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Doctor insights on: Pancreatic Cancer Spread To Liver Prognosis

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Pancreatic cancer, ampullary tumor. Whipple procedure. Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Pancreatic cancer, ampullary tumor. Whipple procedure. Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Poor: While Whipple is the best approach for a primary pancreatic or ampullary lesion, the recurrence rate at 1-2 yrs is 90%. Chemo either of the FOLFIERI or Genciabine /Abraxane combo have limited effects on liver mets which in pancreas are not considered amenable to resection. There is an FDA protocol using specific monoclonals targeting pancreas that might be available but only after chemo failure ...Read more

Dr. Barry Rosen
4,351 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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My mom has pancreatic cancer & just learned it spread to her liver. She is in the hospital w/jaundice, chill, her biliruban is 3.9. What is happening?

My mom has pancreatic cancer & just learned it spread to her liver. She is in the hospital w/jaundice, chill, her biliruban is 3.9. What is happening?

Sorry to hear this: First off I wish your mother and family the best. Also, your best bet is to ask this very important question to her oncologist and/or covering doctor. They have access to more information than you can readily provide us here and it will be more meaningful/accurate. ...Read more

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My dad have pancreatic cancer that has spread to his liver. He took chemo and the doctor stopped it because it did not help. How long will live?

My dad have pancreatic cancer that has spread to his liver. He took chemo and the doctor stopped it because it did not help. How long will live?

No sure answer: Pancreatic ca, is very hard to treat, and frequently painful.
Help him stay well nourished.
See that he gets the best pain control he can.
Be realistic on stage and tx benefits. ...Read more

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How is pancreatic cancer with liver metasis treated?

How is pancreatic cancer with liver metasis treated?

Chemotherapy: Generally chemotherapy. If the cancer has spread to the liver, it probably has also spread to other organs in amounts too small to be seen by even the highest quality scans. Since chemo enters the blood stream, that's why this is the best treatment. After chemo, if there is only 1 or 2 liver spots, sometimes these can ablated (radiation or heat probes). ...Read more

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Can you tell me about pancreatic cancer with liver metasis?

Can you tell me about pancreatic cancer with liver metasis?

This is not good...: Pancreas cancer is very difficult cancer to treat, mostly because when found, it has already spread to many other areas -- adjacent organs, lymph nodes, liver, lungs, or brain. That makes "early" treatment impossible.

Fortunately new medications that can kill pancreas cancer cells (depending on the kind that one has) have helped many people live longer & better, but it is still a bad cancer. ...Read more

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Pancreatic cancer extended to the liver. Can it be treated still?

Pancreatic cancer extended to the liver. Can it be treated still?

Yes: Primarily with chemotherapy. There are several regimens that can be utilized but depends on how well the person is doing, other medical issues, and extent of the liver involvement. You need to meet with a medical oncologist. Hope this helps. ...Read more

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Can you please list specific symptoms of liver or pancreatic cancer?

Unfortunately: There are no specific symptoms, mostly non-specific symptoms. Abdominal discomfort, malaise, weight loss, GI symptoms are typical presentations, but really very non-specific. Sometimes, even doctors can't tell without special imaging tests. ...Read more

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Are liver and pancreatic enzymes always elevated with liver and pancreatic cancer?

Are liver and pancreatic enzymes always elevated with liver and pancreatic cancer?

Short answer: No: Most often if a malignant mass presses on the ductal system of liver or panc. (see picture), it can cause abn. Blood enzymes. If the mass is small and ducts drain, routine enzymes are usually normal.
Gilbert Syndrome, a genetic abn. Of up to 7% of folks, has the significance like your fingerprints, and is discussed nicely in: http://ghr. Nlm. Nih. Gov/condition/gilbert-syndrome ...Read more

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Are there any cures for liver cancer or pancreatic cancer?

Are there any cures for liver cancer or pancreatic cancer?

Surgery: With favorable tumors of either the liver or the pancreas, surgery, often combined with chemo may be curative. Both of these types of cancer and the surgical treatments for them are highly specialized and should be performed by a surgeon with experience and training in hepatobiliary surgery. ...Read more

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My son has pancreatic cancer and it has matastized to the liver. That tumor is small and the cancer is no where else. Why not remove the liver tumor?

My son has pancreatic cancer and it has matastized to the liver. That tumor is small and the cancer is no where else. Why not remove the liver tumor?

Thanks for asking!: Patients with stage 4 cancer (metastatic disease) are usually not considered as candidates for surgery (unless it's for alleviation of symptoms). Consult medical oncologist for systemic chemotherapy or targeted therapy. ...Read more

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My son has pancreatic cancer which is also in the liver. The liver tumor is small. They found no other places with cancer. Why not remove liver tumor?

My son has pancreatic cancer which is also in the liver. The liver tumor is small. They found no other places with cancer. Why not remove liver tumor?

