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Doctor insights on: Pancytopenia Chemotherapy Aplastic Anemia

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Is chronic pancytopenia anemia curable?

Is chronic pancytopenia anemia curable?

Depends on cause: Chronic pancytopenia means low white & red cells and low platelets. Reversible causes such as nutritional deficinecies, immune disorders, drug-related can be treated effectively. However, patientsw with inherited conditions or bone marrow disorders need a detailed work-up and treatments may not be effective. ...Read more

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Dr. Sheila Smith
38 doctors shared insights

Pancytopenia (Definition)

This is a decrease in all the cell lines of your blood. Meaning the white count, hemoglobin and platelets. If someone is anemic, the hemoglobin is low. If someone us thrombocytopenic, the platelet count is low. If someone is pancytopenic, all cell lines are ...Read more


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Can normochromic or normocytic anemia cause leukemia?

Can normochromic or normocytic anemia cause leukemia?

No: Anemia (normochromic/cytic or not) can be a sign of leukemia (or a variety of other cancerous or non-cancerous conditions). That is it can associated with leukemia. However, it does not cause leukemia. Correlation does not equal causation. ...Read more

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Is polychromasia typically associated with microcytic anemia (iron deficient anemia)?

Is polychromasia typically associated with microcytic  anemia (iron deficient anemia)?

Iron deficiency is: Usually hypo chromic. Polychromasia is seen in rapidly changing circumstances like hemolytic anemia. ...Read more

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Can aplastic anemia be cured?

Can aplastic anemia be cured?

Possible: Aplastic anemia can be treated with immunosuppressive medications with resolution in a significant percentage of patients. Younger patients can be successfully treated with donor bone marrow transplants. ...Read more

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Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Aplastic anemia: Aplastic anemia is a condition where for some unclear reason the bone marrow fails to produce normal blood cells. It could be due to underlying genetic mutation plus environmental -i.e. Drugs, chemical agent, infection, etc. Immunosupressant agent has been used to treat aplastic anemia with some response. Allogeneic bone marrow transplant will be the treatment of choice to cure the disease. ...Read more

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How is pancytopenia developed during aplastic anemia?

How is pancytopenia developed during aplastic anemia?

Production stops: The body continuously recycles & replaces different cells in the blood. Red cells last ~100days, platelets several hours, other cells vary. The healthy system acheives a steady state of producing cells as fast as they break down. If an event such as a toxic exposure (chloramphenacol) or tumor invasion shuts down the "factory", no new material will be made & you get low on everything. ...Read more

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Reticulocytes low, pancytopenia, & bone marrow destruction indicates which type of anemia?

Reticulocytes low, pancytopenia, & bone marrow destruction indicates which type of anemia?

Complex problem: It appears that your bone marrow is not making new blood, so you have anemia due to the failure of production. If you have pancytopenia then the problem is much more than anemia alone. Such situation are either due to leukemia or preleukemic conditions like Myelodysplastic syndrome(MDS). You need a blood specialist to help you sort it out and guide you further. ...Read more

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How are aplastic and hemolytic anemia differentiated?

How are aplastic and hemolytic anemia differentiated?

See below: Aplastic anemia is when the bone marrow stops producing blood cells. Hemolytic anemia is when red blood cells are being destroyed outside of the bone marrow. ...Read more

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Can rituxan (rituximab) treat my hairy cell leukemia?

Can rituxan (rituximab) treat my hairy cell leukemia?

Generally, yes: Rituxan (rituximab) is an antibody that binds the surface of B lymphocytes, which includes hairy cell leukemia. By itself it can induce remissions, but it is more effective when given in combination with other agents. Here is a link to a recent paper: http://www.ncbi.nlm.nih.gov/pubmed/25195120 ...Read more

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Is sickle cell anemia painful?

Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Can aplastic anemia cause infertility?

Yes: Any severe illness can have a negative impact on fertility. In this specific case the therapies can also haver an impact on long term reproductive issues. ...Read more

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What medications treat aplastic anemia?

Many: Immune suppression with drugs like steroids, cyclosporine, and anti-thymocyte globulin (horse). Bone marrow transplantation is another important type of treatment for aplastic anemia in young people. ...Read more

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What causes sickle cell anemia besides malaria?

What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

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Can sickle cell anemia be fatal?

Can sickle cell anemia be fatal?

Yes: Individuals with sickle cell anemia are at high risk to develop invasive bacterial infections, e.g., meningitis and bacteremia, especially by pneumococcus. Penicillin prophylaxis, immunization, and prompt medical attention for febrile illness have greatly reduced fatality from serious infection. ...Read more

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Can Lamotrigine cause aplastic anemia?

Unfortunately, yes: Unfortunately, the very good drug for epilepsy and to some extent mood disorders, Lamotrigine can cause aplastic anemia in a very rare number of individuals. AA is present worldwide at a rate of about 4 cases per 1 million (word wide). 3.2 cases per million would be ACQUIRED such as from exposure to medication or other reasons. Usually found in younger individuals on the drug. ...Read more

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Could hydroxyurea therapy cause leukemia and/or lymphoma among patients?

Could hydroxyurea therapy cause leukemia and/or lymphoma among patients?

Possibly: The agent is considered mutagenic and although the risk is low, it is a real one. ...Read more

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What is sideroblastic anemia?

Sideroblastic anemia: The marrow produces ringed nucleated cells instead of healthy RBC's. This may be genetic or myelodysplatic - the latter is bad as there is a high rate of a blood cancer. The ringed cells cannot use the Iron that is available. ...Read more

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Can neglis aplastic anemia be cured?

What is neglis?: Regarding aplastic anemia, yes there are good treatments for it. Standard of care for a young person with severe aplastic anemia and a matched sibling donor is an hematopoietic stem cell transplant. For those without a suitable donor, immune suppression is standard of care. If you can clarify the word "neglis" for us, we are happy to provide additional info. Cheers. ...Read more

Dr. Devon Webster
972 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more


Dr. Steven Ginsberg
1,283 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more