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Doctor insights on: Nephrolithiasis Caused From Multiple Myeloma

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Can nephrotic syndrome be caused by multiple myeloma?

Can nephrotic syndrome be caused by multiple myeloma?

Yes: This can happen but usually myeloma causes a decrease in the kidney function. Some patients with myeloma can also have a protein deposited in the kidney (amyloidosis) that can lead to nephrotic syndrome. ...Read more

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Dr. Howard Schneider
125 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Are there specific symptoms from renal vascular calcification in bilateral kidneys.

Are there specific symptoms from renal vascular calcification in bilateral kidneys.

No, usually...: Seeing renal vascular calcification is not uncommon and usually an incidental finding on imaging studies for other causes such as hematuria, kidney infection, stones, etc. . Of course, such patient needs to look into if having similar calcification in other arteries like aorta, since it is merely a part of systemic vascular disease. Besides, kidney function and size have to be watched and.... ...Read more

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What is non-igm myeloma? Isn't it different from multiple myeloma?

What is non-igm myeloma?  Isn't it different from multiple myeloma?

The myeloma: Family is a proliferation of plasma cells, which produce antibodies or immunoglobulins. Igm is ass.Ociated with waldenstrom macro globulin, igg is the most familiar, but there is also iga, these further produce subunits, kappa and lambda chains. The abnormal clone usually is a xerox machine gone bad producing a copy of one of these chains. Myeloma causes problems by these cells destroying bone. ...Read more

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Is increase in plasma cell 15 percent only related to multiple myloma of other malignancies or infection also?

Is increase in plasma cell 15 percent only related to multiple myloma of other malignancies or infection also?

Myeloma or infection: Multiple myeloma is based on all three of the following for diagnosis: 1) 10% or more monoclonal plasma cells; 2) serum or urine monoclonal protein; 3) organ dysfunction (high serum calcium, high serum creatinine, low hemoglobin, or lytic bone lesions/osteoporosis). If 2) is not present, then bone marrow needs 30% plasma cells. Plasma cells can occur with infections. See a doctor for further help ...Read more

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Could having multiple kidney stones cause death?

Could having multiple kidney stones cause death?

It's possible: Having multiple kidney stones can cause blockage of the urine drainage, infection and even kidney failure. So, in theory, yes, you could die from multiple kidney stones but this would be unusual. ...Read more

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Aside from thyroid dysfunction, what underlying diseases are associated with granuloma annulare?

Aside from thyroid dysfunction, what underlying diseases are associated with granuloma annulare?

Unknown cause: The cause of granuloma annulare is not known. You may consult this sire for more information. http://www.mayoclinic.org/diseases-conditions/granuloma-annulare/basics/definition/con-20026647 ...Read more

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Which kind of blood cancer cause idiopathic thrombocytopenia ? Including chronic malignancy

Which kind of blood cancer cause idiopathic thrombocytopenia ? Including chronic  malignancy

By itself: Essential thrombocythemia is a low-grade blood cancer that often requires no treatment. Most unexplained thrombocytosis in people who seem well otherwise is due to iron deficiency. Nobody understands how this works. Hoping you find the answers you need, and glad you asked. ...Read more

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Granulosa cell tumor can be acquired from sex?

Granulosa cell tumor can be acquired from sex?

No: Granulosa cell tumors of the ovary (and more rarely the testicle in men) are not aquired from sexual activity. These are rare tumors and know specific risk factors are known. However, some studies have shown that the majority if these tumors have a mutation in the flox2 gene. It is not known what causes this mutation to occur or if it is the cause if the tumor. ...Read more

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Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

7 YO? Can't post yet: Have to be 17 to post. Seven years old is too young to post, and requires speaking to your pediatrician about your questions until you're old enough to post. Thanks! ...Read more

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How severe are the possibilities of leukemia caused by radiation ?

How severe are the possibilities of leukemia caused by radiation ?

