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Doctor insights on: Oxaliplatin

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Dr. Ihab Ibrahim
14 doctors shared insights

Oxaliplatin (Overview)

Oxaliplatin is a cancer agent.


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What is the oxaliplatin mechanism..How?

What is the oxaliplatin mechanism..How?

DNA replication: It forms dna adducts that block dna replication and transcription, resulting in cell death in actively dividing cells. It forms bulkier platinum-dna adducts that may be more difficult to repair. Journal of clinical oncology vol 20, no 7 (april 1), 2002. Hope this helps. ...Read more

Dr. Ihab Ibrahim
14 doctors shared insights

Oxaliplatin (Overview)

Oxaliplatin is a cancer agent.


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2
Oxaliplatin mechanism..How does it work?

Oxaliplatin mechanism..How does it work?

Platinum analog: Is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is a platinum derivative. It binds to dna forming cross-links which inhibit dna replication and transcription, resulting in cell death. ...Read more

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For a 59 year old stomach cancer patient, should leg pain be taken as a chemotherapy's side effect? Patient is on eloxatin (oxaliplatin) and capecitabina... Thanks.

For a 59 year old stomach cancer patient, should leg pain be taken as a chemotherapy's side effect? Patient is on eloxatin (oxaliplatin) and capecitabina... Thanks.

Maybe related: You are having leg pain and wonder if it is related to chemotherapy drugs. It is important to relay your leg pain to your doctor. This could be related to electrolyte imbalance, blood clot, among other things. Your doctor will want to know what makes the pain get better and when you notice it, if it resolves on its own. There may be additional studies ordered to look for clots. ...Read more

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70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?

70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?

Chemo : If you can tolerate capecitabine, the regiment will be good for the type of cancer. Also, consider to check her2-neu receptor status of the cancer - as if her2-neu receptor is positive, Herceptin (trastuzumab) which is an inhibitor to the her2-neu receptor should be considered as one of treatment options. ...Read more

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Who should not use Eloxatin (oxaliplatin)?

Who should not use Eloxatin (oxaliplatin)?

Eloxatin (oxaliplatin): "ELOXATIN (oxaliplatin) should not be administered to patients with a history of known allergy to ELOXATIN (oxaliplatin) or other platinum compounds." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3c740b43-f396-4998-bc66-6964a21f7161 ...Read more

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What is the oxaliplatin mechanism..How?

DNA replication: It forms dna adducts that block dna replication and transcription, resulting in cell death in actively dividing cells. It forms bulkier platinum-dna adducts that may be more difficult to repair. Journal of clinical oncology vol 20, no 7 (april 1), 2002. Hope this helps. ...Read more

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Oxaliplatin mechanism..How does it work?

Platinum analog: Is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is a platinum derivative. It binds to dna forming cross-links which inhibit dna replication and transcription, resulting in cell death. ...Read more

Eloxatin (Definition)

Eloxatin ...Read more