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Doctor insights on: Neonatal Cholestasis

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Meaning of neonatal jaundice?

Meaning of neonatal jaundice?

Jaundice : Physiologic neonatal jaundice is yellowing of the skin and whites of the eyes due to elevation of a breakdown product of old blood cells called bilirubin that builds up in newborns due to immaturity of liver enzymes. Pathologic neonatal jaundice can also result from various disease states. Phototherapy with special lights, or more aggressive therapy, may be needed to lower bilirubin to safe levels. ...Read more

Dr. William Singer
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Neonatal (Definition)

The term neonatal is generally used to describe events that occur with an infant within the first 30 days after birth.Some practitioners are looser with the definition & extend the ...Read more


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What causes most neonatal jaundice?

What causes most neonatal jaundice?

Jaundice: Most physiologic neonatal jaundice is caused by immaturity of the liver and inability to process all of the breakdown products of red blood cells leading to a build up of bilirubin. This may be exacerbated in breast fed infants. There are causes of neonatal jaundice that can represent disease states, but these are not the most n cause of neonatal jaindice. ...Read more

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What is acute neonatal hydramnios?

About the fetus: When the fetus is developing their is too much fluid in the uterine sac for fetal development. ...Read more

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How common is neonatal jaundice?

How common is neonatal jaundice?

Very: Most term normal newborns become jaundiced peaking around the 3rd to 5th day of life. Their livers being a bit immature have trouble breaking down bilirrubin, the substance that make you jaundiced. This type of jaundice resolves in the first 2 weeks. If you are nursing your baby, the yellow pigment may linger a bit. Babies that are premature or have medical problems, may have more serious jaundice. ...Read more

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What causes neonatal encephalopathy?

What causes  neonatal encephalopathy?

See below:: In ne, it is not always possible to document a significant hypoxic-ischemic insult. There are potentially several other etiologies, specifically, it is important to exclude metabolic disease, infection, drug exposure, nervous system malformation and neonatal stroke as possible causes of the encephalopathy. The nature of brain injury causing neurologic impairment in a newborn is poorly understood. ...Read more

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What causes neonatal jaundice in breastfed baby?

What causes neonatal jaundice in breastfed baby?

Depends,often normal: Mild jaundice is common & results from the baby's GI system just maturing & being able to excrete bilirubin. This happens when the liver becomes more functional during the first week or so of life. As the baby feeds, bilirubin leaves the body in the stool (hence yellow stools) & urine. If breastmilk is not yet in, more jaundice may occur. In other babies, it can be due to more serious conditions. ...Read more

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Neonatal alloimune thrombocytopenia treatment?

Neonatal alloimune thrombocytopenia treatment?

Platelet transfusion: If the fetus has an antigen on platelets that the mother lacks, she may make antibodies that destroy the fetal platelets. Infusing platelets that lack the antigen is the treatment. Platelets can be infused into the fetus in utero, if needed, . ...Read more

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Is neonatal sepsis related to hbo incompatibility?

Neonatal sepsis: No it is caused from infection and has nothing to do with ABO incompatibilty. ...Read more

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Is intrahepatic cholestasis of pregnancy painful?

Is intrahepatic cholestasis of pregnancy painful?

NO: Cholestasis of pregnancy does not generally cause pain. The most common symptoms is pruritis (itching). It almost always starts with itching on the palms of the hands and soles of the feet, and it is first noticed at night. The itching spreads to other parts of the body over time. Treatment with ursodiol (bile salts) can improve symptoms. Consultation with a high risk OB is recommended. ...Read more

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Meaning of neonatal jaundice? Heard brain damage.

Meaning of neonatal jaundice? Heard brain damage.

Rarely: Jaundice caused by high level of bilirubin in blood can lead to brain damage by compromising the integrity of neuronal cells. Infants with hemolytic disease, e.g., ABO incompatiblity, are at higher risk. Extreme preemies are also at high risk even with modestly elevated bilirubin level. ...Read more

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Is biliary atresia detected before birth?

Is biliary atresia detected before birth?

No: Biliary atresia is unsuspected until there is a persistent rise in bilirubin of the direct type. Initial imaging study should be a preprandial gall bladder ultrasound to see if gall bladder is present. ...Read more

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Neonatal alloimune thrombocytopenia, what is this?

Low platelets count: Neonatal alloimmune thrombocytopenia occurs when fetal platelets contain an antigen inherited from the father that the mother lacks. The mother forms antiplatelet antibodies against the this antigen; these cross the placenta and destroy fetal platelets, resulting in fetal and neonatal thrombocytopenia. Minority of affected newborns (about 20%) experiences severe bleeding including intracranial bl ...Read more

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How common is neonatal sepsis?

How common is neonatal sepsis?

2 per 1000: Fore every 1000 babies born alive, 2 get neonatal sepsis. Many more get treated for suspicion of sepsis. ...Read more

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Whats hemolytic disease of newborn?

Different blood type: Hemolytic disease of newborn is caused by different blood types in mom and baby. Classically, mom is rh negative (a- or o-, etc). The baby is rh positive. Mom then make rh antibodies that cross over to the baby and cause breakdown of the red blood cells. This can make the baby very sick. ...Read more

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What are the tests for neonatal jaundice?

What are the tests for neonatal jaundice?

Bilirubin: Jaundice is caused by an excess of bilirubin in the blood. Blood can be tested to see how high the bilirubin is. Blood type is important as is the hemoglobin and hematocrit. ...Read more

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How severe is neonatal lupus?

Transient-permanent: Some of the transient problems can reverse but are still serious. The rash can resolve, low platelets can improve but the heartblock can be permanent. ...Read more

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How rare is placenta abruption with polyhydramnios?

Less rare: Placental abruption is one of the increased risks associated with poly-hydramnios. Even then it is still fairly uncommon. ...Read more

Dr. William Singer
79 doctors shared insights

Cholestasis (Definition)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by ...Read more