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Doctor insights on: Neuroblastoma In Children

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Is there any really effective treatment of neuroblastoma in children?

Is there any really effective treatment of neuroblastoma in children?

Yes: Thankfully treatment of neuroblastoma has improved dramatically over the last decade. That is not to say that all children are curable; the outcome is greatly dependent on the risk stratification that your oncologist perform to tailor treatment. As expected children in the high risk group do not do as well as those in the low risk group. ...Read more

Dr. Troy Reyna
554 Doctors shared insights

Neuroblastoma (Definition)

A type of cancer that forms in certain types of nerve tissue. It most frequently starts from one ...Read more


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Are there any long term stage IV neuroblastoma survivors for children over 1 year old?

Yes.!: Most kids with neuroblastoma have widespread disease by the time they're diagnosed. 5-year survival rates have improved from 24% in the 1960's to 38% or higher now, with improved treatments (including autologous bone marrow transplant). ...Read more

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How do you treat children with neuroblastoma?

How do you treat children with neuroblastoma?

Depends on the stage: Low stage disease, which occurs mainly in very young infants, at times needs surgical resection followed by observation (no chemo). More advanced stages or neuroblastoma occuring in older children usually requires surgery and chemo. Very high risk disease (based on many factors) requires chemo, high dose chemo, stem cell infusion, radiation and more chemo. Good luck. ...Read more

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Is neuroblastoma stage 4 deadly in teenagers and children in general?

Is neuroblastoma stage 4 deadly in teenagers and children in general?

Improving: We are constantly trying to improve therapy for children with high-risk neuroblastoma (stage 4). Within the last couple of years, the addition of immunotherapy to standard of care therapy greatly improved overall survival from 46% to 66%. Thus, immunotherapy should now be standard of care. ...Read more

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What is neuroblastoma?

What is neuroblastoma?

Cancer: Neuroblastoma is a cancer of the nerve cells in the adrenal gland, neck, chest or spinal cord. It is usually found in young children under the age of 5, most under 2. The outcome of treatment is determined by the age of the child, stage of the tumor, location, spread and histology. ...Read more

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What is a neuroblastoma?

Cancer: Neuroblastoma is a cancer of the nervous system. It usually occurrs in children ages 1-5. The younger the child the better the prognosis. There are four stages of the disease from mild to severe and this affects prognosis also. Ttreatment requires surgery and/or chemotherapy. ...Read more

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How common is neuroblastoma?

How common is neuroblastoma?

Relatively common: Childhood cancer is rare. That being said, neuroblastoma makes up 8-10% of childhood cancer, and is the most common cancer in infants. About 700 children are diagnosed with neuroblastoma in the us each year. ...Read more

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What is occult neuroblastoma?

What is occult neuroblastoma?

Difficult to say: Neuroblastoma is a pathological diagnosis depending upon a certain tissue type. It may be referring to a variant of neuroblastoma, since neuroblastoma is well known to evolve into more mature or less malignant tissue types like ganglioneuroma. Etc. ...Read more

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How can we cure neuroblastoma?

How can we cure neuroblastoma?

Support new research: Depending on the risk group, we cure the majority of children with neuroblastoma using a combination of surgery, chemotherapy, radiation and stem cell transplant. However, there are a significant number of children with high-risk neuroblastoma that ultimately succumb to their disease. Immunotherapy, alk inhibitors, mibg therapy and others are being tested now. More targeted therapy is needed... ...Read more

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How does neuroblastoma show up?

How does neuroblastoma show up?

Early: Neuroblastoma usually shows up in childhood. Usually under two years of age. It is a cancer of the sympathetic nervous system. It can appear anywhere from head and neck to pelvis. There are four stages plus a special 4s. The higher the stage the more extensive and virulent the tumor. It is treated with combination surgery, chemotherapy and sometimes radiation. ...Read more

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Could neuroblastoma cause pain?

Different forms of: Pain are possible. Mayo clinic is an excellent resource: http://www. Mayoclinic. Org/diseases-conditions/neuroblastoma/basics/symptoms/con-20027487. ...Read more

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Can an adult have neuroblastoma?

Can an adult have neuroblastoma?

Rare; but yes...: Neuroblastoma is usually in children; and the most common cancer in infants...But unfortunately (and rarely) it can occur in adults, too. ...Read more

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Help! Exactly what is neuroblastoma?

Help! Exactly what is neuroblastoma?

Apparently none: The cause of paget's disease of bone remains unknown. Current speculation centers on a viral origin. The problem is local, not systemic. The bone self-repair, called remodeling, is accelerated, and there is more removal than replacement, which weakens the bone and sometimes causes pain and fractures. The parathyroid gland, which is an endocrine gland controlling bone metabolism, is not involved. ...Read more

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What does occult neuroblastoma mean?

