Doctor insights on:
Nicotinic Acid Medication
Are irreversible damages caused by taking nicotinic acid (more than 1000 mg per day) for years? or if the intake is blocked, is the damage eliminated?
Likely reversible.: Many have taken niacin at doses greater than 1000 mg per day, and inflammation of the liver, muscle aches, rise in blood sugar, gout attacks are usually totally reversible once the medication is discontinued. The body is a remarkable thing, very good at healing itself once insults are removed. Take heart! ...Read more
Would 1000mg of Nicotinic Acid be sufficient to help manage triglycerides 218, HDL 19 in diabetic male?
No: My first choice would be a statin combined with 4000mg of fish oil and 1 cup of pureed red grapes daily. Should raise the HDL significantly and is much safer. Flush free niacin does not work. Prescription niacin works better however may cause sugar problems. If on niacin however, aspirin 30-60min prior to niacin along with an apple. Prevents flushing. ...Read moreSee 2 more doctor answers
Could the intake of 150 mg per day of nicotinic acid (for 6 months) cause liver damage? if so, could be these irreversible damage?
Not likely: The dose of 150 mg/day is far below the recommended doses used for medical conditions. The likelihood of causing liver issues is essentially zero. I would question why you are taking the vitamin specifically. For most healthy people with sensible diet, at most a comprehensive one-a-day multivitamin should be sufficient to maintain optimal vitamin levels in the body ...Read more
Are liver damage, caused by taking very high doses of nicotinic acid for years, irreversible?if you block the intake, will the liver return as before?
Liver Damage: Possibly. Get evaluated by a liver specialist (hepatologist) GI doctor. ...Read more
Is OTC slo-niacin or OTC enduracin ask effective as niaspan in lowering triglycerides? All 3 products are extended release versions of nicotinic acid
Should be same.: Milligram for milligram, they should all be similarly effective. That being said, there's more regulation and quality control placed over medication (NiaSpan) compared to OTC agents so the dosing of such might be more accurate and reliable, technically speaking. ...Read moreSee 1 more doctor answer
250mg magnesium 500mg slow niacin with nicotinic acid and potassium gluconate.Healthy male 35 yes. Take these, or no?
Wallet drain: If healthy and normal diet, no reason to take supplemental potassium or niacin, both of which can have bad side effects. As most people tend to run low on magnesium, and it has a weak muscle relaxer & cathartic effect, you could take the magnesium, but it isn't essential either. Save you cash for good quality food. ...Read moreSee 1 more doctor answer
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more
Is it possible that succinylcholine drugs(nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure?
Can succinylcholine drugs (nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure? Any answers appreciated!
No.: Succinylcholine actually causes an increase in intraocular pressure for about 10 minutes after administration. Classic teaching was not to use succ in people with open globe injuries. There are situations, though, where using succ with other agents that lower IOP is preferred because it makes intubation more smooth, avoiding hypertension and airway reactivity that is worse for the situation anyway ...Read moreSee 1 more doctor answer
Could asupplement with aminoacids, vitamins(l-carnitine, l-tartaric acid, potassium chloride, l-leucine, isoleucine, valine, nicotinic)cause damage on brain?
Please explain why would the flexibility in the responses of body in nicotinic receptors be useful?
Unclear question: Could you please restate your question. Ligand receptors are usually not characterized as flexible or non-flexible. ...Read more
Yes.: Your statement is correct.Get a more detailed answer ›
In Bronchial Epithel: Very interesting question, regarding nicotine related damage to bronchial epithelia cell BEC. Nic decreased the relative numbers of alpha 5-containing nAChRs, suggesting a role for receptor desensitization. This was demonstrated by biphasic increase in the concentrations of intracellular calcium ([Ca++]i) in response to activation of the channel by Nicotine and damage to delicate cell lining. ...Read more
What could a nicotinic receptor antagonist do to the post-synaptic response to nerve stimulation?
Good question: It depends on the agent. Your possibilities include permanent blockade, transitory blocking or nothing. The next neuron in series fires if there is spatial and / or temporal summation of EPSP's relative to inhibitory inputs. The rate of subsequent firing also depends on weather or not you are dealing with a neuron that is acing as a pacemaker (eg lateral geniculate nucleus) ...Read more
Hi I am a pharmacist i want to know if nicotine can bind to nicotinic receptor on neuromuscular junction or only on ganglionic receptors ?
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