Top
30
Doctor insights on: Norepinephrine

Share
Dr. Ravi Chand
758 doctors shared insights

Norepinephrine (Overview)

Norepinephrine is an inotrope which is a kind of heart failure drug (cardiovascular drug).


1

1
What is norepinephrine?

What is norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in nuclei in the brainstem and pons. One of the largest of these is in the locus coeruleus. Along with serotonin and dopamine, norepinephrine serves as a neurotransmitter in the brain. Antidepressants effect these in various ways, providing different results. ...Read more

Dr. Ravi Chand
758 doctors shared insights

Norepinephrine (Overview)

Norepinephrine is an inotrope which is a kind of heart failure drug (cardiovascular drug).


3

3
Why norepinephrines cause sexual side effects?

Why norepinephrines cause sexual side effects?

Norepinephrine: Norepinephrine and some other neurotransmitter can have side effects because of their inherent pharmocokinetics... Or how they work. If you have side effect, discuss other options with your physician. ...Read more

4

4
In general, should people with high normal heart rate not be prescribed ssri's due to increased norepinephrine effect?

In general, should people with high normal heart rate not be prescribed ssri's due to increased norepinephrine effect?

No -- incorrect: Ssri's affect serotonin reuptake only. There are some like effexor, cymbalta, and pristiq, (desvenlafaxine) which have additional effects beyond serotonin -- these are technically "snris" (serotonin-norepinephrine reuptake inhibitors). Reports of tachycardia are rare with ssri's, and can happen with snri's. BP can also be affected with snri's. These effects need monitoring, but ssri's ; snri's can be safe. ...Read more

5

5
How does norepinephrine work?

How does norepinephrine work?

Neurotransmitter: Norepinephrine (ne) is a molecule used to carry signals to organs in the body. Ne is present throughout the body including the heart, blood vesssels and brain. Ne work with certain adrenergic receptors. Outside of the brain, ne primarily cause blood pressure to increase. Ne can be given intravenously to support blood pressure. In the brain, it is thought to effect attention and emotion. ...Read more

8

8
Side effects to expect with norepinephrine, adderall (dextroamphetamine and racemic amphetamine)?

Side effects to expect with norepinephrine, adderall (dextroamphetamine and racemic amphetamine)?

Heightened sensorium: Commonly used to treat "adhd", this compound is a mix of amphetamine and dextroamphetamine, the combination acts on the "mesolimbic" section of the brain producing a heightened level of awareness. Palpitations, hyperactivity, decreased apetite are common side effects. Beware, this medication is a class 2 substance with a significant abuse potential. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
9

9
How can I raise serotonin norepinephrine and dopamine levels in my system?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
How can I raise serotonin norepinephrine and dopamine levels in my system?

Raising nor./ser./do: Mental and physical activity with healthy diet and lifestyle. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
10

10
Intense anxiety all day long, plasma norepinephrine is very high. Dr. Not sure what to do? Any ideas?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
Intense anxiety all day long, plasma norepinephrine is very high. Dr. Not sure what to do?  Any ideas?

Anxiety: Would be good idea to run workup to rule out organic causes, such as high thyroid function, hormonal changes, etc. ...Read more

11

11
What is the difference between norepinephrine and epinephrine?

What is the difference between norepinephrine and epinephrine?

1 extra carbon atom: Epinephrine has 1 more carbon & 2 more hydrogen atoms than norepinephrine. This small difference makes the molecules look different, so they interact differently with receptors, and have different effects. One example: norEpinephrine narrows blood vessels, increasing blood pressure; Epinephrine can narrow some arteries while dilating others, and can raise or lower blood pressure. ...Read more

12

12
Is there any bad interaction between ecstasy (mdma) and nris (norepinephrine reputake inhibitors)?

Is there any bad interaction between ecstasy (mdma) and nris (norepinephrine reputake inhibitors)?

Yes: You don't need a bad interaction to have a bad experience with ecstasy. Both have stimulant like properties which can cause flushing, palpitations and psychosis. Ecstasy can be very dangerous in chronic use leading to depression which is hard to treat. It burns out your pleasure centers like Cocaine and other stimulants. ...Read more

13

13
What happenes when the brain is exosed to too much norepinephrine?

What happenes when the brain is exosed to too much norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in the brainstem and pons. Along with serotonin and dopamine, norepinephrine is a neurotransmitter in the brain. "Too much" could lead to activation &anxiety. It may enhance some types of aggression in animals, plus impulsivity and episodic violence in humans. ...Read more

15

15
What is norepinephrine?

What is norepinephrine?

