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Doctor insights on: Oligoclonal Bands

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Dr. Herman Hammerstead
15 Doctors shared insights

Oligoclonal Bands (Overview)

Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf.


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What is the definition or description of: oligoclonal bands?

What is the definition or description of: oligoclonal bands?

Immunoglobulins: Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf. ...Read more

Dr. Herman Hammerstead
15 Doctors shared insights

Oligoclonal Bands (Overview)

Oligoclonal bands are bands of immunoglobulins that are seen when a patient's blood serum, gained from blood plasma, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal bands are an important indicator in the diagnosis of multiple sclerosis. Approximately 79%-90% of all patients with multiple sclerosis have permanently observable oligoclonal bands in their csf.


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My CSF results show normal cell count but show inflammatory proteins-oligoclonal bands, what does this mean please?

My CSF results show normal cell count but show inflammatory proteins-oligoclonal bands, what does this mean please?

Oligoclonal bands: These proteins are immunoglobulins usually detected by separating the proteins in an electric field-charged gel. Many CNS diseases are associated with their presence, but most commonly they are tested for when there is concern about multiple sclerosis. Since many diseases can cause the abnormality, finding them is not specific and must be correlated with symptoms and other findings. ...Read more

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I had a spinal puncture done and the results said CSF/serum oligoclonal bands negative and CSF Oligoclonal bands 0 bands. Does that mean I have ms?

I had a spinal puncture done and the results said CSF/serum oligoclonal bands negative and CSF Oligoclonal bands 0 bands. Does that mean I have ms?

Multiple sclerosis: Presence of CSF oligoclonal bands is consistent and normally diagnostic of multiple sclerosis in the right circumstances. The absence does not rule out MS and the diagnosis has to be based on clinical findings and MRI results. There may also be some ethnic differentiation of oligoclonal bands present in patients with MS. You can review the article below
http://dx. Doi. Org/10.1155/2015/217961 ...Read more

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2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?

Other causes: Oligoclonal bands can be present in some other conditions such as infections and inflammation of the central nervous system. Increasing the threshold for diagnosing MS by requiring at least 4 oligoclonal bands, allows to exclude these other causes and diagnose MS with greater certainty. ...Read more

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Had lhermittes as CIS (no other symptoms, went after 3mths). Brain & C MRIs clear but oligoclonal bands in CSF. Now 18mths on (high vit D). Am I cured?

Had lhermittes as CIS (no other symptoms, went after 3mths). Brain & C MRIs clear but oligoclonal bands in CSF. Now 18mths on (high vit D). Am I cured?

Cured? Strong word: Your syndrome unclear. Lhermitte's is a sign seen in spinal cord disease. CIS is often an abbreviation for carcinoma in situ. What "CIS" are you referring to?

"Cured" a strong word -meaing illness CAUSE has resolved. Can you prove that? Bands seen in autoimmune processes - may produce intermittent syndromes. Good to hope. ...Read more

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Dizziness, one sided numbness, one sided temp loss of function, uncontrollable body jerks, oligoclonal bands in CSF and serum. Neuro behcets or ms?

Dizziness, one sided numbness, one sided temp loss of function, uncontrollable body jerks, oligoclonal bands in CSF and serum. Neuro behcets or ms?

Suggest: The oligoclonal bands should be significantly increased in spinal fluid as contrasted to serum to be c/w multiple sclerosis, and some of your problems are likewise supportive of ms. However, do you have history of eye and skin problems more in keeping with behcets, and are MRI studies of both head and neck c/w ms? This should be fairly easy to sort out, and if ambiguous, perhaps a second opinion. ...Read more

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Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Consistent: But diagnosis of MS should be based on history, physical exam, results of MRI films, and spinal fluid is useful in ambiguous cases. However, elevation of oligoclonal bands can be seen in several disorders and NOT definitive on its own. Have your doctor now put the whole picture in place. Most likely MS, but other possibilities exist. ...Read more

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Lhermitte's sign & oligoclonal bands found in csf. Had no other MS symptoms and mris (cervical & brain), bloods & evokes all normal. Will I get ms?

Lhermitte's sign & oligoclonal bands found in csf. Had no other MS symptoms and mris (cervical & brain), bloods & evokes all normal. Will I get ms?

CIS: Lhermitte's sign is consistent with spinal cord lesion, and bands are about 95% predictive of onset of clinically definite ms in future, but if no lesions seen on either mri, it is not fully clear that your future deflinitely involves ms. If no symptoms, recommend supplementing vitamin d-3, approx 5000 units twice daily (level 50-60 ng/ml), and repeating mri's in 6 months, and if spots, start med. ...Read more

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Vit B12 def. Corrected for 5 yrs. Previous +rheumatoid factor, elevated igg, oligoclonal bands, high erythropoietin now large red cells. Possibilities?

