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Doctor insights on: Nexavar

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My husband has been diagnosed with hepatocellular carcinoma and he is taking nexavar; I would like to know if you have experience with this drug resu?

My husband has been diagnosed with hepatocellular carcinoma and he is taking nexavar; I would like to know if you have experience with this drug resu?

Yes: Nexavar, also called sorafenib, is an oral drug that was approved in 2007 for treating hepatocellular carcinoma that cannot be surgically removed. It delays the growth of the tumor, but it does not cure it. Diarrhea, hair loss, and hand/foot syndrome (redness and peeling of hands and feet) are the main side effects. Good luck to you both! ...Read more

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Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Yes, for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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Can you tell me about liver cancer (hepatocellular carcinoma) and used nexavar (sorafenib)?

Can you tell me about liver cancer (hepatocellular carcinoma) and used nexavar (sorafenib)?

Used for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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What to expect at the last few days of life for my mom, 84, stage 4 hepatoma, on nexavar, (sorafenib) but she is refusing to use the med. What to expect?

What to expect at the last few days of life for my mom, 84, stage 4 hepatoma, on nexavar, (sorafenib) but she is refusing to use the med. What to expect?

Refusing meds: At age 84 let her be. Going with dignity and on her own accord is most important. Respect her wishes. Organs are going slowly to shut down. Keep her comfortable as much as you can. Talk to local hospice, thay may help. ...Read more

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My father 62 year is being treated with stage4 hcc. Tace is done 3 week s ago. He has been put on nexavar (sorafenib). How much time left for him. Please help?

My father 62 year is being treated with stage4 hcc. Tace is done 3 week s ago. He has been put on nexavar (sorafenib). How much time left for him. Please help?

It varies: Hcc is a serious disease with a variable survival depending on his liver functions (child pugh score). Average surviival is 6-12 months, with occasional surviors living up to two years. ...Read more

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Nexavar (sorafenib) is useful in multi concetric haptoma?

Nexavar (sorafenib) is useful in multi concetric haptoma?

Nexavar (sorafenib): Nexavar (sorafenib) is a targeted therapy that can block the ability of tumor to recruit blood vessels and stop the tumor from growing. This can be used in conjunction with locoregional therapy (chemoembolization) in certain situations or on its own. ...Read more

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What to expect at the last few days of life for my mom, 84, stage 4 hepatoma, on nexavar, (sorafenib) but she is refusing to use the med. What to expect?

Refusing meds: At age 84 let her be. Going with dignity and on her own accord is most important. Respect her wishes. Organs are going slowly to shut down. Keep her comfortable as much as you can. Talk to local hospice, thay may help. ...Read more

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Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Yes, for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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My husband has been diagnosed with hepatocellular carcinoma and he is taking nexavar; I would like to know if you have experience with this drug resu?

Yes: Nexavar, also called sorafenib, is an oral drug that was approved in 2007 for treating hepatocellular carcinoma that cannot be surgically removed. It delays the growth of the tumor, but it does not cure it. Diarrhea, hair loss, and hand/foot syndrome (redness and peeling of hands and feet) are the main side effects. Good luck to you both! ...Read more

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My father 62 year is being treated with stage4 hcc. Tace is done 3 week s ago. He has been put on nexavar (sorafenib). How much time left for him. Please help?

It varies: Hcc is a serious disease with a variable survival depending on his liver functions (child pugh score). Average surviival is 6-12 months, with occasional surviors living up to two years. ...Read more

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Hi dear doctor my son 21 yo is inoperabl stage 4a sınce dıagnosed october 2013 with pvt. He use sorafenib and he had yıtrıum embolization in march 2014.the tumor diagnosed withaout any symptom or marcer by me at usg. The tumor minimized 2 CM and now sin

Hi dear doctor my son 21 yo is inoperabl stage 4a sınce dıagnosed october 2013 with pvt. He use sorafenib and he had yıtrıum embolization in march 2014.the tumor diagnosed withaout any symptom or marcer by me at usg. The tumor minimized 2 CM and now sin

Sounds complicated: With a question like this you are best suited trying to find an oncologist on HealthTap that has a "Concierge" practice. You may then inquire to join his/her practice and consult them directly in regards to your question (s). Otherwise, this is too complicated to be answered in this 400 character or less format. Remember if you seek a formal online consultation, have all available info ready. ...Read more

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A 50 yr-old male patient has liver cancer, used to take Sorafenib. He couldn't take it anymore because of the heavy side effect. Is PD-1 suitable for him?

A 50 yr-old male patient has liver cancer, used to take Sorafenib. He couldn't take it anymore because of the heavy side effect. Is PD-1 suitable for him?

Liver cancer: A lot more information would need to be taken into account by a specialist who deals with Anti PD-1 drugs before that can be answered. Were you aware that this question went to the health education site of Health Tap? We provide medical education and can not provide diagnosis or treatment plans. ...Read more

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My mother treated with RFA and TACE. Now taking sorafenib but due to this medicine she is gone weaker can we discontinue? AFP range is 700

My mother treated with RFA and TACE. Now taking sorafenib but due to this medicine she is gone weaker can we discontinue? AFP range is 700

Not enough: Your question did not include critical information. It sounds like your mom suffers from liver malignancy (cancer). The only person I would suggest to ask for further recommendations would be her oncologist or the person who prescribed her sorafenib as from now on and going forward the oncologist and their team would be best to differentiate symptoms related to her disease from drug side effects. ...Read more

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What r the chances of getting back renal cell carcinoma for an old male (63 yrs) after being cured by nephrectomy & taking nexavar (sorafenib)?

