Doctor insights on:
Opioid Peptides Naltrexone And Gluten
How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?
interrelated: All receptor systems are interrelated and interact with each other. Whatever induces nausea, the reaction is triggered by dopaminergic pathways in a part of the brain called the chemoreceptor trigger zone. Most anti-emetics work by antagonizing dopamine. The combination of opioids and antinausea medications is quite common, both for synergism and to reduce nausea. ...Read more
Wheat barley rye contains gluten, a protein molecule that in susceptible people can cause reactions and long term illness. There is celiac, the most well known and severe gluten disease. There is gluten sensitivity, affecting more people, but usually milder. There is wheat allergy, less common than the others. The treatment, for now, is to avoid all gluten in ...Read more
If endorphins bind to opioid receptors then why don't they cause nausea and vomiting like opioid painkillers such as morphine?
Endorphins: Because C-fibers release several excitatory neurotransmitters (e.g., substance P. CGRP), activation of opioid receptors will reduce the release of these transmitters from the presynaptic terminals of afferent sensory neurons. The opioids peptides that occur naturally in the human body are endorphins. ...Read more
Do med assisted therapy drugs like Suboxone & Methadone continue to hinder dopamine production in the opiate abused brain?
More than likely: yes. All opioids have the potential to release histamine from mast cells, which is what causes hives. The ones that do it most are morphine, codeine and hydrocodone, and the ones that do it the least are oxycodone, heroin and fentanyl. Levorphanol is metabolized into morphine and codeine, and if you have had problems before with these meds, very likely you will with levorphanol. ...Read more
Serotonin : Most opioids have no direct effect on serotonin. However, a newer opiate called Nucynta (tapentadol) acts on the usual narcotic receptors in the central nervous system (CNS), but also inhibits the re-uptake of serotonin & norepinephrine in the CNS which may help with certain types of pain conditions & depression. ...Read more
What type of chemical substance will be produced if respin, diazepam, codeine, hexobarbitone and morphine are mixed?
A scary one: Why would you be planning to mix these substances? Hoping you're not wanting to use them on yourself or sell them to anyone else. Please remember that there is help if you are addicted, suicidal, or both. Your question indicated that you're in nigeria, and unfortunately i don't know what the equivalent of calling "911" is, in your country. ...Read more
Are there selective opioids that antagonize only certain opioid receptors to relieve pain but without the euphoric high or nausea?
Is suboxone withdrawal as severe as methadone withdrawal? Or normal opiate withdrawals? I've been on 18mg for about 3 months & have a high metabolism.
Its probably not: as severe,but everyone is different and reacts differently. ...Read more
What are the pros/cons and differences between suboxone, methadone, and naltrexone for heroin addiction?
Many: Each form of treatment is different , suboxone is a partial agonist and anatgonist which can induce precipted withdrawal when used with opioids, it can be prescribed out of a data licensed physician office. Methadone is a full agonist advantage inexpensive prescribeed at a Methadone cliniccon tolearnce and use of other narcotics.Naltrexone is a anatagonist that is requires abstinence can be costly. ...Read moreSee 3 more doctor answers
What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?
None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read moreSee 1 more doctor answer
Chronic impactions and constipation bc of long term opioid use, tried miralax, (polyethylene glycol) lactulose, no help. How's methylnaltrexone?
Are propranolol, synthroid, zyrtec, & amitiza (lubiprostone) gluten free? I am on gluten free diet
Most likely: Gluten is not usually used in formulating any medication. However given that your medications are likely generic, there is no 100% sure way to tell. In general , i would say no, but if you are unsure, read the ingredient label and ask your pharmacist to check if you have doubts. ...Read more