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Doctor insights on: Normal Dosage Of Zoloft

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Hi, I normally take a 100mg of Zoloft (sertraline) daily but today I accidentally took two of the 100mg pills making the dosage 200mg. Should I do something?

Hi, I normally take a 100mg of Zoloft (sertraline) daily but today I accidentally took two of the 100mg pills making the dosage 200mg. Should I do something?

Yes: Be more careful. 200 mg of Zoloft (sertraline) never killed anybody. Skipping tomorrow shouldn't disrupt the effect of the drug. BUT: Call your doctor and let him/her know. Don't personalize this: He/she's your doctor, not yout mother. ...Read more

Dr. Heidi Fowler
1,087 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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I just started taking a generic Zoloft (sertraline) today and my chest hurts and im afraid if I get up ill fall over. Is this normal for the first dosage?

I just started taking a generic Zoloft (sertraline) today and my chest hurts and im afraid if I get up ill fall over. Is this normal for the first dosage?

Probably not zoloft (sertraline): Zoloft (sertraline) takes days--even weeks to start to work your symptoms are likely due to the anxiety disorder you are trying to treat hang in there with the zoloft (sertraline) & give it a chance to work. ...Read more

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I have been on Zoloft (sertraline) since april of 1998, been on max dosage awhile w/no problems. Threw up after taking normal dosage last night. Please help.

I have been on Zoloft (sertraline) since april of 1998, been on max dosage awhile w/no problems. Threw up after taking normal dosage last night. Please help.

See doc if repeats: You can't blame it on the medication if you throw up 1x in 12 years after taking medication. If it happens again see your physician. If you are going to change dosages you should review the plan with the treating doctor. ...Read more

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I was on 100mg of Zoloft (sertraline) & 1000mg of Depakote, my Dr. Increased my dosage to 150mg Zoloft (sertraline) & 1500mg of Depakote, I feel like I cant function, normal?

I was on 100mg of Zoloft (sertraline) & 1000mg of Depakote, my Dr. Increased my dosage to 150mg Zoloft (sertraline) & 1500mg of Depakote, I feel like I cant function, normal?

? Side effects: You appear to be experiencing adverse effects of the higher dosing. Be sure to call your Treating Dr. And let them know, so you can be treated effectively and with continuity of care. Best wishes. ...Read more

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I am diagnosed with severe OCD. Doc put me on Zoloft (sertraline) 300mg QD and Anafranil 75mg OD. My question is that, this is a normal dosage to tackle anxiety???

I am diagnosed with severe OCD. Doc put me on Zoloft (sertraline) 300mg QD and Anafranil 75mg OD. My question is that, this is a normal dosage to tackle anxiety???

OCD: Use of higher doses of anti-depressants such as zoloft (sertraline) is effective for OCD. The Anafranil dose if moderate but could cause an interaction with the very high dose of zoloft (sertraline). Contact your doctor if you experience any side effects chills, diarrhea, muscle pain, excessive sweating, agitation. ...Read more

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Sinus infection symptoms. Feeling dizzy/almost nauseous from blowing nose so much. Also increase Zoloft (sertraline) dosage...Is dizziness/nasea normal with this?

Sinus infection symptoms. Feeling dizzy/almost nauseous from blowing nose so much. Also increase Zoloft (sertraline) dosage...Is dizziness/nasea normal with this?

Assoc with sinus: Sinus issues can affect inner ear, which can cause dizziness and nausea, but so can change in your zoloft (sertraline) dosage. Call your doc to discuss, and maybe get treated. ...Read more

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My psych increased my Zoloft (sertraline) dose to 150 mgs (75 2x a day)since a month after being on 100 for 45 days. Is it normal that no benefit after a month now?

My psych increased my Zoloft (sertraline) dose to 150 mgs (75 2x a day)since a month after being on 100 for 45 days. Is it normal that no benefit after a month now?

Zoloft (sertraline): It depends on why you're taking zoloft, (sertraline) and what specific benefits you're looking for. I see that you list ocd but not depression in your additional information. Ocd often requires higher doses than depression, and your psychiatrist may have some more dose adjusting to do. Hoping you'll speak with your own psychiatrist about this, and that you'll have some relief soon. ...Read more

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Doing pretty well with Zoloft; just upped from 100 to 150mg; feeling a bit anxious &jittery; normal for a dose increase? Taking for anxiety

Doing pretty well with Zoloft; just upped from 100 to 150mg; feeling a bit anxious &jittery; normal for a dose increase? Taking for anxiety

Sertraline: Can sometimes work wonders for anxiety, I am glad you are having some success with it. It is normal practice to increase doses of this medicine by 25-50mg. ...Read more

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My pdoc put me on Zoloft (sertraline) 300mg in divided dose. Is it normal dose? Can I combat depression without medications?

