Doctor insights on:
Ovarian Cancer Risk Hypothyroid Hormone Replacement Therapy
34 y/o female w/hormone imbalance, endo, Hashi's. Symptoms poss. early menopause. Seeking low-risk and natural hormone replacement therapy. Advice?
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Increases risk: Hormone replacement therapy (hrt) has been shown to increase one's risk for breast cancer if taken for longer than 5 years. The current recommendation is to take low doses for a limited amount of time and then stop. There are some other non hormonal medications that can be used to help manage menopausal symptoms. ...Read moreSee 3 more doctor answers
Not exponentially: Data from the whi (women's health initiative) study show that estrogen alone does not significantly increase the risk of breast cancer, especially if started within 5 years of menopause. However, estrogen + Progesterone (needed when women still have a uterus to prevent uterine cancer) increases the risk of breast cancer to about 2x the baseline risk. Progesterone appears to be the "bad guy". ...Read moreSee 2 more doctor answers
Complex issues: Female hormones increase thromboembolism, deep venous thrombosis--progesteron is blamed, more than estrogen--because at menopause, there is changes in blood coagulation?Increase weight, arteriosclerosis, metabolic syndrome all of this increase risk of cardiovascular disease-- estrogen can be given at low dose for brief periods. ...Read moreSee 2 more doctor answers
Very low Risk: With due respect. The landmark study, whi, is called into question in so many ways. The nih spent millions to answer very little. As an re, i feel there are many facets to HRT and a careful and comprehensive evaluation of the literature supports a very minimal at best increase in breast cancer and the evidence points to the progestin component only (provera). Consultation warranted. ...Read moreSee 2 more doctor answers
NO BUT INCREASE RISK: Hormone therapy does not cause breast cancer but it does increase your risk of breast cancer. According to the national nurses health study using hormone replacement therapy for 10-15 yrs increases risk about 20%, if used more than 15 yrs it doubles to around 40%. Talk to your doctor to help you decide how to better manage postmenopausal symptoms. ...Read more
Varies: If a first order relative (mother, sister, daughter) has bc i would take ert only briefly and then only for severe symptoms. Remember that we try to prevent breast cancer by prescribing tamoxifen - which blocks estrogen. Adding ert definitely increases risk, somewhat, so you have to balance risks/benefits. Some women are miserable without it - and a short course may be appropriate for them. ...Read moreSee 1 more doctor answer
Usually no: During the time a woman is perimenopausal hormonal manipulation can cause some spotting or bleeding depending on how the hormones are dosed. Once a woman is truly menopausal hrt does not usually cause menstruation. Vaginal bleeding in the post-menopausal woman is considered abnormal & worthy of investigation. ...Read moreSee 1 more doctor answer
It can: If not monitored. Estradiol and estriol levels are much higher in ovulating women & pregnant women, respectively. Birth control estrogen is 5x more potent than the estrogen used in hrt and carries risks of blood clots, heart attack etc. Estrone levels are high in overweight women who carry the same risks. Hrt that is not converted to estrone is the key, in my opinion. ...Read moreSee 2 more doctor answers
Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?
Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more
Treatment: Hormone therapy consists of medications that decrease the effects of testosterone on prostate cancer and a man's body. Prostate cancer growth is primarily fueled by testosterone. If testosterone is absent/ineffective, prostate cancer hopefully would stop growing. Hormone therapy has several varieties including pills and injections. Given for advanced disease or at times prior to radiation. ...Read moreSee 1 more doctor answer
Yes, an option: There are many things you can do to avoid osteoporosis. Things you can't change: your family history, race, aging. Things you can change: get adequate calcium: 1500 mg per day, vit d 2000 iu per day, physical activity: 150 minutes per week (or 50 jumps per day), have normal tsh, get regular screening, and know your personal risk factors. Have a frax score done to help you decide what to do. ...Read moreSee 2 more doctor answers
Probably none: There does not appear to be a correlation with hormone replacement therapy and ovarian cancer. Nevertheless, i always balance estrogen treatment with progesterone. There is some evidence that women estrogen dominance (overweight, infertile, polycystic ovaries and women who don't ovulate) have higher estrogen dependent cancers like breast, colon, uterine and ovarian. It's all about balance. ...Read moreSee 1 more doctor answer
35 years, childless, hypothyroidism, 50 mcg Thyronorm daily. Read long term use of thyroid HRT can increase risk of breast cancer. Is this true?
No: this medication is a synthetic Thyroid hormone which you need to survive. The levels should be monitored and adjusted by a doctor. It should not increase your Breast cancer risk. The replacement hormones people use for hot flushes (estrogen/progesterone) during and after menopause do cause increased risk. ...Read more
On hormone replacement therapy since hysterectomy at age 31 for ovarian cancer- now 50. Do i need to end HRT for normal menopause age?
Usually done to provide the hormones that would be deficient upon surgical removal or inactivity or malfunction of a hormone producing gland or organ. The endocrinologist is the medical specialist that specializes amongst other things , in doing just that. Insulin/glucagon-pancreas, thyroid hormone-thyroid, ovaries, testicles, hypothalamus, ...Read more
Biological therapy means treatment with agents that are natural biologic products (such as antibodies from other species, etc.). The new drugs like Humira (adalimumab) (that are constantly advertised on tv) are examples; these are usually used for immune caused diseases like ulcerative colitis, rheumatoid ...Read more
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