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Doctor insights on: Ocular Carbonic Anhydrase Enzyme Blocker Medication

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Will latisse have interactions with other medications I take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Will latisse have interactions with other medications I take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Should: Should not have any adverse affect but may result in an even lower eye pressure. You may see if you eye doctor can switch you form the carbonic anydrase inhibitor to Lumigan eye drops which will help the glaucoma and your lashes at the same time (lumigan and Latisse (bimatoprost) are the same medicine). ...Read more

Enzyme (Definition)

An enzyme causes the transformation of a compoond to another compound. In living structures, it is the transformation of a protein to another form. An example is from an inactive state ...Read more


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I want to know what is the function of carbonic anhydrase in the brain.

I want to know what is the function of carbonic anhydrase in the brain.

Acid-base regulation: Carbonic anhydrase (CA) is found throughout the brain. It is concentrated in the areas producing cerebro-spinal fluid and helps maintain that pressure. But all cells have this important enzyme involved in keeping the acid-base balance of the brain and body. ...Read more

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Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.)

Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Maybe: The science is a bit sketchy, and mostly Internet based, which does cast suspicion on validity, but seems to be some possible mechanisms by thiamine on CO2 metabolism. If pseudo tumor is present, would certainly try Diamox (acetazolamide) or glycerol, but would not hurt to add thiamine (vitamin B-1), but would not use B-1 exclusively, as I am not convinced of its efficacy. ...Read more

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I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?

I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?

Then by all means: Speak to your neurologist. We all have to learn about these condition, frankly, they are heavily tested on our board exams; however, rarely actually seen. I'd consider seeing a neurologist with expertise in neuromuscular disorders. ...Read more

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I've read studies that high doses of thiamine can be as effective as acetezolomide in terms of Carbonic anhydrase inhibitor. True? I have IIH.

Maybe so: I can confirm that I have also read studies that suggest that thiamine is a significant carbonic anhydrase inhibitor. Considering the seriousness of the condition that you are treating, you should probably stick with the known effect of diamox (acetazolamide). However, you could discuss this with your treating physician. ...Read more

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Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Channelopathies: Your question is interesting. Here is a reference that answers it: channelopathies.
Moxley iii rt.
Curr treat options neurol. 2000 jan;2 (1):31-47.
Pmid: 11096735 [pubmed - as supplied by publisher]
in short, yes. Longer answer, in some situations it can help, in others, it can make matters worse. The reasons are not understood. Go to pubmed and search for that article, then read the abstract. ...Read more

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Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more

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I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more

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Do narcotic pain medications cause elevated enzyme levels?

Do narcotic pain medications cause elevated enzyme levels?

Depends: Depends on base line liver function and dose of narcotics ...Read more

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Is there a medication I could take to lower my liver enzyme levels?

Is there a medication I could take to lower my liver enzyme levels?

You need: To find out the cause of the enzyme elevation. There are treatments if it is a virus, and youshould steer clear of alcohol if that is a potential cause and until one is found, but many medications can cause the "trans-aminitis". No heal-all for this serious finding need to see an internist/hepatologist. ...Read more

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Recent labs showed Liver enzymes elevated should I stop any medications? What can I take to help lower the enzymes?

Recent labs showed Liver enzymes elevated should I stop any medications? What can I take to help lower the enzymes?

High liver enzymes: 28 F just found high liver enzymes. Asks should I stop medications?
This will depend on the medications and the cause of the liver problem.

Check with your team as they know you best. ...Read more

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67 yrs. Angiotensin 1 converting enzyme (ace) serum 126.7, what should be done? Bad? What does this mean? Life style changes. Medication? Thank you

ACE levels: 51 M Notes: 67 yrs angiotensin 1 converting enzyme (ace) serum 126.7, what should be done? Bad? What does this mean? Life style changes. Medication? Thank you
ANS: not enough information to help at this point. Are you 51 or 67? Need to know why it was measured, what meds, other illnesses, & what is normal in that lab. Get this information & will be happy to do 2nd opinion as I specialize in RAAS ...Read more

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Hello, my sgpt is 113, sgot 50. No hepa b or c. I have a fatty liver. What is the best medication to normalize my enzyme in 1 month? Thanks

Hello, my sgpt is 113, sgot 50. No hepa b or c. I have a fatty liver. What is the best medication to normalize my enzyme in 1 month? Thanks

No meds for Liver: There are no medications to heal the liver. Honestly. You must change your life, your diet and your weight. You must avoid anything else that can stress the liver like tylenol (acetaminophen) and Acetaminophen products, no alcohol.

Please use this wake up call to get healthy. You need your liver to grow old. ...Read more

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Is a gastroenterologist the expert one goes to in order to regulate enzyme insufficiency with a medication, such as creon? Medical oncologist?

Yes: Why on Creon??? Cancer??? You should consult whatever Dr gave you Creon in the first place. What is the reason? Exactly what are the details of "enzyme insufficiency"? How was it diagnosed? What is the cause? ...Read more

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Can the medication serequel hurt my liver? Becuz im 18 years old and a male and I already have enough mental problems going on and high liver enzymes.

