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Doctor insights on: Neoadjuvant Chemotherapy Breast Cancer

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Colon cancer chemo necessary?

Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

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Dr. Barry Rosen
4,344 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Chemotherapy hormone receptor positive node breast cancer?

Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

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Is dcis breast cancer genetic?

Is dcis breast cancer genetic?

It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read more

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Breast cancer prevention?

Breast cancer prevention?

5 steps: 1. Maintain a healthy weight. Obesity increases your risk of breast cancer 2. Have babies and breast feed. These decrease your risk 3. Limit hormone therapy after menopause. 4. Decrease alcohol intake 5. Exercise - women who have regular physical exercise have a decreased risk of breast cancer. ...Read more

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What is inflammatory breast cancer?

What is inflammatory breast cancer?

Type of cancer: Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast. This type of breast cancer is called “inflammatory” because the breast often looks swollen and red, or “inflamed.” inflammatory breast cancer accounts for 1 to 5 percent of all breast cancers diagnosed in the United States. ...Read more

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Breast cancer chemotherapy in hepatitis b patients?

Breast cancer chemotherapy in hepatitis b patients?

Challenging : Appropriate involvement of hepatologist and treatment (or prophylaxis) of hep b is imperative. ...Read more

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Prognosis stage 3 breast cancer?

Prognosis stage 3 breast cancer?

Curable!: Stage 3 means the tumor is large and/or the cancer has spread to many lymph nodes. It can still be cured with a combination of surgery, chemotherapy and radiation therapy. The risk of cancer returning depends on many factors-- age, # of involved lymph nodes, and whether the cancer has hormone receptors or her2. About 50% of stage 3 breast cancer patients are cured. Have hope! ...Read more

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Is stage 3c breast cancer curable?

Is stage 3c breast cancer curable?

Yes: ...In theory, with aggressive multi modality therapy (surgery plus chemo plus radiation +/- hormones +/- herceptin). The risk of relapse is high but you do all you can and hope for the best. If this is about you, fight well and best wishes. ...Read more

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Abdominal carcinamatosis from breast cancer metastasis?

Abdominal carcinamatosis from breast cancer metastasis?

Could Be: You have a known breast ca? Any other mets? Typically, one would expect mets to bone before abdomen. If pathology on both sites is the same then probably mets. If not, possible second primary (like ovary). Good luck. ...Read more

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Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

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What is metastatic breast cancer?

What is metastatic breast cancer?

Spread : This means that the cancer has spread to other areas outside of the breast. This is known as stage 4. With the use of modern chemotherapy, this disease can be controlled. I recommend you meet with your medical oncologist to determine options available for treatment. ...Read more

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How is stage IV breast cancer different from stage III breast cancer?

How is stage IV breast cancer different from stage III breast cancer?

Location: In stage iii, the cancer still hasn't spread far beyond the breast and nearby lymph nodes. However, in this stage there typically are many lymph nodes involved or the tumor is so large it extends to the chest wall or involves the skin of the breast. stage IV breast cancer has spread to distant sites of the body. ...Read more

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Do people with stage IV metastatic breast cancer often undergo chemo?

Do people with stage IV metastatic breast cancer often undergo chemo?

Yes.: Under certain circumstances hormone therapy might be the initial treatment, but most stage 4 patients eventually undergo chemotherapy treatment. This will depend on age, tolerence for treatment, hormone responsiveness and other tumor characteristics. ...Read more

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Hormonal effects of chemotherapy for breast cancer?

Hormonal effects of chemotherapy for breast cancer?

Please clarify.: It is unclear from your question what you are asking. Most breast cancers are estrogen-sensitive and can be treated with anti-estrogen medication (tamoxifen, aromatase inhibitors). Many women who are peri menopausal when receiving traditional chemotherapy develop ovarian suppression from the chemo and effectively "go into" menopause. I hope this helps. ...Read more

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Metastatic breast cancer usually spread to liver?

Metastatic breast cancer usually spread to liver?

It may: Breast cancer can metastascise to many organs. Regionally to the lymph nodes and distantly to other organs. More commonly to the bones, lung, liver, brain and other visceral structures in the abdomen or pelvis. ...Read more

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How effective is Xeloda (capecitabine) for metastatic breast cancer?

How effective is  Xeloda (capecitabine) for metastatic breast cancer?

It depends: As the first treatment for metastatic breast cancer, Xeloda (capecitabine) works in 40-60% of people treated. If it is the second, third or later treatment after failure of other agents, the effectiveness is much less. ...Read more

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Describe breast cancer staging according tnm?

Describe breast cancer staging according tnm?

Tumor,Nodes,Mets: The t, n, m system classifies breast cancers based upon tumor size(t), lymph node status(n), and presence of cancer elsewhere in the body(m). Stage i is limited to small cancers +/- microscopic ln disease. Stage ii describes tumors 2-5cm +/- ln disease. Stage iii is for more advanced tumors (>5cm, skin/chest wall involvement) +/- multiple/distant ln. Stage IV describes metastatic disease. ...Read more

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How effectice is Xeloda (capecitabine) for metastatic breast cancer?

Quite effective: Xeloda (capecitabine) is quite an effective drug and has been used in metastatic breast cancer. The response will be higher when it is combined with other chemotherapy agent- with additional possible side effects. Discuss further with you oncologist in detail. ...Read more

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What is breast cancer sentinel node micro metastases?

What is breast cancer sentinel node micro metastases?

Spread of cells: Micrometastasis means that a few tumor cells have left the breast tumor and traveled to the lymph nodes under the arm. In most cases, this is treated as a negative lymph node. I encourage you to review your pathology report with your surgeon and oncologists (ideally they are communicating with each other through a meeting called a tumor board). ...Read more

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Dr. Barry Rosen
1,378 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Neoadjuvant (Definition)

Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and ...Read more