Doctor insights on:
Natural Mao Inhibitors
What is the natural inhibitor of insulin in the body or does it break down and what makes it break down and into what?
Glucagon: Insulin stimulates glucose uptake into cells, and glucagon stimulates glucose release by cells, mostly the liver. Glucagon is not really an Insulin inhibitor, but a counterregulatory hormone. If your glucose is low, you need glucagon and adrenaline to get glu back up. Insulin is cleared from plasma quickly mostly by liver and kidney; chopped up by protease enzymes into inactive pieces. ...Read more
Info-"whole flaxseed has natural enzyme inhibitors to prevent digestion. Milling or grinding does not reduce the inhibitors. Only sprouting helps".True?
Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.)
Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more
Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?
Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more
Are there any good 5-alpha-reductase inhibitors that are natural products to treat female pattern alopecia? Shampoos, cleansers or caplets etc...
No - beta-sitosterol: No -there are no 5-aris available indicated to treat female-patterned alopecia. As far as otc products, beta-sitosterol probably does have activity similar to the 5-aris, but is only 1/1000th as potent, and, again, is not indicated for female-patterned alopecia. ...Read more
If a natural weightlifter took anti cancer medication (aromatase inhibitor), shouldn't his testosterone level increase dramatically?
Increase somewhat: Aromatase inhibitors inhibit the effect of estrogen on the pituitary gland as well as elsewhere. As a result they can increase pituitary hormones that stimulate testosterone production modestly, not usually dramatically. By the way, these medications are banned by most major sports ...Read more
I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?
Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more
Will cause severe BP: Tyramine in large doses can raise your blood pressure, that can cause a stroke and death. Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam. ...Read more
Increase BP: Tyramine in large doses can raise your blood pressure, that can cause a stroke and death. Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam. ...Read more
Ok: Neither one are MAO inhibitors. OK to take together. ...Read more
Certain ones: In my practice and with my patients with various anxiety disorders, I often find the tricyclic antidepressant nortriptyline to be quite beneficial. Some doctors who did not receive their training until the 90s, may not feel comfortable prescribing some of the older medications. ...Read more
In general, MAO inhibitors refer to specific prescription antidepressant drugs & are highly regulated. Many foods & herbs have mild MAO inhibiting actions, such as carrots, chocolate, coffee, ginger, grape & onions, but these effects are not clinically significant & they don't need to be avoided if on a med that interacts with MAO inhibitors:
http://www. Botanical-online. Com/english/vegetalmaois. Htm ...Read more
What happens if I take Zoloft and a mao inhibitor like marplan, nardil, and parnate (tranylcypromine)?
Contraindicated: Taking a monoamine oxidase inhibitor (maoi), such nardil, marplan, or Parnate (tranylcypromine) with a serotonin selective reuptake inhibitor (ssri) such as zoloft is contraindicated. When taken together they can lead to serotonin syndrome. This potentially deadly syndrome may cause agitation or restlessness, fast heart beat, hallucinations, increased body temperature, loss of coordination, and nausea. Seek help! ...Read more
My mom (75 years old but biologically younger) has early parkinson's. Any downside to mao-b inhibitor instead of levodopa if symptoms minimal?
Neurologist can help: A small amount of information is on the internet regarding MAO inhibitors (such as selegiline) and l-dopa to treat parkinson's. Among elderly patients, individuals can react quite differently to various meds & doses, so a person's treatment has to be customized. It appears that using both meds allows one to use a lower dose of l-dopa. The list of selegiline side effects looks milder than l-dopa's. ...Read more
Also called inhibiter a person or thing that inhibits
2. (chemistry) also called anticatalyst a substance that retards or stops a chemical reaction compare catalyst
3. (life sciences & allied applications / biochemistry) biochem
a. A substance that inhibits the action of an enzyme
b. A substance that inhibits a metabolic or physiological process a plant growth inhibitor. ...Read more
Pain med: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read more
Different: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read more
Question unclear: Inhibitors of what? Substances which are inhibitors block a physiologic pathway and often there is a balance between stimulators and inhibitors which shifts with body needs. There are also numerous medications which inhibit physiologic or pathophysiological functions. ...Read more
No and Yes: Cox-1 (cyclooxygenase-1) is an enzyme that regulates prostaglandins, and is important for a healthy stomach lining and kidneys. Inhibition turns this off, leading to gastrointestinal bleeding. Cox-2 (cyclooxygenase-2) is an enzyme that makes the prostaglandins which increase inflammation, pain and fever. So a cox-2 inhibitor is, in effect, a pain blocker. ...Read more
Come again?: Are you asking about endogenous substances like inhibitory neurotransmitters or exogenous substances (drugs)? Physicians and neuroscientists don't generally think in the terms in which you've framed your question. Put another way, your question is too vague. Try reposting it with a more specific (and longer) description of what question you're trying to get answered. ...Read more
Biochemistry enzymes: One induces and other inhibits action of enzyme. Great Wikipedia question. If you have never heard of it always go there first before coming here. ...Read more
Drug out of China: Huperzine a might have some benefit similar to drugs such as donepezil, rivastigmine, or galantamine, (galantamine hydrobromide) as it too, is a cholinesterase inhibitor. Has received hype in the alternative literature, due to lack of branding and commercial ownership, but it is unlikely to be any better than the above prescription meds. Do not waste money pursuing the "chinese aricept". ...Read more
Complex question!: D, there exists a situation where a single drug acts as both inducer and affected drug, called autoinduction. Carbamazepine and artemisinin are examples of cyp3a4 and cyp2b6 substrates and inducers, respectively, that are known to exhibit autoinduction. Autoinduction is a phenomenon that can occur anytime a drug induces an enzyme which is also predominately involved in its own metabolic clea. ...Read more
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