Top
40
Doctor insights on: Oligoclonal Bands

Share
Dr. Mathew Chengot
15 Doctors shared insights

Oligoclonal Bands (Overview)

Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf.


1

1
What is the definition or description of: oligoclonal bands?

What is the definition or description of: oligoclonal bands?

Immunoglobulins: Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf. ...Read more

Dr. Mathew Chengot
15 Doctors shared insights

Oligoclonal Bands (Overview)

Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf.


2

2
My CSF results show normal cell count but show inflammatory proteins-oligoclonal bands, what does this mean please?

My CSF results show normal cell count but show inflammatory proteins-oligoclonal bands, what does this mean please?

Oligoclonal bands: These proteins are immunoglobulins usually detected by separating the proteins in an electric field-charged gel. Many CNS diseases are associated with their presence, but most commonly they are tested for when there is concern about multiple sclerosis. Since many diseases can cause the abnormality, finding them is not specific and must be correlated with symptoms and other findings. ...Read more

3

3
I had a spinal puncture done and the results said CSF/serum oligoclonal bands negative and CSF Oligoclonal bands 0 bands. Does that mean I have ms?

I had a spinal puncture done and the results said CSF/serum oligoclonal bands negative and CSF Oligoclonal bands 0 bands. Does that mean I have ms?

Multiple sclerosis: Presence of CSF oligoclonal bands is consistent and normally diagnostic of multiple sclerosis in the right circumstances. The absence does not rule out MS and the diagnosis has to be based on clinical findings and MRI results. There may also be some ethnic differentiation of oligoclonal bands present in patients with MS. You can review the article below
http://dx. Doi. Org/10.1155/2015/217961 ...Read more

4

4
2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

Other causes: Oligoclonal bands can be present in some other conditions such as infections and inflammation of the central nervous system. Increasing the threshold for diagnosing MS by requiring at least 4 oligoclonal bands, allows to exclude these other causes and diagnose MS with greater certainty. ...Read more

5

5
Had lhermittes as CIS (no other symptoms, went after 3mths). Brain & C MRIs clear but oligoclonal bands in CSF. Now 18mths on (high vit D). Am I cured?

Had lhermittes as CIS (no other symptoms, went after 3mths). Brain & C MRIs clear but oligoclonal bands in CSF. Now 18mths on (high vit D). Am I cured?

Cured? Strong word: Your syndrome unclear. Lhermitte's is a sign seen in spinal cord disease. CIS is often an abbreviation for carcinoma in situ. What "CIS" are you referring to?

"Cured" a strong word -meaing illness CAUSE has resolved. Can you prove that? Bands seen in autoimmune processes - may produce intermittent syndromes. Good to hope. ...Read more

6

6
Dizziness, one sided numbness, one sided temp loss of function, uncontrollable body jerks, oligoclonal bands in CSF and serum. Neuro behcets or ms?

Dizziness, one sided numbness, one sided temp loss of function, uncontrollable body jerks, oligoclonal bands in CSF and serum. Neuro behcets or ms?

Suggest: The oligoclonal bands should be significantly increased in spinal fluid as contrasted to serum to be c/w multiple sclerosis, and some of your problems are likewise supportive of ms. However, do you have history of eye and skin problems more in keeping with behcets, and are MRI studies of both head and neck c/w ms? This should be fairly easy to sort out, and if ambiguous, perhaps a second opinion. ...Read more

7

7
Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Consistent: But diagnosis of MS should be based on history, physical exam, results of MRI films, and spinal fluid is useful in ambiguous cases. However, elevation of oligoclonal bands can be seen in several disorders and NOT definitive on its own. Have your doctor now put the whole picture in place. Most likely MS, but other possibilities exist. ...Read more

8

8
Lhermitte's sign & oligoclonal bands found in csf. Had no other MS symptoms and mris (cervical & brain), bloods & evokes all normal. Will I get ms?

Lhermitte's sign & oligoclonal bands found in csf. Had no other MS symptoms and mris (cervical & brain), bloods & evokes all normal. Will I get ms?

CIS: Lhermitte's sign is consistent with spinal cord lesion, and bands are about 95% predictive of onset of clinically definite ms in future, but if no lesions seen on either mri, it is not fully clear that your future deflinitely involves ms. If no symptoms, recommend supplementing vitamin d-3, approx 5000 units twice daily (level 50-60 ng/ml), and repeating mri's in 6 months, and if spots, start med. ...Read more

9

9
Vit B12 def. Corrected for 5 yrs. Previous +rheumatoid factor, elevated igg, oligoclonal bands, high erythropoietin now large red cells. Possibilities?

Vit B12 def. Corrected for 5 yrs. Previous +rheumatoid factor, elevated igg, oligoclonal bands, high erythropoietin now large red cells. Possibilities?

See your doctor: This problem can only be solved by seeing your doctor and being evaluated face-to-face. After a thorough examination, your doctor should be able to tell you what's wrong and what to do about it. ...Read more

10

10
I had an MRI which found one lesion on my brain stem with fingerlike projections. I had a positive lumbar puncture of 14 oligoclonal bands. MS?