Depends: It really depends on type of cancer. Adenocarcinoma is not resectable once outside the pancreas because there are other areas that u can't see yet. If it is neuroendocrine tumor then surgery is an option. Also liver lesion needs to be biopsied or pet positive to reliably say that there is cancer there. Get another opinion. ...Read more

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Panc elastase test shows insufficiency. Have fatty liver. Is pei cause of fatty liver? Is there connection between fatty liver and pancreatic cancer?

Panc elastase test shows insufficiency. Have fatty liver. Is pei cause of fatty liver? Is there connection between fatty liver and pancreatic cancer?

No, just description: Like most dx, just a label for a pattern, as judged by whatever metrics. Yes, there is observed relation between fatty liver ; developing liver cancer. Fatty liver most commonly due to persistent low-fat, hi-carb (i.e. All sugars, simple ; complex) foods. Liver, to protect rest of body from ↑sugar (toxic), converts sugars into triglyceride fats. If can't export into external fat, then fatty liver. ...Read more

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Can clinical trials be of any benefit for a person with pancreatic cancer and extensive mets to the liver?

Pancreatic cancer: "Benefit" in such situation depends on patient / family's expectation from treatment that is being offered. Seems like you know that it is not a definitive treatment. ...Read more

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Can the pancreatic cancer get treated after there was a mass between it and the liver which grows quickly? What's percentage of patient live?

Can the pancreatic cancer get treated after there was a mass between it and the liver which grows quickly? What's percentage of patient live?

Lymph node: I guessing that you are describing cancer that spread to a lymph node that is located between the pancreas and the liver. If this is the only place the cancer has spread, and the pancreas cancer is otherwise fully removed, the average survival is about 2 years if you get chemotherapy after the operation. Talk to your surgeon and oncologist for more details. ...Read more

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My mom has pancreatic cancer that started spreading to liver. Her oncologist not sure if continuing (gemzar) chemo would benefit her. Any suggestions?

Probably not: Your question implied that she developed liver metastasis while on gemzar (gemcitabine). If so, it is not llikely that continuing Gemzar (gemcitabine) alone will be helpful. She should speak with her oncologist about newer and more promising chemotherapy regimens such as adding nab-paclitaxel or trying folfirinox. Recent studies have shown encouraging results! ...Read more

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If you have pancreatic cancer, do you always get jaundice? Also is there a link between P/C and fatty liver? Both found by U/S at same time

If you have pancreatic cancer, do you always get jaundice? Also is there a link between P/C and fatty liver? Both found by U/S at same time

While jaundice,: Result of obstruction to bile ducts, is very common in pancreatic cancer, especially in more advanced disease, it is not always present. I would think the majority of cases, though, over 50%, would reveal themselves (present) with obstructive symptoms: jaundice, dark urine, pale stool, itching. Fatty liver does not cause pancreatic cancer but, you are correct, can be discovered with an ultrasound. ...Read more

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If someone has pancreatic cancer and an MRI was done that showed a new tumor (liver) does this mean it is always cancerous? Does a biopsy make sense?

If someone has pancreatic cancer and an MRI was done that showed a new tumor (liver) does this mean it is always cancerous? Does a biopsy make sense?

Maybe: Every lesion seen doesn't mean its cancer. A biopsy would make sense if you would do something different with either a positive, negative, or non-diagnostic result. If there would be nothing different done in terms if treatment, life planning, etc., twgardless of the result, them don't do it. Hope this helps! ...Read more

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Will a ct scan without contrast show pancreatitis or pancreatic cancer? Or damage to the liver?

Will a ct scan without contrast show pancreatitis or pancreatic cancer? Or damage to the liver?

Yes: In some cases a noncontrast ct scan can show pancreatic cancer, changes that could suggest pancreatic inflammation and liver diseases. However a negative scan does not rule out these diseases. ...Read more

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A friend, stage 4 pancreatic cancer, 1yr. Pain, machine controls her digestion, chemo 7 mo, tumors in pancreas & liver. In hospital 3 wks now. Dying?

A friend, stage 4 pancreatic cancer, 1yr. Pain, machine controls her digestion, chemo 7 mo, tumors in pancreas & liver. In hospital 3 wks now. Dying?

Bad news: While no person can say how long your friend has, you paint a pretty grim picture. I am very sorry.
Be with her and help her last days be as good as possible. God bless. ...Read more

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For what reasons won't a doctor attempt a liver transplant in a stage IV pancreatic cancer patient?

For what reasons won't a doctor attempt a liver transplant in a stage IV pancreatic cancer patient?

Problematic: Generally if pancreas cancer has traveled to the liver, then there is too much disease to expect benefit of a liver transplant. If the original cancer in the pancreas is still present, then the liver transplant will not help. Medications to lower the immune system to allow for an organ transplant will also cause cancer in other sites (such as in the pancreas) to rapidly grow further. ...Read more

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Pancreatic cancer symptoms MRI showed chronic pancreatitis, heart disease and fat liver, what is the chance that they might find a cancer there too?

