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Doctor insights on: Oxaliplatin

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Dr. Lois Freisleben-Cook
14 doctors shared insights

Oxaliplatin (Overview)

Oxaliplatin is a cancer agent.


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What is the oxaliplatin mechanism..How?

What is the oxaliplatin mechanism..How?

DNA replication: It forms dna adducts that block dna replication and transcription, resulting in cell death in actively dividing cells. It forms bulkier platinum-dna adducts that may be more difficult to repair. Journal of clinical oncology vol 20, no 7 (april 1), 2002. Hope this helps. ...Read more

Dr. Lois Freisleben-Cook
14 doctors shared insights

Oxaliplatin (Overview)

Oxaliplatin is a cancer agent.


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Oxaliplatin mechanism..How does it work?

Oxaliplatin mechanism..How does it work?

Platinum analog: Is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is a platinum derivative. It binds to dna forming cross-links which inhibit dna replication and transcription, resulting in cell death. ...Read more

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For a 59 year old stomach cancer patient, should leg pain be taken as a chemotherapy's side effect? Patient is on eloxatin (oxaliplatin) and capecitabina... Thanks.

For a 59 year old stomach cancer patient, should leg pain be taken as a chemotherapy's side effect? Patient is on eloxatin (oxaliplatin) and capecitabina... Thanks.

Maybe related: You are having leg pain and wonder if it is related to chemotherapy drugs. It is important to relay your leg pain to your doctor. This could be related to electrolyte imbalance, blood clot, among other things. Your doctor will want to know what makes the pain get better and when you notice it, if it resolves on its own. There may be additional studies ordered to look for clots. ...Read more

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70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?

70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?

Chemo : If you can tolerate capecitabine, the regiment will be good for the type of cancer. Also, consider to check her2-neu receptor status of the cancer - as if her2-neu receptor is positive, Herceptin (trastuzumab) which is an inhibitor to the her2-neu receptor should be considered as one of treatment options. ...Read more

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Who should not use Eloxatin (oxaliplatin)?

Who should not use Eloxatin (oxaliplatin)?

Eloxatin (oxaliplatin): "ELOXATIN (oxaliplatin) should not be administered to patients with a history of known allergy to ELOXATIN (oxaliplatin) or other platinum compounds." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3c740b43-f396-4998-bc66-6964a21f7161 ...Read more

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What is the oxaliplatin mechanism..How?

DNA replication: It forms dna adducts that block dna replication and transcription, resulting in cell death in actively dividing cells. It forms bulkier platinum-dna adducts that may be more difficult to repair. Journal of clinical oncology vol 20, no 7 (april 1), 2002. Hope this helps. ...Read more

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Oxaliplatin mechanism..How does it work?

Platinum analog: Is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is a platinum derivative. It binds to dna forming cross-links which inhibit dna replication and transcription, resulting in cell death. ...Read more

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Why can't you have cold food or drinks when taking oxaliplatin?

Why can't you have cold food or drinks when taking oxaliplatin?

Increased Neuropathy: Patients report severe weakness, numbness, and tingling/shocking sensations after minimal exposure to cold. In some cases, the effects are startling - they have been described as feeling like spasms in the throat. Some find that the side effects decrease after warming or massaging the area. However, cold exposure during treatments may having lasting nerve effects, up to 14 days after infusion. ...Read more

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My chemo is 5-FU and oxaliplatin, tablet for one and intrevenus for the other?

My chemo is 5-FU and oxaliplatin, tablet for one and intrevenus for the other?

YES: Yes, sounds right. Xeloda (capecitabine) is a 5-FU oral prodrug given with Oxaliplatin IV usually for colorectal cancer. This regimen is known as XELOX. ...Read more

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What to do if I had an allergic reaction to oxaliplatin chemo?

What to do if I had an allergic reaction to oxaliplatin chemo?