I had an MRI which found one lesion on my brain stem with fingerlike projections. I had a positive lumbar puncture of 14 oligoclonal bands. MS?

Speak to your doctor: There is a set of diagnostic criteria for the diagnosis of MS, which also includes clinical symptoms. Please speak to your doctor/neurologist with respect to a diagnosis of the disease, and potential other tests and/or therapies. ...Read more

12

12
Are oligoclonal bands present in rheumatoid arthritis?

Are oligoclonal bands present in rheumatoid arthritis?

No: Not part of the diagnosis, but may be associated with lymphoproliferative disease, which can mimic or even rarely complicate ra. ...Read more

13

13
Ebv cause elevated IgG and olioclonal bands yrs. After infection? And cause slightly elevated rheumatoid factor?

Ebv cause elevated IgG and olioclonal bands yrs. After infection? And cause slightly elevated rheumatoid factor?

Yes: Any chronic type infection can cause a disruption of your immune system, and can make lab test positive that are not often clinically relevant. For example, the rheumatoid factor does not mean that you hae rheumatoid arthritis especially if there is little clinical suspicion (this can be determined by your rheumatologist). ...Read more

14

14
Oligoclonal Banding found in CSF not in blood. Is there other diseases they are found in besides MS?

Good question: While oligoclonal bands are often found in the CSF of people with MS, they are also found in people with infection, inflammation, and sometimes in normal cases. By themselves, they are not supportive of anything. Combined with MRI, history and physical exam data, they can support the diagnosis of MS. ...Read more

15

15
Spinal cord lesion on t3/4, negative brain mri, positive for oligoclonal banding. Neurologist says ms. Can this be with negative brain mri?

Spinal cord lesion on t3/4, negative brain mri, positive for oligoclonal banding. Neurologist says ms. Can this be with negative brain mri?

Can occur: Although less common, isolated spinal cord involvement can be seen in absence of demonstrable brain lesions. But make certain that you do no have NMO presenting atypically, and an anti-aquaporin blood test can help confirm diagnosis. ...Read more

16

16
? +oligoclonal in csf, + opt neuritis, vep abn, EMG Abn, ocular CT abn, neuro cog test abn. No lesions.? MS. +s/s- n/t legs, balance, speech. Ms imitat. Neg

Clarification: You have multiple issues, and most would strongly implicate MS. But if an MRI of both brain and spinal cord is normal, you do NOT have MS. However, several other possibilities exist, and you need to clarify your diagnosis. May help to obtain another opinion. ...Read more

17

17
Limbs tingling/weak/tired/mscle crmps/tremors/trouble sensing pain and temp. 3 brain mris:30white matter lesions w/2 enhancements. No oligoclonal or Lyme in csf. Vb6 high: 86ng. No dx. Thanks 4 ideas.

Limbs tingling/weak/tired/mscle crmps/tremors/trouble sensing pain and temp. 3 brain mris:30white matter lesions w/2 enhancements. No oligoclonal or Lyme in csf. Vb6 high: 86ng. No dx. Thanks 4 ideas.

SUGGESTIONS: If not yet done, get MRI of neck and gray matter (latter using dir). If one or more lesions in either area, plus the new and old MRI lesions, almost certainly ms. Could consider cadasil, or lyme disease, but MRI data points to a different direction. Would also get an opinion at your nearest medical school. Your situation is challenging but not unique, and this can be treated. ...Read more

18

18
What does polyclonal n biclonal bands mean?

Multiple and 2: Polyclonal means there are at least several. Biclonal means there are two. ...Read more

19

19
What causes bands to show up in csf?

Two things: You can have bands (immature neutrophils or acute inflammatory cells) in the CSF from blood contamination or acute inflammation in the CSF from diseases such as meningitis. ...Read more

20

20
Can partial braces have the rubber bands?

Can partial braces have the rubber bands?

Partial Braces: This partial braces technology uses "self-ligating" brackets -- no rubber bands or additional wire are required. ...Read more

21

21
Do the sea-bands actually work for flying?

Do the sea-bands actually work for flying?

Who knows?: No one really knows if they actually work for anything. There aren't any evidence-based studies to support their use, but it certainly can't hurt to try it. ...Read more

22

22
Do the rubber bands for braces actually work?

Do the rubber bands for braces actually work?

Absolutely: Elastics provide reciprocal force, pulling at both ends. Talk to your Orthodontic Specialist about what movement is being influenced by the elastics. Sometimes they are used to move teeth, sometimes influence growth, sometimes to stabilize segments. ...Read more

23

23
What is right fibrotic bands tiny pneumatoceles?

What is right fibrotic bands tiny pneumatoceles?

