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Doctor insights on: Neuroleptic Malignant Syndrome

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Dr. Scott Mackinnon
86 Doctors shared insights

Neuroleptic Malignant Syndrome (Overview)

Neuroleptic malignant syndrome is a rare, potentially life-threatening disorder usually caused by an unpredictably bad reaction to an antipsychotic drug. Typically there is muscle rigidity, fever, unstable pulse and blood pressure, mental impairments and characteristic laboratory changes. Treatment relies on stopping the drug and supportive hospital care.


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Of all the health problems, why would I get neuroleptic malignant syndrome?

Of all the health problems, why would I get neuroleptic malignant syndrome?

Drugs: You may get this syndrome due to a genetic predisposition, usually unknown to you, upon receiving certain medications. Some of these medicines are used to treat nausea, stomach motility problems or emotional and psychiatric problems. Always tell your doctor if anyone in your family had adverse neurologic problems with medication. ...Read more

Dr. Scott Mackinnon
86 Doctors shared insights

Neuroleptic Malignant Syndrome (Overview)

Neuroleptic malignant syndrome is a rare, potentially life-threatening disorder usually caused by an unpredictably bad reaction to an antipsychotic drug. Typically there is muscle rigidity, fever, unstable pulse and blood pressure, mental impairments and characteristic laboratory changes. Treatment relies on stopping the drug and supportive hospital care.


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What are the symptoms of neuroleptic malignant syndrome?

What are the symptoms of neuroleptic malignant syndrome?

Fever, stiff muscles: Fever, stiff muscles, changes in personality and thinking, and autonomic instability (racing heart, low or high blood pressure, sweating, leaking urine...) are symptoms of neuroleptic malignant syndrome.

This is a very serious and life-threatening reaction to treatment with antipsychotic medications or withdrawal from certain medications. ...Read more

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Living with Polycystic Ovarian Syndrome (Checklist)

Eliminate low-fat, high-carb foods from your diet
once
Monitor your weight and review your diet daily
daily
Blend exercises that make sense into your daily routine
daily
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What are the tests for neuroleptic malignant syndrome?

What are the tests for neuroleptic malignant syndrome?

Several!: Neuroleptic malignant syndrome is a diagnosis of exclusion, so we have to make sure there isn't another problem like an infection.

Blood count may show high white blood cells, urine test may have myoglobin. If tests like blood and urine culture show no signs of infection, ct/mri of the head show no brain problems and the patient is on or has taken an antipsychotic this points us towards nms. ...Read more

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How to tell if I have neuroleptic malignant syndrome?

How to tell if I have neuroleptic malignant syndrome?

You don't.: Nms is so severe that you will not be asking questions. Google can be good resource if you need to know more. ...Read more

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Living with Down Syndrome (Checklist)

Enroll in an early intervention program
Once
Get help from local and national support groups
Once
Consider getting help from mental health professionals
Once
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What causes neuroleptic malignant syndrome?

NMS: Neuroleptics (antipsychotics) block certain Dopamine receptors in the hypothalamus (hypothalamic d-2 receptors) resulting in an elevated temperature set point and  impairment of the bodies ability to dissipate heat; it is also associated with blockade of other Dopamine receptors, which can  result in muscle rigidity and increased body temperature.. ...Read more

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How do you treat neuroleptic malignant syndrome?

Supportive: Mainly supportive treatment by controlling blood pressure, oxygenation, cardiac irregularity, electrolyte water balance, seizure treatment. Some drugs are used that seem to be helping. ...Read more

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Living with Irritable Bowel Syndrome (Checklist)

Try to notice and avoid precipitating factors
Once
Start a trial of increased dietary fiber
Once
See your primary care physician or gastroenterologist if symptoms persist
Once
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Do I need to report neuroleptic malignant syndrome as a long-term health condition, or does it go away after being treated?

Do I need to report neuroleptic malignant syndrome as a long-term health condition, or does it go away after being treated?

Yes, let doctor know: Even though a previous occurrence of nms has resolved, it may recur, especially if the causative agent, or one similar to it, is administered again. Let doctor know, so that a similar medication can be safely avoided. ...Read more

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I need to know what is neuroleptic malignant syndrome and is it cureable?

Life threatening.: It is a life threatening condition that can develop while on antipsychotic medications and will manifest with high fever, sweating, stupor and muscle rigidity. It can be fatal but outcome is good if early detection and intensive care is accorded. ...Read more

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Managing Restless Leg Syndrome (Checklist)

See a vein specialist
Once
Check your cholesterol medications
Once
Have a venous ultrasound to check for reflux
Once
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Is it possible that the drug Neurontin (gabapentin) cause neuroleptic malignant syndrome?

No: I have not been able to find any data that says that it can. It has no effect on Dopamine either, so it should not be expected to. Best wishes and happy holidays. ...Read more

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Who is at risk of neuroleptic malignant syndrome?

NMS: Can occur in anyone exposed to a neuroleptic/ drug blocker d2 (dopamine receptos). Although it can occur at any time during treatment it is more common after starting the medication or increasing the dose. It is very rare with  an incidence of 0.07-0.2%. Men are at greater risk than women. Other risk factors include  history of nms, increased environmental temperature,  dehydration,  agitation. ...Read more

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Managing Carpal Tunnel Syndrome (Checklist)

Wear a wrist brace at night
daily
Take pain medications as directed
Once
Use proper posture when performing tasks
Once
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What causes neuroleptic malignant syndrome?

NMS: Neuroleptics (antipsychotics) block certain Dopamine receptors in the hypothalamus (hypothalamic d-2 receptors) resulting in an elevated temperature set point and  impairment of the bodies ability to dissipate heat; it is also associated with blockade of other Dopamine receptors, which can  result in muscle rigidity and increased body temperature.. ...Read more

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How do you treat neuroleptic malignant syndrome?

Supportive: Mainly supportive treatment by controlling blood pressure, oxygenation, cardiac irregularity, electrolyte water balance, seizure treatment. Some drugs are used that seem to be helping. ...Read more

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Living with Asperger's Syndrome (Checklist)

Learn about your condition
once
Practice stress management and mindfulness
2x day
Do not be afraid to ask for feedback
3x day
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Who is at risk of neuroleptic malignant syndrome?

NMS: Can occur in anyone exposed to a neuroleptic/ drug blocker d2 (dopamine receptos). Although it can occur at any time during treatment it is more common after starting the medication or increasing the dose. It is very rare with  an incidence of 0.07-0.2%. Men are at greater risk than women. Other risk factors include  history of nms, increased environmental temperature,  dehydration,  agitation. ...Read more

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Can you please define neuroleptic malignant syndrome?

NMS: Neuroleptic malignant syndrome (nms) is a rare, but life-threatening, idiosyncratic reaction to a neuroleptic (antipsychotic) medication. The syndrome is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction. ...Read more

Dr. Heidi Fowler
379 Doctors shared insights

Antipsychotics (Definition)

These are medications used among other things to treat psychosis. There are two poorly named classes: the typicals, because they used to be typically used, and the atypicals, which are now typically used. They differ in that the so called atypicals are non-neuroleptics and interact with both serotonin and Dopamine receptos, while the typicals ...Read more


Malignant (Definition)

The term “malignant” is mainly used in the context of cancer, but can also be used to describe a condition that can be acutely damaging to the body, ...Read more