Can the medication serequel hurt my liver? Becuz im 18 years old and a male and I already have enough mental problems going on and high liver enzymes.

Define "hurt"!: Check out https://online. Epocrates. Com/noframe/showpage. Do? Method=drugs&monographid=1230&activesectionid=5 which notes that liver enzymes alt & ast can be transiently elevated. Then have a discussion w/your prescribing doc to weigh risks & benefits. Ask about alternative medications which may not offer same benefit, may be too expensive, may cause other side effects, etc. Make sure no other reason. ...Read more

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I recently discovered I take three medications that metabolize by the same liver enzyme, paroxetine 20mg, wellbutrin300mg, risperidone. 75mg for 3 yea?

I recently discovered I take three medications that metabolize by the same liver enzyme, paroxetine 20mg, wellbutrin300mg, risperidone. 75mg for 3 yea?

Med interactions: Medications taken together can have interactions with each other, in part because of what you noted--being metabolized by the same liver enzyme. These interactions can have the results of making medications either stronger or weaker (depending on the specific interaction). I would base the evaluation on whether the medications are addressing the symptoms--if not, you should let your doctor know. ...Read more

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Elevated liver enzymes fr 6mos. No alcohol no medications. Not hep a.B.C CMV & ebv. Autoimune & u/s neg- not wilson not hemochro not alpha1 antripsin?

Possible fatty liver: If you are not on any medication or taking any herbal supplements that can cause elevated liver enzymes, the most likely diagnosis would still be non-alcoholic fatty liver disease ("fatty liver") even with a normal sonogram. Other imaging studies could confirm this, but the most definitive way to diagnose the cause is a liver biopsy. ...Read more

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Could anti-thyroid medication cause elevated liver enzymes? I am a 68 year old female.

Could anti-thyroid medication cause elevated liver enzymes? I am a 68 year old female.

Yes: Yes, particularly a medication abbreviated ptu (propylthiouracil). The other available medication, methimazole, can do so as well, but not as commonly. Contact your physician asap. ...Read more

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Digestive enzymes, medication Pepcid (famotidine) and anything related cause me to be very hungry even on a a full stomach. What could cause this? Normal? Abnormal

Digestive enzymes, medication Pepcid (famotidine) and anything related cause me to be very hungry even on a a full stomach. What could cause this? Normal? Abnormal

Large range of possibilities: There are a large range of possibilities that could cause that to be occurring. First, some ulcers can make people feel a hunger type of pain. You should make sure your doctor has checked for this. Also, depending on what you are eating, some people have postprandial hypoglycemia, which just means that sugar levels fall after eating, causing the hunger. ...Read more

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How can we reduce jaundice, high burlibun enzyme? Cause is liver metastatic cancer... Any medications!

How can we reduce jaundice, high burlibun enzyme? Cause is liver metastatic cancer... Any medications!

Jaundice: Sounds like the cause is not treatable unless obstruction can be relieved. See your oncologist first and possibly a GI for an ERCP evaluation. ...Read more

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I have liver enzymes increasing for the past 3 years. ALT 57 AST 43. I don't drink alcohol, eat paleo, don't take medication. Should I see a specialist?

I have liver enzymes increasing for the past 3 years. ALT 57 AST 43. I don't drink alcohol, eat paleo, don't take medication. Should I see a specialist?

Maybe: You'll want to rule out hepatitis B and C, Wilson's (unlikely with these low levels at your age but not to be missed), early hemochromatosis, and autoimmune hepatitis. Non-alcoholic fatty liver is mostly hereditary and should be sought as well. Stay proactive. ...Read more

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Why some drugs causes elevated liver enzymes?

Why some drugs causes elevated liver enzymes?

Liver clears out: The liver does things such as clean your blood by removing toxins like medicines and alcohol. It contains thousands of enzymes which are special types of protein cells that help necessary chemical reactions to take place. Some medicines may be too much for the liver to handle and the result is that the enzymes are elevated and this is a sign that the liver needs help. ...Read more

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Chronic pancreatitis are there any known drugs that can stop the enzymes from destroying the pancreas? In trials?

Chronic pancreatitis are there any known drugs that can stop the enzymes from destroying the pancreas? In trials?

Haven't heard of...: Haven't heard of a successful treatment to block the secretion or damaging effect of the pancreatic enzymes (the G.I. Specialists have tried some meds to decrease secretion on enzymes). ...Read more

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For TB patients with high liver enzymes, what would be the best possible drug combination?

Second line meds: Since majority of the TB meds can cause elevated liver enzymes, substituting them in someone with active TB disease requires careful consideration of several factors. These include - site of tb, duration of treatment, current stage of treatment, concurrent use of other meds & their interactions with TB meds etc. Talk to an infectious disease specialist for an individualized regimen based on above. ...Read more

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What happens if a drug isn't inhibitory toward an enzyme, is there still a ki and ic50?

Ki and ic50: May be if you go high enough. But Great google question. You can also go to Google Books and look at Pharmcology texts for details. ...Read more