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Doctor insights on: Nilotinib

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Can gleevec (imatinib) cure retinoblastoma?

Can gleevec (imatinib) cure retinoblastoma?

No data yet...: Gleevec (imatinib) inhibits a number of tyrosine kinases in cells (c-kit, pdgfralpha, c-abl) . There is very recent data that Gleevec (imatinib) may have activity in retinoblastoma, but these experiments where done on isolated retinoblastoma cells grown in culture. There are no clinical trials showing that Gleevec (imatinib) can treat retinoblastoma. Future clinical trials may be planned to address this question. ...Read more

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I have cml. I take 600 mg tasigna-nilotinib daily, and4000 mg vit c per day and 5000iu vit d3. Is it safe to take as much? My doc says yes.

I have cml.  I take 600 mg tasigna-nilotinib daily, and4000 mg vit c per day and 5000iu vit d3.  Is it safe to take as much?  My doc  says yes.

Vitamins: Vitamins a, d, e, & k are fat soluble vitamins and so too much supplement can lead to toxic levels. Vitamin c is water soluble and so excess can be eliminated in the urine. Your likely ok taking the vit d due to your ongoing treatment. However, your physician should check your level every 6 to 12 months to insure the level is optimal and not a risk. ...Read more

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Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

While gefitinib was: Developed first, it is hard to find in america (iressa (gefitinib)). Erlotinib (tarceva) has more side effects, but a trial showed a survival advantage. Probably more related to the characteristics of the study participants than the drug. These are small molecule, tyrosine kinase inhibitors in the erb family of receptors. Canada and europe has iressa (gefitinib). Erlotinib is in us. ...Read more

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Whats imatinib mesylate?

Whats imatinib mesylate?

Enzyme inhibitor: This drug, gleevec, (imatinib) is used to treat chronic myeloid leukemia and gastro-intestinal stromal tumors. It acts by inhibiting and enzyme produced by tumor cells. ...Read more

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What is tarceva (erlotinib)?

Targeted therapy: It is a targeted therapy. It is an oral tyrosine kinase inhibitor pill that targets part of the egfr pathway. Recently we have learned that there a several gene mutations that are found in lung cancer. If a patient has a mutation of the egfr system that their lung cancer developed, this drug can be more effective than chemotherapy in controlling their cancer. ...Read more

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What is tarceva (erlotinib)?

What is tarceva (erlotinib)?

Erlotinib: Technical: inhibitor of the thyrosine kinase activity of egfr. King's english: oral medication in the category of targeted therapies that interferes with the molecular mechanisms that make cancer cells grow. The idea is to cause damage to the cancer cell with minimal collateral damage to normal cells. Currently approved for treatment of lung cancer and pancreatic cancer too if i'm not mistaken. ...Read more

Dr. Liawaty Ho Dr. Ho
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Can doxil (liposomal doxorubicin) treat multiple myeloma?

Dr. Liawaty Ho Dr. Ho
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Can doxil (liposomal doxorubicin) treat multiple myeloma?

Yes: Yes, Doxil (liposomal doxorubicin) can be used to treat multiple myeloma. Discuss further in detail with your oncologist -whether the chemotherapy would be appropriate for your case. ...Read more

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Dr. Liawaty Ho Dr. Ho
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How effective iressa (gefitinib) for lung cancer after chemo?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
How effective iressa (gefitinib) for  lung cancer after chemo?

Only if ..: Gefitinib will only work if there is a egfr mutation detected on the cancer. It will not be effective if there is no egfr mutation detected. ...Read more

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Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Yes, for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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How is chemo drug - docetaxel (taxotere)?

How is chemo drug - docetaxel (taxotere)?

?: Sorry but your question makes no sense. What do you want to know about docetaxel? ...Read more

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When is tarceva (erlotinib) indicated?

Cancer: Specifically lung cancer, but perhaps others, in which a specific mutation is present. For now it is only used for people with metastatic lung cancer, but some other forms of cancer in which specific activating egfr mutations are present. For those with the proper activating mutations, it is very effective, but the response typically does not last. Tumors evolve the means to adapt to the drug. ...Read more

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Is cytoxan (cyclophosphamide) chemotherapy?

Is cytoxan (cyclophosphamide) chemotherapy?

Yes.: Generic name of Cytoxan is cyclophosphamide. It is a drug commonly used to treat a variety of cancers, but may also be used to treat some autoimmune disorders, such as lupus. ...Read more

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How effectice is Xeloda (capecitabine) for metastatic breast cancer?

How effectice is Xeloda (capecitabine) for metastatic breast cancer?

Quite effective: Xeloda (capecitabine) is quite an effective drug and has been used in metastatic breast cancer. The response will be higher when it is combined with other chemotherapy agent- with additional possible side effects. Discuss further with you oncologist in detail. ...Read more

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What is Toposar (etoposide)?

What is Toposar (etoposide)?

Toposar (etoposide): Toposar (etoposide) treats cancer of the testicles and small cell lung cancer. ...Read more

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How effective is Xeloda (capecitabine) for metastatic breast cancer?

How effective is  Xeloda (capecitabine) for metastatic breast cancer?

It depends: As the first treatment for metastatic breast cancer, Xeloda (capecitabine) works in 40-60% of people treated. If it is the second, third or later treatment after failure of other agents, the effectiveness is much less. ...Read more

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Is revlimid (lenalidomide) effective for acute myelogenous leukemia?

Is revlimid (lenalidomide) effective for acute myelogenous leukemia?

Possibly: If the leukemia develops out of a myelodysplasia and has evidence of a 5q-, then possibly. But, the results are mediocre at best. Not curative by any stretch but could possibly slow the leukemia down for a short time. Hope this helps. ...Read more

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Can gemcitabine be substituted for taxotere (docetaxel)?

Can gemcitabine be substituted for taxotere (docetaxel)?

Gem for taxotere (docetaxel): Short answer is no. It cannot be substituted. Now depending upon the underlying cancer whether lung, breast, pancreatic or any other primary solid tumor, one can use taxol, Abraxane or Navelbine (vinorelbine) (they are taxanes like taxotere). If we want to move to a different agent altogether, then Gemzar or a no of other drugs would be available depending upon what the primary tumor is. ...Read more

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What are interferon alpha-2a and pegylated interferon alfa-2a (pegasys)?

What are interferon alpha-2a and pegylated interferon alfa-2a (pegasys)?

2 versions 1 drug: They are the same drug except that the pegylation makes that drug longer acting, so it can be given less often. ...Read more

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