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Doctor insights on: Norepinephrine

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Dr. Ravi Chand
754 Doctors shared insights

Norepinephrine (Overview)

Norepinephrine is an inotrope which is a kind of heart failure drug (cardiovascular drug).


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What is norepinephrine?

What is norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in nuclei in the brainstem and pons. One of the largest of these is in the locus coeruleus. Along with serotonin and dopamine, norepinephrine serves as a neurotransmitter in the brain. Antidepressants effect these in various ways, providing different results.

Dr. Ravi Chand
754 Doctors shared insights

Norepinephrine (Overview)

Norepinephrine is an inotrope which is a kind of heart failure drug (cardiovascular drug).


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In laymans terms, what does the norepinephrine in cymbalta (duloxetine) do exactly?

In laymans terms, what does the norepinephrine in cymbalta (duloxetine) do exactly?

Flight or fight: Remember flight or fight response:focus, energy, motivation.

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Why norepinephrines cause sexual side effects?

Why norepinephrines cause sexual side effects?

Norepinephrine: Norepinephrine and some other neurotransmitter can have side effects because of their inherent pharmocokinetics...Or how they work. If you have side effect, discuss other options with your physician.

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In general, should people with high normal heart rate not be prescribed ssri's due to increased norepinephrine effect?

In general, should people with high normal heart rate not be prescribed ssri's due to increased norepinephrine effect?

No -- incorrect: Ssri's affect serotonin reuptake only. There are some like effexor, cymbalta, and pristiq, (desvenlafaxine) which have additional effects beyond serotonin -- these are technically "snris" (serotonin-norepinephrine reuptake inhibitors). Reports of tachycardia are rare with ssri's, and can happen with snri's. BP can also be affected with snri's. These effects need monitoring, but ssri's ; snri's can be safe.

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How does norepinephrine work?

How does norepinephrine work?

Neurotransmitter: Norepinephrine (ne) is a molecule used to carry signals to organs in the body. Ne is present throughout the body including the heart, blood vesssels and brain. Ne work with certain adrenergic receptors. Outside of the brain, ne primarily cause blood pressure to increase. Ne can be given intravenously to support blood pressure. In the brain, it is thought to effect attention and emotion.

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Side effects to expect with norepinephrine, adderall (dextroamphetamine and racemic amphetamine)?

Side effects to expect with norepinephrine, adderall (dextroamphetamine and racemic amphetamine)?

Heightened sensorium: Commonly used to treat "adhd", this compound is a mix of amphetamine and dextroamphetamine, the combination acts on the "mesolimbic" section of the brain producing a heightened level of awareness. Palpitations, hyperactivity, decreased apetite are common side effects. Beware, this medication is a class 2 substance with a significant abuse potential.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Intense anxiety all day long, plasma norepinephrine is very high. Dr. Not sure what to do? Any ideas?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
Intense anxiety all day long, plasma norepinephrine is very high. Dr. Not sure what to do? Any ideas?

Anxiety: Would be good idea to run workup to rule out organic causes, such as high thyroid function, hormonal changes, etc.

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What is the difference between norepinephrine and epinephrine?

What is the difference between norepinephrine and epinephrine?

1 extra carbon atom: Epinephrine has 1 more carbon & 2 more hydrogen atoms then norepinephrine. This small difference makes the molecules look different, so they interact differently with receptors, and have different effects. One example: norEpinephrine narrows blood vessels, increasing blood pressure; Epinephrine can narrow some arteries while dilating others, and can raise or lower blood pressure.

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Is there any bad interaction between ecstasy (mdma) and nris (norepinephrine reputake inhibitors)?

Is there any bad interaction between ecstasy (mdma) and nris (norepinephrine reputake inhibitors)?

Yes: You don't need a bad interaction to have a bad experience with ecstasy. Both have stimulant like properties which can cause flushing, palpitations and psychosis. Ecstasy can be very dangerous in chronic use leading to depression which is hard to treat. It burns out your pleasure centers like Cocaine and other stimulants.

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What happenes when the brain is exosed to too much norepinephrine?

What happenes when the brain is exosed to too much norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in the brainstem and pons. Along with serotonin and dopamine, norepinephrine is a neurotransmitter in the brain. "too much" could lead to activation &anxiety. It may enhance some types of aggression in animals, plus impulsivity and episodic violence in humans.

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What is norepinephrine?

What is norepinephrine?

It is a: Catecholamine made by your body. It can cause an increase in your heart rate and blood pressure. It can be released during the fight or flight response. You might know it as noradrenaline.

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What is norepinephrine?

Neurotransmitter: Norepinephrine (ne) is a sympathomimetic catecholamine that is synthesized in the adrenal medulla, in sympathetic neuron terminals, and in nuclei in the brainstem and pons. One of the largest of these is in the locus coeruleus. Along with serotonin and dopamine, norepinephrine serves as a neurotransmitter in the brain. Antidepressants effect these in various ways, providing different results.

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What is norepinephrine for?

What is norepinephrine for?

As a medication: It is used to constrict you blood vessels and raise your blood pressure

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How does norepinephrine work?

Neurotransmitter: Norepinephrine (ne) is a molecule used to carry signals to organs in the body. Ne is present throughout the body including the heart, blood vesssels and brain. Ne work with certain adrenergic receptors. Outside of the brain, ne primarily cause blood pressure to increase. Ne can be given intravenously to support blood pressure. In the brain, it is thought to effect attention and emotion.

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Can you get norepinephrine levels checked? If so how?

Can you get norepinephrine levels checked? If so how?

Catecholemines: Norepinephrine is a hormone produced in the body. There are specific blood tests which can measure these levels in your body. Norepinephrine is related to your bodies "fight or flight" response. It can also related to your mood and possibly depression.

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Why should norepinephrine be given only by central line?

Why should norepinephrine be given only by central line?

To avoid necrosis: Of the skin and subcutaneous tissues in the event of accidental extravasation, i.e. injection of medicine outside of the vein due to very potent vasoconstrictive effect of the drug that can lead to a prolonged spasm of the blood vessels.

Dr. Ravi Chand
76 Doctors shared insights

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