Not a high: Risk if you are talking on a percentage of all patients receiving therapeutic radiation, but secondary acute myeloid leukemia does occur and late (many years later) chronic myeloid leukemia can be seen after radiation exposure. ...Read more

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What differentiates primary biliary cirrhosis from other types of cirrhosis?

What differentiates primary biliary cirrhosis from other types of cirrhosis?

Location of inflam: Agree with dr. Edmisson. Pbc is autoimmune disease affecting bile ducts; can eventually lead to progressive liver disease and cirrhosis (scarring). Othe types of cirrhosis usually involve inflammation of the liver cells, due to infection (like hep b, c), toxic chemicals, metabolic disease e.g.Nonalcoholic fatty liver (seen in obesity, diabetes) iron overload, damage from alcohol, autoimmune. ...Read more

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What kind of urinary problems are caused by Lyme disease?

What kind of urinary problems are caused by Lyme disease?

See below: The lyme spirochete can infect the bladder and cause frequent urination, pain on urination, even blood and protein in the urine. The typical urinalysis may show blood or protein in the urine and the culture will not grow out the spirochete infection. ...Read more

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What could be the cause of multiple sclerosis or spinal tumors?

What could be the cause of multiple sclerosis or spinal tumors?

Unknown: We do not know why some folks get spinal tumors, although some could be secondary to tumor spread from elsewhere, such as lung cancers, maybe associated with smoking. Genetics may play a role. Ms susceptibility can be associated with genetics and environmental influences, but the final cause remains unclear. ...Read more

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What the management of multiple renal stone?

What the management of multiple renal  stone?

See a urologist.: The management of multiple kidney stones depends on the size, position, and location of the stones. If they are small & unobstructing, they may be observed. If treatment is necessary, many techniques such as shockwave lithotripsy, ureteroscopy with laser lithotripsy and removal are possible. Large stones may require pcnl or percutaneous removal. See a urologist for assessment and evaluation. ...Read more

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Can you have benign microscopic hematuria that isn't caused by bladder cancer, kidney stones, kidney disease etc?

Can you have benign microscopic hematuria that isn't caused by bladder cancer, kidney stones, kidney disease etc?

Here are some ...: More than 100 reasons can be listed for microhematuria, i.e., >3 RBCs / HPF, and the odd from urinary malignancy is low at around 3 % in thorough work-up with imaging studies and cystoscopy, etc. Although Doc could not specifically give definite DX for all occasions, a proper attention to ?UTI, ?obstruction, ?stones, ?tumors, and ?kidney inflammation of a wide range of causes should well cover... ...Read more

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Treatment for multiple calcified densities at pelvis could represent phleboliths versus distal uretral lithiasis?

Treatment for multiple calcified densities at pelvis could represent phleboliths versus distal uretral lithiasis?

Treatment different: Phleboliths are calcified small veins that are not usually clinically important. There usually is no treatment unless associated with hemangiomas, usually in children. Calculus or stone in ureter is referred to ureterolithiasis. This can cause pain and obstruction to the ureter. The stone either passes on its own, or sometimes has instrumentation by urologist. ...Read more

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Please explain: renal cortex contains 29 glomeruli, 13 of which are globally sclerosed. There is focal segmental mesangial hypercellularity.

Please explain: renal cortex contains 29 glomeruli, 13 of which 
are globally sclerosed. There is focal segmental mesangial 
hypercellularity.

Sclerosis: So Glomeruli are Filteration units of Kidney. Since kidney's main function is Filteration; the health of glome is directly related to renal function. Sclerosis in layman term means scarring. So 13/29 glomes are scarred. Which means approximately 50% of functional units are scarred or non functional. Mesengial hypercellularity refers to the inflammation in the kidney. Very common with FSGS ...Read more

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Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more

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Kidney Stone (Definition)

Solutes precipitate and combine to form stones formed of calcium oxalate usually around a nidus of uric acid. Other solutes that form stones are ca and mg phosphates, cystine, and uric acid staghorn calculi form in the presence of chronic urinary tract infections. Stones can be painful, may require ...Read more


Dr. Liawaty Ho
753 doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more