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Doctor insights on: Neoadjuvant

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Neoadjuvant (Overview)

Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed.


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What is adjuvant chemo?

What is adjuvant chemo?

Adjuvant chemo: Adjuvant chemo is chemotherapy that is given after curative surgical resection of a cancer. It is given to reduce risk of recurrence of cancer. ...Read more

Neoadjuvant (Overview)

Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed.


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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

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Colon cancer chemo necessary?

Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

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Dr. Liawaty Ho Dr. Ho
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Chemotherapy hormone receptor positive node breast cancer?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

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Is adjuvant therapy(chemo) effective for non-hodgkin's lymphoma cases?

Is adjuvant therapy(chemo) effective for non-hodgkin's lymphoma cases?

Yes: Chemotherapy is the primary treatment for non hodgkins lymphoma. It's effectiveness depend on several favors like stage, type of lymphoma, and the international prognostic index. ...Read more

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What exactly is neoadjuvant chemotherapy?

Chemo before surgery: When chemotherapy is given before surgery it's called neoadjuvant. When chemo or radiation is given in addition to and after surgery it's called adjuvant. It is only describing the order of the treatments. ...Read more

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Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more

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What exactly is adjuvant chemotherapy?

Preventative: Adjuvant therapy, is treatment given following the primary, main or initial treatment. It is usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to occult disease In contrast neoadjuvant therapy, is given before the main treatment to reduce the size of the tumor so as to facilitate more effective surgery. ...Read more

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How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

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Chemotherapy after bladder radical cystectomy needed?

Chemotherapy after bladder radical cystectomy needed?

Perhaps: Chemotherapy following bladder cancer removed by radical cystectomy may be advised depending on the stage of the cancer. A deeply invasive cancer, or a cancer with lymph nodes involved may be treated post-operatively with chemotherapy if chemotherapy was not used preoperatively. ...Read more

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Prognosis stage 3 breast cancer?

Prognosis stage 3 breast cancer?

Curable!: Stage 3 means the tumor is large and/or the cancer has spread to many lymph nodes. It can still be cured with a combination of surgery, chemotherapy and radiation therapy. The risk of cancer returning depends on many factors-- age, # of involved lymph nodes, and whether the cancer has hormone receptors or her2. About 50% of stage 3 breast cancer patients are cured. Have hope! ...Read more

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Is stage IV pancreatic cancer terminal?

Is stage IV pancreatic cancer terminal?

Yes?: As a rule, stage 4 cancer of the pancreas is incurable. As to being terminal, it depends on the definition. If you mean it will kill the patient at some point, the vast majority of the times the answer is yes. If you mean it will kill the patient right away, it depends on the situation. Never say never, though, some patients have surprised me in the past. Sorry if it is about you or a loved one. ...Read more

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Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Yes: Chemotherapy regimens based on the drug Fluorouracil (5-fu) have been part of the treatment for high-risk stage ii or stage iii colon cancer. Many clinical trials have shown that these regimens improve overall survival primarily by reducing the high risk of recurrence within the first two years after surgery. ...Read more

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Pancoast tumor metastisis survival rate?

Pancoast tumor metastisis survival rate?

Pancoast tumor: Occurs at the top of the lung and invades out and up to involve muscles, nerves, and thereby causing pain and horner's syndrome. Metastasis usually means going to another organ. If confined to chest and outward extension (?Metastasis), outlook is more optimistic. If it metastasized to brain, lung, liver or distant bones, the outlook is bleak, seek symptom management, there is no cure. ...Read more

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How effective is neoadjuvant therapy for treating colon cancer?

How effective is neoadjuvant therapy for treating colon cancer?

Partially: Chemotherapy in all of its forms is only partially helpful in improving the survival of colon cancer. When there is an effective neoadjuvant response the remaining lesion can be successfully resected. complete surgical extirpation is the needed result. As immunochemo becomes more effective then the combination with surgery will even produce better results. ...Read more

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Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

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How effective is Xeloda (capecitabine) for metastatic breast cancer?

