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Doctor insights on: Palpable Purpura Differential Diagnosis

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Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?

Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?

Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more

Non Blanching Red Or Purple Spots (Definition)

Non blanching red or purple spots can describe purpura, which is bleeding beneath the skin that does not blanch with pressure. It can be caused by platelet disorders, coagulation disordes, vascular ...Read more


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Please explain: 5 CM irregular splenic lesion. Differential diagnosis lymphoma and splenic metastasis. Could this be cancer?

Please explain: 5 CM irregular splenic lesion. Differential diagnosis lymphoma and splenic metastasis. Could this be cancer?

Yes: Both are forms of cancer. It could also be a benign hemangioma, an epidermoid cyst, an infart (how's your overall vascular health?) or any of a number of other entities. What to do next will depend on your history and physical exam. You're in no immediate danger but this very much needs to be followed up. Many of the lymphomas especially are very curable with today's biotech. ...Read more

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Ultrasound report of popliteal fossa showed lipomas. Is this unusual? Differential diagnosis?

Ultrasound report of popliteal fossa showed lipomas. Is this unusual? Differential diagnosis?

Popliteal Lipoma : A lipoma is an extremely common benign lipid (fat) tumor. It can easily be identified on exam & verified by ultrasound. Lipomas can be seen anywhere on the body under the skin where there is fat. Malignant transformation is extremely rare. Lipomas formed from liponeogenesis, usually seen after a blunt trauma, has a higher incidence of liposarcoma transformation. Bakers cyst is not a lipoma. ...Read more

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Differential diagnosis for acute appendicitis?

RLQ Pain: Long list including diverticulitis, crohn's disease, pelvic inflammatory disease, cholecystitis(gallbladder), ovarian cyst or twisted ovary, colon cancer, kidney stone, perforated ulcer, pancreatitis, bacterial infection and urinary tract infection to name a few. ...Read more

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Differential diagnosis for following pediatric fact pattern?

Confusing question: Your question makes no sense.Please submit appropriate basic facts and a clear question if you seek an answer.The questions are not linked on the site so each question should stand alone & be submitted as an open question, not to a specific person. ...Read more

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

Dr. Ira Katz Dr. Katz
1 doctor agreed:
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Inhomogeneous thyroid w/ 1cm nodule. blood tests normal. Wrists in severe pain with swelling, possible hashimotos diagnosis? Need autoimmune test?

Dr. Ira Katz Dr. Katz
1 doctor agreed:
Inhomogeneous thyroid w/ 1cm nodule. blood tests normal. Wrists in severe pain with swelling, possible hashimotos diagnosis? Need autoimmune test?

Probabl: Hashimoto's is something your doctor can say you have or do not have. IT IS AN AUTOIMMUNE DISEASE that can effect thyroid function. People with Hashimoto's are at significant increased risk of other autoimmune diseases. If there is any concern the wrist pain is autoimmune a work-up should be done! Don't panic! Autoimmune risk low in general and increased risk of a low risk is still low! ...Read more

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Bruises on leg - derm biopsy report dx: vascular telangiectasias, sparse perivascular lymphocytic inflammation & hemorrhage. What does this mean?

Bruises on leg - derm biopsy report dx: vascular telangiectasias, sparse perivascular lymphocytic inflammation & hemorrhage. What does this mean?

The biopsy shows no: The biopsy shows nothing remarkable. I wonder why it was done. What was the DR looking for? Ask the DR who did it to interpret it for you. ...Read more

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Would blood tests diagnose testicular cancer?

Would blood tests diagnose testicular cancer?

Some can help..: The diagnosis of testicular cancer requires a tissue biopsy to determine that cancer is present and the specific type. There are some tumor markers for testicular cancer that can be detected in the blood to help determine response to chemotherapy and disease activity. These are not present in all patients with testicular cancer and are not used for the actual diagnosis of the cancer. ...Read more

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Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy  give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

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Picture of purpura for leukemia

Picture of purpura for leukemia

Leukemia: Pictures of examples of the purpura of leukemia can be found on the picture section of the search engine of your choice. ...Read more

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2cm rt jd node excisional biopsy: "many cells present, unable to identify." ongoing sx, several 1cm painless neck nodes, unilat face/neck puffy/full.

2cm rt jd node excisional biopsy: "many cells present, unable to identify." ongoing sx, several 1cm painless neck nodes, unilat face/neck puffy/full.

More info. needed,,,: You seem to have many nodes involved with something, and your puffy face can mean that you have a swelling issue that likey has backed up your lymph drainage there. But the biopsy report, and the underlying illness is too vague to know what this can be. It might be infection, an auto-immune preocess, or something else, but a visit to the doctor especially head and neck is needed to find out. ...Read more

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What does a diagnosis of purpura fulmicans and lupus anticoagulant w/possible phophosilid syndrome mean?

What does a diagnosis of purpura fulmicans and lupus anticoagulant w/possible phophosilid syndrome mean?

Complicated question: Complicated question. Depends on severity, comlications and treatment. See rheumatologist. ...Read more

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Mammogram report:benign appearing calcification are present on the left.2 obscured masses are seeing 0.7 and 1.0cm.is the rprt describing dif finding?

Mammogram report:benign appearing calcification are present on the left.2 obscured masses are seeing 0.7 and 1.0cm.is the rprt describing dif finding?

Without the: benefit of the full report, hard to say for sure, but it sounds like they are describing three findings: a benign calcification of no concern, and two partially visualized masses measuring 0.7 and 1cm. It is probable that the partially obscured masses will need additional evaluation with specialized mammographic views and possibly ultrasound. ...Read more

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Hx breast ca, US spleen meaning?: Multiple hyperechoic solid lesions, indeterminate nature. Hemangiomata possible but metastatic disease not excluded.

Hx breast ca, US spleen meaning?: Multiple hyperechoic solid lesions, indeterminate nature. Hemangiomata possible but metastatic disease not excluded.

Your doc can explain: Your spleen has some shadows which require better imaging than what the Ultrasound produced. Your doctor should guide you further because it will take a CT scan or MRI test/s to provide a more clear picture of what the nature of these shadows in your spleen is. ...Read more

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What causes an inhomogeneous spleen in hodgkin lymphoma?

What causes an inhomogeneous spleen in hodgkin lymphoma?

Lymphoma vs. other: The spleen in hl may be heterogeneous/inhomogeneous/non-uniform due to lymphoma involvement, spleen infarction (death) due to cancer death in the spleen, or infection, or "other". The radiologist may or may not be able to determine that and your oncologist might be able to say more about it with knowing the clinical history. ...Read more

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Describe morphological and clinical features in common lymphoid neoplasms, please!?

Big subject!: I wish i could do everybody's homework assignments in 400 characters. Get a good pathology textbook such as robbins or a website you trust and read up on the lymphocytic and lymphoblastic leukemias, hodgkin's disease, and the non-hodgkin's lymphomas. Good luck. ...Read more

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Purpura (Definition)

Purpura are non blanching red or purple spots caused by bleeding beneath the skin. The spots do not blanch with pressure. They can be caused by platelet disorders, coagulation disordes, vascular ...Read more


Dr. Neigatha Graney
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Differential Diagnosis (Definition)

Is a process of elimination, to look at several possibilities for diagnosing a probable illness, through process of elimination, to narrow those probabilities, so as a ...Read more