Ask: Ask your oncologist about your options. Depending on the malignancy, oxaliplatin may be your best option even after having a reaction. An Allergist can help to evaluate the reaction, and depending on its nature, suggest an effective premedication regimen or even assist with a desensitization procedure (basically fooling the immune system into accepting the drug). ...Read more

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Would "4 life factor plus" or max international's products do any good on a 59 year old cancer patient? He's on chemo with eloxatin (oxaliplatin) and capecitabina.

Would "4 life factor plus" or max international's products do any good on a 59 year old cancer patient? He's on chemo with eloxatin (oxaliplatin) and capecitabina.

SORRY (:-( - NO: Unfortunately no. "tranfer factor" is one of the current fads, just see who is selling these products, literally your neighbors or friends. From what i can gather this person has colon cancer. These two chemotherapy agents are appropriate in this setting. Stick to what we know works. ...Read more

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Anyone using oxaliplatin and 5-FU for colon cancer?

Yes, absolutely: 5fu (fluorouracil) based chemotherapy is the standard chemotherapy in colon cancer. Combination of 5-FU and oxaliplatin is widely used and a standard regiment of chemotherapy in colorectal cancer. A big randoomized clinical trial in colon cancer ( mosaic study) has demonstrated the overall survival benefit of using combination of 5fu (fluorouracil)/oxaliplatin in stage iii colon cancer and limited case of stage ii disease. ...Read more

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What are your treatment options for colon cancer (allergic reaction to oxaliplatin)?

What are your treatment options for colon cancer (allergic reaction to oxaliplatin)?

Immunotherapy: If primary lesion present it is essential to be resected. If lesion already removed and oxaliplatin advocated as part of chemo, other option are Xelodac given orally or avastin (bevacizumab) as a monoclonal antibody. In addition there is Erbitux, an epidermal growth factor 1 inhibitor, radiation to the site of potential recurrence and newer monoclonals in FDA trials targeting tumor protein. ...Read more

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What are typical side effects of liver cancer chemo therapy consisting of Gemcitabine + Oxaliplatin ( GEMOX) ?

What are typical side effects of liver cancer chemo therapy consisting of Gemcitabine + Oxaliplatin ( GEMOX) ?

Modest side effects: Gemcitabine is a well tolerated chemo drug. It can cause some decrease in blood counts, so monitor your CBC periodically(something your oncologist will discuss and do it for you). Oxaliplatin has some additional side Effects like nausea and neuropathy, yet these are manageable by any good oncologist. So I would advice you to proceed with chemo and wait to worry if you have any side effects. ...Read more

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For a 59 year old stomach cancer patient, should leg pain be taken as a chemotherapy's side effect? Patient is on eloxatin (oxaliplatin) and capecitabina... Thanks.

Maybe related: You are having leg pain and wonder if it is related to chemotherapy drugs. It is important to relay your leg pain to your doctor. This could be related to electrolyte imbalance, blood clot, among other things. Your doctor will want to know what makes the pain get better and when you notice it, if it resolves on its own. There may be additional studies ordered to look for clots. ...Read more

See 1 more doctor answer
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70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?

Chemo : If you can tolerate capecitabine, the regiment will be good for the type of cancer. Also, consider to check her2-neu receptor status of the cancer - as if her2-neu receptor is positive, Herceptin (trastuzumab) which is an inhibitor to the her2-neu receptor should be considered as one of treatment options. ...Read more

See 1 more doctor answer
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What is the most effective treatment for neuropathy and swollen hands that is caused by oxiplaten (a chemo drug)?

What is the most effective treatment for neuropathy and swollen hands that is caused by oxiplaten (a chemo drug)?

Difficult to treat: There are 2 forms acute and chronic. There are mixed benefits from use of calcium and magnesium infusion in the acute situation. The drug venlafaxine, an antidepressant has had some benefit in both situations. There are other drugs like Amitriptyline and Gabapentin has been helpful in some cases. It is hard to treat. It may very slowly improve if the drug is stopped. ...Read more

Dr. Amrita Dosanjh
10 doctors shared insights

Eloxatin (Definition)

Eloxatin ...Read more