How effective is  Xeloda (capecitabine) for metastatic breast cancer?

It depends: As the first treatment for metastatic breast cancer, Xeloda (capecitabine) works in 40-60% of people treated. If it is the second, third or later treatment after failure of other agents, the effectiveness is much less. ...Read more

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Is metastatic anal cancer terminal?

Is metastatic anal cancer terminal?

Unfortunately: Metastatic disease (also known as stage 4) is usually not curable by todays treatments. Although use of chemotherapy may improve survival and may rarely put someone into a temporary remission the disease usually returns or more often does not go away and eventually progresses and the patient will eventually succumb to it. ...Read more

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Is stage IV metastatic cancer treatable?

Depends: Some cancers are curable with today's chemotherapy even if they have spread extensively. Others (for example, the common lung cancers) may someday be curable when they have reached stage iv, but not today. I've just seen reports of possible cures of stage IV colon and stomach cancers; i'm hopeful. ...Read more

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What is the definition or description of: neoadjuvant?

What is the definition or description of: neoadjuvant?

Pre-Therapy: Neoadjuvant therapy is the administration of therapeutic agents before a main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. Neoadjuvant therapy aims to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed. ...Read more

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What exactly is neoadjuvant chemotherapy?

Chemo before surgery: When chemotherapy is given before surgery it's called neoadjuvant. When chemo or radiation is given in addition to and after surgery it's called adjuvant. It is only describing the order of the treatments. ...Read more

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Can you explain neoadjuvant therapy in cancer treatment?

Can you explain neoadjuvant therapy in cancer treatment?

Neoadjuvant therapy: Is typically used when a patient needs a tumor surgically removed but the doctors think it would be best to shrink the tumor some before the surgery actually happens. Neoadjuvant therapy can be chemotherapy and/or radiation therapy. Typically, after a few weeks of this treatment, the surgeons remove the tumor, hopefully with greater success than they would have had before the additional therapy. ...Read more

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What are side effects of adjuvant and neoadjuvant therapy?

What are side effects of adjuvant and neoadjuvant therapy?

Side effects: Side effects are same either neo or adjuvant. It also depends on type of therapy use. Nausea, vomiting, hair loss, lowering blood counts, lower immunity and some specific effects related to type of chemo. ...Read more

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How effective is neoadjuvant therapy for treating colon cancer?

Partially: Chemotherapy in all of its forms is only partially helpful in improving the survival of colon cancer. When there is an effective neoadjuvant response the remaining lesion can be successfully resected. complete surgical extirpation is the needed result. As immunochemo becomes more effective then the combination with surgery will even produce better results. ...Read more

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The doctor is talking about neoadjuvant therapy. What is this?

The doctor is talking about neoadjuvant therapy.  What is this?

Add. therapy first: Neoadjuvant therapy involves giving an initial form of therapy before the main therapy in order to improve the overall outcome. For example, chemotherapy may be given first prior to resection of a tumor to improve the chances of a complete resection. ...Read more

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Had last a/c/t chemo for neoadjuvant breast cancer, was told to make appt this month to measure toxicity from chemo. How is this done & what to expect?

Had last a/c/t chemo for neoadjuvant breast cancer, was told to make appt this month to measure toxicity from chemo. How is this done & what to expect?

Blood counts: Medical oncologists often check blood counts (CBC) in the few months after chemotherapy to make sure they are recovering appropriately. Women who had neoadjuvant chemo should also be seeing their breast surgeon to plan for surgery. ...Read more

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What neoadjuvant chemotherapy treatment would you recommend for Triple Negative Breast Cancer, staged T1N0M0?

What neoadjuvant  chemotherapy treatment would you recommend for Triple Negative Breast Cancer, staged T1N0M0?

