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Doctor insights on: Negative Ana

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Can low IgA cause false negative ana?

Can low IgA cause false negative ana?

No: Two diff entities one is autoimmune other one immunity of mucosal lining. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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What does it mean when you have symptoms and have had several positive and both negative ANA tests and autoimmune tests? I want answers to my sympt.

Not enough info: You have not provided enough specifics about you symptoms to draw a conclusion. Have you seen a rheumatologist? ...Read more

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Could a person with 2 different negative ANA tests have lupus?

Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: Negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info.

http://www. Webmd. Com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

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I have ds DNA of 1:20, but negative ANA. What would this indicate?

How do you FEEL?: Both the dsDNA tube test and the fluorescent ANA are fraught with pitfalls. This is information useful toward ruling lupus in or out, but the decision to treat will be made clinically, and that's what matters. I'm sorry it's confusing and I wish you the best. ...Read more

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Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Yes: There is such a thing as ANA negative lupus. The ANA is nehative in 5-10% of lupus patients. ...Read more

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I have 10 out of 12 symptoms of lupus but a negative ana. Can my ANA be negative one time and positive another?

ANA negative SLE: About 5% of the patients with systemic lupus are ANA negative. Read the information at the site given below. Please discuss the issue with your doctor sle is not a topic for self diagnosis.
http://www. Lupus. Org/webmodules/webarticlesnet/templates/new_aboutfaq. Aspx? Articleid=380&zoneid=19. ...Read more

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Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast.?

Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast.?

See details: Have you seen a rhematologist? If not, do so. If you have, get a second rheumatology opinion. If the doc has ruled out lupus ask for your diagnosis and treatment options. ...Read more

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Does a negative ANA rule out all autoimmune diseases?

No.: The ANA test is not perfect. It is positive in some people who do not have an autoimmune disease. Also, there are other tests that are important in checking for some autoimmune diseases. Finally, an ANA test (positive or negative) has to be interpreted along with a patient's clinical symptoms under the guidance of a physician. ...Read more

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Would a negative ANA rule out lymphoma? Does lymphoma cause a positive ANA test result?

It does not: At your age, if you have lymphoma it's probably Hodgkin's. ANA really has nothing to do with malignant lymphoma. If you're worried about big lymph nodest, trust me -- lymphoma nodes are obviously very abnormal. Best wishes, and I hope you'll always stay actively involved with your health. ...Read more

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What could be causing my joint pain? Negative ana?

What could be causing my joint pain? Negative ana?

Many causes: There are over one hundred causes of musculoskeletal pain. A negative ANA only rules out a few causes. A negative ANA is a good thing but you need to be more specific about joint pain. ...Read more

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Can you still have lupus if you have a negative ANA and normal sed rate?

Yes: However, the diagnosis becomes much less likely unless several other diagnostic criteria for lupus are present. ...Read more

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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I have a elevated temperature 99.2 during the day. Could stress cause this? I have a normal CBC & negative ANA test.

I have a elevated temperature 99.2 during the day. Could stress cause this? I have a normal CBC & negative ANA test.

Possible: Possible that stress than cause this. I would also have your thyroid checked. You may just run a bit warm, most of us are not exactly 98.6. Also depends on where you are checking your temperature and with what kind of device. ...Read more

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After positive Ana1:80 antism 13 then to negative Ana? Still lupus? Urobilinogen 3, still sick with symptoms esp pluerisy for months

Clinical correlation: The anti-nuclear antibody titer not only fluctuates, but is also prone to lab error. The urobilinogen pad on the urine test is also fraught with pitfalls. If the anti-Sm was a tube test and the level is clearly in the lab's positive range, consider that it's most likely that you have lupus but that it may have gone quiescent. Try to exercise hard; consider distance swimming, for fibromyalgia. ...Read more

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I have a high ch50 level but negative ana. I was just informed that I have ecoli in my urine...Could that cause the ch50 level to be high?

Yes infections can: Infections can cause elevation of the ch50levels and it may be the case here. But discuss with your doctor as he has more information as to why he or she ordered the test in first place. ...Read more

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I had a negative ANA test but positive double stranded DNA test do I have lupus?

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

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What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.

Lab problem: The ANA screening test is fraught with pitfalls, and if you have a way-high titer of U1-RNP on the tube test and symptoms / signs of mixed connective tissue disease (which is a rough thing) but ANA is negative, perhaps there's a problem with the substrate. Your physician will want to call the lab's pathologist -- he / she would be interested in knowing. Best wishes. ...Read more

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Kidney nephritis- can high dose Valacyclovir/Valtrex (4g daily)cause it? Negative ANA but mild kidney nephritis consistent with ckd.

Kidney nephritis- can high dose Valacyclovir/Valtrex (4g daily)cause it? Negative ANA but mild kidney nephritis consistent with ckd.

?: Unlikely, this is complex, depends on several factors, underlying conditions, and other medications taken concomitantly, your treating doctors can answer you better, but why are you on this high dose of valacyclovir? ...Read more

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If I have an elevated CRP and est with a negative ANA what could this indicate? I have type 1 dm and fibromyalgia. They were suspecting lupus

The: The ESR and CRP are both markers of inflammation. However, they are very non-specific and can be elevated in a wide variety of conditions including infections, malignancies, and auto-immune diseases. The ANA is the screening test for lupus and similar conditions. It has many false positives but very few false negatives. In your case, the negative ANA most likely means that you elevated ESR and CRP are not due to lupus. ...Read more

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What does a high positive ELISA but negative ANA mean for a Lupus Screening? How are they different and how can 1 be positive and one negative?

ANA: 1. ELISA is an immunoassay used to screen for ANA (high sensitivity, relatively low specificity). Can have false positive even with high titer. 2.If ELISA positive, usually a confirmation test will follow. Indirect Fluorescent Antibody Assay (IFA) is more specific test used as a golden standard to detect ANA. Hope that helps. ...Read more

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I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

NOT LUPUS: Seek a second opinion from a rheumatologist. You may have other medical conditions that mimic lupus. You will need additional blood and urine testing. ...Read more

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Can someone obese with only malar rahs and physical urticaria and negative ANA have lupus?

Yes: Discoid lupus most often will not have a positive ana. See a dermatologist. A biopsy of the rash may provide the specific diagnosis. ...Read more

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Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Rheumatologist: This test alone is insufficient to diagnose lupus. It has to be supplemented with appropriate symptoms and physical findings. A rheumatologist is best qualified to evaluate, advise, and treat you, if needed. ...Read more

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I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

See a rheumatologist: A positive lupus band test on a skin biopsy suggests cutaneous lupus but not necessarily systemic lupus. See a rheumatologist. It is presumptuous for a primary care physician to tell you what he/she did. ...Read more

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I've had a high c reactive protein for a year. I've had facial flushing and joint pain. Negative Ana test. What could this be?

Rheumatologic.: This does point to some rheumatologic condition. More testing is warranted. The ANA doesn't tell the whole story in this regard. ...Read more

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Prime doc says positive rnp, rheumy says negative ana, and false positive for mctd. No symptoms but hashimotos. Does this sound conclusive?

See below: There a lot of false positive rnps. There are certain criteria that must be met to be labeled with mctd. If your rheumatologist says that is not consistent with mctd, he or she may be right, but we cannot comment definitive without performing an exam and reviewing your history and labs. ...Read more