My pdoc put me on Zoloft (sertraline) 300mg in divided dose. Is it normal dose? Can I combat depression without medications?

Yes, it is Normal: Usually this dose is given to get you back into base line meaning on normal functioning, over time your doctor can lower the dosage as the symptoms show improvement. Along with other depression manage therapies, exercise, diet one can in most cases over time may not even need medication. ...Read more

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Accidentally skipped a dose of my zoloft, and now I feel kind of nauseous and anxious. Normal? Also, how is wellbutrin (bupropion) different than zoloft?

Accidentally skipped a dose of my zoloft, and now I feel kind of nauseous and anxious. Normal? Also, how is wellbutrin (bupropion) different than zoloft?

Yes; very different: First, abrupt discontinuation of zoloft (an ssri antidepressant) can lead to a variety of physical symptoms, including nausea; and possibly a return of some anxiety (if it was prescribed to treat anxiety). Wellbutrin (bupropion) is in a different chemical class - it works on norepinephrine and dopamine, and not serotonin. It is also an antidepressant but is not generally prescribed for anxiety conditions. ...Read more

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I've lowered Zoloft (sertraline) dose from 200mg to 150mg for around 2 weeks. I have muscle aches and starting to get head spasms! Is this normal?

Lowering Zoloft (sertraline) dose: Muscle aches and 'head spasms' or shock-like sensations may be seen in Zoloft (sertraline) withdrawal. Suggest you discuss with prescribing doc and taper dose more slowly - maybe increase dose a little until you feel better. Discontinuing Zoloft (sertraline) or similar med need not result in any physical discomfort. Changing med dose should be individualized and carefully monitored by prescribing doctor. Hope this helps. ...Read more

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Doc put me on Zoloft (sertraline) 50mg yesterday. Took 1 dose. Lightheaded, dizzy, shaky, headaches and nauseous. Is this normal?

Doc put me on Zoloft (sertraline) 50mg yesterday. Took 1 dose. Lightheaded, dizzy, shaky, headaches and nauseous. Is this normal?

That can occur.: You might want to ask your doctor about starting at 25mg for a week - so that your body can adjust to the zoloft (sertraline) before dose is raised to 50mg per day. Take care. ...Read more

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What is the average dosage of Zoloft (sertraline) people should take?

What is the average dosage of Zoloft (sertraline) people should take?

Zoloft (sertraline): Up to 200mg. Per day in divided dosages, for average adult. ...Read more

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Can I still take Zoloft (sertraline) that is six months passed the expiration date? 50mg dosage.

Can I still take Zoloft (sertraline) that is six months passed the expiration date? 50mg dosage.

Should be OK: Expiration dates tend to be artificial. It's not like one day the medicine is fine and the next day it goes bad. Over time a medication may gradually lose some of its potency but most likely Zoloft (sertraline) that's 6 months past the expiration date is still very potent and should be as effective as if it was prior to the expiration date. If it was 2 or 3 years after exp. Date I'd reconsider. ...Read more

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Is it possible to only need 25 mg dosage of zoloft (sertraline). Taking it for 7 days, feeling better. Do I need to increase to prescribed 50 mg?

Zoloft (sertraline): Not knowing your age, weight, other meds and health status, it is hard to say. This medication takes up to 4 weeks to get to steady state. Since you have such early positive effects, it would not be a bad idea to talk to your doctor about staying for another week at 25mg. How you are feeling in an important indicator to the meds effectiveness. ...Read more

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Could splitting Zoloft (sertraline) tablets lead to recurrence of mdd symptoms due to dosage discrepancies? Was trying to use leftover pills my dr. Had me split.

Could splitting Zoloft (sertraline) tablets lead to recurrence of mdd symptoms due to dosage discrepancies? Was trying to use leftover pills my dr. Had me split.

Not necessarily: It depends if you are splitting the pills and now taking too low of a dose- that could cause a recurrence of depressive symptoms. But in general, it should be ok to split sertraline. The pills have a "score" which means it intends for the patient to cut or split it. ...Read more

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Would side effects be present with increasing Zoloft (sertraline) dosage of 25 to 50mg? Although no bad side effects when taking 25mg, but many with 50mg.

Maybe: In my practice, I start most adults on zoloft (sertraline) at 50 mgs daily, and they do well. I then have them increase the dose to 100 - 200 mgs gradually, so they can be at a therapeutic dose.
If you are having side effects now, see your physician and discuss all of your medications, over the counter medicines, and concerns. It may be that your side effects are due to medication interactions. ...Read more

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Related to a question I asked earlier about when to take zoloft (sertraline). Do the side effects go away after the body gets used to the dosage and time change.

