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Doctor insights on: Opioid Peptides Naltrexone And Gluten

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How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?

How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?

interrelated: All receptor systems are interrelated and interact with each other. Whatever induces nausea, the reaction is triggered by dopaminergic pathways in a part of the brain called the chemoreceptor trigger zone. Most anti-emetics work by antagonizing dopamine. The combination of opioids and antinausea medications is quite common, both for synergism and to reduce nausea. ...Read more

Gluten (Definition)

Wheat barley rye contains gluten, a protein molecule that in susceptible people can cause reactions and long term illness. There is celiac, the most well known and severe gluten disease. There is gluten sensitivity, affecting more people, but usually milder. There is wheat allergy, less common than the others. The treatment, for now, is to avoid all gluten in ...Read more


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If endorphins bind to opioid receptors then why don't they cause nausea and vomiting like opioid painkillers such as morphine?

If endorphins bind to opioid receptors then why don't they cause nausea and vomiting like opioid painkillers such as morphine?

Dosage: The amount of endorphins we produce are a very tiny fraction of the kind of activity you get with a dose of morphine or other opioids. This is why they produce such significant painkilling ability, as well as significant euphoria/highs. ...Read more

Dr. Paul Grin Dr. Grin
2 doctors agreed:
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What neurotransmitters are released by opioid usage?

Dr. Paul Grin Dr. Grin
2 doctors agreed:
What neurotransmitters are released by opioid usage?

Endorphins: Because C-fibers release several excitatory neurotransmitters (e.g., substance P. CGRP), activation of opioid receptors will reduce the release of these transmitters from the presynaptic terminals of afferent sensory neurons. The opioids peptides that occur naturally in the human body are endorphins. ...Read more

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Do med assisted therapy drugs like Suboxone & Methadone continue to hinder dopamine production in the opiate abused brain?

Do med assisted therapy drugs like Suboxone & Methadone continue to hinder dopamine production in the opiate abused brain?

Still studied: Currently the thought is that although suboxone initially increases dopamine ultimately it blocks dopamine activity. Methadone may stimulate dopamine synthesis but recent brain studies do not see effect in the brain Stimulents are very potent dopamineric medications. ...Read more

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Oxycodone, hydrocodone and morphine cause hives. Will levorphanol do that as well?

Oxycodone, hydrocodone and morphine cause hives. Will levorphanol do that as well?

More than likely: yes. All opioids have the potential to release histamine from mast cells, which is what causes hives. The ones that do it most are morphine, codeine and hydrocodone, and the ones that do it the least are oxycodone, heroin and fentanyl. Levorphanol is metabolized into morphine and codeine, and if you have had problems before with these meds, very likely you will with levorphanol. ...Read more

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How can opiates and opioids affect serotonin system?

How can opiates and opioids affect serotonin system?

Serotonin : Most opioids have no direct effect on serotonin. However, a newer opiate called Nucynta (tapentadol) acts on the usual narcotic receptors in the central nervous system (CNS), but also inhibits the re-uptake of serotonin & norepinephrine in the CNS which may help with certain types of pain conditions & depression. ...Read more

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What type of chemical substance will be produced if respin, diazepam, codeine, hexobarbitone and morphine are mixed?

What type of chemical substance will be produced if respin, diazepam, codeine, hexobarbitone and morphine are mixed?

A scary one: Why would you be planning to mix these substances? Hoping you're not wanting to use them on yourself or sell them to anyone else. Please remember that there is help if you are addicted, suicidal, or both. Your question indicated that you're in nigeria, and unfortunately i don't know what the equivalent of calling "911" is, in your country. ...Read more

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Can you block opiate receptors and endorphins receptors through your diet?

Can you block opiate receptors and endorphins receptors through your  diet?

No: The receptors are specific for these chemicals. The only way you can block the receptors with diet is if you diet includes percocet. There is no food or nutritional supplement that will bind to the receptors. ...Read more

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Can a urine test detect opiates like mscontin, roxycodone, and some non narcotic medicines?

Can a urine test detect opiates like mscontin, roxycodone, and some non narcotic medicines?

Yes: depending on what kind of kit is being used, and whether it is sent for confirmatory testing, most opiates and opioids can be detected by urine drug screening, as well as many other classes of drug. ...Read more

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What are the pros/cons and differences between suboxone, methadone, and naltrexone for heroin addiction?

What are the pros/cons and differences between suboxone, methadone, and naltrexone for heroin addiction?

Many: Each form of treatment is different , suboxone is a partial agonist and anatgonist which can induce precipted withdrawal when used with opioids, it can be prescribed out of a data licensed physician office. Methadone is a full agonist advantage inexpensive prescribeed at a Methadone cliniccon tolearnce and use of other narcotics.Naltrexone is a anatagonist that is requires abstinence can be costly. ...Read more

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Chronic impactions and constipation bc of long term opioid use, tried miralax, (polyethylene glycol) lactulose, no help. How's methylnaltrexone?

Chronic impactions and constipation bc of long term opioid use, tried miralax, (polyethylene glycol) lactulose, no help.  How's methylnaltrexone?

Get help: Methylnaltrexone is part of the answer. You'll also need medical support and counselling to successfully and permanently come off the opiates. ...Read more

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Are propranolol, synthroid, zyrtec, & amitiza (lubiprostone) gluten free? I am on gluten free diet

Are propranolol, synthroid, zyrtec, & amitiza (lubiprostone) gluten free? I am on gluten free diet

Most likely: Gluten is not usually used in formulating any medication. However given that your medications are likely generic, there is no 100% sure way to tell. In general , i would say no, but if you are unsure, read the ingredient label and ask your pharmacist to check if you have doubts. ...Read more

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Is vivitrol effective for alcohol and opiate addiction?

Is vivitrol effective for alcohol and opiate addiction?

Yes: In my experience Vivitrol can be very effective for treatment of alcohol and opiate addiction. But Vivitrol alone is the answer. Motivation is the first key followed by working closely with a doctor who treats addiction on a regular basis, in consuling program. ...Read more

Dr. Jeff Blixt
214 doctors shared insights

Naltrexone (Definition)

Naltrexone is an addiction reducing agent which is a ...Read more


Dr. M. Hytham Beck
67 doctors shared insights

Depade (Definition)

Depade is an addiction reducing agent which is a ...Read more