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Doctor insights on: Norpramin

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Dr. Jeffrey Wint
26 Doctors shared insights

Norpramin (Overview)

Norpramin is a secondary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting drug, atypical anti-psychotic drug).


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Imipramine (tofranil) and desipramine (norpramin), what are these?

Imipramine (tofranil) and desipramine (norpramin), what are these?

Antidepressants: Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression

Dr. Jeffrey Wint
26 Doctors shared insights

Norpramin (Overview)

Norpramin is a secondary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting drug, atypical anti-psychotic drug).


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Can someone tell me how safe is the norpramin (desipramine) medication?

Can someone tell me how safe is the norpramin (desipramine) medication?

Norpramine: A tricyclic antidepressant, it has been used for many years. Is better tolerated than other tricyclics due to less sedation & effects on GI tract & minimum drying effect. As long as dose is therapeutic, it is safe.

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Can someone tell me how safe is the norpramin (desipramine) medication?

Norpramine: A tricyclic antidepressant, it has been used for many years. Is better tolerated than other tricyclics due to less sedation & effects on GI tract & minimum drying effect. As long as dose is therapeutic, it is safe.

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What is the definition or description of: Norpramin allergy?

What is the definition or description of: Norpramin allergy?

Norpramin allergy: Desipramine (Norpramin) is a tricyclic antidepressant. It is FDA approved for treatment of depression. It is used off-label for anxiety, panic disorder, ADHD, bulimia, neuropathic pain, cataplexy & chronic itching. Allergic reactions could include swelling of tongue, throat, lips, mouth, face, hives or difficulty breathing.

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How effective is Norpramin (desipramine) for treating depression?

Norpramin (desipramine): This is a Tricyclic antidepressant nowadays replaced by newer antidepressants with fewer side-effects, such as SSRIs & SNRIs.

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Imipramine (tofranil) and desipramine (norpramin), what are these?

Antidepressants: Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression

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Can you please tell me how safe is the nardil, (phenelzine) mellaril, and norpramin medication?

Can you please tell me how safe is the nardil, (phenelzine) mellaril, and norpramin medication?

Somewhat depends: All three have been used for more than 40 years. Nardil needs to be taken in context of care diet modification, but it works quite well. Mellaril is an antipsychotic used for years and years, until eli lilly got scared of Geodon (ziprasidone) and forced the fda to study other antipsychotics for qtc changes. Again, quite safe. Norpramin is despiramine, one of the first antidepressants; again, used for years.

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What is the definition or description of: desipramine?

What is the definition or description of: desipramine?

Desipramine: Desipramine (norpramin) is a non-selective tricyclic antidepressant used to treat major depression, ocd, enuresis, and various anxiety disorders. It is more directed towards inhibiting norepinephrine than serotonin reuptake, but affects both.

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Has anyone ever had problems/symptoms when withdrawing from desipramine?

Desipramine: Depends on dose, what it's prescribed for, and how long you've been on it. Main concern is recurrence of original symptoms.

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Will I get withdrawals from Desipramine if I go from 150mg to 75mg in one day?

Most likely not: But if you do just taper more slowly. Should not be a big problem. Of course you may need antidepressant medication so you should be discussing this with your psychiatrist.

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Every morn I wake up with headache. Take topamax (topiramate) 50 mg qam & 100 mg qhs & desipramine 50 mg qhs. What do you suggest?

Reason for meds: Desipramine is an antidepressant. Depression can cause many somatic symptoms including headache, so an increase in desipramine may be indicated. Topamax (topiramate) can be used for several different conditions including migraine headache prophylaxis. Doses up to 200 mg daily may be used for this indication. Talk to your prescribing doctor about a possible increase in topomax or desipramine.

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Can I take anything for menopause with my depression medication desipramine 50mg?

Can I take anything for menopause with my depression medication desipramine 50mg?

Drugs and menopause: You can certainly speak to your provider and discuss this issue. You need to be able to define the problems menopause is challenging you with. Menopause cannot be treated, however, many of the uncomfortable effects can be managed. It appears that you are taking your medication to assist you with sleeping. There are drugs that may better target your depression and still help with sleep.

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Is giving half of a desipramine hci 25mg. Pill safe to give to a 6 yr. Old for bedwetting?

Is giving half of a desipramine hci 25mg. Pill safe to give to a 6 yr. Old for bedwetting?

Yes: 25 mg would also not be too much providing child does not experience side effects such as nightmares, cofusion or excessive dryness of mouth, headaches, costipation etc. Have you tried, and is your child mature enough to use a bedwetting alarm? This is the most effective curative treatment for bedwetting and effective in up to 70% of kids if used correctly.

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Is desipramine a better antidepressant than nardil (phenelzine) for motivation?

Depends: Desipramine is an old medication from the tca group. It is relatively norepinergic, that can possibly increase motivation. Nardil (phenelzine) belongs to the group of maoi, which are supposed to increase all three neurotransmitters, promote alertness etc., which also can improve motivation. I normally let my patients to try both and choose. (nb! Cannot be taken in the same time!).

Desipramine (Definition)

Desipramine (norpramin) is a non-selective tricyclic antidepressant used to treat major depression, ocd, enuresis, and various anxiety disorders. It is more directed towards inhibiting norepinephrine than serotonin ...Read more