugs are at increased risk due to damage to the bone marrow dna from some chemo drugs. There is a higher risk of mds as people age. Certain genetic disorders (such as down syndrome) put people at risk for mds. Tobacco use is also associated with an increased risk of mds. ...Read more
Possibly: This would depend upon your brothers age, and his risk factors. For instance if he is elderly, and has significant chemical exposure, than no. If he is young, under the age of 50, mds is uncommon and I would seek a second opinion to confirm the diagnosis. If it turns out to actually be mds than yes, you would be at a higher risk. ...Read more
Bone marrow disease: MDS is a disease of bone marrow that causes blood precursor cells to have an abnormal appearance ("dysplasia"), and prevents normal production of mature RBC or WBC. This can cause seriously low blood cell counts. It arises from gene mutations acquired during your lifetime, in bone marrow cells. There is a risk that, with additional mutations, it can evolve into acute leukemia. ...Read more
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