Vit B12 def. Corrected for 5 yrs. Previous +rheumatoid factor, elevated igg, oligoclonal bands, high erythropoietin now large red cells. Possibilities?

See your doctor: This problem can only be solved by seeing your doctor and being evaluated face-to-face. After a thorough examination, your doctor should be able to tell you what's wrong and what to do about it. ...Read more

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I had an MRI which found one lesion on my brain stem with fingerlike projections. I had a positive lumbar puncture of 14 oligoclonal bands. MS?

I had an MRI which found one lesion on my brain stem with fingerlike projections. I had a positive lumbar puncture of 14 oligoclonal bands. MS?

Speak to your doctor: There is a set of diagnostic criteria for the diagnosis of MS, which also includes clinical symptoms. Please speak to your doctor/neurologist with respect to a diagnosis of the disease, and potential other tests and/or therapies. ...Read more

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Are oligoclonal bands present in rheumatoid arthritis?

Are oligoclonal bands present in rheumatoid arthritis?

No: Not part of the diagnosis, but may be associated with lymphoproliferative disease, which can mimic or even rarely complicate ra. ...Read more

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Ebv cause elevated IgG and olioclonal bands yrs. After infection? And cause slightly elevated rheumatoid factor?

Ebv cause elevated IgG and olioclonal bands yrs. After infection? And cause slightly elevated rheumatoid factor?

Yes: Any chronic type infection can cause a disruption of your immune system, and can make lab test positive that are not often clinically relevant. For example, the rheumatoid factor does not mean that you hae rheumatoid arthritis especially if there is little clinical suspicion (this can be determined by your rheumatologist). ...Read more

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Oligoclonal Banding found in CSF not in blood. Is there other diseases they are found in besides MS?

Good question: While oligoclonal bands are often found in the CSF of people with MS, they are also found in people with infection, inflammation, and sometimes in normal cases. By themselves, they are not supportive of anything. Combined with MRI, history and physical exam data, they can support the diagnosis of MS. ...Read more

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Spinal cord lesion on t3/4, negative brain mri, positive for oligoclonal banding. Neurologist says ms. Can this be with negative brain mri?

Spinal cord lesion on t3/4, negative brain mri, positive for oligoclonal banding. Neurologist says ms. Can this be with negative brain mri?

Can occur: Although less common, isolated spinal cord involvement can be seen in absence of demonstrable brain lesions. But make certain that you do no have NMO presenting atypically, and an anti-aquaporin blood test can help confirm diagnosis. ...Read more

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? +oligoclonal in csf, + opt neuritis, vep abn, EMG Abn, ocular CT abn, neuro cog test abn. No lesions.? MS. +s/s- n/t legs, balance, speech. Ms imitat. Neg

Clarification: You have multiple issues, and most would strongly implicate MS. But if an MRI of both brain and spinal cord is normal, you do NOT have MS. However, several other possibilities exist, and you need to clarify your diagnosis. May help to obtain another opinion. ...Read more

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Limbs tingling/weak/tired/mscle crmps/tremors/trouble sensing pain and temp. 3 brain mris:30white matter lesions w/2 enhancements. No oligoclonal or Lyme in csf. Vb6 high: 86ng. No dx. Thanks 4 ideas.

Limbs tingling/weak/tired/mscle crmps/tremors/trouble sensing pain and temp. 3 brain mris:30white matter lesions w/2 enhancements. No oligoclonal or Lyme in csf. Vb6 high: 86ng. No dx. Thanks 4 ideas.

SUGGESTIONS: If not yet done, get MRI of neck and gray matter (latter using dir). If one or more lesions in either area, plus the new and old MRI lesions, almost certainly ms. Could consider cadasil, or lyme disease, but MRI data points to a different direction. Would also get an opinion at your nearest medical school. Your situation is challenging but not unique, and this can be treated. ...Read more

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What does polyclonal n biclonal bands mean?

Multiple and 2: Polyclonal means there are at least several. Biclonal means there are two. ...Read more

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What causes bands to show up in csf?

Two things: You can have bands (immature neutrophils or acute inflammatory cells) in the CSF from blood contamination or acute inflammation in the CSF from diseases such as meningitis. ...Read more

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Can partial braces have the rubber bands?

Can partial braces have the rubber bands?

Partial Braces: This partial braces technology uses "self-ligating" brackets -- no rubber bands or additional wire are required. ...Read more