Doctor insights on:
Necrotizing Respiratory Granulomatosis
Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan. If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more
Granulomatosis is also known as Wegener's Granulomatosis. A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive ...Read more
ANCA and biopsy: The most useful blood test is an anca with titer and pattern, and pr3/mpo confirmation. Biopsy of the affected tissue is also important. Imaging studies of the lungs and sinuses can be useful as well as blood and urine tests looking for kidney damage. Finally, EMG might be needed if there is concern for nerve damage. ...Read moreSee 1 more doctor answer
Rash sinus lung: It is called polyangiitis with granulomatosis and is different in different people. This problem is caused by inflammation in the blood vessels which go everywhere in the body. Common symptoms include rash, sinus inflammation, lung problems which can be manifest by a cough. The kidney can be involved also but often this is asymptomatic. We can see other sites like the eyes, nose, etc. ...Read more
Immune vasculitis: The antobodies found in the test and that cause the disease are directed against an antigen within neutrohils. Untreated, Wegener's (granulomatous angiitis for those who cannot forgive Dr. Wegener's being a German during WWII) is fatal. Nowadays it can be managed using cyclophosphamide and/or perhaps other powerful agents and most people eventually recover. ...Read more
It is not: It is an autoimmune illness that strikes at random. ...Read more
Serious condition: This is a very rare disease which is a form of vasculitis(inflammation of the blood vasculitis) it commonly causes, sinusitis, has associated lung nodules and is associated with varying degrees of kidney damage which can lead to kidney failures. But it is treatable, usually requiring chemotherapy(although it is not cancerous!). ...Read more
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