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Doctor insights on: Ok To Take Either Allegra Or Benadryl When On Prednisone

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Dr. Tanya Russo
360 Doctors shared insights

Fexofenadine (Definition)

Fexofenadine is an antihistamine which is used to treat allergies such as hayfever, and hives. It can be taken once or twice a day. It is a second generation antihistamine and does not cause as much drowsiness as other antihistamines such as Diphenhydramine (benaryl) or chlorpheniramine. Always be careful about drowsiness with any antihistamine especially if driving ...Read more


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I know prednisone lowers your immune system, so can I take Benadryl (diphenhydramine) instead?

I know prednisone lowers your immune system, so can I take Benadryl (diphenhydramine) instead?

Yes, in occasions: You've got an excellent point. For example, in treating sinusitis caused by allergic nasal congestion, Benadryl (diphenhydramine) treatment has much less side effects than prednesone. ...Read more

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"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

See derm: Pregnancy alone can be associated with skin rash sometimes severe. A short-course of prednisone is the usual treatment. Benadryl (diphenhydramine) does help by making you a little drowsy and probably not from its antihistamine effect. If the problem continues, consult a dermatologist. ...Read more

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Can I take prednisone, Zantac and Benadryl (diphenhydramine) for allergies?

Can I take prednisone, Zantac and Benadryl (diphenhydramine) for allergies?

Yes, but: It is bit much, especially the prednisone. And the Benadryl (diphenhydramine) makes most people sleepy. I would recommend a non-sedating antihistamine, such as loratadine, cetirizine, or fexofenadine. ...Read more

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Is it ok to take Allegra in morning and Benadryl (diphenhydramine) at knight?

Is it ok to take Allegra in morning and Benadryl (diphenhydramine) at knight?

Yes: Both are effective anti-allergic medications. The major difference is that Allegra has much less tendency to cause sleep, while Benadryl (diphenhydramine) commonly induces sleep. So taking Benadryl (diphenhydramine) at night might help you sleep better. Hopefully these will relieve your allergic symptoms. ...Read more

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I have taken 360 mg of Allegra for hives, is it ok to take 25mg of Benadryl (diphenhydramine) also?

I have taken 360 mg of Allegra for hives, is it ok to take 25mg of Benadryl (diphenhydramine) also?

Yes, but only once: Seems that you have uncontrolled hives, you need to be evaluated by an allergist, check www. Acaai. Org and look for an allergist locator to spot an allergist close to where you live ...Read more

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Can I take Zoloft and Allegra in the morning and then Benadryl before bed?

Can I take Zoloft and Allegra in the morning and then Benadryl before bed?

In general, seems ok: If a person had no problems taking Zoloft by itself in the morning, and no problems taking Allegra by itself in the morning, then he should expect no problems taking them together in the morning. Some people (but not everyone) do find additional benefit from taking Benadryl at bedtime even though they already took once-a-day Allegra in the morning. ...Read more

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Is it bad if I take benadryl, (diphenhydramine) claritin, amd allegra-d all in one day?

Is it bad if I take benadryl, (diphenhydramine) claritin, amd allegra-d all in one day?

Similar medicines: All of these medicines are antihistamines. Taking combinations of antihistamines increases the possibility of side effects. If antihistamines are not working at recommended doses see a doctor. You may need a different type of treatment for your problem. ...Read more

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I'm currently taking Allegra-D 24hr daily, can I also take the occasional Diphenhydramine? I mainly would use the Benadryl (diphenhydramine) for sedative effects.

I'm currently taking Allegra-D 24hr daily, can I also take the occasional Diphenhydramine? I mainly would use the Benadryl (diphenhydramine) for sedative effects.

Yes: You can do that occasionally, don't exceed dosage, mind you allegra-D can deprive you from sleep, so don't take it in the pm period, and be cautious with diphenhydramine if you drive, take care ...Read more

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What happens if child takes Benadryl (diphenhydramine) and allegra together?

What happens if child takes Benadryl (diphenhydramine) and allegra together?

Not much: They are both antihistamines and would reduce allergic symptoms. The Benadryl (diphenhydramine) might make him/her a bit sleepy. ...Read more

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Can you take nasacort, Allegra-D, and Benadryl (diphenhydramine) all together without problems?

Can you take nasacort, Allegra-D, and Benadryl (diphenhydramine) all together without problems?

