Doctor insights on:
Non Congenital Adrenal Hyperplasia
Male or Female?: This would depend on the age and sex of the patient in addition to the degree of severity. If cortisol response is normal and a male is affected, often times steroid suppression is stopped after puberty. This is more complicated in females who may otherwise suffer from irregular periods, hirsutism, recalcitrant acne. They may need treatment through adulthood. Please discuss with endocrinologist. ...Read more
Many similarities: Women with pcos or non-classical cah can have essentially identical symptoms: irregular periods, hirsutism, even virilization, infertility, acne. Both usually have features of metabolic syndrome/insulin resistance. Non-classical cah can have precocious puberty. The test to distinguish the two is a baseline and acth stimulated 17-oh progesterone. An endocrinologist is needed for this situation. ...Read more
If someone has non classical congenital adrenal hyperplasia, how long once on treatment until effects are visible?
It depends: If you are referring to non classic 21 hydroxylase deficiency in a woman, it will depend on the treatment. Both treatment with adrenal suppression with steroids and androgen blockade will result in decreased testosterone effect. Clinical effects generally take 3-6 month to see. It can take longer to have the full effect, particularly with hair. Blood pressure changes can happen faster. ...Read moreSee 1 more doctor answer
What are the fertility treatment options for a woman diagnosed with non classic congenital adrenal hyperplasia?
Enzyme defeciency: This disease results from deficiency of an enzyme, 21 hydroxylase, that is essential for synthesis of adrenal hormones. Block in the synthesis of glucoroticoids causes excess production of male sex hormones. See this site for more information. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001448/. ...Read more
Missing enzyme: There are different types. They all involve a deficiency of an enzyme needed in cortisol production. Since the pituitary senses there isn't enough cortisol, it keeps trying to make the adrenals make cortisol. But because that enzyme is missing, the building blocks of cortisol build up. These substances get turned into androgens - male hormones - and cause abnormalities in sexual development. ...Read moreSee 2 more doctor answers