What r the chances of getting back renal cell carcinoma for an old male (63 yrs) after being cured by nephrectomy & taking nexavar (sorafenib)?

It depends: This is not an easy answer, because it depends upon the stage of your original tumor and your surgical pathology. I would ask this question of your urologist or oncologist, who know the specifics of your case. ...Read more

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Is Sutent an alternative for liver cancer patients who cannot tolerate Nexavar?

Is Sutent an alternative for liver cancer patients who cannot tolerate Nexavar?

Liver Cancer: This drug is not approved in USA. For liver cancer
You should check with MD in Saudi arabia ...Read more

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Can you tell me about liver cancer (hepatocellular carcinoma) and used nexavar (sorafenib)?

Used for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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My mom, 84, if she stop her nexavar (sorafenib) for her primary liver cancer, what would her life expectancy be?

My mom, 84, if she stop her nexavar (sorafenib) for her primary liver cancer, what would her life expectancy be?

8 months: Without more details it's hard to know. Best supportive care would be 8 months. Why has she not had liver directed therapy? An elevated AFP is not a contraindication to treatment. I recently treated an 84 yo otherwise healthy woman with hcc with an AFP of 3500. The tumors are now gone and her AFP is 2! if your mom is healthy and you wish more aggressive treatment, it can be done. ...Read more

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My dad has an advanced liver cancer an dis taking nexavar (sorafenib) for 3 months. The AFP keeps rising. Does that absolutely mean the cancer is growing?

My dad has an advanced liver cancer an dis taking nexavar (sorafenib) for 3 months. The AFP keeps rising. Does that absolutely mean the cancer is growing?

Possible: Elevation of tumor maker AFP in most of the time is an indication of additional tumor, of course a additional tests also needed to come to that conclusion, speak to his doctor for more information. ...Read more

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Experts, might someone recommend nexavar (sorafenib) for a stage 4 inactive neuroendocrine pancreatic cancer patient?

Experts, might someone recommend nexavar (sorafenib) for a stage 4 inactive neuroendocrine pancreatic cancer patient?

Possibly: Stage 4 indicates that you have net at a site distant from the pancreas or regional lymph node, likely the liver. Not clear what you mean by"inactive", whether you mean it is stable or not secreting any substance. In any case, sorafenib (nexavar) is being tested in metastatic net in clinical trials (http://clinicaltrials. Gov/ct2/show/nct00131911) & (http://www. Ncbi. Nlm. Nih. Gov/pubmed/23475104). ...Read more

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What does it mean to have a high monocytes and low neutrophils absolute count while I am taking Nexavar, (sorafenib) a chemotherapy for advanced thyroid cancer?

What does it mean to have a high monocytes and low neutrophils absolute count while I am taking Nexavar, (sorafenib) a chemotherapy for advanced thyroid cancer?

Effect of chemo: Low neutrophils are expected with chemotherapy agents, as the drugs destroy them (in the process of destroying the cancerous cells.) High monocyte count can be due to an infection or inflammation. Also, as the blood counts recover after a dose of chemo, the monocyte count can also be temporarily improved. Good luck with your cancer treatment. ...Read more

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Sorafenib decreased platelet count of my father at 72 who's diabetic, diagnosed with hcc & decompensated liver cirrhosis & now unable to take sorafenib?

Sorafenib decreased platelet count of my father at 72 who's diabetic, diagnosed with hcc & decompensated liver cirrhosis & now unable to take sorafenib?

My friend,: ..You paint a very bleak picture. Your dad is elderly and his bad cirrhosis makes it likely that any treatment for his hcc will cause more harm than good. I would respectfully suggest that you guys start focusing on confort measures rather than additional therapy. Of course, I do not know all the details so this is a conversation to have with his treating oncologist. Best to both. ...Read more

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What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?

Other drugs worked: Nexavar, torisel, and sutent all received FDA approval because they improved progression free survival.

The initial Trovax trial was terminated early because there was little or no prospect of demonstrating a statistically significant survival benefit compared to placebo.

http://clincancerres. Aacrjournals. Org/content/16/22/5539.long ...Read more

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80 yr old w/ cancer btween kidney/colon with lung metastasis, giving her nexavar (sorafenib) & pain patches overall health has decreased is radiation good option?

80 yr old w/ cancer btween kidney/colon with lung metastasis, giving her nexavar (sorafenib) & pain patches overall health has decreased is radiation good option?

Complicated question: I don't think I or anyone can answer this for you as welll as the oncologist can or the team who is treating your loved one. Nexavar (sorafenib) is for a few advanced stage cancers. At age 80 with metastatic disease and overall decline in her health, sounds like whatever is being done including radiation would be palliative (to ease her suffering). Talk openly with providers about goals. God bless you. ...Read more

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