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Doctor insights on: Negative Western Blot Lyme

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

Dr. Randy Baker
657 doctors shared insights

Lyme Disease (Definition)

A tick-borne illness caused by the bacterium borrelia burgdorferi that results in symptoms of fever, headache, fatigue, and a characteristic skin ...Read more


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Tested false positive ELISA HIV test last month. Negative ifa and western blot and naat. 2 negative oraquick all 1 1/2 year post exposure. Hiv?

Tested false positive ELISA HIV test last month. Negative ifa and western blot and naat. 2 negative oraquick all 1 1/2 year post exposure. Hiv?

Negative: If nat was negative at 6 months after exposure you not likely to have hiv. Given all the negative test results, you should not worry about the one apparently false positive. ...Read more

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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

see details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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Can an HIV antibody screening test be positive but the western blot negative?

Yes: There are 2 reasons for this kind of result: (1) a false positive, or (2) early infection before seroconversion. In someone at low risk for HIV without symptoms, another negative WB in 1 month means there's no infection. In someone at risk or with symptoms of acute infection, a viral load can be helpful. The new 4th generation antigen/antibody tests will eliminate this problem. ...Read more

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2009- ELISA HIV test- positive, western blot- neg. 2010-oraquick negative. 2014- elisa-indeterminate wb- neg. Low risk for hiv. Could I have lupus?

2009- ELISA HIV test- positive, western blot- neg. 2010-oraquick negative.  2014- elisa-indeterminate wb- neg. Low risk for hiv. Could I have lupus?

Not a test for lupus: The HIV test is not a test for lupus. What's clear is that you don't have hiv. You'll never know why your elisa was positive and then indeterminate, and it's not worth investigating. False positive elisas are not uncommon; that's why they have to be confirmed with western blot. ...Read more

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how accurate is Lyme disease western blot?

how accurate is Lyme disease western blot?

High disease area?: The Western Blot is the 2nd (after the ELISA) in a 2-step process. An individual in an area where Lyme disease is common & with high exposure to Lyme-disease carrying tick bite who has been bitten by an engorged tick is highly likely to have Lyme disease if these tests are positive. Without these risk factors, a positive test could be falsely positive. ...Read more

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Does the western blot trump the elisa? Tested positive via ELISA IgG for hsv2,but later tested negative via western blot. No symptoms. Do I have hsv2?

Does the western blot trump the elisa? Tested positive via ELISA IgG for hsv2,but later tested negative via western blot. No symptoms. Do I have hsv2?

Western blot more: specific, ELISA more sensitive. One positive ELISA and one negative Western blot says that you do not have enough antibodies to HSV 2 for confirmation of diagnosis. It may be prudent to repeat the tests in 3-4 months to make sure that negative Western blot was not due to incomplete/early immune response. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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Positive HIV screener test at blood donation... Negative IFA and Negative NAT... False positive?

Positive HIV screener test at blood donation... Negative IFA and Negative NAT... False positive?

Yes: The initial screening test for HIV is very sensitive, but not very specific. The back up screening tests are much more specific for HIV. ...Read more

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2 false pos ELISA HIV tests, all 1 1/2 years post exposure. Neg western blot, ifa, naat and 2 neg oraquick home tests. What is my HIV status? Help!

2 false pos ELISA HIV tests, all 1 1/2 years post exposure. Neg western blot, ifa, naat and 2 neg oraquick home tests. What is my HIV status? Help!

Likely negative: There is typically a "window" of 3-6 months after exposure where you could be HIV positive but test negative. Since you didn't get your testing until well after that, i'd say the confirmatory tests (western blot, ifa) are what you should go by. The elisa is very sensitive and can have false positives- that's why we rely on the confirmatory tests. I would consider your status to be negative. ...Read more

Dr. John Chiu Dr. Chiu
2 doctors agreed:
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Postive Elisa test,positive band 41 western blot positive Ana antibodies- soar throat and extreme fatigue after eating ANYTHING- autoimmune disease?

Dr. John Chiu Dr. Chiu
2 doctors agreed:
Postive Elisa test,positive band 41 western blot positive Ana antibodies- soar throat and extreme fatigue after eating ANYTHING- autoimmune disease?

No: I think it may be a good idea for you to consult an allergist. Autoimmune disease is not related to foods although there is no reason why you cannot have more than one illness. ...Read more

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

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Can western blot tests be wrong?

Yes: There are no lab tests that are perfect. But there are usually alternative tests that can be used if there is a valid question about the results. ...Read more

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Is an HIV ELISA test always done with an western blot test?

No: In general, the elisa is done first, and the lab then does a western blot if the elisa is positive. However, it is possible to order just the western blot, in which case the elisa usually isn't done. ...Read more

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Are Lyme tests Elisa & western blot actually unreliable half the time like holistic/naturopath doctors or LLMD's say?

Not true: Naturopaths spend a great deal of time and effort promoting themselves by debunking conventional medicine. But who do you think they go to when they are sick? The tests you mention are mostly reliable but there is a small margin of error for any tests. To say these are unreliable at the 50% level is marketing and untrue. ...Read more

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Hiv 7months ELISA test negative 100% accurate?

Hiv 7months ELISA test negative 100%  accurate?

No: If positive, it will be followed up with a confirmatory test. If negative, you are almost certainly okay but if you are very worried you might be able to pay for a pcr assay, which is the gold standard. ...Read more

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Can MS cause false positive ELISA HIV test?

No: MS does not affect blood tests, and specifically does not cause positive ELISA HIV test, See infectious disease doctor. ...Read more

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