It is a : Catecholamine made by your body. It can cause an increase in your heart rate and blood pressure. It can be released during the fight or flight response. You might know it as noradrenaline. ...Read more

16

16
What is norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in nuclei in the brainstem and pons. One of the largest of these is in the locus coeruleus. Along with serotonin and dopamine, norepinephrine serves as a neurotransmitter in the brain. Antidepressants effect these in various ways, providing different results. ...Read more

18

18
How does norepinephrine work?

Neurotransmitter: Norepinephrine (ne) is a molecule used to carry signals to organs in the body. Ne is present throughout the body including the heart, blood vesssels and brain. Ne work with certain adrenergic receptors. Outside of the brain, ne primarily cause blood pressure to increase. Ne can be given intravenously to support blood pressure. In the brain, it is thought to effect attention and emotion. ...Read more

19

19
Can you get norepinephrine levels checked? If so how?

Can you get norepinephrine levels checked? If so how?

Catecholemines: Norepinephrine is a hormone produced in the body. There are specific blood tests which can measure these levels in your body. Norepinephrine is related to your bodies "fight or flight" response. It can also related to your mood and possibly depression. ...Read more

20

20
Why should norepinephrine be given only by central line?

Why should norepinephrine be given only by central line?

To avoid necrosis: Of the skin and subcutaneous tissues in the event of accidental extravasation, i.e. injection of medicine outside of the vein due to very potent vasoconstrictive effect of the drug that can lead to a prolonged spasm of the blood vessels. ...Read more

22

22
What is the appropriate dosage range for levophed (norepinephrine)?

What is the appropriate dosage range for levophed (norepinephrine)?

See below: LevophedÂ’s dosing is variable, depends on the condition treated, and may itself change depending on the reference or guideline you consult). A common treatment is for low blood pressure/shock, 0.1-0.5 mcg/kg/minute, adjusted to desired pressure response. An older approach some still use is flat dosing (without regard to patient weight) of 8-12mcg/minute to start and a maintenance dose of 2-4mcg/min. ...Read more

23

23
What are some causes of excessive norepinephrine? What tests are used to determine this?

What are some causes of excessive norepinephrine? What tests are used to determine this?

Noradrenalin: Comes from dopamine which is another neurotransmiter and it is a hormone that helps us stay alive during stress. It has many important other function from the memory to the heart rate and wellbeing sensation. Regulators" such as angiotensine II and epinephine increase it.Also, cocaine, amphetamines(speed), and antidepressants increase the reuptake. Can be an adrenal tumor (pheochromocitoma) ...Read more

24

24
Why norepinephrines cause sexual side effects?

Norepinephrine: Norepinephrine and some other neurotransmitter can have side effects because of their inherent pharmocokinetics... Or how they work. If you have side effect, discuss other options with your physician. ...Read more

25

25
What are the effects of norepinephrine and dopamine?

What are the effects of norepinephrine and dopamine?

Catecholamines: Behavior is much more complex than neurotransmitter levels alone. But norepinephrine (ne) acts mainly in an area of your brainstem called the locus coeruleus. When released, ne triggers the stress response. Ne is also involved in pain, cognition, mood, emotions, movement and blood pressure. Dopamine is involved in regulating mood, pleasure, delusions, psychosis and drug abuse -- and more. ...Read more

26

26
What anti-depressants out there contain norepinephrine?

What anti-depressants out there contain norepinephrine?

They don't: Antidepressants don't actually contain norepinephrine (ne), but several can affect ne reuptake into the neuronal synapse. The result is more ne available in the synapse, one theory of antidepressants' effectiveness. Antidepressants with this kind of activity include tricyclics, effexor, pristiq, cymbalta, savella, (milnacipran) and fetzima. They also affect serotonin reuptake. Wellbutrin affects ne ; da. ...Read more

27

27
Is there difference between norepinephrine vs. Dopamine?

Is there difference between norepinephrine vs. Dopamine?

Catecholamines: These are both catecholamines, synthesized from the Amino Acid tyrosine. Norepinephrine (ne) acts mainly in an area of your brainstem called the locus coeruleus -- triggering the stress response. Ne is also involved in pain, cognition, mood, emotions, movement and blood pressure. Dopamine is involved in regulating mood, pleasure, delusions, psychosis and drug abuse -- and more. ...Read more

28

28
What is the difference between norepinephrine and dopamine?

What is the difference between norepinephrine and dopamine?

Nor./dop.: Norepinephrine is the fight-flight neurotransmitter. Dopamine is for executive functions such as planning and alertness, etc. ...Read more

29

29
What kind of disease is related to norepinephrine deficiencies?

What kind of disease is related to norepinephrine deficiencies?

Extremely rare one: Some people who suffer from depression are helped with drugs that increase the norepinephrine stores in nerve endings. Drugs such as Effexor (venlafaxine) or wellbutrin do this. Haveing a severe deficiency of these neurotransmitters is very rare and life threatening.
http://www.ehow.com/way_6158789_norepinephrine-deficiency-drooling-treatment.html. ...Read more

Dr. Ravi Chand
78 doctors shared insights

Levophed (Definition)

Levophed is an inotrope which is a kind of heart ...Read more