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Doctor insights on: Omeprazole Long Term Use Problems

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What long term GI problems can omeprazole cause?

What long term GI problems can omeprazole cause?

Omeprazole: In long-term it may lower the magnesium level and may cause 'atrophic gastritis'. Lactation is safe. Your doctor needs to monitor above problems. ...Read more

Dr. Tri Huynh
843 doctors shared insights

Omeprazole (Definition)

Omeprazole is the generic equivalent of prilosec, the first oral acid-reducer agent of the proton pump inhibitor ...Read more


Emily Lu Dr. Lu
3 doctors agreed:
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Is long term use of omeprazole dangerous?

Emily Lu Dr. Lu
3 doctors agreed:
Is long term use of omeprazole dangerous?

Yes: It is not recommended to take Omeprazole for longer than four months at a time. Long-term use can lead to weakening of the stomach lining and increased risk of wrist, hip or spine fracture. ...Read more

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Was on Omeprazole for the majority of 8 years. What kind of long term damage may I have caused to my body?

Was on Omeprazole for the majority of 8 years. What kind of long term damage may I have caused to my body?

No harm done: There are conflicting observational studies regards long term use of PPI's like Omeprazole. PPI's reduce the adsorption of Vit B12 and can cause B12 deficiency,but only in the elderly. PPI's decrease adsorption of Calcium
Carbonate and some studies show it may promote osteoporosis. ...Read more

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Can taking omeprazole 20mg. Long term cause bleeding?

Can taking  omeprazole 20mg.  Long term cause bleeding?

Omeprazole long term: To what sort of bleeding do u refer—spitting up blood, or rectal bleeding? Hematemesis might more commonly be related to bleeding ulcer(s), esophageal tears, or esophageal varices (varicose veins in esophagus). Hematochezia could result from clostridium difficile diarrhea associated with long-term ppi (omeprazole & others) use. See prescribing doc or GI specialist. ...Read more

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What are the long-term side effects of taking omeprazole?

PPI's: Generally PPIs are relatively safe. Short term they have very few side effects. Long-term there are some concerns over kidney, electrolytes, and possible pneumonia risks. Talk to your doctor to manage this. Good luck. ...Read more

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Can you please lay out the long term side effects of omeprazole?

Omeprazole side eff.: Omeprazole can change the gut ph or acid such that you may have trouble absorbing certain vitamins with long term use (b12 and folate) also there have been some studies that note that people who took Omeprazole had a higher rate of thinning out the bones (takes calcium from the bones). These studies were prelominary and further study needs to be done. If you are worried a bone study can be done. ...Read more

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Are there side effects related to the long term use of omeprazole in 2013?

Nothing serious: There is not much data available. Yet it is a fairly safe drug and can be sued for the long term. But try to skip it for one day off and on. ...Read more

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Would take omeprazole for a month be considered long term? Is it safe to take for a month?

Discuss with doc: Some get relief from heartburn or other symptoms of GERD by using a short course (2-4 wks ) of omeprazole. Avoiding aggravating factors such as alcohol,caffeine,or laying down within an hour of eating can also help.Longer term use of these meds (for years) is sometimes needed, but you should discuss your needs with your doc to make sure other conditions that would need treatment are not overlooked ...Read more

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Has anyone been on omeprazole (prilosec) for years, without experiencing any long-term side effects?

Yes, but: The longer you take the medicine, the more prone you are to have rare side effects. Nonetheless, there are conditions that require long term use and many people have taken it for years safely. ...Read more

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I saw on the news there is a new study of long term effects caused by Omeprazole. Where do I find this study?

See answer: http://www.medscape.com/viewarticle/804146_4

See if this helps. Caveat - these associations have not been shown to be cause and effect. ...Read more

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I've been prescribed omeprazole 20mg for acid reflux long term, what are the concerns taking continually for years on end?

I've been prescribed omeprazole 20mg for acid reflux long term, what are the concerns taking continually for years on end?

Long term use: Long term use has been associated with Vitamin B-12 deficiency, osteoporosis and fractures as well as hypomagnesemia, atrophic gastritis. Other side effects includes pancreatitis, blood count problems, liver function. These are issues to discuss with your physician. ...Read more

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If omeprazole is not recommended for long term use, what would you suggest as a suitable alternative? Ranitidine has been tried and did not work.

Long term use?: The question is why? and at what dose? I recommend using Nexium (esomeprazole) or Zegerid however, you must understand that the over the counter medications are usually 1/2 strength of the prescription dose. ...Read more

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What dosage of Prilosec omeprazole should I take if am on long term NSAIDS ? should I take the 20 mg or the 40 and what is the frequency? thank u drs

What dosage of Prilosec omeprazole should I take if am on  long term NSAIDS ? should I take the 20 mg or the 40 and what is the frequency? thank u drs

20mg daily before...: ...breakfast might suffice, but you haven't told us what NSAID and at what dose you're taking, nor what kind of NSAID damage you may already have suffered. No drug is without risk, so use the lowest effective acid blocker medication for prophylaxis against NSAID-injury. ...Read more

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What can be the long term effects of prolonged ppi use. (omeprazole )?

What can be the long term effects of prolonged ppi use. (omeprazole )?

Infection/absorption: The most common concerns are infection, electrolytes, and metabolic bone disease. The stomach acid kills bacteria. Less acid may cause GI infections and pneumonia (from reflux into the lungs). Decreasing acid may cause malabsorption leading to changes in the blood salts (electrolytes). Malabsorption of calcium can lead to osteoporosis. Multiple polyps can also occur. ...Read more

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How much calcium should I take if taking omeprazole long term, i heard this med prevents absorption of calcium?