Pancreatic cancer symptoms MRI showed chronic pancreatitis, heart disease and fat liver, what is the chance that they might find a cancer there too?

Plan to live: Chronic pancreatitis only has a slight tendency to produce cancer especially if it's hereditary, and if it was not seen on imaging, it's very unlikely to be there and you should plan to live. If you are not a longtime heavy drinker, then we need to seek the cause of your liver, heart and pancreatic disease. It may be that a healthier future awaits you with aerobic fitness as the key. Best wishes. ...Read more

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Hi, this is probably me being over concerned but recently I've noticed 2 or 3 yellow patches of skin on my legs and its making me nervous. Liver failure but I don't drink excessively. Pancreatic cancer? Should I be worried?

Hi, this is probably me being over concerned but recently I've noticed 2 or 3 yellow patches of skin on my legs and its making me nervous. Liver failure but I don't drink excessively. Pancreatic cancer? Should I be worried?

See your doc: It's tough to diagnose skin problems with words... it's best to see them in person. Is there a chance that these are areas where you could have bruises? Bruises can appear yellow. Hope this helps! ...Read more

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A friend w/ advanced pancreatic cancer. Chemo helped. Tumors in pancreas & liver. Intrathecal pump. Digestion problems. Released to go home. Hospice?

A friend w/ advanced pancreatic cancer. Chemo helped. Tumors in pancreas & liver. Intrathecal pump. Digestion problems. Released to go home. Hospice?

Advanced cancer: It seems reasonable and sensitive to engage hospice; hospice can help at home or he can go to a facility; hospice team can engage for many weeks. It is a good service. ...Read more

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Can high liver enzymes lead to pancreatic cancer? Can't take aspirin for headaches, take fiorcet, has acetaminophen take 6 times a day!

Can high liver enzymes lead to pancreatic cancer? Can't take aspirin for headaches, take fiorcet, has acetaminophen take 6 times a day!

Elevated liver: Function tests do not cause cancer, but if pancreatic cancer or anything else causes obstruction of the bile duct, it can cause elevated blood tests. Acetaminophen intake in amounts that exceed recommended amount can cause liver damage. ...Read more

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Pancreatic cancer. Whipple. Chemo 7 months. Tumors in pancreas and liver. Recent blood clot. Pain. New intestinal blockage. Is my body shutting down?

Pancreatic cancer. Whipple. Chemo 7 months. Tumors in pancreas and liver. Recent blood clot. Pain. New intestinal blockage. Is my body shutting down?

Difficult disease: Some blockages are due to scar tissue inside the abdomen (called adhesions), and other blockages are due to cancer growth. A CT scan may be able to tell the difference between the 2. If the blockage is cancer-related, then it may be time to think about a different chemotherapy regimen. But if it's just adhensions, then sometimes an operation helps. Talk to your doctor to investigate further ...Read more

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Mom has jaundice w elevated liver enzymes, and elevated amylase and lipase. Ct w contrast was done, no tumors seen. Could this be pancreatic cancer?

Mom has jaundice w elevated liver enzymes, and elevated amylase and lipase. Ct w contrast was done, no tumors seen. Could this be pancreatic cancer?

It is unclear: Hi kitten40047. The jaundice and elevated enzymes are concerning. It is reassuring to hear that the ct was negative. There may be other reasons for her symptoms. However, in the absence of any other explanation for the symptoms she has, you may want to have mom undergo additional tests, including perhaps MRI or endoscopy, which may shed more light on the pancreatic and liver areas. ...Read more

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Pancreatic cancer? I had a pancreatic protocol ct/hida/liver, pancreas, CBC blood test/stool test/colonoscopy. All perfect. I still have light/yellow stool

Pancreatic cancer? I had a pancreatic protocol ct/hida/liver, pancreas, CBC blood test/stool test/colonoscopy. All perfect. I still have light/yellow stool

Stop worrying: You have nothing to worry about except that fact that you are still a smoker, which I hope you'll stop. If everybody with light-colored stools consumed health-care dollars searching for pancreatic cancer, it'd be a huge waste. Evidently you're not even jaundiced. Please stop reading internet scare stuff, look for another cause of your abdominal pain ; stop reading internet scare stuff. ...Read more

Dr. Mark Pack
2 Doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


Dr. Jeffrey Wint
3 Doctors shared insights

Pancreas (Definition)

Abdominal organ. It is digestive organ: it secretes enzymes into the small bowel which break down food and help its absorption. It is also an endocrine organ: it produces hormones involved in sugar control and control of digestion. Insulin is one of these hormones. Diabetics either lack Insulin (type 1 diabetes) or have inadequate ...Read more