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Doctor insights on: Pancreatic Triacylglycerol Lipase

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Normal lipase levels means healthy pancreas?

Normal lipase levels means healthy pancreas?

Not really: All it means is that you don't have pancreatitis at the time of the blood draw. If the pancreas were damaged by previous episodes of pancreatitis, the lipase would still be normal. ...Read more

Dr. Todd Igel
359 doctors shared insights

Lipase (Definition)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of ...Read more


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How is it that lipase is elevated when no pancreatic disease?

How is it that lipase is elevated when no pancreatic disease?

No other causes: Of lipase elevation except pancreatitis. You probably had a mild case that went away before you had the test, because it takes several days to a week for lipase test to return to normal. ...Read more

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No pain, amylase back in May was 184, lipase was 66(range was until 60 the highest, amylase range is 110 the highest). Pancreas problems or what?

No pain, amylase back in May was 184, lipase was 66(range was until 60 the highest, amylase range is 110 the highest).   Pancreas problems or what?

Not likely: It sounds like you had some issues, maybe abdominal pain sometime in May, when you had your pancreatic enzymes checked, but you no longer have pain now. Based on the minimal elevation of your enzymes even in May I doubt their origin was pancreatic even then. ...Read more

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My lipase was too high after having a pancreas blood test. What does that mean?

My lipase was too high after having a pancreas blood test. What does that mean?

Lipase: It may mean inflamation of the pancreas, inflamation of pancreas may come from alcohol abuse, infection, tumor or too much fat( hypertriglyceridemia) in the blood stream. ...Read more

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What is lipase and how is it released? Is it different frm the digestive juices that pancreas produce?

What is lipase and how is it released? Is it different frm the digestive juices that pancreas produce?

Lipase ...: is an enzyme that catalyzes the hydrolysis of fats (lipids). Lipases are a subclass of the esterases. Lipases perform essential roles in the digestion, transport & processing of dietary lipids (e.g. triglycerides, fats, oils). More broadly, "pancreatic juice" contains many enzymes, including trypsinogen, chymotrypsinogen, elastase, carboxypeptidase, pancreatic lipase, nucleases & amylase. ...Read more

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How can kidney problems cause elevated lipase? Tests to differentiate between pancreas cause vs. Kidney? I have both panc and kidney type symp.

Lipase elevations: Can come from different causes, two of which are pancreas and kidney problems. Usually, very high lipase levels along with elevated amylase levels are seen in acute pancreatitis, whereas lipase elevations in kidney diseases are not that high. Pancreatitis can show on ct scan, and kidney problems, can elevate BUN and creatinine levels. Ask your dr about specific advice. ...Read more

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Is lipase always elevated in acinar cell carcinoma of the pancreas? If yes, how elevated does it usually get?

Is lipase always elevated in acinar cell carcinoma of the pancreas? If yes, how elevated does it usually get?

Only about half: Maybe half of folks have it up in this rare cancer. If there's nothing on imaging, I'd get over the idea that you have acinar carcinoma of the pancreas and get on with your life. We're not going to operate without a visible lesion, and you're doing yourself a disservice worrying about something unlikely. If I recall, your major concern is a very slightly elevated lipase. ...Read more

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"human pancreatic exocrine response to nutrients in health and disease" bmj 2005 figure 2 says lipase post-lundh meal should rise 5x. Is this correct?

"human pancreatic exocrine response to nutrients in health and disease" bmj 2005 figure 2 says lipase post-lundh meal should rise 5x. Is this correct?

Maybe, but...: That graph is a generalization, based on other scientists' studies (one would have to review the original studies). The graph shows pancreatic "enzyme delivery into the duodenum increases rapidly and reaches maximal values within the first postprandial hour", which means it's an estimate of the amount of enzyme put into the small intestine to digest food... Not a measure of lipase on a blood test. ...Read more

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seen earlier for chronic pancreatitis flare. Lipase level normal dr refused admit. Told him pancreas is burned out levels no longer rise. Stillinpain?

Other cause: Has your doctor considered other causes for your pain?
Since your lipase is normal this is not likely to be due to pancreatitis, but I would suggest having labs rechecked in 24 hours if symptoms persist.
There are many other causes of abdominal pain and nausea/fever which should be explored ...Read more

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How to diagnose pancreatic dysfunction? Amylase, lipase and insulin blood test?

History & physical: If the pancreas is inflamed or damaged, amylase and lipase are often up, and it's not subtle. If your pancreas isn't functioning properly, you'll be losing weight with no explanation and probably have diarrhea / steatorrhea. Your physician can check your stool for pancreatic enzymes. It's rare but with a suggestive history, a screen may show something that could respond to enzyme replacement. ...Read more

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What is the usual level of lipase in someone with pancreatic cancer? How elevated does it get?

Poor test for cancer: Lipase is usually not elevated in Cancer arising from the Pancreas...so it is not a test we do to check for Cancer. Lipase and Amylase are tests done to make a diagnosis of Pancreatitis ...Read more

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How elevated do lipase levels typically get in someone with acinar cell carcinoma of the pancreas?

How elevated do lipase levels typically get in someone with acinar cell carcinoma of the pancreas?