How much calcium should I take if taking omeprazole long term, i heard this med prevents absorption of calcium?

1000 mg to 1500 mg: 1000 mg to 1500 mg but you need to be monitored to be sure what your risk for osteoporosis is. Your physician can evaluate that, your vitamin d, your urinary calcium output would give us a clue to your absorption of calcium. ...Read more

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Is it wise for someone with a dysfunctional gallbladder to be on omeprazole long term since the gallbladder is causing the reflux? Eject. Frac. - 15%

OK: A poorly functioning gallbladder, will not improve with time. It is ok to use Omeprazole for symptomatic treatment of the heartburn often associated with the problem. The gallbladder really needs to be removed. Please see your physician. ...Read more

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Suffer from chronic gerd. No Barrett's. Is it better to stay on omeprazole long term, or have surgery?

Suffer from chronic gerd. No Barrett's. Is it better to stay on omeprazole long term, or have surgery?

Pros & cons: Avoid issues that delay stomach emptying &/or relax LES--spicy, greasy food, mints, alcohol, tobacco, chocolate, tomato-based products, caffeinated & fizzy drinks, eating before bedtime. Lose weight. Elevate head of bed on blocks. Acid blockers are generally safe, but long-term PPI's can promote bone-thinning, low magnesium, C.difficile--balance against risks of Barrett's & diminished lifestyle. ...Read more

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Which is more effective Dexilant (dexlansoprazole) or omeprazole? Which is safer? Is atrophic gastritis risk with these high with long term use?

Which is more effective Dexilant (dexlansoprazole) or omeprazole? Which is safer? 

Is atrophic gastritis risk with these high with long term use?

They are equivalent.: Both of these work equally well. However, some patients respond well to one and not the other, and sometimes trial and error is the only method to determine which medication is best for a particular patient. The risk of atrophic gastritis, although small, would be essentially equal for each of the medications. I would recommend returning to your gastroenterologist to discuss this. Good luck. ...Read more

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I am 38, and can't use dairy and citrus much, using gabapentin and omeprazole long term, how much calcium & vit d in mg, should I take per day thanks?

I am 38, and can't use dairy and citrus much, using gabapentin and omeprazole long term, how much calcium & vit d in mg,  should I take per day
thanks?

At least 2000 Vit D: Vitamin d should be at least 2000iu possibly 5000. Calcium, depends on your diet, what type of calcium and how much. If you are a vegetarian your requirements for calcium are different than if you aren't. One good calcium supplement is raw code calcium, it has 1600 iu vitamin d and food based calcium in addition to other minerals. ...Read more

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I took omeprazole for 1 month for gastritis, GERD. Will this antibiotic cause any harmful long term effects to my body?

I took omeprazole for 1 month for gastritis, GERD. Will this antibiotic cause any harmful long term effects to my body?

No: Omeprazole, which is not an antibiotic, by the way, is usually well-tolerated and will not cause permanent harm to your digestive tract. Any side effects will be gone shortly after stopping it. Some people require Omeprazole long-term for their GERD, and most people do not have any side effects while taking it. Good luck. ...Read more

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What are the treatments for intestinal gastritis alongside edema, which is seen in colonoscopy, i ve taken omeprazole long term without finding cure ?

What are the treatments for intestinal gastritis alongside edema, which is seen in colonoscopy, i ve taken omeprazole long term without finding cure ?

See GI doc: I am confused by your question. Gastritis is an inflammatory condition thta may/ may not be complicated by infection. See you GI please or you will feel miserable. ...Read more

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What are the long term health effects of having severe GERD since birth and being on adult doses of prevacid (lansoprazole) and omeprazole since he was 6 months old?

Possible : Intestinal overgrowth of bacteria and infection susceptibility but sounds like he is doing ok so far. Sometime you have to outweigh benefits and risks. Talk to your provider about this question. You deserve this answer from the provider in this case. ...Read more

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What are the effects of proton pump inhibitors used long term? prescription omeprazole, 40mgm sig 1 cap daily

Malabsorption: The major concern with long-term use is poor absorption of nutrients such as magnesium and many vitamins. Stomach is there for a purpose - it helps in the digestive process. I'd suggest at least annual monitoring by your doctor with blood tests. ...Read more

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Taken omeprazole for 10 yrs. Is there long term effects? Indigestion is worsening & is no longer controlled with 1 pill a day. H-pylori semi high.

PPIs: Long term effects of Omeprazole and other proton pump inhibitors are being studied ; more information gets to surface. Long term use causes damage to acid secreting cells in the stomach and some folks may end up having troubles with digesting food later in life. Also, there is an increased risk of intestinal infection such as clostridium difficile. Also, bone related side effects are being seen. ...Read more

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10mg (low dose) omeprazole for long term GERD treatment? Will this cause magnesium or B12 deficiency?

It is possible: Taking Omeprazole for a long time could lead to mineral and Vitamin deficiencies due to resulting lack of acid in the stomach. Many natural supplements and home remedies are available, but discuss them with your doctor first. Take care. ...Read more

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I'ma long term user of omeprazole & also on domperidone. I get fatigued a lot cud this b vitamin B12 deficiency & if so when would b best to supplement?

I'ma long term user of omeprazole & also on domperidone. I get fatigued a lot cud this b vitamin B12 deficiency & if so when would b best to supplement?

Many causes: There's so many causes for fatigue. If this is really troubling you get a check up. B12 deficiency, among other causes are really easy to check. It's unlikely B12 def it's the cause but again anything possible. Stress, other causes of anemia and thyroid are among some things to look into. ...Read more

Dr. John Landi
515 doctors shared insights

Losec (Definition)

Losec is a proton pump inhibitor which is a kind of ...Read more