Yes, but...: 19 yo female taking nasacort, allegra-D and benadryl (diphenhydramine) all together. Yes, it is safe to take these together. For allergies, often a nasal spray and one oral antihistamine improve symptoms greatly. Don't use Allegra-D for more than 3 days at a time, try just regular Allegra. Also benadryl (diphenhydramine) can make you tired and only last a few hours. See allergist if this combo of meds still not helping symptoms ...Read more

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Can you take 25mg Benadryl 12 hours after taking regular allegra? I take toprol (metoprolol) XL 50 mg for blood pressure

Can you take 25mg Benadryl 12 hours after taking regular allegra? I take toprol (metoprolol) XL 50 mg for blood pressure

Benadryl (diphenhydramine) Use: It should be "safe" unless you get too much sedation. Ask your primary care doc then take it only at night when you need to sleep anyway.

There are numerous other (possibly more effective) options as well.

Check with an ENT or allergy doc. ...Read more

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Can I take Benadryl (diphenhydramine) with allegra?

Yes: You can take them together. If you are sensitive to the sedating effects of antihistamines, you should not take them at the same time. It would be better to take Allegra in the morning or afternoon and then Benadryl (diphenhydramine) in the evening before bed. However, if you don't feel sleepy after taking antihistamines, it would not be harmful to take them together. ...Read more

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Can I take allegra and Benadryl (diphenhydramine) together?

Can I take allegra and Benadryl (diphenhydramine) together?

Yes, but why: Allegra (fexofenadine) and Benadryl (diphenhydramine) are both antihistamines. Allegra doesn't cross into the brain, so no sedation. Benadryl commonly causes sedation. Typically there is no advantage to taking the 2 together, but also there is no harm at usual doses. ...Read more

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Can you take allegra and Benadryl (diphenhydramine) together?

Can you take allegra and Benadryl (diphenhydramine) together?

2 antihistamines: At usual doses, there should not be significant side effects from taking these 2 antihistamines together. If a person is needing this much for relief, consider seeing an allergist for an evaluation. ...Read more

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Can I take Allegra D and Benadryl (diphenhydramine) together?

ANTIHISTAMINES: Both allegra and benadryl (diphenhydramine) are Anti-hitamines, while there is no contraindication, there effects may be additive. Monitor for excess sedation. ...Read more

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I take flonase and allergra for seasonal allergies, and that usually controls it. Today it is not. Can I take allegra, claritin, or benadryl?

I take flonase and allergra for seasonal allergies, and that usually controls it. Today it is not. Can I take allegra, claritin, or benadryl?

Allergy treatment: If taking Allegra already you should not double up on a long acting antihistamine (Allegra, Claritin, Zyrtec). This can cause heart issues.
Intra-nasal steroids (Flonase) should be used routinely. Adding Allegra is fine on an-needed basis. Adding short acting (Benadryl) is ok but indicates need for better preventive care (environmental controls, more consistent Flonase use, allergy shots). ...Read more

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I started itching and have hives, took a allegra at 3:30 am, applied Benadryl (diphenhydramine) ant-itch cream this morning. Noticed hives now can I take Benadryl (diphenhydramine) tablet?

I started itching and have hives, took a allegra at 3:30 am, applied Benadryl (diphenhydramine) ant-itch cream this morning. Noticed hives now can I take Benadryl (diphenhydramine) tablet?

Yes, but...: The Allegra (fexofenadine) is a long acting, non-sedating anti-histimine. If the itching hasn't been controlled, it is ok to take Benadryl (diphenhydramine) which is a short acting and sedating anti-histimine- so be aware of the potential for drowsiness.....Limit the Benadryl to one or two tablets per day, if continuing the allegra (fexofenadine). ...Read more

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If I took an allegra at 11am, can I take Benadryl (diphenhydramine) 12 hours later?

If I took an allegra at 11am, can I take Benadryl (diphenhydramine) 12 hours later?

Yes: Benedryl has some benefits as a really tenacious antihistamine that binds well with histamine & is very effective in that work. Its drawback is sedation which occurs because it enters the brain & messes with messages between nerve cells. You can take benedryl along with a non-sedating antihistamine as long as you can handle the side effects. ...Read more

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Can I take Allegra & Benadryl (diphenhydramine) together or one or the other? Thanks!

Can I take Allegra & Benadryl (diphenhydramine) together or one or the other? Thanks!

Better not together: One or the other, space them out if you have to take both, but under doctor's supervision ...Read more

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Is it okay to take Allegra and Benadryl (diphenhydramine) in the course of one day (24hrs) if Allegra alone is not providing the relief I seek?

Is it okay to take Allegra and Benadryl (diphenhydramine) in the course of one day (24hrs) if Allegra alone is not providing the relief I seek?

Yes, but: For what do you seek relief? If you have nose/eye/ear symptoms related to allergy, then there are more effective treatment strategies compared with oral antihistamines. An Allergist can help with this. If you have uncontrolled hives, might also see allergist or dermatologist, but using higher doses of long-acting antihistamine is common. Read labels and be aware of side effects (like sedation) ...Read more

Dr. Thomas Namey
2,568 Doctors shared insights

Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more