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Doctor insights on: Pagets Disease Myelofibrosis

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Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Progressive: Yes, you described it well. New treatments are becoming available all the time, and they could extend your life! get treated! ...Read more

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Could mastectomy is the only option of treatment for paget"s disease?

Could mastectomy is the only option of treatment for paget"s disease?

For best results: Unfortunately it is diffuse diseases , it involves nipple and areola complex , when this area is removed will be cosmetically unacceptable , and is a aggressive disease are the reasons for mastectomy , although wide resection with good margins possible along with chemo-radiation is possible . It is also easier to reconstruct breast after mastectomy , if needed take a second opinion., discuss. ...Read more

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Is paget's disease common?

Is paget's disease common?

1-2% of population: Paget's disease of bone affects 1-2% of the population over 50 years of age. It is inherited in about 20% of patients. ...Read more

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What are the symptoms of Paget's disease?

What are the symptoms of Paget's disease?

Bone pain: Some people who have paget's disease will have absolutely no symptoms. Others may experience symptoms that are confused with arthritis. Others may have bone pain not in the joints. ...Read more

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Is paget's disease fatal?

Is paget's disease fatal?

Which?: Paget's disease of bone is a relatively benign and self-limited condition which can sometimes cause pain and in the worst case, deformity or fragility. But paget's disease of the breast is often a manifestation of an underlying breast cancer, which can certainly be fatal if untreated. ...Read more

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Is paget's disease treatable?

Is paget's disease treatable?

Yes: Paget's disease is very treatable. I have several paget's patients who do very well on yearly Reclast (zoledronic acid) infusions. ...Read more

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Can paget's disease be contagious?

Can paget's disease be contagious?

No: Some evidence suggests a virus might be involved in the cause but it still is not contagious. ...Read more

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Does paget's disease show up on an x-ray?

Does paget's disease show up on an x-ray?

Paget's disease: Of bone appears on bone scans and plain x-rays of the effected bone. Paget's disease of nipple and skin are distinct, different and not visible on imaging of any kind, suspected by exam, proven by biopsy. ...Read more

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Is paget's disease cancerous in all cases?

Is paget's disease cancerous in all cases?

In Situ or Invasive: Paget's dz represents less than 5% of all breast cancers; cancer cells are found involving the skin of the nipple, resembling eczema.Over 95% of the time an underlying cancer is found elsewhere in the breast, more commonly in-situ rather than invasive. Traditional rx was mastectomy however central lumpectomy (removal of nipple and areola) followed by radiation therapy is an acceptable alternative. ...Read more

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Is there a paget's disease support group online?

Is there a paget's disease support group online?

Several: Try http://www.Experienceproject.Com/groups/have-pagets-disease-of-bone/99046.

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What can you tell me about paget's disease? Is this deadly?

What can you tell me about paget's disease? Is this deadly?

Occassionally: Pagets disease of bone is seen as marked swelling with bone deformity, altering the shape of the bone involved such as femur hip region. In some instances malignant transformation to Pagets sarcoma develops. this is especially true in the skull where marked deformity in the side or top of head seen and sarcomatous malformation can lead to brain invasion. ...Read more

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Is there a national organization for paget's disease patients?

Paget Foundation: The paget foundation, http://www.Paget.Org, is one organization. Related groups: http://www.Pagetitalia.Com, http://www.Paget.Org.Uk, http://www.Paget.Nl, http://www.Rarebonedisease.Org, http://www.Magicfoundation.Org, http://www.Fibrousdysplasia.Org, http://www.Nof.Org, http://www.Bones.Nih.Gov, http://www.Oif.Org, and http://www.Boneandcancerfoundation.Org. ...Read more

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Does paget's disease significantly decrease a persons lifespan?

Does paget's disease significantly decrease a persons lifespan?

Stage-Dependent: Paget's dz represents less than 5% of all breast cancers; cancer cells are found involving the skin of the nipple, resembling eczema.Over 95% of the time an underlying cancer is found elsewhere in the breast, more commonly in-situ rather than invasive. Traditional rx was mastectomy however central lumpectomy (removal of nipple and areola) followed by radiation therapy is an acceptable alternative. ...Read more

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I was wondering whether paget's disease is cancerous in all cases?

I was wondering whether paget's disease is cancerous in all cases?

Depends: Paget's disease of the breast is cancer, paget's disease of the bone is generally not. See these sites for the two main types of paget's disease. http://www.mayoclinic.com/health/pagets-disease-of-bone/ds00485 http://www.Cancer.Gov/cancertopics/factsheet/sites-types/paget-breast. ...Read more