What symptoms?: I usually tell patients to start 25 mgs with food at dinner. This accomplishes several things. It usually diminishes the effect of sedation, nausea and fatigue that can often occur when you start an ssri. Increase the dose every 5 to 7 days by 25 mgs. Until I see a therapeutic effect. At 100 mgs. I wait another two to four weeks so that treatment "catches up" to onside effects. Talk to yourdoc! ...Read more

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How to titrate down Zoloft (sertraline) from 25mg to say 20mg and so on instead of 25mg to 12.5mg which is too big of a jump? Difficult to cut dosage of pill exact

How to titrate down Zoloft (sertraline) from 25mg to say 20mg and so on instead of 25mg to 12.5mg which is too big of a jump? Difficult to cut dosage of pill exact

Ask a pharmacist: You may want to ask a pharmacist if there is something you can do. Your pharmacist is a great resource of information for formulation and dosing of medications. ...Read more

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Zoloft (sertraline)- from 100 to 150mg Ativan-.5mg Could a change in my dosage of Zoloft (sertraline) affect how Ativan effects me? I was VERY addled the last time I took it.

Zoloft (sertraline)- from 100 to 150mg Ativan-.5mg Could a change in my dosage of Zoloft (sertraline) affect how Ativan effects me? I was VERY addled the last time I took it.

Depression, Anxiety: I understand your concern. Zoloft (sertraline) is a medication for depression and anxiety.
Ativan is a medication for anxiety.
Ask yourself for reasons to take 2 medications for anxiety; and for increase of dose of Zoloft (sertraline) to 150mg/day which is a high dose.
Using Ativan together with Zoloft (sertraline) may increase dizziness, difficulty concentrating and confusion.
See a Psychiatrist for Diagnosis, Medication and Therapy ...Read more

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What is the equivelant dosage of for 100mg of Zoloft (sertraline). My doctor is thinking of changing me from Zoloft (sertraline) because it doesn't seem to be working?

What is the equivelant dosage of for 100mg of Zoloft (sertraline). My doctor is thinking of changing me from Zoloft (sertraline) because it doesn't seem to be working?

Zoloft (sertraline): You didn't provide another medication that your doctor is considering a change to, so I can't answer specifically. Nonetheless, there's still room to increase your zoloft (sertraline) dose to see if that could increase effectiveness. In situations like this, many primary care physicians ask their patients to see psychiatrists for review of medications & suggestions for dose adjustments or changes, etc. ...Read more

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What's the dosage equivelant of 100mg Zoloft to the same amount of paxil (paroxetine). I'm aware Paxil (paroxetine) only comes in 20mg, 30mg and 40mg doses.?

What's the dosage equivelant of 100mg Zoloft to the same amount of paxil (paroxetine). I'm aware Paxil (paroxetine) only comes in 20mg, 30mg and 40mg doses.?

No equivilency: They are both in the ssri family of anti-depressants/anti-anxiety medications but are different chemicals and are metabolized differently. Also, often highly individual responses are seen with this family of drugs. If zoloft works for you, Paxil (paroxetine) may not work well. You also may experience new, unwanted side effects. If necessary to change, start at a low dose and titrate to effective dose. ...Read more

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Is dosage of Zoloft (sertraline) equivalent to dosage of prozac?

Is dosage of Zoloft (sertraline) equivalent to dosage of prozac?

No: There is not a 1:1 relationship between doses of zoloft (sertraline) and prozac. Zoloft (sertraline) doses range from 25 to 200mg whereas Prozac ranges from 10mg to 80mg. ...Read more

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Are there any medications for ptsd other than zoloft (sertraline)? What is the maximum dosage for zoloft (sertraline)?

Are there any medications for ptsd other than zoloft (sertraline)? What is the maximum dosage for zoloft (sertraline)?

Max 200mg per day: There are a number of ssri's that can work similar to the same way zoloft (sertraline) does, but zoloft (sertraline) has some stronger research behind it for ptsd. You can ask your physician to try other ssri medication. However, make sure, with ptsd, that you include therapy and include a support system. This is not something that should be dealt with by meds only. Best of luck and I hope that helps. ...Read more

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I may have taken twice my 200mg dosage of Zoloft (sertraline). When would I be able to tell? Would I get serotonin syndrome? What should I do?

I may have taken twice my 200mg dosage of Zoloft (sertraline). When would I be able to tell? Would I get serotonin syndrome? What should I do?

If you get: Serotonergic syndrome from an extra dose of Zoloft (sertraline) the symptoms would likely be mild and short lived. Get a multi day pill box to avoid this issue in the future. If your pulse is less than 120 your fine. If you are not sure how to take your pulse look it up. (Its a good thing to know) If you have an elevated temperature and are sweating a lot or have confusion have someone take you to the ER. ...Read more

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Can topamax (topiramate) be used with riperdol at low dosage? Topamax (topiramate) 25mg & riperdol. 5mg. Also at 50 mg of zoloft. How will these interact together?

