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Doctor insights on: Orinase First Generation Sulfonylurea

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What is the best alternative medication to sulfonylurea for type 2 diabetics to prevent weight gain in combination with metformin?

What is the best alternative medication to sulfonylurea for type 2 diabetics to prevent weight gain in combination with metformin?

DPP4 inhibitor: Newer medications like januvia, onglyza, (saxagliptin) and tradgenta are all effective additions to metformin for the treatment of diabetes, and generally have less weight gain than the older sulfonylurea medications like glucotrol. ...Read more

Dr. Zahid Niazi
3 doctors shared insights

Tolbutamide (Definition)

Tolbutamide is a first generation sulfonylurea which is a kind of diabetes-related drug ...Read more


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An article came out on stop using sulfonylureas, l'm using glimepride. What is your opinion?

An article came out on stop using sulfonylureas, l'm using glimepride.   What is your opinion?

Individualize: It depends on an individual's characteristics. Glimepiride is the best one in the sulfonylurea group. There's a place for it in clinical practice. ...Read more

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How do sulfonylureas cause weight gain?

How do sulfonylureas cause weight gain?

Insulin secretion: Sulfonylureas induce weight gain mainly by increasing Insulin levels and, therefore, utilization of glucose and other metabolic fuels. Other adverse effects include abdominal upset, hypersensitivity reactions, and headache. ...Read more

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Why would sulfonylureas cause rash ?

Why would sulfonylureas cause rash ?

Side effects: While potentially any medication can cause a rash, sulfonylureas are known to cause it. The immune mechanism is complex to explain online but discontinuing the medication and switching to other products controls the problem. ...Read more

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I just had my first generation braces today but my doctor didn't placed rubber bands around the brackets and he told me that it is not time yet. Why?

I just had my first generation braces today but my doctor didn't placed rubber bands around the brackets and he told me that it is not time yet. Why?

Glue setting period: Your braces are glued or cemented on - so putting stress on the brackets is not a good idea. Also, you need to get used to the braces themselves. Your Doctor will examine you on follow up and will see if your gums are well healed before he applies the rubber bands. You will need to make sure you are brushing around the braces well or you will have inflammation of your gums. ...Read more

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Can you tell me how are antibiotics classified as first generation, second generation or third generation antibiotics?

Can you tell me how are antibiotics classified as first generation, second generation or third generation antibiotics?

Cephalosporins: Only one type of antibiotic, the cephalosporins, normally is classified by "generation". There have been three groups of cephalosporins since the first ones (now called first generation) were developed in the 1960s. Second (1970s-80s) and third generation (1990s to now) each were chemically different and are active against more types of bacteria. There are several drugs in each group. ...Read more

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Doctors, what is the difference between first and second generation antihistamines?

Doctors, what is the difference between first and second generation antihistamines?

CNS: The 1st generation AH gets into the brain area thereby blocking the stimulatory effect on alertness from histamine. The 2nd generations ones do not get into the brain and thus do not usually induce drowsiness. 1st gen- more drying and better for runny nose , the sedating effect also better for itching than 2nd gen. ...Read more

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What is the difference between first and second-generation antihistamines?

What is the difference between first and second-generation antihistamines?

Side effects: The second generation antihistamines were developed to try and decrease the side effects of the first generations. Many are "purified" first generation antihistamines so they have the active effects without the side effects of drowsiness, sedation, dry mouth etc. They also tend to have longer half lives, meaning they can be taken once or twice a day not every 4 hours. ...Read more

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Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Sedation: 1st generation are sedating because many people, up to 40%, get sleepy when taking them. 2nd generation antihistamines are chemically modified and are less likely to cause sedation. The generics of the less sedating are cetirizine, fexafenadine, and loratidine. They cause sedation in some people, up to 11%, but much less than the older drugs. ...Read more

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Are first generation antihistamines more effective than second generation? I always wonder why some are still on drugstore shelves, like chlorpheniram

Are first generation antihistamines more effective than second generation? I always wonder why some are still on drugstore shelves, like chlorpheniram

Less side effects: There are many medications that remain on shelves for over-the-counter use that probably should be removed. New generation antihistamines are as effective as old ones. Of interest is that some individuals respond favorably to one over the other. The side effect profile and frequency of dosing is what really separates the new from the old antihistamines. In this case, newer is better. ...Read more

Orinase (Definition)

Orinase is a first generation sulfonylurea which is a kind of diabetes-related drug ...Read more