Ask your...: It would be much easier and most logical to ask your medical and surgical oncologists since they know more of your individual situation than anyone online and nowadays the care for malignancy is multi-disciplinary. There are not many oncologists around online. To make you abler to interact with doc, please peruse articles in http://formefirst.com/onLifeBasics.html. ...Read more

Dr. Liawaty Ho Dr. Ho
1 doctor agreed:
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Stage 2B idc breast cancer-neoadjuvant ... Had taxol/herceptin (trastuzumab) for 16wks. Now a/c chemo.. Is it risky to be without herceptin (trastuzumab) until surgery in jan?

Dr. Liawaty Ho Dr. Ho
1 doctor agreed:
Stage 2B idc breast cancer-neoadjuvant ... Had taxol/herceptin (trastuzumab) for 16wks. Now a/c chemo.. Is it risky to be without herceptin (trastuzumab) until surgery in jan?

Should be okay: You are receiving ac now and i think (and i hope) it should take care you cancer well --to shrink it down further- so you can have surgery in january. It is not safe to combine adriamyicn and Herceptin (trastuzumab) as it could give you significant problem with your heart. Once you are done with surgery- you will need Herceptin (trastuzumab) to be continued for 1 year. ...Read more

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Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

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Stage 2b, her 2 breast cancer, 40 yrs old-dx 4/13-neoadjuvant treatment. Just recently diagnosis with several pulmonary emboli. What should I ask my doctor?

Stage 2b, her 2 breast cancer, 40 yrs old-dx 4/13-neoadjuvant treatment. Just recently diagnosis with several pulmonary emboli. What should I ask my doctor?

Cause and Treatment: Cancers can cause blood clots most often as a result of not walking after recent surgery with a blood clot forming in the legs which then breaks off and goes to the lungs. This is treated with blood thinning medications and if contraindicated a vena caval filter can be placed which catches the clots. Why you developed this and how long and what type of treatment for this is advisable to ask. ...Read more

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Would you do neadjuvant therapy for a 37 year old women with a fast growing tumor, er+, pr+, her- ?

Would you do neadjuvant therapy for a 37 year old women with a fast growing tumor, er+, pr+, her- ?

Depends on reason: Neoadjuvant chemotherapy is typically given in a situation where mastectomy is indicated but with treatment the tumor is shrunk to allow breast conserving surgery. Another situation would be in inflammatory breast cancer. ...Read more

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Who am i?

A little more: Your question will need to have a little more context in order to receive a meaningful answer. If it was meant to check if questions are answered here you have your answer. ...Read more

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Am I dying?

Am I dying?

We all are: A 3-word question with no details... well, life is short on Earth, regardless of whether a person lives 3 days, 3000 days, or 30,000 days. It is not length of one's life that matters, but the quality of the life lived. The goal is not to live a long life, but to live a good life. Even if a person makes it all the way to age 82, that's only 30,000 days. ...Read more

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I have cold?

I have cold?

Symptoms?: The most common symptoms of a cold are sneezing, running nose, congestion and scratchy throat. Additional symptoms can be coughing, headaches, mucus dripping down the back of the throat, loss of appetite and fever (in children). ...Read more

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I have cold?

I have cold?

Cold: Tips: sore throat – gargle with warm salt water (1/2 tsp salt in 8 oz of water). Get strep test/culture if very sore. Congestion – saline nose drops or netti pot. For anti-inflammatory effect & mobilizing mucus- homemade chicken noodle soup. Hydrate- lots of water/clear broth/ add honey & a small amt. Of lemon juice to chamomile tea.. Fever/ pain – Acetaminophen / nsaid’s rest! ...Read more

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What is asp?

What is asp?

In acupuncture an: Asp is an acupuncture semi-permanent needle. They are made in germany & come in stainless steel, gold, silver & titanium. They are used for auricular (ear) acupuncture. They are usually referred to as "asp's". ...Read more

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Pls help me?

Help: In order to assist you - you need to provide us with more information. Please re-ask and clarify the question that you need help with. Take care. ...Read more

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