See below: Ms. Amanda: Unfortunately there are no good tests for screening for pancreatic cancer. Lipase is not reliable and lumpy fat is a quack thing.
You may consult this site for info on this topic:
http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer-detection ...Read more

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Normal ameylase lipase with slightly coarse echotexture pancreas gallblader removed 5y ago no pain wt cod be wrong?

Normal ameylase lipase with slightly coarse echotexture pancreas gallblader removed 5y ago no pain wt cod be wrong?

Why all the tests?: What are you or your doctor looking for? If there is no pain or symptoms & normal labs, why do an ultrasound? These ultrasound findings may be just a normal finding. Sounds like enough normal tests have been done unless I am missing some important information. ...Read more

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My lipase has been at 937 for 3 days now but when they did an EGD and MRCP my pancreas had no signs of inflammation. Whats wrong ?

Symptoms: Did you have symptoms consistent with pancreatitis? Was the serum amylase elevated? Sometimes the lipase remains elevated after the inflammation of the pancreas subsides and the amylase returns to normal. Your gastroenterologist is best qualified to advise you,however. ...Read more

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My labs came back should I be worried my lipase are elevated to 59, wondering what could it be. Hoping its not pancreatic cancer?

Why was it tested?: That's the most important question to ask. The context in which the lab was drawn will inform how it is interpreted. Lots of things can raise your lipase (e.g. Alcohol use, gallstones, medications, etc.) while pancreatic cancer is a (remote) possibility, have a positive attitude and follow up with your doctor. They can better help interpret the test. 59 is normal in my hospital, btw. ...Read more

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When lipase levels do elevate because of pancreatic cancer, how high do the levels tend to get? Very high or just slightly elevated?

When lipase levels do elevate because of pancreatic cancer, how high do the levels tend to get? Very high or just slightly elevated?

May/may not. Unrelia: Lipase is not a reliable test for making a diagnosis of Pancreatic Cancer. It is test which is largely limited in its usfulness, mostly for cases of pancreatitis. ...Read more

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Lipase- 307 to 297 to 238 over 4 week period. Never had a pancreas problem until after VSG. Surgeon not taking it serious. Is it serious? Please reply

Lipase levels: If I’m not mistaken, those lipase numbers are within the range of normal. Is there something else going on that might suggest an issue with your pancreas? ...Read more

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Would amylase and lipase be high or low with pancreatic cancer?

Amylase and lipase: Are usually elevated with inflammation such as pancreatitis and could be normal with pancreatic cancer. A tumor marker ca 19-9 is usually elevated with pancreatic tumors. Depending on the location of tumor biliary enzymes could be elevated too. ...Read more

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What would cause an elevated lipase test, but normal CT scan of pancreas?

What would cause an elevated lipase test, but normal CT scan of pancreas?

Mild and transient: Mild and transient pancreatitis. It can resolve quickly, m particualrly if mild. The ct scan was probably obtained to make sure you did not have cancer of that organ, which is a terrible disease. Be glad that the ct was normal. ...Read more

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Can pancreatic enzymes with protease, amylase and lipase hurt or help cancer?

Health fraud: Giving the pancreatic enzymes that help in pancreatic insufficiency (cystic fibrosis, chronic pancreatic scarring) as a cancer treatment is a cynical, cruel fraud. It's often packaged with "detoxification" and coffee enemas. Don't pay money to the people who've tried to deceive you on the thought "what if it did work?". ...Read more

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Had slightly elevated lipase (80 when normal reference range was 13-60). I'm terrified of pancreatic cancer! I'm only 33! ?

Had slightly elevated lipase (80 when normal reference range was 13-60). I'm terrified of pancreatic cancer! I'm only 33! ?

Lipase, not reliable: Lab tests are only done if the doctor suspects something, based on your symptoms. So you need to tell us why was this test done? Did the ordering doctor tell you what may be wrong and what the Lipase test means? It is important to tell us the complete story!
Basically Lipase is not a particularly useful test and rarely helps in making any diagnosis. So it is not likely to indicate Cancer at all. ...Read more

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Why is my husbands lipase 450 and amylase 250 so high. They said he has cirrossis of the liver. Those are pancreatic enzyme's.

I'm sorry: Elevated lipase and amylase can result from ongoing damage to the pancreas from alcohol -- perhaps refluxing up a damaged duct, or he may have a cystic fibrosis variant, a hereditary pancreatitis, or any of several other entities. Few diseases truly involve only one organ, and he may have more than one thing going on. This sounds serious and I am glad he has you to care for & love him. ...Read more

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All tests normal except lipase.lipase started at 930 a wk ago has dropped to 775.still unable to eat w/out pain near pancreas,nausea,vomiting.

Sounds like: You are suffering from pancreatitis. Hopefully you are reviewing your symptoms with your doctor(s) continually. Unfortunately with a more involved understanding of your exact situation it's more difficult to guide you. As there are many reasons for pancreatitis and nonpancreatitis elevations in a persons lipase. ...Read more

Dr. Janice Alexander
3 doctors shared insights

Pancreas (Definition)

Abdominal organ. It is digestive organ: it secretes enzymes into the small bowel which break down food and help its absorption. It is also an endocrine organ: it produces hormones involved in sugar control and control of digestion. Insulin is one of these hormones. Diabetics either lack Insulin (type 1 diabetes) or have inadequate ...Read more