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Doctor insights on: Non Germinoma Germ Cell Tumor

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Extragonadal germ cell tumor?

Extragonadal germ cell tumor?

The gonads produce: Sperm in men (&testosterone) and eggs/ova in women (& estrogens), and these are also the sites of germ cell tumors. Outside the gonads, the mediastinum and brain (pineal) are the most common extragonadal sites. These are known to produce markers (hcg, alphafeto-protein) and responsve and curable with chemotherapy. Hope this helps. ...Read more

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Neoplasms (Definition)

"tumor" literally translates as "mass", so even a fresh bruise could be called a "tumor". Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. These may be benign or malignant; "malignant" = cancer. In everyday usage, we use "tumor" ...Read more


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Testicular cancer: what is a non seminomous germ cell tumor?

Testicular cancer: what is a non seminomous germ cell tumor?

Potentially serious: A nonseminomatous germ cell tumor is a malignancy that has multiple origins within the testicle. It is less common, but potentially more serious, than seminomas of the testicle. Early and aggressive treatment is necessay and can lead to cure in many patients that present with limited disease. Systemic chemotherapy is now available for patients that present with advanced tumors. ...Read more

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With germ cell tumor that to deal with germ cell tumor cancer?

With germ cell tumor that to deal with germ cell tumor cancer?

Clarify, can be CA.: These can be cancer. These are tumors of germ cells which can be from the gonads, or ovary and testis, or from outside these areas and occur during embryonic development. These can be cancerous or non-cancerous. Prognosis varies. Some, like seminoma, have a very good prognosis. ...Read more

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Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more

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What is extracranial germ cell tumor of childhood?

Rare family: This is a family of tumors that can be diagnosed by a pathologist (i suggest you get a consensus from 3 of us) that resemble to some degree the gametes and/or the cells of the unborn child. They run from totally benign to very malignant; thankfully today's treatment produces many good responses. ...Read more

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Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?

Complicated question: Carcinoids are carcinomas, usually more slow growing than adenocarcinomas. For information in this topic you may consult this link: http://www.webmd.com/cancer/carcinoid-tumors#1 ...Read more

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Are mast cell tumors people tumors or dog tumors?

Are mast cell tumors people tumors or dog tumors?

I know humans: I don't know about dogs, but humans can get systemic mastocytosis. An uncommon clonal growth of mast cells. Mast cells may also be reactive, such as from allergies. ...Read more

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Is metastatic squamous cell carcinoma genetic?

Genetic component?: There could be genetic component to a squamous cell cancer, although the exact implications on treatment aren't known. Obviously if there is a strong family history of cancers, or if it strikes someone who is young and/or a non smoker/drinker i would suspect a strong genetic contribution. Without more details, it is hard to say with any certainty. ...Read more

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Dr. Liawaty Ho Dr. Ho
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Odds of germ cell cancer?

Dr. Liawaty Ho Dr. Ho
2 doctors agreed:
Odds of germ cell cancer?

Germ cell: Are you referring to testicular cancer? Or germ cell cancer of the ovary? The lifetime risk of developing testicular cancer is 1: 270 =0.37. http://www.cancer.org/cancer/cancerbasics/lifetime-probability-of-developing-or-dying-from-cancer. ...Read more

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What is the incidence for extragonadal germ cell tumors?

Very low: Compared to the gonadal germ cell tumors. The most common locations are the mediastinum, the pineal gland in the brain and the abdomen. ...Read more

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Non-small cell carcinoma vs small cell carcinoma?

Non-small cell carcinoma vs small cell carcinoma?

Small cell was: Distinguised because there is almost never a role for surgery, and always a role for chemotherapy. Non-small cell prior to 1980 never had chemotherapy. Both are caused by smoking sclc 100%; /nsclc 90-95%. Nsclc just in lung usually treated with surgery. Any + node gets chemo. If mediastinal nodes are positive, standard is chemo/xrt. Get more than 1 opinion before starting treatment if yo have ? ...Read more

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Is infiltrative basal cell carcinoma an aggressive cancer?

Is infiltrative basal cell carcinoma an aggressive cancer?

Can Be: Usually basal cell carcinoma tend to be less aggressive than some other types of skin cancers. Here is a good resource for more on the topic http://www.Cancer.Net/cancer-types/skin-cancer-non-melanoma. ...Read more

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Is oligodendroglioma a malignant tumor?

Is oligodendroglioma a malignant tumor?

Yes it is: It is a low grade type of cancer. It usually has a fairly good prognosis when treated properly. ...Read more

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Is a squamous cell something that forms squamous cell carcinoma?

Is a squamous cell something that forms squamous cell carcinoma?

Not necessarily: Squamous cells are normal constituents of skin and some of the other linings, e.g., vagina. Squamous cells per se do not give rise to any cancer. Some cancer have squamous cell features. ...Read more

Dr. Liawaty Ho Dr. Ho
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How useful are circulating tumor cells as a tumor marker?

Dr. Liawaty Ho Dr. Ho
3 doctors agreed:
How useful are circulating tumor cells as a tumor marker?

For certain cancers: Circulating tumor cell count is done and quite useful to see the response of treatment given for certan type of metastatic cancers only -i, e, metastatic breast cancers, prostate, and colon cancer. Not indicated / used for other type of cancers and not used for earlier stage of cancer. ...Read more

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Has anyone cured extragonadal germ cell cancer?

Has anyone cured  extragonadal germ cell cancer?

Yes: This is treated by a medical oncologist and may be cured with appropriate therapy. ...Read more

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Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Marker not prognosis: CK7 and calretinin are used to verify that the tumor is mesothelial in origin (versus adenocarcinoma of the lung). It does not provide information about prognosis. Factors associated with pleural mesothelioma prognosis include: functional status, blood counts, histology (epithelial best vs fibrosarcomatous poorest), and tumor size (degree of involvement of pleural cavity). Several new trials. ...Read more

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Is hurtle cell neoplasm defined as cancer?

Is hurtle cell neoplasm defined as cancer?

Not necessary: Hurtel cell neoplasm can be adenoma (not cancer) or carcinoma (cancer). There is not much difference between the two with regards to age, sex, or history of head and neck radiation. However, hurtle cell carcinoma (cancer) tends to be larger in size (4.0 +/- 0.4 cm) compared with hurtle cell adenoma (2.4 +/- 0.2 cm). ...Read more

Germ Cell (Definition)

Gamete. As often used in pathology, one of the diploid cells from which these may arise; for example, a germ cell tumor mimics the cells from which sperms and eggs arise. The future germ cells enter the embryo by a curious route and may also ...Read more