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Doctor insights on: Non Selective Serotonin Reuptake Inhibitors

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


Dr. Irv Loh Dr. Loh
3 doctors agreed:
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Are selective serotonin reuptake inhibitors safe to use if you have high blood pressure?

Dr. Irv Loh Dr. Loh
3 doctors agreed:
Are selective serotonin reuptake inhibitors safe to use if you have high blood pressure?

Yes, BUT: Ssri's can be used, but certain medications used in managing hypertension can produce serious drug-drug interactions. Make sure all of your doctors know all of your medications, even the seemingly innocuous ones, and notify all of your doctors about any new medications added or deleted, including over the counter ones you may buy on your own! ...Read more

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What are alternatives to serotonin reuptake inhibitors (ssris)?

What are alternatives to serotonin reuptake inhibitors (ssris)?

Several: Although ssris have been by far the most popular class of antidepressants for many years, there are several other options that focus on different systems. Wellbutrin is thought to work through dopamine; remeron, cymbalta, effexor, (venlafaxine) & others, also affect norepinephrin; and deprenyl and others are MAO inhibitors. Each has pluses and minues and may work when ssris don't. ...Read more

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Are mild auditory hallucinations linked to withdrawal from mood disorder medications, serotonin reuptake inhibitors in particular?

Are mild auditory hallucinations linked to withdrawal from mood disorder medications, serotonin reuptake inhibitors in particular?

No: Auditory hallucinations are not associated with withdrawals from ssri's unless they are ringing in the ears. Instead, they can be associated to the mood disorder itself. ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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What is the definition or description of: selective serotonin reuptake inhibitor?

What is the definition or description of: selective serotonin reuptake inhibitor?

SSRI's: Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. ...Read more

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When should someone take selective serotonin re-uptake inhibitors?

When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

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How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

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Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Like perfume: There is no best without considering personal context. Also, there may be quite a few that will work for any given patient. Your insurance company will prefer you start with lowest price product. Like perfume, if you like the effect, then it is best for you. Potential for drug-drug interaction can also be a consideration, but that is a complex analysis that you need to figure out with your doctor. ...Read more

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How does lyrica (pregabalin) work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?

Lyrica (pregabalin): Dear pika89800
lyrica enhances GABA in the brain and suppresses pain at a cortical level, pain has 3 main levels, local, spinal and brain (cortex), it is non narcotic, it is an antiseizure medication and can sometimes help both pain and anxiety
the answer is purely for educational purposes, please contact your md. ...Read more

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Does Benadryl (diphenhydramine) share any of the anti-serotoninergic effects that periactin has? Or is a sert inhibitor the opposite? Having seritonin migraine..

Does Benadryl (diphenhydramine) share any of the anti-serotoninergic effects that periactin has? Or is a sert inhibitor the opposite? Having seritonin migraine..

Neither. 4 most part: Benadryl (diphenhydramine) is an antihistamine. As a potent antagonist to acetylcholine in muscarinic receptors, Diphenhydramine is used to treat parkinson's disease-like extrapyramidal symptoms caused by typical antipsychotics.
It haslso been shown to weakly inhibit the reuptake of serotonin. ...Read more

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If SSRI's block reuptake of serotonin, when/how often is serotonin released? Since changes take a month, is it infrequent? Or you just need sooo much?

It's more complicate: When a neuron fires, after it does so it will reabsorb or "reuptake" some of the serotonin it released when it fired. To inhibit this process, the neuron needs to change so it has fewer openings available at that end. The drug causes some of the openings to close, a change which takes a while. It's called "down-regulating." ...Read more

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I was wondering does the antidepressant Effexor (venlafaxine) have a stronger serotonin reuptake blocker than paxil?

I was wondering does the antidepressant Effexor (venlafaxine) have a stronger serotonin reuptake blocker than paxil?

It is different: Paxil is only an SSRI. Effexor (venlafaxine) works on two receptor sites. They work in different ways and it depends on what helps more. They both work on serotonin but it is hard to compare strength. ...Read more

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Can serotonin levels be tested?

Please repost: Please repost and include the tissue or organ of interest: Blood? Brain? Left kidney? Right big toe? Also why you are asking: are you asking because you've fallen for the misconception that low serotonin "levels" in the brain cause depression? (They don't. That notion has been debunked over and over again.) ...Read more

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What is the definition or description of: serotonin?

Neurotransmitter: Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating molecule between nerve cells). ...Read more

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How to remove high levels of serotonin from the body?

Serotonin: My first question is why you would think you need to remove serotonin from your body. This pleasure giving chemical that creates a sense of balance and well being is a good thing to have. Do you have mania? Are you on any medications that are causing mental health problems.

Sometimes questions cause more questions to be asked. Keep talking to us here. ...Read more

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What happens to your body if you don't produce serotonin?

Serotonin: Serotonin is a neurotransmitter used by many different types of nerve (and muscle) cells throughout the body.
I think it would be impossible for body not to produce serotonin.
There are many medications intended to affect serotonin signaling. Their effects and side effects vary depending on the nature of the drug, the type of illness present, and other medications to which they may be added. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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How is serotonin syndrome treated?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
How is serotonin syndrome treated?

