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Doctor insights on: Osteonecrosis Of The Jaw Bone

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I need bisophanates but am so frightened of the side effects of osteonecrosis of the jaw, thrombosis, stroke, bone cancer etc etc how common are these?

I need bisophanates but am so frightened of the side effects of osteonecrosis of the jaw, thrombosis, stroke, bone cancer etc etc how common are these?

Not so common: And much less common than the dread complications of osteoporosis. I'm not impressed with what i've read about the stroke or cancer risk; good oral hygiene and early recognition should help with the uncommon jaw osteonecrosis. Would like to hear from others about what they've decided. ...Read more

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Dr. Pietro Seni
215 doctors shared insights

Avascular Necrosis (Definition)

Also known as osteonecrosis, avascular necrosis is the death of bone from interruption of blood supply. This can result in tiny bone fractures and eventual destruction of the entire bone. It can be caused by trauma, blockage of circulation with lipids in the blood, certain diseases like sickle cell disease, Gaucher, and occasionally after exposure to corticosteroids. Sometimes, there ...Read more


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How painful is osteonecrosis of the jaw?

How painful is osteonecrosis of the jaw?

Osteonecrosis: This most often is painful but there are times where there is not much pain. You cannot use this as diagnostic symptom. You need to have your dentist evaluate things to make sure what is going on. ...Read more

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I was wondering what are symptoms of osteonecrosis of the jaw?

I was wondering what are symptoms of osteonecrosis of the jaw?

Pain swellilng: Pain swelling of the jaw, sometimes exposed bone. Usually after tooth extraction. not always. See oral surgeon to sort things out. ...Read more

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I was wondering what is the risk of Fosamax (alendronate) to osteonecrosis of the jaw?

Risk is low.: Risk of osteonecrosis is low but not zero. If you plan on having an extraction, make sure you see an oral surgeon. He knows what to do to minimize the risk. ...Read more

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How much of a risk of osteonecrosis of the jaw is associated with fosamax (alendronate)?

How much of a risk of osteonecrosis of the jaw is associated with fosamax (alendronate)?

Rare, but: It is rare with oral bisphosphonates like Fosamax (alendronate). More common with IV bisphosphonates. However, medicine related osteonecrosis of the jaws (MRONJ) is suck a devastating disease, that precautions are in order for any dental extraction procedure. Oral surgery evaluation recommended for any patient on Fosamaz. ...Read more

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Can you tell me more about problem with Fosamax (alendronate) and osteonecrosis of the jaw?

Can you tell me more about problem with Fosamax (alendronate) and osteonecrosis of the jaw?

Low risk: There is a definite but low risk of developing osteonecrosis (dead bone) in patients who have taken fosamax (alendronate). The risk is higher for other bone building medications taken intravenously. Patients taking Fosamax (alendronate) should discuss any dental procedures with the dentist to see if special precautions must be taken. Sometimes, a 3 month holiday from Fosamax (alendronate) is helpful to minimise the risk of osteonecrosis. ...Read more

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What is osteonecrosis of the jaw?

What is osteonecrosis of the jaw?

A drug side-effect: The drugs for osteoporosis and metastatic bone cancer called bisphosphonates (includes fosamax, actonel, boniva, reclast, (zoledronic acid) zometa, aredia) are associated with a side-effect where part of the bone of the jaw dies, the gum sloughs off, and bone shows where the gum was lost. It is treatable but not always curable. It has also been found with bevicizumab, an anti-cancer drug, and after jaw radiation. ...Read more

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Why could you have to have your jaw removed with osteonecrosis of the jaw?

Why could you have to have your jaw removed with osteonecrosis of the jaw?

Dead bone: Osteonecrosis is dead bone. If the disease keeps progressing, the jaw may have to be resected for cure. Difficult problem. Make sure you are managed by an oral & maxillofacial surgeon. ...Read more

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What are the risks of Fosamax (alendronate) to osteonecrosis of the jaw?

What are the risks of Fosamax (alendronate) to osteonecrosis of the jaw?

Biphosphonates: From: http://www.merck.com ONJ, which can occur spontaneously, is generally associated with tooth extraction and/or local infection with delayed healing, and has been reported in patients taking bisphosphonates, including FOSAMAX (alendronate). Clinical judgment of the treating physician and/or oral surgeon should guide the management plan of each patient based on individual benefit/risk assessment. ...Read more

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Dr. Austina Cho
77 doctors shared insights

Aseptic Necrosis (Definition)

Aseptic necrosis is also called osteonecrosis, avascular necrosis (AVN), or ischemic bone necrosis. It is a condition that occurs when there is diminished blood to the bone. An interruption to the blood supply causes bone to die. If the environment is not altered or improved, the involved bone may eventually collapse and ...Read more


Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more