More info needed: Was that seen on a chest X-ray or CT of the chest? What are your symptoms. Recommend discussing with your doctor who ordered the test. Fibrotic bands - are just that bands (think of ribbons) of fibrous tissue. Tiny pneumatoceles are small, but abnormal air pockets within the lungs. Without more info, I can't be more specific ...Read more

24

24
Can using rubber bands cause serious brace pain?

It shouldn't: While the use of rubber bands (elastics) can create discomfort and at times be considered painful, the pain should never be serious. When instructions for wear provided by your orthodontist is followed, the discomfort should be minimal. If not, your doctor can modify the forces using different sizes and strengths. ...Read more

25

25
Why do partial braces have or need the rubber bands?

Why do partial braces have or need the rubber bands?

Makes it work better: Rubber bands are used to help teeth move in the desired direction. These allow the teeth to move with more control. ...Read more

26

26
Am I supposed to eat with my rubber bands in my braces?

Am I supposed to eat with my rubber bands in my braces?

Definitely, no: You do not have to wear your rubber bands while eating or brushing your teeth. ...Read more

27

27
How long would you wear elastic bands with braces for!?

How long would you wear elastic bands with braces for!?

Depends: Treatment varies according to your personal need. You may need elastics the whole time you're in braces, or you may not need elastics at all' or anything in between. Your treatment requirements are unique, and only your orthodontist will know what treatment is planned for you. Ask your orthodontist. ...Read more

28

28
Can it matter where I put my elastic bands on my braces?

Can it matter where I put my elastic bands on my braces?

Rubber bands & brace: Absolutely. We use rubber bands to move teeth in a certain direction. If you put them on different teeth you will move them in the wrong direction. ...Read more

29

29
How to know when to stop wearing rubber bands for braces?

How to know when to stop wearing rubber bands for braces?

Orthodontist Knows: Your orthodontist will prescribe your rubber bands duration, direction and force level. Wear your rubber bands exactly as directed by your orthodontic team. Your periodic check appointments are to monitor tooth movement and elastic progress. Ask him/her at your next appointment. ...Read more

30

30
I haven't been wearing my bands (braces). What could happen?

I haven't been wearing my bands (braces). What could happen?

Wasting time/money: If your orthodontic specalist has given you instructions and you are not following them to the letter, your malocclusion will not be as well corrected and it will take considerably longer to achieve a compromised result. You can actually do harm. If braces have been removed and you are not wearing retainers as directed the correction may relapse. You're throwing away time and money. ...Read more

31

31
I'm wondering what is the purpose of rubber bands for braces?

I'm wondering what is the purpose of rubber bands for braces?

Bite correction: Rubber bands contribute significantly to bite correction like underbite, overbite and crossbite. ...Read more

32

32
Are rubber bands really effective for correcting a cross bite?

Are rubber bands really effective for correcting a cross bite?

Yes: They can create forces that we need to move teeth that the braces alone are unable to create. ...Read more

33

33
Adding rubber bands to braces manually.? Is that going to help?

Adding rubber bands to braces manually.? Is that going to help?

See your Orthodontist: Because: 1. You don't know if you need rubber bands. 2. You don't know what size or shape rubber bands you need. 3. You don't know where exactly and how you would hook the rubber bands. See your orthodontist for consultation. ...Read more

34

34
Are there different ways to fix your rubber bands on your braces?

Are there different ways to fix your rubber bands on your braces?

Yes: There are many different ways to wear rubber bands along with wearing braces. Your doctor may prescribe front to back, back to front, triangles on the side, and many other ways. ...Read more

36

36
Is snapping rubber bands on my wrist better or worse than cutting?

Is snapping rubber bands on my wrist better or worse than cutting?

Better: Popping rubber bands is a popular and safe way of relieving anxiety. Cutting is never safe, and it can result in infection and injury. A noninvasive way of relieving tension is better. Another option is to seek counseling or therapy for issues causing distress. ...Read more

37

37
How would I know if I have an allergic reaction to the rubber bands?

How would I know if I have an allergic reaction to the rubber bands?

Symptoms on contact: Rubber bands may contain natural latex rubber, but based on how they are made, the latex protein may be in very low levels. Typically, symptoms after contact would lead to suspicion of an allergy. This includes itching, swelling, hives, etc after contact with the rubber bands. ...Read more

39

39
Can a person still have Lyme disease with only p18 bands and p41 bands?

Can a person still have Lyme disease with only p18 bands and p41 bands?

Yes and No: Have you been treated with antibiotics? If so you are likely cured.
If you haven't been treated and you are healthy you most likely have nothing to worry about.
If you develop symptoms including fatigue I would see an infectious disease doctor for a full assessment. ...Read more

40

40
Why does my orthodontist have me wearing bands in the shape of a square?

Why does my orthodontist have me wearing bands in the shape of a square?

Square elastics: Elastics are often placed in a square configuration to help "settle" the upper and lower teeth (close the bite). The same configuration can be used to lengthen a group of teeth to get a nicer smile. If there are spaces the elastic may have been placed to close them ...Read more