Neuroblastoma: I have not heard of the term "occult" neuroblastoma - a patient either has a neuroblastoma or does not, the use of the term "occult" is not typically used here. ...Read more

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What are the tests for neuroblastoma?

Urine VMA/HVA: In about 90 % of children with neuroblastoma, the chemicals called vma and/or hva in urine are increased. Thus this can be used as a screening if one suspects neuroblastoma. But it does not detect 100 % of patients, thus normal urine vma/hva does not exclude the diagnosis of neuroblastoma. This is particularly true in newborn infants with neurobllastoma or children with neuroblastoma in the chest. ...Read more

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Is neuroblastoma strongly hereditary?

Is neuroblastoma strongly hereditary?

Some are: See http://omim. Org/entry/256700
nb in derived from early fetal tissue & some pts inherit a germline defect or pick it up as a new mutation or gene defect. It can occur in syndromes of family cancer tendency, all of which point to small defects on various chromasomes and give rise to several types of cancer. Very refined testing is required to separate the ones that are from those that are not. ...Read more

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Is neuroblastoma common in teenagers?

Is neuroblastoma common in teenagers?

Rare.: Neuroblastoma is very rare in teenagers and is typically more difficult to treat than younger children with the disease. It is essential for a teenager diagnosed with neuroblastoma be treated at an academic medical center. In addition, because of the rarity, nationally recognized experts in neuroblastoma should be consulted by the local physician if needed. ...Read more

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What are the symptoms of neuroblastoma?

What are the symptoms of neuroblastoma?

Mass, pain: Neuroblastoma is a solid cancer of infants and children. It presents with a swelling in the abdomen, pain, weakness, pallor. If it occurs in the chest it may be silent until a chest xray is done for some other purpose and found by accident or if big enough can cause resiratory symptoms. ...Read more

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How common is it to survive neuroblastoma?

Depends: It depends on the stage and the age at the time of diagnosis and treatment. Survival can be as high as 80-90%. It will of course go down if untreated or if tumor is poorly differentiated or metastatic or if patient is older than one year of age. ...Read more

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How do I know exactly what is neuroblastoma?

How do I know exactly what is neuroblastoma?

Neuroblastoma is. ..: A malignant tumor of childhood that arises from cells of the neural crest (an embryologic precursor of the structures that make up the autonomic nervous system). Staging of neuroblastoma is complex. Age, stage and molecular features determine treatment, which varies widely from observation to tandem autologous stem cell transplant. Your pediatric oncologist can guide you more specifically. ...Read more

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How do you inhibit neuroblastoma cell growth?

How do you inhibit neuroblastoma cell growth?

Chemotherapy: Chemotherapy has become quite effective for some types of neuroblastoma. Please see a pediatric oncologist. ...Read more

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What are the common symptoms of neuroblastoma?

What are the common symptoms of neuroblastoma?

Variable: Weakness secondary to anemia. Pain secondary to tumor in bone marrow. Pallor, bruising, bleeding. Inability to walk and loss of developmental milestones. ...Read more

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What's the oldest age you can get a neuroblastoma?

Variable: Peak age is first three years of life. My oldest patient was nine years old. ...Read more

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What's the oldest age people can get neuroblastoma?

What's the oldest age people can get neuroblastoma?

Any age: While neuroblastoma is typically a disease of younger children, even infants, it can occur in adults. I have personally treated patients who were diagnosed in their 20s and there is a report of a 77-year old in japan who was diagnosed wtih this type of cancer. ...Read more

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What does it mean to have a stages of neuroblastoma?

What does it mean to have a stages of neuroblastoma?

It is for treatment: Cancers are given stages to help with prognosis and treatment. Low stage numbers are better than higher numbers in general. ...Read more

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What is the definition or description of: Neuroblastoma?

Neuroblastoma: Neuroblastoma originate from neural crest cells that normally give rise to the adrenal medulla and sympathetic ganglia, they are believed to be congenital in origin, and most common malignant tumors in infancy. ...Read more

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What is the usual course for someone with neuroblastoma?

Surgery: Initially surgery to biopsy and/or remove tumor. Chemotherapy based upon type. Sometimes radiation, and/or bone marrow transplant depending upon extent of tumor and risk of mets. ...Read more

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When do you normally begin to see the effects of neuroblastoma?

Anytime: There is not a specific time for this to show up. Symptoms occur when a tumor is big enough to create dysfunction. Neuroblastoma occurs in children under 5 years usually. The first symptoms are usually fever, a general sick feeling (malaise), and pain. There may be loss of appetite, weight loss, and diarrhea. This website has some good information.
http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002. ...Read more