Doctor insights on:
Natural Pde5 Inhibitors
What is the natural inhibitor of insulin in the body or does it break down and what makes it break down and into what?
Glucagon: Insulin stimulates glucose uptake into cells, and glucagon stimulates glucose release by cells, mostly the liver. Glucagon is not really an Insulin inhibitor, but a counterregulatory hormone. If your glucose is low, you need glucagon and adrenaline to get glu back up. Insulin is cleared from plasma quickly mostly by liver and kidney; chopped up by protease enzymes into inactive pieces. ...Read more
Info-"whole flaxseed has natural enzyme inhibitors to prevent digestion.Milling or grinding does not reduce the inhibitors.Only sprouting helps".True?
Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.) Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more
Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?
Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more
Are there any good 5-alpha-reductase inhibitors that are natural products to treat female pattern alopecia ? Shampoos, cleansers or caplets etc...
No - beta-sitosterol: No -there are no 5-aris available indicated to treat female-patterned alopecia. As far as otc products, beta-sitosterol probably does have activity similar to the 5-aris, but is only 1/1000th as potent, and, again, is not indicated for female-patterned alopecia. ...Read more
If a natural weightlifter took anti cancer medication (aromatase inhibitor), shouldn't his testosterone level increase dramatically?
Increase somewhat: Aromatase inhibitors inhibit the effect of estrogen on the pituitary gland as well as elsewhere. As a result they can increase pituitary hormones that stimulate testosterone production modestly, not usually dramatically. By the way, these medications are banned by most major sports ...Read more
I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?
Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more
Inhibitors: Also called inhibiter a person or thing that inhibits 2. (chemistry) also called anticatalyst a substance that retards or stops a chemical reaction compare catalyst 3. (life sciences & allied applications / biochemistry) biochem a. A substance that inhibits the action of an enzyme b. A substance that inhibits a metabolic or physiological process a plant growth inhibitor. ...Read moreSee 1 more doctor answer
Pain med: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read moreSee 1 more doctor answer
Different: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read moreSee 1 more doctor answer
Question unclear: Inhibitors of what? Substances which are inhibitors block a physiologic pathway and often there is a balance between stimulators and inhibitors which shifts with body needs. There are also numerous medications which inhibit physiologic or pathophysiological functions. ...Read more
No and Yes: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read more
Come again?: Are you asking about endogenous substances like inhibitory neurotransmitters or exogenous substances (drugs)? Physicians and neuroscientists don't generally think in the terms in which you've framed your question. Put another way, your question is too vague. Try reposting it with a more specific (and longer) description of what question you're trying to get answered. ...Read more
Biochemistry enzymes: One induces and other inhibits action of enzyme. Great Wikipedia question. If you have never heard of it always go there first before coming here. ...Read more
Can you build tolerance to a pde5 inhibitor?How to reverse it/avoid it?What can I take to make it more effective?Will a detox help reverse tolerance?
Here are some...: What are your age and overall health background? Just like any drug, PDE-5i boosts up the marginal functional impairment so to enhance erectile dysfunction but would not stop continual accumulation of undesirable ill effects of aging. On top of that, as men age, esp. after 30, physiological replenishing ability gradually diminishes. So, nothing can reverse aging effect... ...Read more
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