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Doctor insights on: Oncovorin

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What does vincristine do?

What does vincristine do?

Vincristine ...: Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons. ...Read more

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Dr. Stephen Hunger
630 doctors shared insights

Vincristine (Definition)

Vincristine is a cell division inhibitor which is a ...Read more


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What is the drug vincristine used for?

What is the drug vincristine used for?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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What is vincristine used for?

What is vincristine used for?

Chemo agent: Vincristine is a chemotherapeutic agent also known as Oncovin. It is primarily employed in the treatment of lymphomas and Hodgkins disease, usually in combination with other drugs such as in CHOPP. Side effects include nausea, hair loss and neurologic loss of balance. It works partly by binding to the tubulin protein, stopping the cell from separating its chromosomes during metaphase ...Read more

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How is vincristine used?

How is vincristine used?

Vincristine is used: To treat a wide array of cancers in children and adults, including hematologic malignancies, central nervous system cancers and a host of solid tumors as well. It impairs the functioning of microtubule assemblies, such as the mitotic spindle, and therefore blocks cell division. Interesting tidbit...It was originally isolated from periwinkle (aka, vinca), hence its designation as a vinca alkaloid. ...Read more

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Alts to vincristine?

Alts to vincristine?

Depends on cancer: Alternative to vincristine -will depend on the type of cancer. Different cancer has different treatment. Please discuss with your oncologist in detail about your options etc. Good luck. ...Read more

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Alternatives to vincristine?

Alternatives to vincristine?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. The alternative is vinblastine. ...Read more

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Why does the drug vincristine have side effects?

It's chief toxicity: Is neuropathy; it is not myelosuppressive. It suppresses the mitotic spindles made up of fibrillary structural piees siilar tto those that make up axons, nerves. Usually distal numbness and tingling of hands and feet. It is easy to blend with other drugs because its toxicty does not overlap with theirs. ...Read more

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Which is more prefered vincristine or vinblastin sulfate?

Which is more prefered vincristine or vinblastin sulfate?

They are in the same: Class but not interchangeable. Vcr is used in many pediatric diseases in combination. It causes constipation in that age group. It used to be used in brca (cmf-vp) and many adult lymphoma. Vbl is used in hd, testis cancer as part of curative regimens. It is also used as a single agent in lung and breast for symptom relief. ...Read more

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How effective is Vincristine for treating leukemia?

How effective is Vincristine for treating leukemia?

Which Leukemia type?: Vincristine is very effective in one type called Acute Lymphoblastic Leukemia(ALL). it is typicalyd used in combination with other chemotherapy agents/drugs. ...Read more

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Why does vincristine have side effects like nerve problems?

Why does vincristine have side effects like nerve problems?

Microtubules!: Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) but microtubules ALSO transport chemicals inside our nerve cells. The longest nerves in our body connect our spinal cord to our fingertips and toes ; this is why vincristine causes nerve problems especially in fingertips and toes. ...Read more

Dr. Tanya Russo
12 doctors shared insights

Oncovin (Definition)

Oncovorin is a cell division inhibitor which is a ...Read more


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