Can topamax (topiramate) be used with riperdol at low dosage? Topamax (topiramate) 25mg & riperdol. 5mg. Also at 50 mg of zoloft. How will these interact together?

MayChangeRisp Dose: Studies have been mixed: indicating no effect between topiramate/risperdal, but other study indicating topiramate reduced Risperdal by 25%. Basicclinpharmtoxicol2007;100:4.Clinneuropsychopharm2007;30:107. Sertraline not an issue. Will need to monitor and md may need to incr risp dose to maintain effect. Work closely with your md! Talk about all of your questions ; concerns! ...Read more

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My doctor just upped my dosage on Zoloft (sertraline) today to 200mg (social anxiety). It hasn't worked for 3 months, so if this doesn't work, what should I try?

My doctor just upped my dosage on Zoloft (sertraline) today to 200mg (social anxiety). It hasn't worked for 3 months, so if this doesn't work, what should I try?

Social anxiety: Different people respond differently to same medication. If not already doing so, cognitive behavior therapy in conjunction with medications is most helpful for your anxiety. Your prescribing doc. Can discuss with you the alternative medications, from supplementing to substituting to augmenting to switching, etc. ...Read more

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I want to self prescribe myself with Zoloft (sertraline). What will be an appropriate dosage for beginners? I can not afford a therapist.

I want to self prescribe myself with Zoloft (sertraline). What will be an appropriate dosage for beginners? I can not afford a therapist.

Depression: I would see a physician once to get a properly prescribed medication however Zoloft (sertraline) is a tablet and 50 or 100 mg I would suggest 50 mg would be an appropriate starting dose and should be continued for 30 days. If symptoms have not improved by then an increase to 100 mg would be appropriate ...Read more

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Decided to go on a low dosage of Zoloft (sertraline) to help with depression. Any bad side effects I should be concerned with? I am otherwise healthy.

Decided to go on a low dosage of Zoloft (sertraline) to help with depression. Any bad side effects I should be concerned with? I am otherwise healthy.

You'll know: Watch yourself and note any unusual reactions. Just keep track for a week and perhaps verify with someone close to you who might notice things. You may have none, or briefly some - Some have bad ones, but you'll find out soon. If you need to stop, let the Dr know ASAP and they'll taper you off. ...Read more

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Can Zoloft (sertraline) cause increased heart rate when dosage is increased?

Can Zoloft (sertraline) cause increased heart rate when dosage is increased?

Yes uncommonly: In a postmarketing survey of over 70, 000 patients, 1.19% of patients reported tachycardia associated with the use of zoloft (sertraline).

Some had preexisting hypertension, depression, pain and other possible contributing factors. All resolved with discontinuation of the agent if persistent. Please make your prescribing physician aware of your issue. Good luck. ...Read more

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Is it safe to take over counter appitite suppressants if I'm taking low dosages of Zoloft and wellbutrin (bupropion)? I have no other medical issues

Is it safe to take over counter appitite suppressants if I'm taking low dosages of Zoloft and wellbutrin (bupropion)? I have no other medical issues

In short, No.: The otc supplements are likely stimulants (which will adversely affect your heart and even how well your antidepressants work) and made by companies that are unregulated by the fda. Eating differently and less is a start along with changing the amount you move. That's the long game to staying healthy. The short? Chew gum after lunch, drink water instead of soda, and eat a nutritious breakfast. ...Read more

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65 yrs old. On 150 mg Zoloft (sertraline) 5 yrs. After very scary severe second clinical depression diagnosed by a psychiatrist, is this dosage ok to continue.

65 yrs old. On 150 mg Zoloft (sertraline) 5 yrs. After very scary severe second clinical depression diagnosed by a psychiatrist, is this dosage ok to continue.

Add expert therapy: That is a high but common dose. In the past use of SSRIs for years was not recommended, but now it is common. Never stop or change dose w/o guidance but do consider adding good talk therapy to optimize gains and resolve issues. All research supports this combo! Best wishes. ...Read more

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I'm depressed im have been on Zoloft (sertraline) 150 mg can I ask my dr if I can up my dosage if its not working? I've been on that dose for 4 or 5 mouth now.

I'm depressed im have been on Zoloft (sertraline) 150 mg can I ask my dr if I can up my dosage if its not working? I've been on that dose for 4 or 5 mouth now.

Major Depression: I know your concern for your depression not responding to zoloft (sertraline) dose of 150mg/day. It seems to indicate diagnosis of major depression. Use of alcohol and drugs can increase intensity of depression and most likely will not respond to zoloft (sertraline).
Please do not increase the dose of zoloft (sertraline) at your own.
See your psychiatrist soon and discuss various medications, benefits, side effects, and dosage. ...Read more

Dr. Heidi Fowler
1,042 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more