Doctor insights on:
Novartis Gene Expression Atlas
Many: There are many genetic disorders that don't become apparent until adulthood. Arguably more of these are dominant singel gene disorders. Please provide more details of the nature of the genetic condition. ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
One study found that isotretinoin, accutane, significantly changed the expression of hundreds of genes in skin after 8 weeks of therapy.
Nelson, am et al (2009). "temporal changes in gene expression in the skin of patients treated with Isotretinoin provide insight into its mechanism of action". Dermato-endocrinology 1 (3): 177–87. ...Read more
Signal transduction: Signal transduction is a way for a cell to convert an extracellular signal into a response. Some protein kinases are part of signal transduction pathways. They are cellular enzymes that modify other cellular components by adding phosphate groups to them. This causes a biochemical chain of events that may result in altered levels of gene expression. ...Read more
Reference: See the paper http://www. Ncbi. Nlm. Nih. Gov/m/pubmed/14557539/. For more information, I recommend a Medline search or check Amazon for book-length reviews. Your question can't be answered in 400 characters, or 400 words, or 400 lines, or even 400 pages. Some neurobiologists spend their entire careers on this kind of research. ...Read more
A recent study published suggests that mindfulness meditation downregulates gene expression rapidly, especially inflammatory cox2. Can I buy this?
Yes, you can:
Authorskaliman p, et al. Show all journal
psychoneuroendocrinology. 2014 feb;40:96-107. Doi: 10.1016/j.Psyneuen.2013.11.004. Epub 2013 nov 15.
Pmid 24485481 [pubmed - in process]
full text: elsevier science
best wishes. ...Read more
We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more
Can't do in 400: The study of micro-rnas is cutting-edge and extremely arcane and you need to go directly to pubmed or one of the other big ways to access the scientific data. If someone is offering a breast cancer treatment to re-regulate your micro-rna's, call your district attorney. Glad you have an inquiring mind and I wish you luck with your project. ...Read more
Gene mutation: If not a genetically inherited, environmental conditions initiate the induction of the breast lesion. The most common mutation occurs with the long terminal repeat of the MMTV virus enters the Wnt-1 gene. This produces an over expression of B-catenin which results in transformation. EBV infection probably needed for FGARAT production that acts to overexpress telomerase inducing immortality. ...Read more
Please advise how rare is a familial mutation on CYP19A1 gene in terms of excessive expression of estrogen synthase in male population. Thank you.
Look it up on Google: Google search "Familial Mutations CYP19A1". Only a single change in DNA base pares is a mutation, most changes minor in consequence, others major. Variations in genes are extremely common &, in 2014, humans are still far from tracking or understanding all variations which exist, much less genetic control mechanisms & what differences which variations make in which outcomes; Too Complex. ...Read more
Gene activation: Turning on and off different genes is a complex process. Some genes turn on 50 years after birth and some are switched off at different phases of our life. We stop growing, we develop hypertension and we may have a genetically associated disease or cancer. There is no way I know of to turn genes on or off. Maybe that's how exercise and weight loss work though. Who knows. ...Read more
You cannot change your genes, but you can definitely affect the expression of your genes - by about 75% in many cases. It depends on the gene.
Environment would include many things, like consumption of certain nutrients, toxins, hormones, stress, sleep, etc.
Epigenetics refers to the expression of your genes. ...Read more
Yes: We are all thought to carry at least 3-4 copies of a gene variant that would produce a significant metabolic or structural disorder if paired with a similar defect at conception. Most taboos about having kids with close relatives are based on this risk/experience. If you have a defect, the type of risk varies with the genetics involved. Those with dominant defects have 50% risk/conception. ...Read more
Yes: This is a work in progress. Some genes (present or absent) determine the efficiency or even presence of enzymes which can chew up toxins in your body. There are certainly many to be discovered that will help in this as well as determine the effectiveness of drugs. This whole area is termed pharmacogenetics. ...Read more
Rarely yes: Almost all patients with tay-sach lack hexosaminidse a activity due to mutations in the hex a gene. The infantile form have less than 5% activity while the juvenile and adult forms have partial deficiencies. A very small subset of patients have normal hex a activity but have a mutation in the gm2 activator gene that codes for the intralysosomal protein, gm2 activator that degrades gangliosides. ...Read more
Maybe: Though no genetic link has been proven, there are studies looking at catecholamine methyltransferase and serotonin transporter genes in fibromyalgia (fms). These genes may predispose persons to a heightened sensitivity to pain and/or depression. Eleven other genes are currently also being investigated. ...Read more
Field of epigenetics: This is a new age for discovering the many factors and processes which can alter the expression of a gene (including when it is expressed, preventing its expression, or even altering the gene product into something else). You would need to study an up-to-date course on this extraordinary field. Read some good articles in magazines like Scientific American. ...Read more
Many: Many diseases and health conditions are influenced by genes. We have the technology today to do genetic testing from the blood which will provide genetic risk factors for many diseases eg heart disease, prostate cancer in men, breast cancer in women, lung cancer, and many other diseases and cancers. ...Read more
No: Everyone has the same chance of having a boy or a girl. It is 50% for a boy and 50% for a girl in any given preganancy, regardless of the number of boys or girls in previous pregnancies.-since a mother contributes an X chromosome and a father contributes a Y chromosome. ...Read more
Depends: Our genes are unchanged as we age, however, the gene expression may change. Actions caused by the genetic material may vary as we age. This may include the ability of our genes to fight certain diseases comon in aging like cancer.Gene regulation is extremely complex and not fully understood. We're on the brink of a better understanding and possible use of genetic medicine to treat/prevent disease. ...Read more
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Best evidence is that sexuality of most gay males is determined while they are still in the uterus. The likelihood of a woman's son being gay increases with each subsequent male child but only right handed males. The first son and all left handed males have a 2% chance of being gay. The third son if right handed is actually more likely to be gay than straight.
https://www. Youtube. Com/watch? V=z6zPh97qYd4 ...Read more
Yes: Homocystinuria is an inherited genetic disorder that impairs the metabolism of the Amino Acid methionine. It is a recessive disorder, which means that you have to have two faulty copies of the gene (inherited singularly from each parent) to be cinically affected. ...Read more
Inheritable: "germline" refers to genes that are present in every cell of the body from conception or shortly afterwards, including sperm/ ova, and thus can be passed down to offspring. This term is used to distinguish these types of inherited genetic mutations from those that are not inherited - not present in the dna of sperm or ova. ...Read more
Yes it can: Accutane and Isotretinoin type drugs have been associated with birth defects. Although the exact mechanism is not known, most of these defects are caused by underlying changes in gene expression due to the drug. However, Accutane does not change the dna of your sperm/egg long term. So taking Accutane does not mean you will have a greater liklihood of inherited disorders. Just avoid during preg. ...Read more
HLA genes regulate the immune system and many diseases, especially auto-immune disorders are linked to certain HLA types. HLA B 27 has a strong link to ankylosing spondylitis. Other HLA linked disorders are diabetes, celiac disease, and rheumatoid arthritis. For a list of other HLA linked disorders, please consult this site:
http://www. Hladiseaseassociations. Com/ ...Read more