Serotonin syndrome: Overactivation due to excess serotonin. See diagram. Treatment is emergency intervention if severe, and discontinuing the medication if less severe. Some medications used are Muscle relaxants, serotonin blockers such as Periactin, (cyproheptadine hydrochloride) Oxygen & intravenous fluids. ...Read more

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Do shrooms alter your serotonin levels?

Shrooms: They contain the indole alkaloid psilocybin, which is a tryptamine compound which is chemically related to tryptophan, & is structurally similar to serotonin. ...Read more

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What will a serotonin blood test show?

Serotonin levels.: This measures the amount of serotonin in your body. Higher than normal levels may mean carcinoid syndrome. The normal range is 101-283 ng/ml. This has a triad of cutaneous flushing, diarrhea, and valvular heart disease, and occurs in 5% of patients with carcinoid tumors. This is important since patients with this syndrome have a 2.5 year median survival from the first episode of flushing. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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What doctors treat serotonin syndrome?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What doctors treat serotonin syndrome?

Serotonin syndrome: Overactivation due to excess serotonin. See diagram. Treatment is emergency intervention if severe, and discontinuing the medication if less severe. Some medications used are Muscle relaxants, serotonin blockers such as Periactin, (cyproheptadine hydrochloride) Oxygen & intravenous fluids. ...Read more

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What does serotonin do for the GI tract?

Serotonin: It stimulates intestinal contractions & secretions. An example is use of SSRIs to treat Irritable bowel. ...Read more

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Can you got serotonin syndrome from a ssri?

Yes, but uncommon: You can get serotonin syndrome. With flushing, fever, rapid heart rate, blood pressure elevation, etc from ssris, but it is very uncommon with these drugs in the normal doses that are given. It can occur however, if you are taking another drug that boosts serotonin along with the ssri, which is why its important to keep you doctor posted on all meds changed or added including over the counter. ...Read more

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Could hydrocodone affect serotonin in any way?

Could hydrocodone affect serotonin in any way?

Depression: Long term use of opioids, such as hydrocodone, can cause depression. Low serotonin levels also cause depression. If you have a history of depression and are not being treated, use of hydrocodone can make the depression worse. Theoretically, this could be due to low serotonin levels. ...Read more

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Can I experience a stroke or serotonin syndrome?

Can I experience a stroke or serotonin syndrome?

RVCS: If the question is can stroke happen as a result of serotonin syndrome, then the answer is: rarely. Serotonin syndrome at times can cause stroke-like symptoms because of blood vessels in the brain temporarily narrowing. It is called reversible cerebral vasoconstriction syndrome. It can be a serious condition, though it often reverses itself. ...Read more

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Would you be born with a set amount of serotonin?

No: This is a neurotransmitter, a messenger chemical that is made continuously by nerve cells and breaks down quickly. Proper level requires the building, release, transfer, uptake and breakdown all be in balance. ...Read more

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Would taking a kolonipin ease serotonin syndrome?

Serotonin Syndrome: I understand your distress.
Serotonin Syndrome is a serious condition.
Taking a Klonopin (clonazepam) will not help.
Please go to ER for Diagnosis and Treatment. ...Read more

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How exactly will mdma affect your serotonin level?

How exactly will mdma affect your serotonin level?

Not sure "exactly": Without "exact" measurements of serotonin levels in people who use mdma, it's hard to quantify numerically. But, mdma binds to serotonin transporters in the brain that when functioning normally, remove serotonin from the synapse (space between neurons). The result is increased & prolonged serotonin signal. Also mdma can enter the neuron & cause excessive serotonin release. All this = neurotoxic. ...Read more

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Do hallucinogenic mushrooms alter serotonin levels?

Do hallucinogenic mushrooms alter serotonin levels?

Magic mushrooms: Hallucinogenic mushrooms in the psilocybe genus do impact the serotonin system. They contain psilocybin and a related metabolite, which are structurally related to serotonin and are about 100 times less potent than lsd. Partial agonist activity at 5-ht2a receptors mediates the psychedelic effect of hallucinogens like psilocybin, lsd, and mescaline (found in peyote). ...Read more

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Can taking Sam-e by itself cause serotonin syndrome?

Can taking Sam-e by itself cause serotonin syndrome?

Sam e: In large amounts can cause serotonergic syndrome. More often this occurs if you take it with another antidepressant, dextromethorphan, triptans, ultram and some other medications. Sam e can also precipitate acute mania if given to someone with Bi-polar Disease. ...Read more

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Are hallucinations possible with serotonin syndrome?

Are hallucinations possible with serotonin syndrome?

Possible: Serotonin syndrome can cause mental status changes such as delirium and disorientation so hallucinations may be part of the spectrum. ...Read more

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Do people with serotonin syndrome have a lot of pain?

Do people with serotonin syndrome have a lot of pain?

Possibly: The pain is secondary to the symptoms, such as muscle cramps, or change in heart rate. ...Read more