Doctor insights on:
Neostigmine Side Effects
Anticholinesterase: neostigmine inhibits the activity of the enzyme responsible for breaking down the acetylcholine, the ubiquitous neurotranmitter. In anesthesia it is commonly used to reverse action of curare-like medications that cause muscle relaxation/ temporary paralysis necessary to facilitate surgery. Hope that helps ...Read more
Hypotension: neostigmine isn't used in hypotensive crisis, read this: https://books.google.com/books?id=5zd_W_PUwvYC&pg=PA193&lpg=PA193&dq=hypotensive+crisis+and+neostygmine&source=bl&ots=SWufyt2QhL&sig=5vWWEMUYn3pGZ3CDqoR_Gdq3hsM&hl=en&sa=X&ei=tj1aVYuZIcLKogSxyILwCg&ved=0CCAQ6AEwAA#v=onepage&q=hypotensive%20crisis%20and%20neostygmine&f=false ...Read more
Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks ?
Less time is ok.: Neostigmine has a very short "half-life". This means that it's eliminated from the body quickly. Virtually all it will be gone within a week of stopping. Studies show elimination of 1/2 of it in just 90 minutes. Another 1/4 in 90 more minutes. Another 1/8 in 90 more minutes, etc...So you can see by doing this math that Neostigmine will be completely gone from your system in quite a short time. ...Read more
Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks
why two weeks?"
Caution in pregnancy: Neostigmine is category c in pregnancy, meaning that we really don't know how safe it is because it hasn't been studied. You have to weigh the risks and benefit to the mother against that unknown. Particularly before conception there may be a higher risk of affecting the fetus during organogenesis, when all of the vital organs are being created. Second trimester may be a little safer. ...Read moreSee 1 more doctor answer
HyPOtensive crisis?: I've never heard of hyPOtensive crisis. HyPERtensive crisis, yes. When someone's blood pressure is dangerously low, that's called "shock." There's hemorrhagic shock & septic shock & shock from low cardiac output due to MI or CHF, etc. Drugs commonly known as pressors such as dopamine, dobutamine, and levarterenol are used to keep BP up. I'll defer to my intensivist colleagues for better answers. ...Read more