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Doctor insights on: Orinase First Generation Sulfonylurea

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Dr. Heidi Fowler
3 doctors shared insights

Tolbutamide (Definition)

Tolbutamide is a first generation sulfonylurea which is a kind of diabetes-related drug ...Read more


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Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Sedation: 1st generation are sedating because many people, up to 40%, get sleepy when taking them. 2nd generation antihistamines are chemically modified and are less likely to cause sedation. The generics of the less sedating are cetirizine, fexafenadine, and loratidine. They cause sedation in some people, up to 11%, but much less than the older drugs. ...Read more

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Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good medicn?

Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good  medicn?

Not fertility meds: The medications you are describing are several antibiotics, vitamins and enzymes. None of these are infertility medications. If you are not sure why he/she prescribed them, you should ask your doctor what they are for. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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Whats the difference between a first generation antihistamine like chlorpheniramine and second generation antihistamines like allegra (fexofenadine)?

Whats the difference between a first generation antihistamine like chlorpheniramine and second generation antihistamines like allegra (fexofenadine)?

1st and second: First generation antihistamines are sedating and short acting and have usually other properties such as anticholinergic or drying properties. Second generation antihistamines are long aciting, usually dosed once a day, and are less or non sedating and selective antihistamines with less active properties on other receptors. ...Read more

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HIV1/2 P24 ab/ag 4th generation combo test, is it conclusive after 25 days of exposure?

HIV1/2 P24 ab/ag 4th generation combo test, is it conclusive after 25 days of exposure?

Probably yes: Officially, that test is conclusive at 28 days. It's probably conclusive at 25 days, but to be absolutely certain, have another test in a week or so. ...Read more

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Why second generation histamine h1 antagonist are the drug of choice in treatment of chronic allergy? Explain please!

Why second generation histamine h1 antagonist are the drug of choice in treatment of chronic allergy? Explain please!

Best allergy medicin: Second generation antihistamines generally have fewer side effects (ie. Sedation and dryness), longer durations of action, and little tachyphlaxis (loose effectiveness with use) than older antihistamines. However for chronic nasal allergies, evidence based medicine places topical nasal steroid sprays as first line therapy ahead of antihistamines, oral or topical. ...Read more

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Has anyone ever taken methyldopa (aldomet) in first trimester?

Has anyone ever taken methyldopa (aldomet) in first trimester?

Yes: This is a central acting medicine for management of high blood pressure. It is an old but safe & effective treatment, though many feel there are better medicines available now for high blood pressure in pregnancy. ...Read more

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Resistant pulmonary htn due to sjogrens. Norvasc (amlodipine) works but isosorbide unpredictable. Beta blocker worsens. Arb acs contraindicated ckd high K. Advice?

Resistant pulmonary htn due to sjogrens. Norvasc (amlodipine) works but isosorbide unpredictable. Beta blocker worsens. Arb acs contraindicated ckd high K. Advice?

Pulmonary HTN: There are a range of molecules available by prescription that address P HTN ;go see a cardiologist or pulmonologist that has an interest in treating this condition ...Read more

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Do you use Cefazedone (first-generation cephaloporins) or Amikacin (Aminoglycosides antibiotic) for treating pelvic inflammatory disease?

Do you use Cefazedone (first-generation cephaloporins) or Amikacin (Aminoglycosides antibiotic) for treating pelvic inflammatory disease?

Not usually: I'm not sure where you are, but in most of the world's countries these drugs are not recommended and would not be used to treat PID. They are of uncertain activity against gonorrhea and definitely will not treat chlamydia. Try to find an infectious diseases or STD expert to advise on treatment. Also see my reply to your other question. ...Read more

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Clonidine as an anti-hypertensive---is it an ACE inhibitor, arb, beta blocker? What class of medication is it in for hbp?

Clonidine as an anti-hypertensive---is it an ACE inhibitor, arb, beta blocker? What class of medication is it in for hbp?

Cental alpha agonist: Clonidine acts on the central Alpha receptors and lowers sympathetic tone which lowers heart rate and blood pressure. Clonidine is not a good long term medication due to numerous side effects and ideally has be used for short duration only. ...Read more

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Are Glimepiride & glipizide the same drug?

Are Glimepiride & glipizide the same drug?

No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read more

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Are these meds more for dad whose bp is 130/80 .Trentol400 2 times,dilizem once, amtas m50 ,tazloc trio80 once & ecosirin & sexaglptin & blisto once!!

Are these meds more for dad whose bp is 130/80 .Trentol400 2 times,dilizem once, amtas m50 ,tazloc trio80 once & ecosirin & sexaglptin & blisto once!!

Blood pressure meds: his BP you have stated is not abnormal- in terms these number meds best to ask the doc who prescribed them and knows your dad's problems ...Read more

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Is buproprion a monoamine oxidase inhibitor (maoi) type of drug?

Is buproprion a monoamine oxidase inhibitor (maoi) type of drug?

No: Bupropion (wellbutrin) inhibits re-uptake of norepinephrine and Dopamine into neurons (nerve and brain cells). It does not inhibit mao, so there are no dietary restrictions or common medication interactions, unlike the the maois. ...Read more

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Why is mhc class 2 more important in renal transplant than mhc class 1?

Why is mhc class 2 more important in renal transplant than mhc class 1?

Rejection Severity: Both are import ant and each can trigger rejection when the host is mismatched for any of these hla antigens. Recipients that develop antibodies to these phenotypes, in particular class ii dq--may have poorly responsive rejections. The antibody generated against class ii may derive from more resilient memory cells. Both are bad though. ...Read more

Orinase (Definition)

Orinase is a first generation sulfonylurea which is a kind of diabetes-related drug ...Read more